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Predictors of stricture after endoscopic submucosal dissection of the esophagus and steroids application

World Journal of Gastrointestinal endoscopy 2024年第9期16卷 509-518页

作者： Qing-Xia Wang Yuan Ding Qi-Liu Qian Yin-Nan Zhu Rui-Hua Shi department of gastroenterology Southeast University Affiliated Zhongda HospitalMedical SchoolNanjing 210009Jiangsu ProvinceChina

BACKGROUND Endoscopic submucosal dissection(ESD)is a reliable method to resect early esophageal *** stricture is one of the major complications after ESD of the *** prophylaxis for esophageal strictures,particularly local injection of triamcinolone acetonide(TA),is a relatively effective method to prevent esophageal ***,even with steroid prophylaxis,stenosis still occurs in up to 45%of *** the risk of stenosis formation after local TA injection would enable additional interventions in risky *** To identify the predictors of esophageal strictures after steroids *** Patients who underwent esophageal ESD and steroid prophylaxis and who were comprehensively assessed for lesion-and ESD-related factors at Southeast University Affiliated Zhongda hospital between February 2018 and March 2023 were included in the *** univariate and multivariate regression analyses were conducted to identify the predictors of stricture among patients undergoing steroid *** A total of 120 patients were included in the *** the oral prednisone and oral prednisone combined with local tretinoin injection groups,the stenosis rates were 44/53(83.0%)and 56/67(83.6%),*** them,univariate analysis showed that the lesion circumference(P=0.01)and submucosal injection solution(P=0.04)showed significant correlation with the risk of stenosis *** regression analyses were then performed using predictors that were significant in the univariate analyses and combined with known predictors from previous reports,such as additional chemoradiotherapy and tumor *** identified a lesion circumference<5/6(OR=0.19;P=0.02)and submucosal injection of sodium hyaluronate(OR=0.15;P=0.03)as independent predictors of on esophageal stricture *** Steroid prophylaxis effectively prevents ***,the lesion circumference and submucosal injection of sodium h

关键词： Endoscopic submucosal dissection Esophageal stricture Oral steroids Triamcinolone acetonide Predictors

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Benefits of endoscopic gallbladder stenting following percutaneous transhepatic gallbladder drainage

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2902-2909页

作者： Fumitaka Niiya Naoki Tamai Masataka Yamawaki Jun Noda Tetsushi Azami Yuichi Takano Fumiya Nishimoto Masatsugu Nagahama Division of gastroenterology Department of Internal MedicineShowa University Fujigaoka HospitalYokohama 227-8501KanagawaJapan

BACKGROUND Endoscopic transpapillary gallbladder drainage is challenging because of the complexity of the procedure and high incidence of adverse events(AEs).To overcome these problems,endoscopic gallbladder stenting(EGBS)after percutaneous transhepatic gallbladder drainage(PTGBD)can be effective,as it mitigates inflammation and *** To examine the benefits of EGBS after PTGBD to assess its efficacy and impact on *** We retrospectively analyzed data from 35 patients who underwent EGBS after PTGBD at a single center between January 2016 and December *** primary outcomes were technical success and AEs,and the rate of recurrent cholecystitis was *** addition,the reasons for the failure of the procedure were *** Among the 35 patients,the technical success rate was 77.1%and the final contrast of the cystic duct was successful in 97.1%of *** incidence of early AEs was relatively low(11.4%),with no instances of cystic duct *** rate of recurrent cholecystitis was 3.7%,and no other biliary events were *** EGBS after PTGBD may be significantly beneficial,with a substantial success rate and minimal AEs in both short-and long-term follow-ups.

关键词： endoscopy Gallbladder Stents Drainage Adverse events Cholecystitis Follow-up Cystic duct

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Upper gastrointestinal bleeding in Bangladeshi children:Analysis of 100 cases

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World Journal of Gastrointestinal endoscopy 2024年第1期16卷 44-50页

作者： Md Wahiduzzaman Mazumder Md Benzamin department of Pediatric gastroenterology and Nutrition Bangabandhu Sheikh Mujib Medical UniversityDhaka 1000Bangladesh department of Pediatric gastroenterology and Nutrition Sylhet M A G Osmani Medical College HospitalSylhet 3100Bangladesh

