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Prognostic value of cardiovascular magnetic resonance in immune checkpoint inhibitor-associated myocarditis:A systematic review and meta-analysis

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Cancer Innovation 2024年第3期3卷 22-32页

作者： Wenhua Song Nan Zhang Tonglian Lv Yang Zhao Guangping Li Gary Tse Tong Liu Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of CardiologySecond Hospital of Tianjin Medical UniversityTianjinChina department of Radiology Second Hospital of Tianjin Medical UniversityTianjinChina School of Nursing and Health Studies Hong Kong Metropolitan UniversityHong KongChina Cardiac Electrophysiology Unit Cardiovascular Analytics GroupPowerHealth LimitedHong KongChina

Background:The role of surgery in metastatic breast cancer(MBC)is currently *** novel statistical and deep learning(DL)methods promise to infer the suitability of surgery at the individual ***:The objective of this study was to identify the most applicable DL model for determining patients with MBC who could benefit from surgery and the type of surgery ***:We introduced the deep survival regression with mixture effects(DSME),a semi-parametric DL model integrating three causal inference *** models were trained to make individualized treatment *** who received treatments in line with the DL models'recommendations were compared with those who underwent treatments divergent from the *** probability weighting(IPW)was used to minimize *** effects of various features on surgery selection were visualized and quantified using multivariate linear regression and causal ***:In total,5269 female patients with MBC were *** was an independent protective factor,outperforming other models in recommend-ing surgery(IPW-adjusted hazard ratio[HR]=0.39,95%confidence interval[CI]:0.19–0.78)and type of surgery(IPW-adjusted HR=0.66,95%CI:0.48–0.93).DSME was superior to other models and traditional guidelines,suggesting a higher proportion of patients benefiting from surgery,especially breast-conserving *** debiased effect of patient characteristics,including age,tumor size,metastatic sites,lymph node status,and breast cancer subtypes,on surgery decision was also ***:Our findings suggested that DSME could effectively identify patients with MBC likely to benefit from surgery and the specific type of surgery *** method can facilitate the development of efficient,reliable treatment recommendation systems and provide quantifiable evidence for decision-making.

关键词： breast surgery causal inference deep learning metastatic breast cancer

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Flexible,efficient,and accurate tests for epidemics

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Science China Mathematics 2024年第8期67卷 1881-1898页

作者： Linjiajie Fang Bing-Yi Jing Shen Ling Qiyue Wang Qing Yang Data Science and analytics Thrust The Hong Kong University of Science and TechnologyHong KongChina department of Statistics and Data Science Southern University of Science and TechnologyShenzhen 518055China department of Mathematics and Statistics Dalhousie UniversityHalifaxNS B 3H 4R 2Canada department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina

group testing involves discovering a small subset of distinguished subjects from a large population while efficiently reducing the total number of *** has been widely used for industrial testing,information technology,and biology,especially epidemic ***,in reality,are noisy for the presence of false *** tests are accurate but time-consuming,while others are cheaper but less *** which test to use is constrained by various considerations,such as availability,cost,accuracy,and *** this paper,we propose flexible,efficient,and accurate tests(FEATs).FEATs are based on group testing with simple but careful designs by incorporating ideas such as close contact cliques and repeated *** could dramatically improve the efficiency or accuracy of existing *** example,for accurate but slow tests,the FEAT can improve efficiency multiple times without compromising *** the other hand,for fast but inaccurate tests,the FEAT can sharply reduce the false-negative rate(FNR)and significantly increase *** justifications are *** point out some scenarios where the FEAT can be effectively employed.

关键词： epidemiology control blood testing testing efficiency testing accuracy

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A dysregulated calcium homeostasis as the earliest pathological sign in stem cell-derived Parkinson's disease neurons?

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Neural Regeneration Research 2024年第7期19卷 1421-1422页

作者： Nilima Prakash Working group Human Stem Cell Research Department Hamm 2Hamm-Lippstadt University of Applied SciencesHammGermany

Parkinson’s disease(PD) is characterized by the slow and progressive demise of dopamine(DA)-synthesizing neurons in the substantia nigra pars compacta(SNc),a nucleus located in the human ventral *** death also affects other regions in the brain at later stages of *** concomitant lack of DA in the human forebrain(striatum) leads to the typical motor symptoms of this still uncurable neurodegenerative disorder.

