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Current Medical Science 2019年第4期39卷 582-588页

作者： Xiao-lu XIONG Rong-xin ZHANG Yan BI Wei-hong ZHOU Yun YU Da-long ZHU department of Endocrinology Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjing 210008China School of biomedical Engineering and informatics Nanjing Medical UniversityNanjing 211166China

Type 2 diabetes mellitus (T2DM) has become a prevalent health problem in China,especially in urban *** prevention strategies are needed to reduce the associated mortality and *** applied the combination of rules and different machine learning techniques to assess the risk of development of T2DM in an urban Chinese adult population.A retrospective analysis was performed on 8000 people with non-diabetes and 3845 people with T2DM in *** Perceptron (MLP),AdaBoost (AD),Trees Random Forest (TRF),Support Vector Machine (SVM),and Gradient Tree Boosting (GTB) machine learning techniques with 10 cross validation methods were used with the proposed model for the prediction of the risk of development of *** performance of these models was evaluated with accuracy,precision,sensitivity,specificity,and area under receiver operating characteristic (ROC) curve (AUC).After comparison,the prediction accuracy of the different five machine models was 0.87,0.86,0.86,0.86 and 0.86 *** combination model using the same voting weight of each component was built on T2DM,which was performed better than individual *** findings indicate that,combining machine learning models could provide an accurate assessment model for T2DM risk prediction.

关键词： type 2 diabetes risk prediction machine learning

Introduction of a digital near-vision reading test for normal and low vision adults:development and validation

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Eye and Vision 2020年第1期7卷 497-511页

作者： Georgios Labiris Eirini-Kanella Panagiotopoulou Eleftherios Chatzimichael Maria Tzinava Asimina Mataftsi Konstantinos Delibasis department of Ophthalmology University Hospital of AlexandroupolisDragana68100 AlexandroupolisGreece department of Computer Science and biomedical informatics University of Thessaly35100LamiaGreece 2nd department of Ophthalmology Aristotle University of Thessaloniki56429ThessalonikiGreece

Background:MNREAD is an advanced near-vision acuity chart that has already been translated and validated in Greek *** that no validated Greek digital near-vision test exists,our primary objective was to develop and validate a digital near-vision reading test based on the fundamental properties of the Greek printed MNREAD(MNREAD-GR).Methods:This is a prospective,comparative study.A digital near-vision chart was developed(Democritus Digital Acuity Reading Test-DDART)with text size calibration,audio recording for automatic reading timing,as well as automatic calculation of reading acuity(RA),maximum reading speed(MRS),critical print size(CPS)and reading accessibility index(ACC).Normal and low vision subjects participated in the validation process,responding to MNREAD-GR and DDART at the same day,at a 40 cm viewing *** in all parameters between the charts were compared with t-test and intraclass correlation coefficients(ICCs).Within 15 days,all participants responded again to DDART in a different set of sentences to assess its test-retest ***:One hundred patients(normal vision group-NVG:70 patients;low vision group-LVG:30 patients)responded to both reading ***-significant differences were detected for all parameters between DDART and MNREAD-GR except for MRS and ACC that were significantly higher in MNREAD-GR in NVG(p<0.01).NVG participants demonstrated sufficient ICCs that ranged from 0.854 to 0.963,while LVG demonstrated ICCs for RA,ACC,MRS and CPS equal to 0.986,0.894,0.794 and 0.723,*** parameters calculated with DDART demonstrated excellent test-retest reliability(ICCs:0.903-0.956).Conclusions:The proposed reading test presented comparable validity and repeatability to MNREAD-GR suggesting that it can be used both in normal and low vision Greek patients.

关键词： Digital near-vision chart Critical print size Reading acuity Reading speed Presbyopia Low vision

Gene expression profile of peripheral blood in colorectal cancer

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World Journal of Gastroenterology 2014年第39期20卷 14463-14471页

作者： Yu-Tien Chang Chi-Shuan Huang Chung-Tay Yao Sui-Lung Su Harn-Jing Terng Hsiu-Ling Chou Yu-Ching Chou Kang-Hua Chen Yun-Wen Shih Chian-Yu Lu Ching-Huang Lai Chen-En Jian Chiao-Huang Lin Chien-Ting Chen Yi-Syuan Wu Ke-Shin Lin Thomas Wetter Chi-Wen Chang Chi-Ming Chu Division of biomedical Statistics and informatics School of Public Health National Defense Medical Center Division of Colorectal Surgery Cheng Hsin Rehabilitation Medical Center department of Surgery Cathay General Hospital department of Epidemiology School of Public Health National Defense Medical Center Advpharma Inc. department of Nursing Far Eastern Memorial Hospital and Oriental Institute of Technology department of Nursing School of Medicine Chang Gung University Air Force Combatant Command National Defense Ministry Institute of Medical Biometry and informatics Heidelberg University Germany department of biomedical informatics and Medical Education University of Washington Seattle United States

AIM: Optimal molecular markers for detecting colorectal cancer (CRC) in a blood-based assay were evaluated.

