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Decoding 17-Beta-hydroxysteroid Dehydrogenase 13:A Multifaceted Perspective on Its Role in Hepatic Steatosis and Associated Disorders

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Journal of Clinical and Translational Hepatology 2024年第10期12卷 857-864页

作者： Coskun Ozer Demirtas Yusuf Yilmaz department of gastroenterology School of MedicineMarmara UniversityIstanbulTurkiye Institute of Gastroenterol-ogy Marmara UniversityistanbulTurkiye department of gastroenterology School of MedicineRecep Tayyip Erdogan UniversityRizeTurkiye The Global NASH Council WashingtonDCUSA

Chronic liver disease(CLD)represents a significant global health burden,with hepatic steatosis-associated disorders—such as metabolic dysfunction-associated steatohepatitis(MASH),alcoholic liver disease,and hepatitis C virus infection—being major *** genome-wide association studies have identified the rs72613567:TA variant in the 17-beta-hydroxysteroid dehydrogenase 13(HSD17B13)gene as a protective factor against the development and progression of these *** this review,we summarized the current evidence surrounding the HSD17B13 rs72613567 variant,aiming to elucidate its impact on CLD risk and outcomes,and to explore the potential mechanisms behind its hepatoprotective *** rs72613567:TA variant induces a splice donor site mutation,resulting in a truncated,nonfunctional HSD17B13 *** studies have demonstrated that this loss-of-function mutation confers protection against the development of cirrhosis and hepatocellular carcinoma(HCC)in patients with MASH,alcoholic liver disease,and hepatitis C virus ***,the rs72613567:TA variant has been associated with reduced liver enzyme levels and improved survival in HCC *** this variant into genetic risk scores has shown promise in predicting the progression of fatty liver disease to cirrhosis and ***,inhibiting HSD17B13 expression through RNA interference and small molecule inhibitors has emerged as a potential therapeutic strategy for ***,the precise molecular mechanisms underlying the hepatoprotective effects of the HSD17B13 rs72613567 variant remain to be fully *** research should focus on clarifying the structure-function relationship of HSD17B13 and its role in liver pathophysiology to facilitate the development of targeted therapies for CLD associated with hepatic steatosis.

关键词： 17-Beta-hydroxysteroid dehydrogenase 13 Chronic liver disease Polymorphism Genetics Risk factor Hepatocellular carcinoma Metabolic dysfunction-associated steatohepatitis

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Risk factors for recurrence of common bile duct stones after surgical treatment and effect of ursodeoxycholic acid intervention

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 103-112页

作者： Wei-Hong Yuan Zheng Zhang Qi Pan Bo-Neng Mao Tao Yuan department of gastroenterology Yixing People’s HospitalYixing 214200Jiangsu ProvinceChina

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is an accurate diagnostic method for choledocholithiasis and treatment option for stone ***,ursodeoxycholic acid(UDCA)can dissolve cholesterol stones and prevent their development and reappearance by lowering the cholesterol concen-tration in *** these treatment options,there are still patients who experience stone *** clinical data of 100 patients with choledochal stones who were hospitalized at the Yixing People’s Hospital and underwent ERCP for successful stone extraction between June 2020 and December 2022 were retrospectively *** to the post-ERCP treatment plan,100 patients were classified into UDCA(n=47)and control(n=53)*** aimed to assess the clinical efficacy and rate of relapse in the two patient *** then collected information(basic demographic data,clinical characteristics,and serum biochemical indicators)and determined the factors contributing to relapse using logistic regression *** secondary goal was to determine the effects of UDCA on liver function after *** to the control group,the UDCA group demonstrated a higher clinical effectiveness rate of 92.45%vs 78.72%(P<0.05).No significant differences were observed in liver function indices,including total bilirubin,direct bilirubin,gamma-glutamyl transpeptidase,alanine aminotransferase,alkaline phosphatase,and aspartate aminotransferase,between the two groups before *** treatment,all liver function indices were significantly *** the control vs UDCA groups,the UDCA group exhibited significantly lower levels of all indices(55.39±6.53 vs 77.31±8.52,32.10±4.62 vs 45.39±5.69,142.32±14.21 vs 189.63±16.87,112.52±14.25 vs 149.36±15.36,122.61±16.00 vs 171.33±22.09,96.98±10.44 vs 121.35±11.57,respectively,all P<0.05).The stone recurrence rate was lower in the UDCA group(13.21%)in contrast with the control group(44.68%).Periampullary divertic