关键词： homeostasis dopamine death

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Multi-scale cross-domain alignment for person image generation

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CAAI Transactions on Intelligence Technology 2024年第2期9卷 374-387页

作者： Liyuan Ma Tingwei Gao Haibin Shen Kejie Huang department of Information Science&Electronic Engineering Zhejiang UniversityHangzhouZhejiangChina Alibaba group HangzhouChina

Person image generation aims to generate images that maintain the original human appearance in different target *** works have revealed that the critical element in achieving this task is the alignment of appearance domain and pose *** alignment methods,such as appearance flow warping,correspondence learning and cross attention,often encounter challenges when it comes to producing fine texture *** approaches suffer from limitations in accurately estimating appearance flows due to the lack of global receptive ***,they can only perform cross-domain alignment on high-level feature maps with small spatial dimensions since the computational complexity increases quadratically with larger feature *** this article,the significance of multi-scale alignment,in both low-level and high-level domains,for ensuring reliable cross-domain alignment of appearance and pose is *** this end,a novel and effective method,named Multi-scale Crossdomain Alignment(MCA)is ***,MCA adopts global context aggregation transformer to model multi-scale interaction between pose and appearance inputs,which employs pair-wise window-based cross ***,leveraging the integrated global source information for each target position,MCA applies flexible flow prediction head and point correlation to effectively conduct warping and fusing for final transformed person image *** proposed MCA achieves superior performance on two popular datasets than other methods,which verifies the effectiveness of our approach.

关键词： artificial intelligence image processing image reconstruction

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From the unknown to spotlight:newly identified hormone adjusts hepatic cholesterol synthesis to dietary uptake

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2845-2847页

作者： Yakum Bertrand Nkeh Resul Gökberk Elgin Gesine Saher Project group Biology of Lipids Department of NeurogeneticsMax Planck Institute for Multidisciplinary SciencesGöttingenGermany

In a study published in Cell,Hu and colleagues discovered that the signaling activity of the intestinal hormone Cholesin leads to the attenuation of hepatic cholesterol synthesis in response to intestinal absorption thereby maintaining homeostatic levels of circulating cholesterol.1 These findings have major translational implications as they provide a potential new target for the management of hypercholesterolemia and associated disorders.

关键词： cholesterol hepatic synthesis

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Lower-order transgressive-regressive cycles within a higher-order transgression at the basin margin: an aberrant intercalation of palaeosol and biostromal ichnofabrics from the early Miocene Kutch Basin, India

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Journal of Palaeogeography 2024年第4期13卷 906-923页

作者： Ayush Srivastava Sudipta Dasgupta Seema Singh Bombay Ichnos Research group Department of Earth SciencesIndian Institute of Technology Bombay (IIT Bombay) department of Geology Panjab University

The Chhasra Formation (CF) of Kutch Basin exemplifies a typical mixed siliciclastic-carbonate system with alternations of biostromal carbonate and fine-grained siliciclastic beds. The CF is subdivided into two members: the lower Claystone (CM) and the upper Siltstone(SM) member. Three CM outcrops (P1-P3) comprising buried palaeosols that formed under a specific environmental set-up involving imperfectly to poorly drained conditions, are exposed along the Berwali River. The biostromal carbonate beds, alternating with the palaeosols, contain invertebrate bioclasts(bivalves, gastropods, echinoids, etc.) and are characterized by a paucispecific firmground Thalassinoides ichnofabric. At section P1, below the contact between the underlying palaeosol and overlying carbonate, Thalassinoides transforms into firmground Gyrolithes inside the palaeosol forming a compound ichnotaxon. The palaeosol intervals of sections P1 and P2 consist of a Vondrichnus-Termitichnus-root trace ichnofabric defining the Termitichnus ichnofacies. At section P3, lenses of fully bioturbated siltstones with a monospecific firmground Thalassinoides ichnofabric can be observed within an overall silty palaeosol horizon, thereby, locally cross-cutting the pedogenic features. The ichnofabrics of section P3 indicate polyphase pedogenesis with three stages:(1) initial stage: pedogenesis in siltstone of undefined depositional affinity which was obscured by pedogenic processes,(2) transient stage: recurring marine incursions and colonization by crustaceans within the lens-shaped palaeotopographic depressions overprinting the palaeosol, and (3) final stage: subaerial exposure and another preserved phase of pedogenesis. The CM shows an apparent low-order T-R(transgressive-regressive) cyclicity within a 3rd-order TST (transgressive systems tract) that is supported by pedogenic intensity, ichnofabrics, and reciprocal sedimentation near the Miocene basin margin, though the cyclicity can be the result of both autoge