关键词： Colorectal cancer Gene expression Microarray Internet

Possible Relations of Cosmic Microwave Background with Gravity and Fine-Structure Constant

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Journal of Modern Physics 2022年第7期13卷 1045-1052页

作者： Qinghua Cui department of biomedical informatics Peking University Beijing China

Gravity is the only force that cannot be explained by the Standard Model (SM), the current best theory describing all the known fundamental particles and their forces. Here we reveal that gravitational force can be precisely given by mass of objects and microwave background (CMB) radiation. Moreover, using the same strategy we reveal a relation by which CMB can also precisely define fine-structure constant α.

关键词： Gravity Gravitational Constant Cosmic Microwave Background Fine-Structure Constant

Variable Physical Constants and Beyond

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Journal of High Energy Physics, Gravitation and Cosmology 2023年第1期9卷 116-123页

作者： Qinghua Cui department of biomedical informatics Peking University Beijing China

We previously revealed that the speed of light in vacuum c, the gravitational constant G, the vacuum permittivity ε, and the vacuum permeability μ can be defined by the temperature T (or the expected average frequency f) of cosmic microwave background (CMB) radiation. Given that CMB is continuously cooling, that is, T is continuously decreasing, we proposed that the above “constants” are variable and their values at some space-time with CMB temperature T (cT, GT, εT, and μT) can be described using their values (c0, G0, ε0, and μ0) and the temperature (T0) of CMB at present space-time. Based on the above observation, a number of physical equations related with these constants are re-described in this study, including relativity equation, mass-energy equation, and Maxwell’s equations, etc.

关键词： Speed of Light in Vacuum Gravitational Constant Vacuum Permittivity Vacuum Permeability Cosmic Microwave Background

On the Possibility of Variable Speed of Light in Vacuum

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Journal of High Energy Physics, Gravitation and Cosmology 2022年第4期8卷 927-934页

作者： Qinghua Cui department of biomedical informatics Peking University Beijing China

We previously revealed a quantitative relation by which the fine-structure constant α can be described by the temperature T of cosmic microwave background (CMB) with several other fundamental constants, including the elementary charge e, the Boltzmann constant k, the Planck constant h, and the light of speed in vacuum c. Given that the value of α is quite conserved but T is variable across CMBs, we propose that c changes with T and can be given by T, the present CMB temperature T0 and the present light speed c0. As T is continuously decreasing, c is thus predicted to decrease at a rate of ~2.15 centimeters/second (cm/s) per year. Moreover, we provide a lot of evidence to support this finding. In conclusion, this study suggests a possibility of variable speed of light in vacuum.

关键词： Speed of Light in Vacuum Fine-Structure Constant Cosmic Microwave Background Earth-Moon Distance

Characterization of Fam20C expression in odontogenesis and osteogenesis using transgenic mice

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International Journal of Oral Science 2015年第2期7卷 89-94页

作者： Er-Xia Du Xiao-Fang Wang Wu-Chen Yang Deborah Kaback Siu-Pok Yee Chun-Lin Qin Anne George Jian-Jun Hao Division of Orthodontics Department of Craniofacial SciencesSchool of Dental MedicineUniversity of Connecticut department of biomedical Sciences Texas A&M Health Science CenterBaylor College of Dentistry department of genetics and Developmental Biology University of Connecticut Health Center department of Oral Biology University of Illinois

Our previous studies have demonstrated that Fam20 C promotes differentiation and mineralization of odontoblasts,ameloblasts,osteoblasts and osteocytes during tooth and bone *** of the Fam20 C gene inhibits bone and tooth growth by increasing fibroblast growth factor 23 in serum and causing hypophosphatemia in conditional knockout ***,control and regulation of the expression of Fam20 C are still *** this study,we generated a transgenic reporter model which expresses green fluorescence protein（GFP） driven by the Fam20 C *** was used to insert a 16 kb fragment of the mouse Fam20 C gene（containing the 15 kb promoter and 1.1 kb of exon 1） intoa pBluescript SK vector with the topaz variant of GFP and a bovine growth hormone polyadenylation *** expression was subsequently evaluated by histomorphometry on cryosections from E14 to adult *** was evident in the bone and teeth as early as *** GFP signal was maintained stably in odontoblasts and osteoblasts until 4 weeks after *** expression of GFP was significantly reduced in teeth,alveolar bone and muscle by 8 weeks of *** also observed colocalization of the GFP signal with the Fam20 C antibody in postnatal 1- and 7-day-old *** generation of Fam20C-GFP transgenic mice will provide a unique model for studying Fam20 C gene expression and the biological function of this gene during odontogenesis and osteogenesis.