关键词： Endoscopic retrograde cholangiopancreatography Recurrence Ursodeoxycholic acid Common bile duct stones Clinical effective rate Risk factors

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Perianal Crohn’s disease:Still more questions than answers

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World Journal of gastroenterology 2024年第39期30卷 4260-4266页

作者： Akhilesh Swaminathan Miles P Sparrow department of Medicine University of OtagoChristchurch 8011CanterburyNew Zealand department of gastroenterology Alfred HealthMelbourne 3004VictoriaAustralia department of gastroenterology The Alfred HospitalMelbourne 3004VictoriaAustralia department of gastroenterology Alfred Health and School of Translational MedicineMonash UniversityMelbourne 3004VictoriaAustralia

In this editorial we comment on the article by Pacheco et al published in a recent issue of the World Journal of *** focus specifically on the burden of illness associated with perianal fistulizing Crohn’s disease(PFCD)and the diagnostic and therapeutic challenges in the management of this ***-ving evidence has shifted the diagnostic framework for PFCD from anatomical classification systems,to one that is more nuanced and patient-focused to drive ongoing decision *** editorial aims to reflect on these aspects to help clinicians face the challenge of PFCD in day-to-day clinical practice.

关键词： Perianal Crohn’s disease Crohn’s disease classification Disease severity Crohn’s disease treatment Anorectal malignancy

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Evaluation of oxaliplatin and tigio combination therapy in locally advanced gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1709-1716页

作者： Teng Wang Li-Yun Zhang department of gastroenterology Xianyang HospitalYan’an UniversityXianyang 712000Shaanxi ProvinceChina

BACKGROUND Locally advanced gastric cancer(LAGC)is a common malignant *** recent years,neoadjuvant chemotherapy has gradually become popular for the treatment of *** To investigate the efficacy of oxaliplatin combined with a tigio neoadjuvant chemotherapy regimen vs a conventional chemotherapy regimen for *** Ninety patients with LAGC were selected and randomly divided into control and study groups with 45 patients in each group,according to the numerical table *** control group was treated with conventional chemotherapy,and the study group was treated with oxaliplatin combined with tigio-neoadjuvant *** primary outcome measures were the clinical objective response rate(ORR)and surgical resection rate(SRR),whereas the secondary outcome measures were safety and Karnofsky Performance Status *** The ORR in the study group was 80.00%,which was significantly higher than that of the control group(57.78%).In the study group,SRR was 75.56%,which was significantly higher than that of the control group(57.78%).There were 15.56%adverse reactions in the study group and 35.56%in the control *** differences were statistically significant between the two *** The combination of oxaliplatin and tigio before surgery as neoadjuvant chemotherapy for patients with LAGC can effectively improve the ORR and SRR and is safe.

关键词： Locally advanced gastric cancer Oxaliplatin and tigio Neoadjuvant chemotherapy Surgical resection rate Objective response rate Clinical efficacy

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Can serum immunoglobulin G4 levels and age serve as reliable predictors of relapse in autoimmune pancreatitis?

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World Journal of gastroenterology 2024年第5期30卷 512-515页

作者： Jun-Min Song Si-Yu Sun department of gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

We are writing in response to the paper published in the World Journal of gastroenterology by Zhou et *** authors identified higher serum immunoglobulin(Ig)G4 levels and age over 55 years as independent risk factors for disease *** notable strengths,it is crucial to address potential ***,the cohort study included 189 patients with autoimmune pancreatitis(AIP)type 1(with higher IgG4 seropositivity and higher relapse)and 24 with type 2(with lower IgG4 seropositivity and lower relapse).Consequently,most,if not all,AIP type 2 patients were assigned to the normal group,possibly inflating the association of higher serum IgG4 levels with relapse and potentially exaggerating the association of older age with ***,the authors did not provide sufficient details regarding AIP diagnosis,such as the ratio of definitive vs probable cases and the proportion of *** cases where histological evidence is unavailable or indeterminate,AIP type 2 may be misdiagnosed as definitive type 1,and type 1 may also be misdiagnosed as probable type 2,particularly in cases with normal or mildly elevated serum IgG4 ***,in this retrospective study,approximately one-third of the consecutive patients initially collected were excluded for various ***,the impact of nonrandom exclusion on relapse outcomes should be carefully *** conclusion,the paper by Zhou et al offers plausible,though not entirely compelling,evidence suggesting a predictive role of elevated serum IgG4 levels and advanced age in AIP *** foundation for future investigations lies in ensuring a reliable diagnosis and accurate disease subtyping,heavily dependent on obtaining histological *** this regard,endoscopic ultrasound-guided fine-needle biopsy emerges as a pivotal component of the diagnostic process,contributing to mitigating biases in future explorations of the disease.

