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IGF2BPs: a family as diagnostic and prognostic biomarkers in digestive system tumors

Medical Data Mining 2023年第2期6卷 50-59页

作者： Xiao-Di Shan Xiao Wang Mian Li Li-Yuan Fan College of Artificial Intelligence and Big Data for Medical Science Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250000China Biomedical Sciences College&Shandong Medicinal Biotechnology Centre Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117China department of Thoracic surgery Qilu Hospital of Shandong UniversityJinan 250012China

The highest morbidity and mortality in the world are attributed to digestive system tumors,such as stomach cancer,liver cancer,and pancreatic *** potential biomarkers is a crucial direction of tumor *** use bioinformatics methods to explore potential biomarkers of the digestive *** and analyzing data from Gene Expression Profiling Interactive Analysis(GEPIA),Kaplan-Meier,cBioPortal,and Metabolic gEne RApid Visualizer(MERAV)to explore the correlation between IGF2BP(insulin-like growth factor-2 mRNA-binding protein)family expression and immune infiltration in digestive system tumors,and further probe the prognostic value of IGF2BP family in digestive system *** cancer tissues showed a significantly higher expression of IGF2BP2 than normal tissues,while IGF2BP3 was notably more expressed in esophageal cancer,pancreatic cancer,and stomach *** the prognosis evaluation,the IGF2BP1 gene in patients with liver cancer and the IGF2BP2 and IGF2BP3 genes in patients with stomach cancer and liver cancer of the low gene expression level groups were *** COX regression analysis further suggested that tumor stage,CD8 positive T cells,macrophages,dendritic cell infiltration,and IGF2BP3 expression were independent risk factors affecting the prognosis of patients with stem cell liver *** IGF2BP family may be a potential marker for immunotherapy and the prognosis of digestive system tumors.

关键词： IGF2BP family digestive system tumors prognosis survival liver cancer stomach cancer

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Retrospective Study Efficacy of pantoprazole plus perforation repair for peptic ulcer and its effect on the stress response

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World Journal of Gastrointestinal surgery 2023年第12期15卷 2757-2764页

作者： Zi-Yan Leng Jia-Hao Wang Lei Gao Ke Shi Hai-Bing Hua The Second Hospital of Traditional Chinese Medicine of Jiangsu Province Affiliated to Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Institute of Literature in Chinese Medicine Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina School of Chinese Medicine&School of Integrated Chinese and Western MedicineNanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina department of Spleen and Gastroenterology Jiangyin Hospital Affiliated to Nanjing University of Chinese MedicineJiangyin 214400Jiangsu ProvinceChina

BACKGROUND Peptic ulcer(PU)is an abnormal phenomenon in which there is rupture of the mucosa of the digestive tract,which not only affects patients'normal life but also causes an economic burden due to its high medical *** To investigate the efficacy of pantoprazole(PPZ)plus perforation repair in patients with PU and its effect on the stress *** The study subjects were 108 PU patients admitted between July 2018 and July 2022,including 58 patients receiving PPZ plus perforation repair[research group(RG)]and 50 patients given simple perforation repair[control group(CG)].The efficacy,somatostatin(SS)concentration,stress reaction[malondialdehyde(MDA),lipid peroxide(LPO)],inflammatory indices[tumor necrosis factor(TNF)-α,C-reactive protein(CRP),interleukin(IL)-1β],recurrence,and complications(perforation,hemorrhage,and pyloric obstruction)were *** The overall response rate was higher in the RG than in the *** in the RG and IL-1β were significantly reduced to lower levels than those in the *** recurrence and complication rates were identified in the RG *** Therefore,PPZ plus perforation repair is conducive to enhancing treatment outcomes in PU patients,reducing oxidative stress injury and excessive inflammatory reactions,and contributing to low recurrence and complication rates.