BACKGROUND Upper gastrointestinal bleeding(UGIB)is defined as bleeding that occurs proximal to the ligament of Treitz and can sometimes lead to potentially serious and life-threatening clinical situations in ***,the cause of UGIB differs significantly depending on the geographic location,patient population and presence of comorbid *** To observe endoscopic findings of UGIB in children at a tertiary care center of *** This retrospective study was carried out in the department of Pediatric gastroenterology and Nutrition of Bangabandhu Shiekh Mujib Medical University,a tertiary care hospital of Bangladesh,between January 2017 and January *** collected from hospital records of 100 children who were 16 years of age or younger,came with hematemesis,melena or both hematemesis and *** patients underwent upper gastrointestinal endoscopy(Olympus CV 1000 upper gastrointestinal video endoscope)after initial *** investigations to diagnose portal hypertension and chronic liver disease with underlying causes for management purposes were also *** A total of 100 patients were *** was common in the age group 5-10 years(42%),followed by above 10 years(37%).Hematemesis was the most common presenting symptom(75%)followed by both hematemesis and melena(25%).UGIB from ruptured esophageal varices was the most common cause(65%)on UGI endoscopy followed by gastric erosion(5%)and prolapsed gastropathy(2%).We observed that 23%of children were normal after endoscopic *** Ruptured esophageal varices were the most common cause of UGIB in children in *** causes included gastric erosions and prolapsed gastropathy syndrome.

关键词： Bangladeshi Children endoscopy Upper gastrointestinal bleeding Esophageal varices

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Gastric fundoplication with endoscopic technique:A novel approach for gastroesophageal reflux disease treatment

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World Journal of Gastrointestinal endoscopy 2024年第10期16卷 557-565页

作者： Eyad Gadour Anna Carolina Hoff department of gastroenterology and Hepatology King Abdulaziz Hospital-National GuardAhsa 31982Saudi Arabia Internal Medicine Zamzam University CollegeSchool of MedicineKhartoum 11113Sudan Bariatric endoscopy Angioskope ClinicSão Josédos Campos 12243-680São PauloBrazil

BACKGROUND Gastric fundoplication with endoscopic technique(GFET)is an innovative approach to managing gastroesophageal reflux disease(GERD).This minimally invasive procedure utilizes the GEN-2 Apollo endosuture device and Olympus H2T180 gastroscope to perform partial fundoplication by strategically placing Prolene 2-0 sutures at the 11,7,5,1,and 3 o’clock positions around the gastroesophageal *** To evaluate whether GFET enhances the lower esophageal sphincter function by creating comprehensive plication to improve the barrier against *** This single-center prospective study included patients undergoing *** beginning GFET,pH metrics and subsequent manometric measurements were *** analysis of variance was performed to determine statistically significant differences between quality of life(QOL)and DeMeester scores at the time of the procedure and 6 and 12 months ***’sχ2 test was performed to identify statistically significant differences between categorical variables at the time of the procedure and 6 and 12 months *** Eighteen participants were enrolled(11 males and 7 females;mean age,35 years).More than 70%had an initial Hill grade of *** adverse event was recorded after the *** patient underwent valve reinforcement at 12 *** mean QOL score was markedly higher at the time of the procedure(39.9±4.0)compared to those at 6 and 12 months postoperatively(P<0.001).Scores at 12 months were slightly higher than those at 6 *** highest mean QOL score was observed at the time of the procedure,followed by those at 6 and 12 months postoperatively(P<0.001).A similar trend was noted for the mean DeMeester scores(P<0.001).CONCLUSION GFET is a minimally invasive alternative to traditional surgical interventions and endoscopic techniques for managing *** research is warranted to validate its long-term efficacy and effectiveness over existing treatments.

关键词： Gastric fundoplication with endoscopic technique Gastroesophageal reflux disease Therapeutic endoscopy

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Future directions of noninvasive prediction of esophageal variceal bleeding:No worry about the present computed tomography inefficiency

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World Journal of Gastrointestinal endoscopy 2024年第3期16卷 108-111页

作者： Yu-Hang Zhang Bing Hu department of gastroenterology and Hepatology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

In this editorial,we comment on the minireview by Martino A,published in the recent issue of World Journal of Gastrointestinal endoscopy 2023;15(12):*** focused mainly on the possibility of replacing the hepatic venous pressure gradient(HVPG)and endoscopy with noninvasive methods for predicting esophageal variceal *** risk factors for bleeding were the size of the varices,the red sign and the Child-Pugh *** intrinsic core factor that drove these changes was the ***,the present studies investigating noninvasive methods,including computed tomography,magnetic resonance imaging,elastography,and laboratory tests,are working on correlating imaging or serum marker data with intravenous pressure and clinical outcomes,such as bleeding.A single parameter is usually not enough to construct an efficient ***,multiple factors were used in most of the studies to construct predictive *** results have been obtained,in which bleeding prediction was partly ***,these methods are not satisfactory enough to replace invasive methods,due to the many drawbacks of different *** is still plenty of room for future *** of the precise timing of bleeding using various models,and extracting the texture of variceal walls using high-definition imaging modalities to predict the red sign are interesting directions to lay investment on.