关键词： Autoimmune pancreatitis Immunoglobulin Endoscopic ultrasound Relapse Age

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Effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease:Clinical implications

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World Journal of gastroenterology 2024年第27期30卷 3264-3267页

作者： Giovanna McGinty Robert Przemioslo department of gastroenterology North Bristol TrustSouthmead HospitalBristol BS105NBUnited Kingdom department of gastroenterology and Hepatology North Bristol TrustSouthmead HospitalBristol BS105NBUnited Kingdom

In this editorial,we comment on the article by Chen et al recently published in *** focus the debate on whether reducing the upper limit of normal of alanine aminotransferase(ALT)would effectively identify cases of fibrosis in metabolic-dysfunction associated fatty liver disease(MAFLD).This is important given the increasing prevalence of MAFLD and obesity ***,a suitable screening test to identify patients in the general population does not exist and most patients are screened after the finding of an abnormal *** authors of this paper challenge the idea of what a normal ALT is and whether that threshold should be lowered,particularly as their study found that 83.12%of their study population with a diagnosis of MAFLD had a normal *** main advantages of screening would be to identify patients and provide intervention early,the mainstay of this being changing modifiable risk factors and monitoring for liver ***,there is not enough suitable therapeutic options available as of yet although this is likely to change in the coming years with more targets for therapy being *** is one example of this which has demonstrated benefit with an acceptable side effect profile for those patients with MAFLD and obesity,although studies have not yet shown a significant improvement in fibrosis *** would also require a huge amount of resource if a reduced ALT level alone was used as criteria;it is more likely that current scoring systems such as fibrosis-4 may be amended to represent this additional ***,there is not a good argument to recommend wide-spread screening with a reduced ALT level as this is unlikely to be *** is compounded by the fact that there is a significant heterogeneity in what is considered a normal ALT between *** studies previously have suggested a more pragmatic approach in screening those over the age of 60,this is likely to change with the increasing inc

关键词： Alanine aminotransferase Metabolic-dysfunction associated fatty liver disease Metabolic syndrome Fibrosis Cirrhosis Semaglutide

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A journey of a thousand miles begins with one small step

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 112-114页

作者： Elke Roeb department of gastroenterology Medical Clinic IIJustus Liebig UniversityGiessenGermany

Liver disease associated with metabolic dysfunction now affects more than 30%of the world’s population(1).Historically known as non-alcoholic fatty liver disease(NAFLD)is caused by obesity,lack of exercise,and a westernised lifestyle(2).To date,numerous attempts have been made to influence the steatohepatitis and liver fibrosis associated with metabolism-associated fatty liver disease(MAFLD)with *** to date,no substance has been authorised for the indication NAFLD/MAFLD/metabolism-associated steatosis liver disease(MASLD)(3).It has long been known that a consistent change in lifestyle with a reduced diet and physical exercise is able to improve fatty liver disease,steatohepatitis.

关键词： Metabolism-associated steatosis liver disease(MASLD) metabolism-associated fatty liver disease(MAFLD) non-alcoholic fatty liver disease(NAFLD) exercise fatty liver

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A DNA micro-complex containing polyaptamer for exosome separation and wound healing

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Chinese Chemical Letters 2024年第9期35卷 257-261页

作者： Jingwen Zhao Jianpu Tang Zhen Cui Limin Liu Dayong Yang Chi Yao department of gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Institute of Digestive DiseaseTianjin Key Laboratory of Digestive DiseasesTianjin 300052China Frontiers Science Center for Synthetic Biology Key Laboratory of Systems Bioengineering(MOE)School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China

Exosomes(EXOs)have showed great potential in regenerative *** separation of EXOs from complex biological media is essential for the down-stream ***,we report a deoxyribonucleic acid(DNA)-based micro-complex(DMC)containing polyaptamers,which realized the specific separation of EXOs from cell culture media and the significant promotion of wound *** synthesis of DMCs was based on a biomineralization process via rolling circle amplification(RCA)under the catalysis of phi29 DNA *** endow DMCs with the ability to capture EXOs,the DNA template of RCA was integrated with complementary sequence of aptamer that specifically recognized the CD63 proteins on *** obtained DMCs contained polyaptamers that can specifically capture the EXOs in cell culture *** EXOs-capturing DMCs were collected by centrifugation,achieving the separation of *** stem cell(MSC)-derived EXOs(MSC-EXOs)were separated by this DMC-based strategy,and the separated MSC-EXOs significantly enhanced the migration ability of *** particular,the significant therapeutic efficacy of the DMCs with MSC-EXOs was verified in full-thickness wound excision mouse models,in which the wounds completely healed in 10 *** envision that this DMC-based separation strategy can be a promising route to promote the development of EXOs in biomedicine.

