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Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1

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Protein & Cell 2024年第6期15卷 419-440页

作者： Wei Ma Lu Zhang Weilong Chen Zhaoxia Chang Juchuanli Tu Yuanyuan Qin Yuwen Yao Mengxue Dong Jiajun Ding Siqin Li Fengkai Li Qiaodan Deng Yifei Yang Tingting Feng Fanrong Zhang Xiying Shao Xueyan He Lixing Zhang Guohong Hu Quentin Liu Yi-Zhou Jiang Shu Zhu Zhi Xiao Dan Su Tong Liu Suling Liu Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences State Key Laboratory of Genetic EngineeringCancer InstitutesDepartment of OncologyKey Laboratory of Breast Cancer in ShanghaiThe Shanghai Key Laboratory of Medical EpigeneticsShanghai Key Laboratory of Radiation OncologyThe International Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyShanghai Medical CollegeFudan UniversityShanghai 200032China Intelligent Pathology Institute and department of Pathology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230071China department of Thyroid Breast and Vascular SurgeryXijing HospitalFourth Military Medical UniversityXi’an 710032China Institute of Immunology CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230027China department of Pathology The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer (IBMC)Chinese Academy of SciencesHangzhou 310022China department of Breast Surgery The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer (IBMC)Chinese Academy of SciencesHangzhou 310022China department of Breast Medical Oncology The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer (IBMC)Chinese Academy of SciencesHangzhou 310022China Shanghai Institute of Nutrition and Health University of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China department of Breast Surgery Xiangya HospitalChangsha 410008China department of Breast Surgery Tumor Hospital of Harbin Medic

Tumor-resident microbiota in breast cancer promotes cancer initiation and malignant ***,targeting microbiota to improve the effects of breast cancer therapy has not been investigated in ***,we evaluated the microbiota composition of breast tumors and found that enterotoxigenic Bacteroides fragilis(ETBF)was highly enriched in the tumors of patients who did not respond to taxane-based neoadjuvant ***,albeit at low biomass,secreted the toxic protein BFT-1 to promote breast cancer cell stemness and *** studies showed that BFT-1 directly bound to NOD1 and stabilized NOD1 ***1 was highly expressed on ALDH+breast cancer stem cells(BCSCs)and cooperated with GAK to phosphorylate NUMB and promote its lysosomal degradation,thereby activating the NOTCH1-HEY1 signaling pathway to increase ***1 inhibition and ETBF clearance increase the chemosensitivity of breast cancer by impairing BCSCs.

关键词： NOD1 breast chemotherapy

A Multi-Scale Study on Silicon-Oxide Etching Processes in C_4F_8/Ar Plasmas

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Plasma Science and technology 2016年第6期18卷 666-673页

作者：眭佳星张赛谦刘增阎军戴忠玲 School of Physics and Optoelectronic technology Dalian University of Technology department of engineering Mechanics Dalian University of Technology

A multi-scale numerical method coupled with the reactor,sheath and trench model is constructed to simulate dry etching of SiO_2 in inductively coupled C_4F_8 ***,ion and neutral particle densities in the reactor are decided using the CFD-ACE＋ commercial ***,the ion energy and angular distributions（IEDs and IADs） are obtained in the sheath model with the sheath boundary conditions provided with CFD-ACE＋.Finally,the trench profile evolution is simulated in the trench *** we principally focus on is the effects of the discharge parameters on the etching *** is found that the discharge parameters,including discharge pressure,radio-frequency（rf） power,gas mixture ratios,bias voltage and frequency,have synergistic effects on IEDs and IADs on the etched material surface,thus further affecting the trench profiles evolution.

关键词： plasma etching multi-scale model trench profile surface process

Development and evaluation of the refined zenith tropospheric delay(ZTD)models

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Satellite Navigation 2021年第1期2卷 296-304页

作者： Fei Yang Xiaolin Meng Jiming Guo Debao Yuan Ming Chen College of Geoscience and Surveying engineering China University of Mining and Technology-Beijing100083 BeijingChina Global Geospatial engineering Ltd. The Sino-UK Geospatial Engineering Centre18 Radford Bridge RoadNottingham NG81NAUK School of Geodesy and geomatics Wuhan University129 Luoyu RoadWuhan 430079China National geomatics Center of China Beijing 100830China.