关键词： Esophageal variceal bleeding Prediction noninvasive Computed tomography Hepatic venous pressure gradient endoscopy

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Analysis of quality of life in patients after transgastric natural orifice transluminal endoscopic gallbladder-preserving surgery

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World Journal of Gastrointestinal endoscopy 2024年第6期16卷 318-325页

作者： Min-Yu Zhang Sen-Yuan Zheng Zheng-Yu Ru Zhi-Qiang Zhang department of gastroenterology The First Affiliated Hospital of Xinjiang Medical UniversityUrimuqi 830011Xinjiang Uygur Autonomous RegionChina

BACKGROUND At present,laparoscopic cholecystectomy(LC)is the main surgical treatment for ***,after gallbladder removal,there are many ***,it is hoped to remove stones while preserving the function of the gallbladder,and with the development of endoscopic technology,natural orifice transluminal endoscopic surgery came into *** To compare the quality of life,perioperative indicators,adverse events after LC and transgastric natural orifice transluminal endoscopic gallbladder-preserving surgery(EGPS)in patients with *** Patients who were admitted to The First Affiliated hospital of Xinjiang Medical University from 2020 to 2022 were retrospectively *** adopted propen-sity score matching(1:1)to compare EGPS and LC *** A total of 662 cases were collected,of which 589 cases underwent LC,and 73 cases underwent *** score matching was performed,and 40 patients were included in each of the *** the EGPS group,except the gastr-ointestinal defecation(P=0.603),the total score,physical well-being,mental well-being,and gastrointestinal digestion were statistically significant compared with the preoperative score after surgery(Phospital stay and cost,LC group were lower than EGPS *** recurrence factors of gallstones after EGPS were analyzed:and recurrence was not correlated with gender,age,body mass index,number of stones,and preoperative *** Whether EGPS or LC,it can improve the patient’s symp

关键词： Gallstones Natural orifice transluminal endoscopic surgery Gallbladder preservation Cholecystolithotomy Laparoscopic cholecystectomy Gastrointestinal quality of life index

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Heterotopic mesenteric ossification caused by trauma:A case report

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World Journal of Gastrointestinal endoscopy 2024年第8期16卷 494-499页

作者： Bi-Fang Zhang Jiang Liu Shuai Zhang Ling Chen Jia-Zheng Lu Ming-Qing Zhang department of gastroenterology The 909th HospitalSchool of MedicineXiamen UniversityZhangzhou 363000Fujian ProvinceChina

BACKGROUND Heterotopic mesenteric ossification(HMO)is a clinically rare condition characterized by the formation of bone tissue in the *** worldwide reporting of such cases is limited to just over 70 instances in the medical *** etiology of HMO remains unclear,but the disease is possibly induced by mechanical trauma,ischemia,or intra-left lower quadrant abdominal infection,leading to the differentiation of mesenchymal stem cells into ***,we present a rare case of HMO that occurred in a 34-year-old male,who presented with left lower quadrant abdominal *** SUMMARY We report the case of a 34-year-old male patient who presented with left lower abdominal pain following trauma to the left lower *** subsequently underwent surgical treatment,and the postoperative pathological diagnosis was *** We believe that although there is limited literature and research on HMO,when patients with a history of trauma or surgery to the left lower abdomen present with corresponding imaging findings,clinicians should be vigilant in distinguishing this condition and promptly selecting appropriate diagnostic and therapeutic interventions.

关键词： Abdominal injuries Heterotopic ossification Mesentery Abdominal pain Case report

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Early adenocarcinoma mixed with a neuroendocrine carcinoma component arising in the gastroesophageal junction: A case report

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 563-570页

作者： Yu-Qing Cheng Geng-Fang Wang Xiao-Li Zhou Min Lin Xin-Wen Zhang Qin Huang department of Pathology The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityChangzhou 213164Jiangsu ProvinceChina gastroenterology Center The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityChangzhou 213164Jiangsu ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina department of Pathology Beth Israel Deaconess Medical Center and Harvard Medical SchoolBostonMA 02215United States

BACKGROUND Early adenocarcinoma mixed with a neuroendocrine carcinoma(NEC)component arising in the gastroesophageal junctional(GEJ)region is rare and even rarer in young ***,we report such a case in a 29-year-old Chinese *** SUMMARY This patient presented to our hospital with a 3-mo history of dysphagia and *** endoscopy revealed an elevated nodule in the distal esophagus 1.6 cm above the GEJ line,without Barrett’s esophagus or involvement of the gastric *** nodule was completely resected by endoscopic submu-cosal dissection(ESD).Pathological examination confirmed diagnosis of intra-mucosal adenocarcinoma mixed with an NEC component,measuring 1.5 ***,both adenocarcinoma and NEC components were positive for P53 with a Ki67 index of 90%;NEC was positive for synaptophysin and ***-generation sequencing of 196 genes demonstrated a novel germline mutation of the ERCC3 gene in the DNA repair pathway and a germline mutation of the RNF43 gene,a common gastric cancer driver gene,in addition to pathogenic somatic mutations in P53 and CHEK2 *** patient was alive without evidence of the disease 36 mo after *** Early adenocarcinoma with an NEC component arising in the distal esophageal side of the GEJ region showed evidence of gastric origin.