关键词： transgenic promoter pBluescript osteogenesis teeth transgene reporter Fluorescence insert alveolar

众脑之力:通过开放神经影像数据和大规模协作催化神经精神疾病的创新发现

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Science Bulletin 2024年第10期69卷 1536-1555页

作者：鲁彬陈骁 Francisco Xavier Castellanos Paul M.Thompson 左西年臧玉峰严超赣 CAS Key Laboratory of Behavioral Science Institute of PsychologyBeijing 100101China department of Psychology University of Chinese Academy of SciencesBeijing 100101China department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew York 10016USA d Nathan Kline Institute for Psychiatric Research Orangeburg 10962USA Imaging genetics Center Mark&Mary Stevens Institute for Neuroimaging&InformaticsKeck School of MedicineUniversity of Southern CaliforniaLos Angeles 90033USA Developmental Population Neuroscience Research Center IDG/McGovern Institute for Brain ResearchBeijing Normal UniversityBeijing 100875China National Basic Science Data Center Beijing 100190China Centre for Cognition and Brain Disorders The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310004China Institute of Psychological Science Hangzhou Normal UniversityHangzhou 310030China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairment Hangzhou 311121China International Big-Data Center for Depression Research Institute of PsychologyChinese Academy of SciencesBeijing 100101China Magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China

Recent advances in open neuroimaging data are enhancing our comprehension of neuropsychiatric *** pooling images from various cohorts,statistical power has increased,enabling the detection of subtle abnormalities and robust associations,and fostering new research *** collaborations in imaging have furthered our knowledge of the neurobiological foundations of brain disorders and aided in imaging-based prediction for more targeted ***-scale magnetic resonance imaging initiatives are driving innovation in analytics and supporting generalizable psychiatric *** also emphasize the significant role of big data in understanding neural mechanisms and in the early identification and precise treatment of neuropsychiatric ***,challenges such as data harmonization across different sites,privacy protection,and effective data sharing must be *** proper governance and open science practices,we conclude with a projection of how large-scale imaging resources and collaborations could revolutionize diagnosis,treatment selection,and outcome prediction,contributing to optimal brain health.

关键词： Magnetic resonance imaging Neuropsychiatric disorders Big data Open science Artificial intelligence

Metagenomic Surveys of Gut Microbiota

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Genomics, Proteomics & Bioinformatics 2015年第3期13卷 148-158页

作者： Rahul Shubhra Mandal Sudipto Saha Santasabuj Das biomedical informatics Centre National Institute of Cholera and Enteric Diseases Bioinformatics Centre Bose Institute Division of Clinical Medicine National Institute of Cholera and Enteric Diseases

Gut microbiota of higher vertebrates is host-specific. The number and diversity of the organisms residing within the gut ecosystem are defined by physiological and environmental factors, such as host genotype, habitat, and diet. Recently, culture-independent sequencing techniques have added a new dimension to the study of gut microbiota and the challenge to analyze the large volume of sequencing data is increasingly addressed by the development of novel computational tools and methods. Interestingly, gut microbiota maintains a constant relative abundance at operational tax- onomic unit （OTU） levels and altered bacterial abundance has been associated with complex diseases such as symptomatic atherosclerosis, type 2 diabetes, obesity, and colorectal cancer. Therefore, the study of gut microbial population has emerged as an important field of research in order to ulti- mately achieve better health. In addition, there is a spontaneous, non-linear, and dynamic interac- tion among different bacterial species residing in the gut. Thus, predicting the influence of perturbed microbe-microbe interaction network on health can aid in developing novel therapeutics. Here, we summarize the population abundance of gut microbiota and its variation in different clinical states, computational tools available to analyze the pyrosequencing data, and gut microbe-microbe inter- action networks.

关键词： Disease Sequencing 16S rRNA Operational taxonomic unit Microbial interactionnetwork

On the connection between the solutions to the Dirac and Weyl equations and the corresponding electromagnetic four-potentials

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Communications in Theoretical Physics 2020年第4期72卷 52-63页

作者： Aristides I Kechriniotis Christos A Tsonos Konstantinos K Delibasis Georgios N Tsigaridas department of Physics University of ThessalyGR 35100 LamiaGreece department of Computer Science and biomedical informatics University of ThessalyGR-35100 LamiaGreece department of Physics School of Applied Mathematical and Physical SciencesNational Technical University of AthensGR-15780 Zografou AthensGreece

In this work we study in detail the connection between the solutions to the Dirac and Weyl equations and the associated electromagnetic ***,it is proven that all solutions to the Weyl equation are degenerate,in the sense that they correspond to an infinite number of electromagnetic *** far as the solutions to the Dirac equation are concerned,it is shown that they can be classified into two *** elements of the first class correspond to one and only one four-potential,and are called non-degenerate Dirac *** the other hand,the elements of the second class correspond to an infinite number of four-potentials,and are called degenerate Dirac ***,it is proven that at least two of these fourpotentials are gauge-inequivalent,corresponding to different electromagnetic *** order to illustrate this particularly important result we have studied the degenerate solutions to the forcefree Dirac equation and shown that they correspond to massless *** have also provided explicit examples regarding solutions to the force-free Weyl equation and the Weyl equation for a constant magnetic *** all cases we have calculated the infinite number of different electromagnetic fields corresponding to these ***,we have discussed potential applications of our results in cosmology,materials science and nanoelectronics.

关键词： Dirac equation Weyl equation degenerate solutions electromagnetic four-potentials electromagnetic fields massless particles