The tropospheric delay is a significant error source in Global Navigation Satellite System(GNSS)positioning and *** is usually projected into zenith direction by using a mapping *** is particularly important to establish a model that can provide stable and accurate Zenith Tropospheric Delay(ZTD).Because of the regional accuracy difference and poor stability of the traditional ZTD models,this paper proposed two methods to refine the Hopfield and Saastamoinen ZTD *** is by adding annual and semi-annual periodic terms and the other is based on Back-Propagation Artificial Neutral Network(BP-ANN).Using 5-year data from 2011 to 2015 collected at 67 GNSS reference stations in China and its surrounding regions,the four refined models were *** tropospheric products at these GNSS stations were derived from the site-wise Vienna Mapping Function 1(VMP1).The spatial analysis,temporal analysis,and residual distribution analysis for all the six models were conducted using the data from 2016 to *** results show that the refined models can effectively improve the accuracy compared with the traditional *** the Hopfield model,the improvement for the Root Mean Square Error(RMSE)and bias reached 24.5/49.7 and 34.0/52.8 mm,*** values became 8.8/26.7 and 14.7/28.8 mm when the Saastamoinen model was refined using the two *** exploration is conducive to GNSS navigation and positioning and GNSS meteorology by providing more accurate tropospheric prior information.

关键词： GNSS Tropospheric delay ZTD Refined model ANN

Sensory Phenotypic and Molecular Identification of Aromatic Rice Accessions Cultivated in Benin

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Advances in Bioscience and Biotechnology 2024年第3期15卷 195-206页

作者： Chimène Nadège Mahoussi Nanoukon Koffi David Montcho Hambada Deless Edmond Fulgence Thiémélé Bignon Meyrix Pamela Franzel Loumedjinon Babatoundé Franel Carel Wenceslas Affolabi Amed Sèmèvo Havivi Kéllya Laurinzo Déguénon Grâce Finagnon Vitoekpon Arielle Bankole Lambert Gustave Djedatin Laboratory of Molecular Biology and Bioinformatics Applied to Genomics National School of Applied Biosciences and Bio-technologies National University of Science Technology Engineering and Mathematics Dassa-Zoumè Benin Laboratory of Molecular Biology and Bioinformatics Applied to Genomics National School of Applied Biosciences and Biotechnologies National University of Science Technology Engineering and Mathematics Dassa-Zoumè Benin Laboratory of Plant Horticultural and Forestry Sciences National University of Agriculture Kétou Benin Genetics Teaching and Research Unit Department of Biochemistry-Genetics Peleforo GON COULIBALY University Korhogo C&#244te d’Ivoire

Rice is one of the most widely cultivated cereals in the world, and its aroma is increasingly in demand. With the advancement of research, a major rice flavor gene has been identified on rice chromosome 8. It encodes non-functional betaine aldehyde dehydrogenase leading to the accumulation of 2-acetyl-1-pyrroline which is the major olfactory compound that confers the fragrant character to rice. The aroma of rice is considered a special trait of enormous economic importance that determines the prime price in world trade. To satisfy the needs of the population and reduce rice imports into Benin, we conducted this study to identify aromatic rice accessions grown in Benin. Seventy-two rice accessions collected across Benin were PCR amplified with three SSR markers RM 7049, Aro 7, and RM 223, linked to the fgr (fragrance of rice) aroma gene. Molecular analysis revealed that 12 of the 72 accessions, namely Bagou 19, Bagou 22, Tchaka 34, Foun 15, Tchaka 41, Nana 32, Kan 61, Kung 69, Kung 67, Bagou 20, Agbab 101 and Koum 55 possess the fgr gene and can be considered as aromatic rice accessions. A sensory phenotypic test using KOH was carried out on rice accessions carrying fgr gene. Of the twelve positives, only one had the smell of aromatic rice, like the Azucena control. These results show that Benin also has aromatic rice varieties that can be sold on national and international markets.