关键词： Palaeosol Biostrome Ichnofabrics Chhasra Formation Transgressive–regressive cycles TST Kutch (Kachchh) Basin

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Analysis of Phenotypes Associated with Deficiency of PAX6 Haplotypes in Chinese Aniridia Families

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Current Medical Science 2024年第4期44卷 820-826页

作者： Xiao-lu HAO Ran CHEN Wei LIU Bao-ke HOU Ling-hui QU Zhao-hui LI Da-jiang WANG Xin JIN Hou-bin HUANG Senior department of Opthalmology the Third Medical Center of Chinese PLA General HospitalBeijing100039China Bolin Eye Care group Beijing100098China department of Ophthalmology Hainan Hospital of Chinese PLA General HospitalSanya572000China department of Ophthalmology the 74th Army Group HospitalGuangzhou510318China

Objective To examine the clinical phenotype and genetic deficiencies present in Chinese aniridia families with PAX6 haplotype *** A comprehensive questionnaire and ophthalmological assessments were administered to both affected patients and unaffected *** clinical feature analysis included the evaluation of visual acuity,intraocular pressure,slit-lamp anterior segment examination,fundus photography,and spectral domain optical coherence *** identify the mutation responsible for aniridia,targeted next-generation sequencing was used as a beneficial *** A total of 4 mutations were identified,consisting of two novel frameshift mutations(c.314delA,p.K105Sfs*33 and c.838_845dup AACACACC,p.S283Tfs*85),along with two recurring nonsense mutations(c.307C>T,p.R103X and c.619A>T,p.K207*).Complete iris absence,macular foveal hypoplasia,and nystagmus were consistent in these PAX6 haplotype-deficient Chinese aniridia families,while corneal lesions,cataracts,and glaucoma exhibited heterogeneity both among the families and within the same *** In our study,two novel PAX6 mutations associated with aniridia were identified in Chinese families,which expanded the phenotypic and genotypic spectrum of PAX6 *** also analyzed the clinical characteristics of PAX6 haplotype deficiency in Chinese aniridia families.

关键词： aniridia PAX6 mutation haplotype deficiency phenotype genotype

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Energy Management of Price-maker Community Energy Storage by Stochastic Dynamic Programming

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 492-503页

作者： Lirong Deng Xuan Zhang Tianshu Yang Hongbin Sun Yang Fu Qinglai Guo Shmuel S.Oren department of Electrical Engineering Shanghai University of Electric PowerShanghai 200000China Tsinghua-Berkeley Shenzhen Institute Tsinghua UniversityShenzhen 518055China department of Industrial Engineering and Operations Research University of California BerkeleyBerkeleyCAUSA Risk analytics and Optimization Chair EPFLSwitzerlandand also with Power Systems LaboratoryETH Zurich8092 ZurichSwitzerland State Key Laboratory of Power Systems Department of Electrical EngineeringTsinghua UniversityBeijing 100084China

In this paper,we propose an analytical stochastic dynamic programming(SDP)algorithm to address the optimal management problem of price-maker community energy *** a price-maker,energy storage smooths price differences,thus decreasing energy arbitrage ***,this price-smoothing effect can result in significant external welfare changes by reduc-ing consumer costs and producer revenues,which is not negligible for the community with energy storage *** such,we formulate community storage management as an SDP that aims to maximize both energy arbitrage and community *** incorporate market interaction into the SDP format,we propose a framework that derives partial but sufficient market information to approximate impact of storage operations on market *** we present an analytical SDP algorithm that does not require state *** from computational efficiency,another advantage of the analytical algorithm is to guide energy storage to charge/discharge by directly comparing its current marginal value with expected future marginal *** studies indicate community-owned energy storage that maximizes both arbitrage and welfare value gains more benefits than storage that maximizes only *** proposed algorithm ensures optimality and largely reduces the computational complexity of the standard *** Terms-Analytical stochastic dynamic programming,energy management,energy storage,price-maker,social welfare.

