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Relationship between Helicobacter pylori infection and colorectal polyp/colorectal cancer

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World Journal of Gastrointestinal surgery 2024年第4期16卷 1008-1016页

作者： Ying Liu Ding-Quan Yang Jun-Nan Jiang Yan Jiao department of general surgery The Affiliated Hospital to Changchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina department of Gastrointestinal and Colorectal surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina department of Hepatobiliary and Pancreatic surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

Helicobacter pylori(***)plays an important role in the development of gastric cancer,although its association to colorectal polyp(CP)or colorectal cancer(CRC)is *** this issue of World Journal of Gastrointestinal surgery,Zhang et al investigated the risk factors for *** infection after colon polyp ***,the researchers used R software to create a prediction model for *** infection based on their *** editorial gives an overview of the association between *** and CP/CRC,including the clinical significance of *** as an independent risk factor for CP/CRC,the underlying processes of ***-associated carcinogenesis,and the possible risk factors and identification of ***.

关键词： Helicobacter pylori Colorectal polyp Colorectal cancer Risk factor

Perioperative outcomes of transvaginal specimen extraction laparoscopic total gastrectomy and conventional laparoscopicassisted total gastrectomy

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World Journal of Gastrointestinal surgery 2024年第6期16卷 1527-1536页

作者： Zhi-Cao Zhang Wen-Sheng Wang Jiang-Hong Chen Yuan-Hang Ma Qi-Fa Luo Yun-Bo Li Yang Yang Dan Ma department of general surgery Xinqiao Hospital of Army Medical UniversityChongqing 400037China

BACKGROUND Natural orifice specimen extraction surgery(NOSES)has emerged as a promising alternative compared to conventional laparoscopic-assisted total gastrectomy(LATG)for treating gastric cancer(GC).However,evidence regarding the efficacy and safety of NOSES for GC surgery is *** study aimed to compare the safety and feasibility,in addition to postoperative complications of NOSES and *** Dual circular staplers were used in Roux-en-Y digestive tract reconstruction for transvaginal specimen extraction LATG,and its outcomes were compared with LATG in a cohort of 51 GC patients with tumor size≤5 *** study was conducted from May 2018 to September 2020,and patients were categorized into the NOSES group(n=22)and LATG group(n=29).Perioperative parameters were compared and analyzed,including patient and tumor characteristics,postoperative outcomes,and anastomosis-related complications,postoperative hospital stay,the length of abdominal incision,difference in tumor type,postoperative complications,and postoperative *** Postoperative exhaust time,operation duration,mean postoperative hospital stay,length of abdominal incision,number of specific staplers used,and Brief Illness Perception Questionnaire score were significant in both groups(P<0.01).In the NOSES group,the postoperative time to first flatus,mean postoperative hospital stay,and length of abdominal incision were significantly shorter than those in the LATG *** in the NOSES group had faster postoperative recovery,and achieved abdominal minimally invasive incision that met aesthetic *** were no significant differences in gender,age,tumor type,postoperative complications,and postoperative survival between the two *** The application of dual circular staplers in Roux-en-Y digestive tract reconstruction combined with NOSES gastrectomy is safe and *** approach offers better short-term outcomes compared to LATG,while long-term survival

关键词： Gastric cancer Circular stapler Natural orifice specimen extraction surgery Laparoscopic-assisted total gastrectomy

Intestinal Behçet's disease: A review of clinical diagnosis and treatment

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World Journal of Gastrointestinal surgery 2024年第6期16卷 1493-1500页

作者： Ying Liu Feng Gao Ding-Quan Yang Yan Jiao department of general surgery The Affiliated Hospital to Changchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina department of Gastrointestinal and Colorectal surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina department of Hepatobiliary and Pancreatic surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

Behçet's disease(BD)is a chronic inflammatory disorder prone to frequent re-currences,with a high predilection for intestinal ***,the ef-ficacy and long-term effects of surgical treatment for intestinal BD are *** the current issue of World J Gastrointest Surg,Park et al conducted a retrospec-tive analysis of 31 patients with intestinal BD who received surgical *** found that elevated C-reactive protein levels and emergency surgery were poor prognostic factors for postoperative recurrence,emphasizing the adverse impact of severe inflammation on the prognosis of patients with intestinal *** work has clinical significance for evaluating the postoperative condition of intestinal *** editorial attempts to summarize the clinical diagnosis and treatment of intestinal BD,focusing on the impact of adverse factors on surgical *** hope this review will facilitate more precise postoperative management of patients with intestinal BD by clinicians.