关键词： Aromatic Rice 2-Acetyl-1-Pyrroline SSR Markers Benin

Early-diverging Titanosauriform(Dinosauria,Sauropoda)Teeth from the Lower Cretaceous Yixian Formation of Southeastern Inner Mongolia,Northeast China

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 303-310页

作者： ZHANG Honggang YIN Yalei PEI Rui ZHOU Changfu College of Earth Science and engineering Shandong University of Science and TechnologyQingdaoShandong 266570China College of Paleontology Shenyang Normal UniversityShenyang 110034China Key Laboratory of Evolution of Past Life in NE Asia Ministry of Natural ResourcesShenyang 110034China Key Laboratory of Evolutionary Systematics of Vertebrates Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China CAS Center for Excellence in Life and Paleoenvironment Beijing 100044China

Three eusauropod teeth(SDUST-V1064,PMOL-AD00176,PMOL-ADt0005)are reported from the Lower Cretaceous Yixian Formation of Ningcheng,southeastern Inner Mongolia,*** of them(SDUST-V1064,PMOL-AD00176)are assigned to early-diverging titanosauriforms in having slightly mesiodistal expansion at the base of the tooth crown,a slenderness index value>2.0 and<4.0,and D-shaped cross ***,SDUST-V1064 and PMOL-AD00176 are referred as an Euhelopus-like titanosauriform on the basis of having a sub-circular boss on the lingual surface and an asymmetrical crown-root margin which slants apically,*** scan data of SDUST-V1064 reveals new dental information of early-diverging titanosauriforms,for example,the enamel on the labial side thicker than that on the lingual side,an enamel/dentine ratio of 0.26 and a boss present on the lingual side of the dentine of the crown.

关键词： teeth Titanosauriformes Lower Cretaceous Yixian Formation Ningcheng

Seawater desalination of arid regions:comparing the policy of the Kingdom of Saudi Arabia and Indonesia

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Chinese Journal of Population,Resources and Environment 2024年第2期22卷 204-211页

作者： Nur Khafifah Rusni Dwita Sutjiningsih Hayati Sari Hasibuan Raldi Hendro Kostoer School of Environmental Sciences Universitas IndonesiaJakarta 10430Indonesia department of Civil engineering Universitas IndonesiaJakarta 10430Indonesia

Problems with clean water in coastal areas alongside an increase in population and community economic activities have diversified community *** settlements bordering the high seas are characterized as arid areas with a lack of clean ***,the use of the range groundwater supply against seawater intrusion means that the water consumed by the community tastes salty and *** availability of abundant seawater,processed through desalination technology,can be used to meet the daily clean water needs of coastal *** development goal(SDG)6 Water and Sanitation is concerned with ensuring that everyone has access to clean water and *** this regard,desalination technology is considered viable to achieve the SDGs in the environmental *** countries have focused on using desalination technology to achieve target 6.4 by *** goal aims to improve the efficiency of water use to reduce the number of people experiencing clean water scarcity by ensuring a sustainable supply of fresh *** objective of this study is to examine the application of seawater desalination technology for clean water in the Kingdom of Saudi Arabia(KSA)and Indonesia,and identify the implications of desalination policies in these *** studies were conducted using secondary data and literature studies on transforming seawater into clean water with *** applies seawater desalination technology to meet water ***,in Indonesia,policymaking has not holistically examined the potential of using seawater desalination technology for clean *** now,unlike in the KSA,Indonesia has not addressed the importance of the use of desalination technology in state policy.

关键词： Clean water Desalination Coastal settlements Kingdom of Saudi Arabia Indonesia

Clear-water scour around semi-elliptical abutments with armored beds

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International Journal of Sediment Research 2010年第3期25卷 233-244页

作者： Hossein AFZALIMEHR Abdolreza Kabiri SAMANI Mehrnoosh MAHERANI department of Water engineering Isfahan University of Technology department of Civil engineering Isfahan University of Technology

Experimental study has been carried out under a clear-water scour condition to explore the local scour around semi-elliptical model bridge abutments with armor-layer bed, compared with the local scour process around semi-circular abutment. Two types of model bridge abutments, namely semi- elliptical and semi-circular abutments have been used in this experimental study. The model abutments had a ratio of streamwise length of abutment to the length of abutment transverse to the flow of 2 for semi-circular abutments and 3 for semi-elliptical abutments. In total, 50 Experiments have been designed and conducted under different flow conditions such as bed shear velocities, flow depth, and dimensions of bridge abutment model, as well as grain size of the bed material. Based on these experiments, the scour process around bridge abutments has been assessed. The dependence of the equilibrium scour depth of the scour hole on hydraulic variables has been studied. Empirical equation describing the equilibrium scour depth of the scour hole around bridge abutments has been developed.