关键词： DNA nanotechnology DNA materials Aptamer Exosomes Wound healing

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MiRNA-145-5p inhibits gastric cancer progression via the serpin family E member 1-extracellular signal-regulated kinase-1/2 axis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2123-2140页

作者： Hong-Xia Bai Xue-Mei Qiu Chun-Hong Xu Jian-Qiang Guo department of gastroenterology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina department of gastroenterology Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina department of Reproductive Center Zaozhuang Maternal and Child Health Care HospitalZaozhuang 277000Shandong ProvinceChina

BACKGROUND MicroRNAs(miRNAs)regulate gene expression and play a critical role in cancer ***,there is still a limited understanding of the function and regulatory mechanism of miRNAs in gastric cancer(GC).AIM To investigate the role and molecular mechanism of miRNA-145-5p(miR145-5p)in the progression of *** Real-time polymerase chain reaction(RT-PCR)was used to detect miRNA expression in human GC tissues and *** ability of cancer cells to migrate and invade was assessed using wound-healing and transwell assays,*** proliferation was measured using cell counting kit-8 and colony formation assays,and apoptosis was evaluated using flow *** of the epithelial-mesenchymal transition(EMT)-associated protein was determined by Western *** of miR-145-5p were predicated using bioinformatics analysis and verified using a dual-luciferase reporter *** family E member 1(SERPINE1)expression in GC tissues and cells was evaluated using RT-PCR and immunohistochemical *** correlation between SERPINE1 expression and overall patient survival was determined using Kaplan-Meier plot *** association between SERPINE1 and GC progression was also tested.A rescue experiment of SERPINE1 overexpression was conducted to verify the relationship between this protein and *** mechanism by which miR-145-5p influences GC progression was further explored by assessing tumor formation in nude *** GC tissues and cells had reduced miR-145-5p expression and SERPINE1 was identified as a direct target of this *** of miR-145-5p was associated with decreased GC cell proliferation,invasion,migration,and EMT,and these effects were reversed by forcing SERPINE1 ***-Meier plot analysis revealed that patients with higher SERPINE1 expression had a shorter survival rate than those with lower SERPINE1 *** mouse tumorigenesis experiments confirmed that miR-145-5p target

关键词： Gastric cancer MicroRNA-145-5p Serpin family E member 1 Epithelial-mesenchymal transition Proliferation Extracellular signal-regulated kinase-1/2

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Fusobacterium nucleatum:Unraveling its potential role in gastric carcinogenesis

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World Journal of gastroenterology 2024年第35期30卷 3972-3984页

作者： Vytenis Petkevicius Konrad Lehr Juozas Kupcinskas Alexander Link department of gastroenterology Lithuanian University of Health SciencesKaunas 44307Lithuania department of gastroenterology Hepatology and Infectious DiseasesOtto-von-Guericke University HospitalMagdeburg 39120Germany Institute for Digestive Research Lithuanian University of Health SciencesKaunas 50161Lithuania

Fusobacterium nucleatum(***)is a Gram-negative anaerobic bacterium that plays a key role in the development of oral inflammation,such as periodontitis and *** the last 10 years,*** has been identified as a prevalent bacterium associated with colorectal adenocarcinoma and has also been linked to cancer progression,metastasis and poor disease *** the role of *** in colon carcinogenesis has been intensively studied,its role in gastric carcinogenesis is still poorly *** Helicobacter pylori infection has histo-rically been recognized as the strongest risk factor for the development of gastric cancer(GC),with recent advances in DNA sequencing technology,other members of the gastric microbial community,and *** in particular,have received increasing *** this review,we summarize the existing knowledge on the involvement of *** in gastric carcinogenesis and address the potential translational and clinical significance of *** in GC.

关键词： Fusobacterium nucleatum Gastric microbiota Gastric cancer Preneoplastic changes Prognosis

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