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Pretreatment inflammatory indices predict Bevacizumab response in recurrent Glioma

Cancer Drug Resistance 2020年第3期3卷 623-635页

作者： Alicia Martínez-González Raquel Cabrera Marta Lloret Pedro C.Lara department de Matemáticas Universidad de Castilla-La ManchaETSI IndustrialesAvdaCiudad Real 13071Spain. Oncología Radioterápica Hospital Universitario de Gran Canaria Dr Negrin Barranco de la Ballena s/nLas Palmas de Gran CanariaLas Palmas 35010Spain. Facultad de ciencias de la Salud Universidad de Las Palmas de Gran CanariaPaseo de Blas Cabrera Felipes/nLas Palmas de Gran CanariaLas Palmas 35016Spain. Fundación Canaria del Instituto Canario de Investigación del Cáncer Avda de la Trinidad 61 Torre Agustín Arevalo 7 planta La LagunaSanta Cruz de Tenerife 38204Spain. San Roque University Hospitals Dolores de la Rocha5Las Palmas de Gran CanariaLas Palmas 35001Spain. Fernando Pessoa Canarias University Dolores dela Rocha 14Las Palmas de Gran CanariaLas Palmas 35016Spain.

Aim:It remains unclear what the best therapeutic option for recurrent glioma patients after Stupp treatment ***(BVZ)is commonly administered in progression,but it appears that only some patients *** would be useful to find biomarkers that determine beforehand who these patients ***:The protocol included 31 high-risk progressing glioma patients after Stupp treatment who received BVZ 5-10 mg/kg every 14 days and temozolomide(3-19 cycles,150-200 mg five days each 28-day cycle)during a mean of eight cycles of BVZ or until tumor progression or unacceptable *** analyzed the clinical outcome values of inflammatory indices measured before BVZ ***:Lymphocyte level before BVZ administration was the best independent predictor of overall survival(HR=0.34;95%ci:0.145-0.81;P=0.015).The area under the receiver operating characteristic(ROC)curve was 0.823,with 1.645 being the optimal cut-off value,and 0.80 and 0.85 the sensitivity and specificity values,*** and non-responder survival curves were also significantly different,considering the first and second tertiles as cut-off *** number of BVZ cycles was not related to *** neutrophil platelet levels,platelet-to-lymphocyte ratio(PLR),and neutrophil-to-lymphocyte ratio(NLR)did not have independent predictive *** variables were not correlated with each ***,patients with high NLR and PLR simultaneously(double positive PLR-NLR)showed a worse clinical outcome than the rest(P=0.043).Conclusion:Pretreatment lymphocyte levels and double positive PLR-NLR could be used as non-invasive hematological prognostic markers for recurrent gliomas treated with bevacizumab.A close relationship emerged between inflammation and angiogenesis.

关键词： Recurrent glioma bevacizumab predictive biomarker inflammatory indices lymphocytes

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前置胎盘植入的危险因素和并发症

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世界核心医学期刊文摘（妇产科学分册） 2006年第1期2卷 16-16页

作者： Usta I. M. Hobeika E. M. Abu Musa A. A. 王佳楣(译) Dr. I.M. Usta Department of Obstetrics and Gynecology American University of Beirut Medical Center Beirut Lebanon 不详

The purpose of this study was to identify risk factors and complications of placenta previa-accreta (PA). Study design: Patients with placenta previa (n = 347) delivered over 20 years were reviewed, divided into PA (cases, n = 22) and no accreta (controls, n = 325), and compared. Results: Cases were older with a higher incidence of smoking and previous cesarean delivery (cs). Grandmultiparity, recurrent abortions, anterior/central placentae, and low socioeconomic status were similar. PA incidence increased with the number of previous cs: 1.9% , 15.6% , 23.5% , 29.4% , 33.3% , and 50.0% after 0, 1, 2, 3, 4, and 5 previous cs, respectively. Hypertensive disorders (odds ratio [OR] 13.9, 95% ci 2.1- 91.2], P = .006), smoking (OR 3.4, 95% ci 1.1- 10.2, P = .031) and previous cs (OR 7.9, 95% ci 1.7- 37.4, P = .009) were selected by the stepwise logistic regression analysis as predictors of PA. Cases had a longer hospital stay, a higher estimated blood loss, and need for transfusion. Cesarean hysterectomy and hypogastric artery ligation were only performed in PA cases. The 2 groups had a similar delivery gestational age and neonatal outcome. Conclusion: Hypertensive disorders, smoking, and previous cesarean are risk factors for accreta in placenta previa patients. Placenta previa-accreta is associated with higher maternal morbidity, but similar neonatal outcome compared with patients with an isolated placenta previa.

关键词：胎盘植入前置胎盘危险因素并发症 logistic回归分析新生儿结局社会经济地位髂内动脉结扎剖宫产后剖宫产史

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妊娠合并贫血是发生低出生体重及早产的独立危险因素

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世界核心医学期刊文摘（妇产科学分册） 2006年第2期2卷 17-17页

作者： Levy A. Fraser D. Katz M. E. Sheiner 张剑萍 department of Obstetrics and Gynecology Soroka University Medical Center Ben-Gurion University of the Negev P.O. Box 151 Beer-Sheva Israel

Objective: The present study was designed to investigate the outcome of pregnancy and delivery in patients with anemia. Methods: A retrospective population-based study comparing all singleton pregnancies of patients with and without anemia was performed. Deliveries occurred during the years 1988-2002 in the Soroka University Medical Center. Maternal anemia was defined as hemoglobin concentration lower than 10 g/dl during pregnancy. Patients with hemoglobinopathies such as thalassemia were excluded from the analysis. Multiple logistic regression models were performed to control for confounders. Results: During the study period there were 153,396 deliveries, of which 13,204 (8.6%) occurred in patients with anemia. In a multivariable analysis, the following conditions were significantly associated with maternal anemia: placental abruption, placenta previa, labor induction, previous cesarean section (cs), non-vertex presentation and Bedouin ethnicity. Higher rates of preterm deliveries (cs were found among anemic women (20.4%versus 10.3%; p ciation between anemia and low birthweight persisted after adjusting for gender, ethnicity and gestational age, using a multivariable analysis (OR = 1.1; 95%ci 1.0-1.2, p = 0.02). Two multivariable logistic regression models, with preterm delivery (city, maternal age, placental problems, mode of delivery and non-vertex presentation. Maternal anemia was an independent risk factor for both, preterm delivery (OR = 1.2; 95%ci 1.1-1.2, p ci 1.1-1.2, p = 0.001). Conclusion: Maternal anemia influences

关键词：妊娠合并贫血顶先露胎盘早剥前次剖宫产单胎妊娠前置胎盘分娩结局孕期贫血胎方位地中海贫

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