关键词： Intestinal Behçet's disease Diagnosis Treatment surgery Recurrence

Pancreatic pseudocyst:The past,the present,and the future

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World Journal of Gastrointestinal surgery 2024年第7期16卷 1986-2002页

作者： Jonathan GA Koo Matthias Yi Quan Liau Igor A Kryvoruchko Tamer AAM Habeeb Christopher Chia Vishal G Shelat department of general surgery Khoo Teck Puat HospitalSingapore 768828Singapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore department of surgery No.2 Kharkiv National Medical UniversityKharkiv 61022Ukraine department of general surgery Faculty of Medicine Zagazig UniversitySharkia 44511Egypt department of Gastroenterology Woodlands General HospitalSingapore 737628Singapore department of general surgery Tan Tock Seng HospitalSingapore 308433Singapore

A pancreatic pseudocyst is defined as an encapsulated fluid collection with a welldefined inflammatory wall with minimal or no *** diagnosis cannot be made prior to 4 wk after the onset of *** clinical presentation is often nonspecific,with abdominal pain being the most common *** a diagnosis is suspected,contrast-enhanced computed tomography and/or magnetic resonance imaging are performed to confirm the diagnosis and assess the characteristics of the *** ultrasound with cyst fluid analysis can be performed in cases of diagnostic *** of the pancreas can lead to complications such as hemorrhage,infection,and *** management of pancreatic pseudocysts depends on the presence of symptoms and the development of complications,such as biliary or gastric outlet *** options include endoscopic or surgical *** aim of this review was to summarize the current literature on pancreatic pseudocysts and discuss the evolution of the definitions,diagnosis,and management of this condition.

关键词： Pancreatic pseudocyst Pancreatic fluid collection Cystic pancreatic lesions Pancreatitis Endoscopic ultrasound

PCAF-mediated acetylation of METTL3 impairs mRNA translation efficiency in response to oxidative stress

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Science China(Life Sciences) 2024年第10期67卷 2157-2168页

作者： Cheng Liu Miao Yu Mengyuan Wang Siyuan Yang Yenan Fu Lei Zhang Chaoyang Zhu Hongquan Zhang Program for Cancer and Cell Biology Department of Human AnatomyHistology and EmbryologySchool of Basic Medical SciencesPeking University International Cancer Instituteand State Key Laboratory of Molecular OncologyPeking University Health Science CenterBeijing 100191China department of general surgery and urological surgery Huaihe HospitalHenan UniversityKaifeng 100084China department of Human Anatomy Histologyand EmbryologyShenzhen University School of MedicineShenzhen 518055China

METTL3 methylates RNA and regulates the fate of mRNA through its methyltransferase ***3 enhances RNA translation independently of its catalytic ***,the underlying mechanism is still ***,we report that METTL3 is both interacted with and acetylated at lysine 177 by the acetyltransferase PCAF and deacetylated by *** the methyltransferase activity nor the stability of METTL3 is affected by its acetylation at ***,acetylation of METTL3 blocks its interaction with EIF3H,a subunit of the translation initiation factor,thereby reducing mRNA translation ***,acetylation of METTL3 responds to oxidative ***,oxidative stress enhances the interaction of PCAF with METTL3,increases METTL3 acetylation,and suppresses the interaction of METTL3 with EIF3H,thereby decreasing the translation efficiency of ribosomes and inhibiting cell ***,we suggest a mechanism by which oxidative stress regulates RNA translation efficiency by the modulation of METTL3 acetylation mediated by PCAF.