关键词： Armor-layer Equilibrium scour depth Local scour Particle grain size Semi-circular abutment Semi-elliptical abutment Shear velocity

Gas-propelled nanomotors alleviate colitis through the regulation of intestinal immunoenvironment-hematopexis-microbiota circuits

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2732-2747页

作者： Bo Xiao Yuqi Liang Ga Liu Lingshuang Wang Zhan Zhang Libin Qiu Haiting Xu Sean Carr Xiaoxiao Shi Rui LReis Subhas CKundu Zhenghua Zhu department of Gastroenterology the First Affiliated Hospital of Nanchang UniversityNanchang 330006China College of Sericulture Textileand Biomass SciencesSouthwest UniversityChongqing 400715China department of Neurology School of MedicineEmory UniversityAtlantaGA 30322USA Atlanta Veterans Affairs Medical Center DecaturGA 30033USA department of Surgery School of MedicineEmory UniversityAtlantaGA 30322USA Bs Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarcoGuimaraes 4805-017Portugal

The progression of ulcerative colitis(UC)is associated with immunologic derangement,intestinal hemorrhage,and microbiota *** traditional medications mainly focus on mitigating inflammation,it remains challenging to address multiple ***,a versatile gas-propelled nanomotor was constructed by mild fusion of post-ultrasonic CaO_(2) nanospheres with Cu_(2)O *** resulting CaO_(2)–Cu_(2)O possessed a desirable diameter(291.3 nm)and a uniform size *** could be efficiently internalized by colonic epithelial cells and macrophages,scavenge intracellular reactive oxygen/nitrogen species,and alleviate immune reactions by pro-polarizing macrophages to the anti-inflammatory M2 *** nanomotor was found to penetrate through the mucus barrier and accumulate in the colitis mucosa due to the driving force of the generated oxygen *** administration of CaO_(2)–Cu_(2)O could stanch the bleeding,repair the disrupted colonic epithelial layer,and reduce the inflammatory responses through its interaction with the genes relevant to blood coagulation,anti-oxidation,wound healing,and ***,it restored intestinal microbiota balance by elevating the proportions of beneficial bacteria(e.g.,Odoribacter and Bifidobacterium)and decreasing the abundances of harmful bacteria(e.g.,Prevotellaceae and Helicobacter).Our gas-driven CaO_(2)–Cu_(2)O offers a promising therapeutic platform for robust treatment of UC via the rectal route.

关键词： Nanomotor Anti-inflammation Blood coagulation Immune regulation Hematopexis Microbiota rebalance Ulcerative colitis Rectal administration

Route Height Connection Across the Sea by Using the Vertical Deflections and Ellipsoidal Height Data

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China Ocean engineering 2013年第1期27卷 99-110页

作者：郭金运陈永宁刘新钟世霞麦照秋 College of Geodesy and geomatics Shandong University of Science and Technology Key Laboratory of Surveying and Mapping technology on Island and Reef of NASMG The 7th Terrestrial Surveying Team of NASMG

Distance between the main land and island is so long that it is very difficult to precisely connect the height datum across the sea with the traditional method like the trigonometric leveling, or it is very expensive and takes long time to implement the height transfer with the geopotential technique. We combine the data of GPS surveying, astro-geodesy and EGM2008 to precisely connect the orthometric height across the sea with the improved astronomical leveling method in the paper. The Qiongzhou Strait is selected as the test area for the height connection over the sea. We precisely determine the geodetic latitudes, longitudes, heights and deflections of the vertical for four points on both sides across the strait. Modeled deflections of the vertical along the height connecting routes over the sea are determined with EGM2008 model based on the geodetic positions and heights of the sea segmentation points from DNSC08MSS model. Differences of the measured and modeled deflections of the vertical are calculated at four points on both sides and linearly change along the route. So the deflections of the vertical along the route over the sea can be improved by the linear interpolation model. The results are also in accord with those of trigonometirc levelings. The practical case shows that we can precisely connect the orthometric height across the Qiongzhou Strait to satisfy the requirement of order 3 leveling network of China. The method is very efficient to precisely connect the height datum across the sea along the route up to 80 km.

关键词： height connection across sea deflection of the vertical astro-geodesy orthometric height ellipsoidal height