关键词： Pantoprazole Perforation repair Peptic ulcer Efficacy Etress response

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Systemic air embolism complicating upper gastrointestinal endoscopy:a case report with post-mortem CT scan findings and review of literature

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Forensic Sciences Research 2016年第1期1卷 52-57页

作者： Zabiullah Ali Ferdia Bolster Eric Goldberg David Fowler Ling Li Office of the Chief Medical Examiner State of MarylandBaltimoreMDUSA Sino-US Forensic Evidence Science Research Center Collaborative Innovation Center of Judicial CivilizationChina University of Political Science and LawBeijingChina Division of Forensic Pathology University of Maryland School of MedicineBaltimoreMDUSA department of Radiology Mater Misericordiae University HospitalDublin 7Ireland Division of Gastroenterology and Hepatology University of Maryland School of MedicineBaltimoreMDUSA

Endoscopy of the gastrointestinal and biliary tract is a common procedure and is routinely performed for therapeutic and diagnostic ***,bleeding and infection are some of the more common reported side *** embolism on the other hand,is a rare complication of gastrointestinal *** report a 77-year-old African-American female with a history of pancreatic cancer,which was resected with a Whipple *** part of diagnostic and therapeutic procedure,an endoscopic retrograde cholangiopancreatography was planned several months after the *** patient’s heart rate suddenly slowed to 40 bpm during the procedure and she became cyanotic and difficult to oxygenate after the endoscope was introduced and CO2 gas was insufflated.A forensic autopsy was performed with post-mortem computed tomography(PMCT)and revealed extensive systemic air *** detailed PMCT and autopsy findings are presented and current literature is reviewed.

关键词： Forensic science forensic pathology air embolism endoscopy,digestive system pancreaticoduodenectomy post-mortem computed tomography scan

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EGF signaling pathway plays an important role in colon cancer stem cell proliferation

EGF signaling pathway plays an important role in colon cance...

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2012中国消化系疾病学术大会

作者： Lu Xia Yanjun Feng Xin Dai Xiaolu Li Haiwei Wang Jiansheng Liu Ji Zhang Yanzhi Du department of Gastroenterology Ruijin HospitalShanghai Jiaotong University of Medicine Key Laboratory of Stem Cell Biology Institute of Health SciencesShanghai Institutes for Biological Sciences(SIBS) Chinese Academy of Sciences(CAS) Shanghai Jiao Tong University of Medicine(SJTU-SM)

Objective Cancer stem cells(CSCs) are a subpopulation of cells within a tumor that can self-renew and *** factors,such as epidermal growth factor(EGF),and basic fibroblast growth factor(b-FGF) promote cancer stem cell proliferation in many solid *** study assessed whether EGF,b-FGF and IGF signaling pathways were essential for colon CSCs proliferation and self-renewal.

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The advances of genetics research on Hirschsprung's disease

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Pediatric Investigation 2018年第3期2卷 189-195页

作者： Juntao Ke Ying Zhu Xiaoping Miao State Key Laboratory of Environment Health(Incubation) Key Laboratory of Environment&Health(Ministry of Education)Ministry of Environmental Protection Key Laboratory of Environment and Health(Wuhan)WuhanChina department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Hirschsprung's disease(HSCR)is a rare and complex congenital disorder characterized by the absence of the enteric neurons in lower digestive tract with an incidence of 1/5 *** infant usually suffer from severe constipation with megacolon and distended abdomen,and face long-term complications even after *** the last 2 decades,great efforts and progresses have been made in understanding the genetics and molecular biological mechanisms that underlie ***,only a small fraction of the genetic risk can be explained by the identified mutations in the previously established *** search novel genetic alterations,new study designs with advanced technologies such as genome/exome-wide association studies(GWASs/EWASs)and next generation sequencing(NGS)on target genes or whole genome/exome,were applied to *** this review,we summaries the current development of the genetics researches on HSCR based on GWASs/EWASs and NGS,focusing on the newly discovered variants and genes,and their potential roles in HSCR pathogenesis.