关键词： METTL3 acetylation PCAF m^(6)A oxidative stress translation SIRT3

Cholangiocarcinoma combined with biliary obstruction:an exosomal circRNA signature for diagnosis and early recurrence monitoring

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2642-2654页

作者： Ningyuan Wen Dingzhong Peng Xianze Xiong Geng Liu Guilin Nie Yaoqun Wang Jianrong Xu Shaofeng Wang Sishu Yang Yuan Tian Bei Li Jiong Lu Nansheng Cheng Division of Biliary surgery Department of General SurgeryWest China HospitalSichuan UniversityChengduSichuanChina Research Center for Biliary Diseases West China HospitalSichuan UniversityChengduSichuanChina

Cholangiocarcinoma(CCA)is a highly malignant biliary tract cancer with currently suboptimal diagnostic and prognostic *** present a novel system to monitor CCA using exosomal circular RNA(circRNA)via serum and biliary liquid biopsies.A pilot cohort consisting of patients with CCA-induced biliary obstruction(CCA-BO,n=5)and benign biliary obstruction(BBO,n=5)was used to identify CCA-derived exosomal circRNAs through microarray *** was followed by a discovery cohort(n=20)to further reveal a CCA-specific circRNA complex(hsa-circ-0000367,hsa-circ-0021647,and hsa-circ-0000288)in both bile and serum *** vitro and in vivo studies revealed the three circRNAs as promoters of CCA *** and prognostic models were established and verified by two independent cohorts(training cohort,n=184;validation cohort,n=105).An interpreter-free diagnostic model disclosed the diagnostic power of biliary exosomal circRNA signature(Bile-DS,AUROC=0.947,RR=6.05)and serum exosomal circRNA signature(Serum-DS,AUROC=0.861,RR=4.04)compared with conventional CA19-9(AUROC=0.759,RR=2.08).A prognostic model of CCA undergoing curative-intent surgery was established by calculating early recurrence score,verified with bile samples(Bile-ERS,C-index=0.783)and serum samples(Serum-ERS,C-index=0.782).These models,combined with other prognostic factors revealed by COX-PH model,enabled the establishment of nomograms for recurrence monitoring of *** study demonstrates that the exosomal triple-circRNA panel identified in both bile and serum samples serves as a novel diagnostic and prognostic tool for the clinical management of CCA.

关键词： biliary diagnosis Serum

Indication of conservative treatment by antibiotics for uncomplicated and complicated acute appendicitis

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World Journal of Gastrointestinal surgery 2024年第8期16卷 2538-2545页

作者： Yuichi Hosokawa Masato Moritani Yosuke Makuuchi Yuichi Nagakawa department of surgery Nishitokyo Central General HospitalTokyo 188-0014Japan department of Gastrointestinal and Pediatric surgery Tokyo Medical UniversityTokyo 166-0023Japan

BACKGROUND Acute appendicitis is one of the most common emergency abdominal disease,and recent studies have evaluated conservative treatment using antibiotics for uncomplicated *** the efficacy of conservative treatment for uncomplicated appendicitis is known,its efficacy for complicated appendicitis remains unknown,so are risk factors for the conservative treatment of *** our institution,conservative treatment has long been the first choice for most appendicitis cases,except for ***,this novel study inves-tigated the outcomes of conservative treatment for uncomplicated and compli-cated acute appendicitis and the risk factors associated with conservative *** significant and independent predictors of resistance to conservative treatment were body temperature≥37.3°C,appendicolith and Douglas sinus fluid visible on computed tomography(CT).The rate of resistance to conservative treatment was 66.7%(6/9)for patients with the above three factors,22.9%(8/35)for patients with two factors(appendicolith and body temperature≥37.3°C),16.7%(2/12)for patients with two factors(Douglas sinus fluid and appendicolith)and 11.1%(1/9)for patients with two factors(Douglas sinus fluid and body temperature≥37.3°C).CONCLUSION A temperature≥37.3°C,appendicolith and Douglas sinus fluid on CT might be clinical risk factors of resistance to conservative treatment for acute appendicitis.