关键词： Analytical stochastic dynamic programming energy management energy storage price-maker social welfare

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Trace fossil evidences of an Early Miocene paleoseismic event and depositional regime change from the Kutch(Kachchh) Basin

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Journal of Palaeogeography 2024年第1期13卷 165-180页

作者： Ayush Srivastava Sudipta Dasgupta Krishanu Chatterjee Mohuli Das Bombay Ichnos Research group Department of Earth SciencesIndian Institute of Technology Bombay(lIT Bombay)PowaiMumbaiMaharashtra400076India

Unconsolidated siliciclastic sediments can undergo post-burial deformation, which leads to the formation of distinctive sedimentary structures, known as soft-sediment deformation structures(SSDS). The presence of a series of sand volcanoes confined to a particular lithostratigraphic horizon can represent a paleoseismic activity and, thereby, exemplifies the concept of “seismite”. The Kutch Basin has been a tectonically active region since the initiation of eastern Gondwana rifting followed by a tectonic inversion during the Cenozoic due to the collision of the Indian and Eurasian plates. A stratum-bound series of sand volcanoes belonging to the Khari Nadi Formation(KNF) is exposed along the banks of Khari River. They separate the shallow marine deposits below and non-marine deposits above with their characteristic marine and paleosol trace fossil suites, respectively. Although a seismogenic origin has been much debated for the SSDS,the ichnofabric analysis of the sand-volcano-bearing stratum unequivocally points toward such an origin under a shallow seafloor condition. In addition to the sedimentary regime change from an open shallow-marine setting to a continental depositional environment concomitant with basinal uplift, the behavior of the burrowing crustaceans testifies to a syn-depositional development of a fault network associated with the fluidization, sand volcanism, and the resilience of the trace-producers in surviving those processes until the sedimentary regime change in the overlying strata. Although the ichno-sedimentological evidence apparently differs from the previous works that proposed a continuous base-level rise from the beginning of deposition of the Khari Nadi Formation up to the middle part of the overlying Chhasra Formation, the paleoseismic activity,its ichnologic signature, and the depositional regime change refer to a higher-resolution(i.e., lower-order)sequence-stratigraphic change causing a short-duration regression within a longer-durat

关键词： Sand volcano Seismite Ichnology Khari Nadi Formation Kutch Basin Kachchh Basin

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An Evidence-Based CoCoSo Framework with Double Hierarchy Linguistic Data for Viable Selection of Hydrogen Storage Methods

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2845-2872页

作者： Raghunathan Krishankumar Dhruva Sundararajan K.S.Ravichandran Edmundas Kazimieras Zavadskas Information Technology Systems and analytics Area Indian Institute of Management Bodh GayaBodh GayaBihar824234India department of Mathematics Amrita School of Physical SciencesAmrita Vishwa VidyapeethamCoimbatore641112India Institute of Sustainable Construction Vilnius Gediminas Technical UniversityVilnius10223Lithuania

Hydrogen is the new age alternative energy source to combat energy demand and climate *** of hydrogen is vital for a nation’s *** of literature provide different methods for storing the produced hydrogen,and the rational selection of a viable method is crucial for promoting sustainability and green ***,hydrogen storage is associated with diverse sustainable and circular economy(SCE)*** a result,the authors consider the situation a multi-criteria decision-making(MCDM)*** infer that previous models for hydrogen storage method(HSM)selection(i)do not consider preferences in the natural language form;(ii)weights of experts are not methodically determined;(iii)hesitation of experts during criteria weight assessment is not effectively explored;and(iv)three-stage solution of a suitable selection of HSM is *** by these gaps,in this paper,authors put forward a new integrated framework,which considers double hierarchy linguistic information for rating,criteria importance through inter-criteria correlation(CRITIC)for expert weight calculation,evidence-based Bayesian method for criteria weight estimation,and combined compromise solution(CoCoSo)for ranking *** applicability of the developed framework is testified by using a case example of HSM selection in *** and comparative analysis reveal the merits and limitations of the developed framework.

关键词： Hydrogen storage methods double hierarchy hesitant fuzzy linguistic term set evidence theory CoCoSo method sustainability circular economy

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