关键词： Genetics Genome/Exome-wide association study Hirschsprung's disease Next generation sequencing

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仿真外科训练系统在微创外科的应用

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中华消化内镜杂志 2002年第6期19卷 343-345页

作者：夏强 Gerhard Hbarth Mustafa Yanik Selman Uranüs Gerhard Bretthauer 上海市第一人民医院普外科 200080 department of Surgical Research Karl-Franzens University School of Medicine Research Center

目的通过比较计算机模拟仿真训练和传统训练模型的训练效果,对模拟仿真训练的有效性和可行性进行评价。方法 17名低年外科医生和24名医学生被随机分成4组,分别受到计算机模拟仿真训练或传统训练模型的训练1 h。在接受训练后,他们将在... 详细信息

目的通过比较计算机模拟仿真训练和传统训练模型的训练效果,对模拟仿真训练的有效性和可行性进行评价。方法 17名低年外科医生和24名医学生被随机分成4组,分别受到计算机模拟仿真训练或传统训练模型的训练1 h。在接受训练后,他们将在传统训练模型中接受连续缝合测试30 min,根据完成缝合的数量和准确性来评价被测试者的能力。结果无论接受何种训练,低年外科医生的测试结果都优于医学生,尤其在缝合速度方面。无论低年外科医生还是医学生,接受计算机模拟仿真训练的测试结果优于传统训练。结论计算机模拟仿真训练将可能在腹腔镜外科训练中发挥重要作用。

关键词：仿真外科训练系统微创外科应用计算机仿真

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中国移植器官保护专家共识(2022版)

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中华消化外科杂志 2022年第2期21卷 169-184页

作者：中国肝移植注册中心国家肝脏移植质控中心国家人体捐献器官获取质控中心国家骨科与运动康复临床研究中心中国医师协会器官移植医师分会移植器官质量控制专业委员会中国医院协会器官获取与分配工作委员会国家创伤医学中心器官保护专业委员会郑树森李建辉徐骁王彦峰谢海洋陈静瑜董念国 Mitesh Badiwala Roberto Vanin Pinto Ribeiro 殷浩海辛立明张浩张建政霍枫杨家印杨洪吉泮辉李绍光贾俊君俞浩梁涵杨思佳乔银标罗佳李浩宇王浩刘鐘阳张里程胡潇逸吴昊胡逸青不详树兰(杭州)医院肝胆胰外科国家卫生与健康委员会多器官联合移植研究重点实验室中国医学科学院肝胆胰肿瘤诊治创新单元及器官移植诊治重点实验室(2019RU019)浙江省器官移植重点实验室杭州310003 济南微生态生物医学省实验室济南250002 树兰(杭州)医院浙江大学医学院附属杭州市第一人民医院武汉大学中南医院浙江大学医学院附属第一医院无锡市人民医院华中科技大学同济医学院附属协和医院 Toronto general Hospital 海军军医大学附属长征医院上海大学解放军总医院第四医学中心解放军南部战区总医院四川大学华西医院四川省人民医院

器官移植是治疗终末期脏器功能衰竭最有效的手段,公民逝世后自愿捐献器官已成为我国移植器官的唯一来源。在临床实践中,移植器官保护技术对提升移植器官质量,改善受者预后发挥重要作用。中国医师协会器官移植医师分会、中华医学会外科... 详细信息

器官移植是治疗终末期脏器功能衰竭最有效的手段,公民逝世后自愿捐献器官已成为我国移植器官的唯一来源。在临床实践中,移植器官保护技术对提升移植器官质量,改善受者预后发挥重要作用。中国医师协会器官移植医师分会、中华医学会外科学分会移植学组及中国肝移植注册中心科学委员会组织专家,基于国内外移植器官保护的基础研究与临床实践,根据牛津循证医学证据分级和GRADE推荐意见系统,针对肝脏、肾脏、胰腺、小肠、心脏、肺脏移植器官编写了《中国移植器官保护专家共识(2016版)》(以下简称2016版共识)。2022年,在中国肝移植注册中心、国家肝脏移植质控中心、国家人体捐献器官获取质控中心、国家骨科与运动康复临床研究中心、国家创伤医学中心器官保护专业委员会等机构的支持下,结合近年来国内外器官移植及器官保护临床实践与研究进展进行总结,形成《中国移植器官保护专家共识(2022版)》(以下简称共识)。此共识重点更新了相关器官获取、保存、转运、质量评估在临床实践中的技术进展及相应循证医学研究证据。此外,增加了包括以肢体移植为主的复合组织移植内容。本共识中器官保护策略旨在促进临床器官移植工作科学、规范开展。