关键词： Acute appendicitis Conservative treatment Antibiotics Appendicolith Uncomplicated appendicitis

Dual innervation method to preserve erectile function following prostatectomy

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Chinese Journal of Plastic and Reconstructive surgery 2024年第3期6卷 159-160页

作者： Nadia Hui Shan Sim Allen Sim Dayna Sim Bien-Keem Tan Allen Wei-Jiat Wong Plastic Reconstructive and Aesthetic Surgery ServiceSengkang General Hospital544886Singapore department of Urology Mount Alvernia Hospital Singapore574623Singapore department of general surgery Sengkang General Hospital544886Singapore department of Plastic Reconstructive and Aesthetic SurgerySingapore General Hospital169608Singapore

Prostate cancer is the second most prevalent cancer in ***-assisted radical prostatectomy(RARP)has altered the landscape of prostate cancer *** the excellent oncological outcomes associated with RARP,the rate of erectile dysfunction(ED)remains *** repair of disrupted cavernous nerves with interpositional nerve grafts has been described;however,the outcomes have been *** hypothesize that this is attributed to Schwann cell atrophy and axonal regeneration limitations caused by long nerve *** proposed the use of nerve transfer to support axonal regrowth via an inter-positional graft with additional donor axons.A cadaveric study was performed to evaluate the anatomical feasibility of a vastus lateralis nerve(VLN)transfer to the distal recipient cavernous nerve *** VLN is long with multiple branching patterns that allow tension-free coaptation of the cavernous *** postulate that a dual innervation method using VLN nerve transfer together with interpositional nerve graft repair of the transacted cavernous nerves may improve the outcomes of ED post-RARP.

关键词： Erectile dysfunction Prostatectomy Interposition nerve graft Nerve transfer Vastus lateralis nerve

Reasons for Elective surgery Cancellations in a Senegalese Pediatric surgery department

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Open Journal of Pediatrics 2024年第5期14卷 783-789页

作者： Cheikh Tidiane Mbaye Cheikh Diouf Florent Tshibwid A Zeng Faty Balla Lô Lissoune Cissé Doudou Gueye Ibrahima Bocar Wellé Souleymane Camara Papa Alassane Mbaye Oumar Ndour Gabriel Ngom department of Pediatric surgery Aristide Le Dantec University Teaching Hospital Universit Cheikh Anta Diop Dakar Senegal department of Pediatric surgery Ziguinchor Regional Hospital Center Universit Cheikh Anta Diop Ziguinchor Senegal department of Pediatric surgery El Hadj Ibrahima Niass Regional Hospital Center Kaolack Senegal department of Pediatric surgery Pikine National Hospital Center Dakar Senegal department of Pediatric surgery Albert Royer National Childrens Hospital Center Universit Cheikh Anta Diop Dakar Senegal Unit of Pediatric surgery Department of Pediatrics Dalal Jamm National Hospital Center Dakar Senegal

Introduction: Cancellation of elective surgery is common in developing countries. This decision is difficult to make as it generates economic and organizational consequences for the healthcare facility and an additional source of stress for patients and their caregivers. This study aimed to analyze the various aspects of this medical problem. Patients and Methods: We conducted a prospective and descriptive study over six months (from January 1st, 2017, to June 30th, 2017) at the pediatric surgery department of Aristide Le Dantec University Teaching Hospital in Senegal. Results: Ninety-one cases were collected. The cancellation rate was 20.8%. Infants were affected in 36.3% of cases. Among anesthesiologists, 83.5% were residents, and 16.5% were specialists. Cancellation in nephroblastoma children with an indication for extended nephrectomy represented 15.4% of cases. Concerning reasons for cancellation, comorbidities, dominated by respiratory infections, accounted for 28.5% of cases, patient absences for 24.2%, and issues related to the anesthesiologist for 17.6%. Cancellations were avoidable in 33% of cases. Patients were responsible for cancellation in 37.4% of cases, the healthcare system in 33%, and medical reasons in 29.7%. Conclusion: Our findings suggest that one-third of cancellations could have been avoided with improvements in the healthcare system. Actions should be taken to reduce the cancellation rate in our context.

关键词： Cancellation Elective surgery Pediatric surgery LMICs Senegal