关键词： Adenocarcinoma Neuroendocrine carcinoma Gastroesophageal junction Next generation sequencing Case report

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In vivo pilot study into superficial microcirculatory characteristics of colorectal adenomas using novel high-resolution magnifying endoscopy with blue laser imaging

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World Journal of Gastrointestinal endoscopy 2024年第4期16卷 206-213页

作者： Hai-Bin Dong Tao Chen Xiao-Fei Zhang Yu-Tang Ren Bo Jiang department of gastroenterology Beijing Tsinghua Changgung HospitalBeijing 102218China Center for Medical Data Science Beijing Tsinghua Changgung HospitalBeijing 102218China

BACKGROUND No studies have yet been conducted on changes in microcirculatory hemody-namics of colorectal adenomas in vivo under *** microcirculation of the colorectal adenoma could be observed in vivo by a novel high-resolution magnification endoscopy with blue laser imaging(BLI),thus providing a new insight into the microcirculation of early colon *** To observe the superficial microcirculation of colorectal adenomas using the novel magnifying colonoscope with BLI and quantitatively analyzed the changes in hemodynamic *** From October 2019 to January 2020,11 patients were screened for colon adenomas with the novel high-resolution magnification endoscope with *** images were recorded and processed with Adobe Premiere,Adobe Photoshop and Image-pro Plus *** microcirculation parameters:Microcirculation vessel density(MVD),mean vessel width(MVW)with width standard deviation(WSD),and blood flow velocity(BFV),were calculated for adenomas and the surrounding normal *** A total of 16 adenomas were *** with the normal surrounding mucosa,the superficial vessel density in the adenomas was decreased(MVD:0.95±0.18 vs 1.17±0.28μm/μm2,P<0.05).MVW(5.11±1.19 vs 4.16±0.76μm,P<0.05)and WSD(11.94±3.44 vs 9.04±3.74,P<0.05)were both *** slowed in the adenomas(709.74±213.28 vs 1256.51±383.31μm/s,P<0.05).CONCLUSION The novel high-resolution magnification endoscope with BLI can be used for in vivo study of adenoma superficial *** vessel density was decreased,more irregular,with slower blood flow.

关键词： Adenoma Microcirculation High-resolution magnification endoscopy Blue laser imaging

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Capsule endoscopy and panendoscopy:A journey to the future of gastrointestinal endoscopy

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World Journal of gastroenterology 2024年第10期30卷 1270-1279页

作者： Bruno Rosa JoséCotter department of gastroenterology Hospital da Senhora da OliveiraGuimarães 4835-044Portugal Life and Health Sciences Research Institute School of MedicineUniversity of MinhoBraga 4710-057Portugal ICVS/3B's PT Government Associate LaboratoryBraga 4710-057Portugal

In 2000,the small bowel capsule revolutionized the management of patients with small bowel ***,the technological development achieved by the new models of double-headed endoscopic capsules,as miniaturized devices to evaluate the small bowel and colon[pan-intestinal capsule endoscopy(PCE)],makes this non-invasive procedure a disruptive concept for the management of patients with digestive *** technology is expected to identify which patients will require conventional invasive endoscopic procedures(colonoscopy or balloon-assisted enteroscopy),based on the lesions detected by the capsule,i.e.,those with an indication for biopsies or endoscopic *** use of PCE in patients with inflammatory bowel diseases,namely Crohn’s disease,as well as in patients with iron deficiency anaemia and/or overt gastrointestinal(GI)bleeding,after a non-diagnostic upper endoscopy(esophagogastroduodenoscopy),enables an effective,safe and comfortable way to identify patients with relevant lesions,who should undergo subsequent invasive endoscopic *** recent development of magnetically controlled capsule endoscopy to evaluate the upper GI tract,is a further step towards the possibility of an entirely non-invasive assessment of all the segments of the digestive tract,from mouth-to-anus,meeting the expectations of the early developers of capsule endoscopy.

关键词： Non-invasive endoscopy Panendoscopy Magnetically controlled capsule endoscopy Crohn’s disease Digestive bleeding

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