关键词：器官移植器官保护机械灌注器官保存液专家共识

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妊娠期Vater壶腹腺癌的诊断及治疗

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世界核心医学期刊文摘（妇产科学分册） 2005年第8期1卷 8-8页

作者： Haddad O. Porcu-Buisson G. Sakr R. 朱国栋 department of Obstetrics Service Pr Gamerre Hospital La Conception 147 Boulevard Baille 13385 Marseille Cedex 05 France

Background: Cancer of the biliary tract has a poor prognosis and its association with pregnancy is uncommon. Early diagnosis allowing curative surgical resection offers the only hope of long-term survival. Case: This report describes the case of a young 26-week-pregnant woman admitted for cholestatis documented by clinical and laboratory examination. Ultrasonography (US) and magnetic resonance cholangiopancreatography (MRCP) were indicative of common bile tract obstruction. Caesarian section was performed at 32 weeks of pregnancy and the tumor was promptly biopsied. Histology demonstrated carcinoma of the ampulla of Vater. The patient underwent a Whipple procedure. Both mother and baby survived. Conclusion:Pregnant patients with digestive cancer require careful management. Acute non-invasive assessment and radical surgery improve outcome for both the mother and fetus.

关键词： Vater 壶腹癌胆汁淤积消化系统肿瘤胆管癌周因根治性手术早期诊断胰胆管子均

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牙龈卟啉单胞菌在消化系统恶性肿瘤中的作用机制的循证评价

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消化肿瘤杂志（电子版） 2023年第4期15卷 346-357页

作者：李晨曦李慕秋魏巍龚忠诚谭小容刘慧郑佞波新疆医科大学第一附属医院(附属口腔医院)口腔颌面肿瘤外科新疆维吾尔自治区口腔医学研究所新疆乌鲁木齐830054 华中科技大学同济医学院附属协和医院口腔医学中心口腔颌面发育与再生湖北省重点实验室湖北武汉430022 复旦大学附属口腔医院上海市口腔医院口腔颌面外科上海市颅颌面发育与疾病重点实验室上海200031 Comprehensive Cancer Center Wake Forest Baptist HealthDepartment of Microbiology&ImmunologyWake Forest School of MedicineWinston-SalemNC 27101USA

目的口腔菌群与人类健康之间的关系已被学界广泛认识,本研究采用系统评价的方法总结分析牙龈卟啉单胞菌在消化系统恶性肿瘤中的作用。方法检索PubMed、Embase、MEDLINE、Cochrane图书馆、Scopus和Web of Science数据库,检索时限均从... 详细信息

目的口腔菌群与人类健康之间的关系已被学界广泛认识,本研究采用系统评价的方法总结分析牙龈卟啉单胞菌在消化系统恶性肿瘤中的作用。方法检索PubMed、Embase、MEDLINE、Cochrane图书馆、Scopus和Web of Science数据库,检索时限均从建库至2023年8月25日。由2位评价员独立筛选文献、提取资料并评价纳入文献的偏倚风险。遵循系统评价和荟萃分析的首选报告项目(preferred reporting items for systematic reviews and Meta-analyses,PRISMA)方法对纳入文献进行系统评价,分析牙龈卟啉单胞菌在各消化道恶性肿瘤中的致癌机制。结果共计28篇文献(包括2项前瞻性队列研究,26项病例对照研究)被纳入本次系统评价,包括胃癌、食管癌、结直肠癌、胰腺癌、肝癌等多种类型。其中研究食管癌的文献有5篇,胃癌有5篇,结直肠癌有9篇(其中1篇同时研究胃癌),胰腺癌有7篇,肝癌有2篇。全部的纳入文献均报道了口腔菌群失调(包括牙龈卟啉单胞菌)与消化系统恶性肿瘤之间的风险关联。结论本研究系统阐述了牙龈卟啉单胞菌在消化系统恶性肿瘤中的作用,对其可能的致病机制进行分析评价。

关键词：牙龈卟啉单胞菌消化系统恶性肿瘤致病机制系统评价

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