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Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth

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World Journal of gastroenterology 2005年第10期11卷 1420-1425页

作者： Guido Schumacher Marijke Oidtmann Anne Rueggeberg Dietmar Jacob Sven Jonas Jan M. Langrehr Ruth Neuhaus Marcus Bahra Peter Neuhaus departments of General department of Anesthesiology

AIM: Standard immunosuppression after organ transplantation stimulates tumor growth. Sirolimus has a strong antiproliferative and a tumor inhibiting effect. The purpose is to assess the effect on tumor growth of the immunosuppressive compounds sirolimus and tacrolimus alone and in combination on cells of human hepatocellular ***: We used the human cell lines SK-Hep 1 and Hep 3B derived from hepatocellular carcinoma. Proliferation analyses after treatment with sirolimus, tacrolimus, or the combination of both were performed. FACS analyses were done to reveal cell cycle changes and apoptotic cell death. The expression of apoptosis-related proteins was estimated by Western ***: Sirolimus alone or combined with tacrolimus inhibited the growth of both cell lines after 5 d by up to 35% in SK-Hep 1 cells, and by up to 68% in Hep 3B cells at 25 ng/mL. Tacrolimus alone stimulated the growth by 12% after 5 ng/mL and by 25% after 25 ng/mL in Hep 3B cells. We found an increase of apoptotic Hep 3B cells from 6 to 16%, and a G1-arrest in SK-Hep 1 cells with an increase of cells from 61 to 82%, when sirolimus and tacrolimus were combined. Bcl-2 was down-regulated in Hep 3B, but not in SK-Hep 1 cells after combined ***: Sirolimus appears to inhibit the growth of hepatocellular carcinoma cells alone and in combination with tacrolimus. Sirolimus seems to inhibit the growth stimulation of tacrolimus.

关键词： Sirolimus Tacrolimus Hepatocellular carcinoma Growth inhibition Apoptosis SK-Hep 1 Hep3B

PREDICTION TECHNIQUES OF CHAOTIC TIME SERIES AND ITS APPLICATIONS AT LOW NOISE LEVEL

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Applied Mathematics and Mechanics(English Edition) 2006年第1期27卷 7-14页

作者：马军海王志强陈予恕 School of Management department of Mechanics

The paper not only studies the noise reduction methods of chaotic time series with noise and its reconstruction techniques, but also discusses prediction techniques of chaotic time series and its applications based on chaotic data noise reduction. In the paper, we first decompose the phase space of chaotic time series to range space and null noise space. Secondly we restructure original chaotic time series in range space. Lastly on the basis of the above, we establish order of the nonlinear model and make use of the nonlinear model to predict some research. The result indicates that the nonlinear model has very strong ability of approximation function, and Chaos predict method has certain tutorial significance to the practical problems.

关键词： chaotic time series noise reduction essential characteristic extraction nonlinear model predict technology

Determining topographic shielding from digital elevation models for cosmogenic nuclide analysis: a GIS model for discrete sample sites

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Journal of Mountain Science 2018年第5期15卷 939-947页

作者： LI Ying-kui department of Geography University of Tennessee

Topographic shielding(TS) is an important factor in cosmogenic nuclide surface exposure dating. The development of geographic information systems(GIS) and the availability of digital elevation models(DEMs) make it possible to derive this factor directly from a DEM. Most available GIS models derive the TS factors for an area(all cells in a DEM) without the consideration of surface conditions of individual sites, such as the strike, dip,and height above ground, into the calculation. This paper presents a new GIS model to derive the TS factors for discrete sample sites. This model uses the Skyline and Skyline Graph functions in ArcGIS to extract the set of azimuth and elevation angles of topographic obstructions around each site from a DEM(considering the sample height above ground)and then incorporates the strike and dip information of the sample surface to derive the TS factor. All processing tools and steps are streamlined in ArcGIS modelbuilder and this model can be run like a standard ArcGIS geoprocessing tool. It provides an easy and user-friendly means to derive the TS factors for discrete samples based on a DEM and the measured strike, dip and sample height for each site.

关键词： Cosmogenic nuclides Topographicshielding Digital elevation models (DEMs) ArcGISmodelbuilder

Lipschitz continuity for solutions of the ?-Poisson equation

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Science China Mathematics 2019年第10期62卷 1935-1946页

作者： Xingdi Chen department of Mathematics Huaqiao University

In this paper, we study the Lipschitz continuity for solutions of the ?-Poisson equation. After characterizing the boundary conditions for the Lipschitz continuity of ?-harmonic mappings, we present four equivalent conditions for the(K, K′)-quasiconformal solutions of the ?-Poisson equation with a nonhomogeneous term to be Lipschitz continuous.

关键词： weighted Laplacian operator Lipschitz continuity Dirichlet boundary problem harmonic mapping (K,K′)-quasiconformal mapping

A Note on the Maximal Functions on Weighted Harmonic AN Groups

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Chinese Annals of Mathematics,Series B 2016年第2期37卷 193-198页

作者： Yurong WU Shiliang ZHAO department of Mathematics Fudan University

In this paper, the authors point out that the methods used by Li(2004, 2005,2007) can be applied to study maximal functions on weighted harmonic AN groups.

关键词： Hardy-Littlewood maximal function Harmonic AN groups Lorentz spaces

Tunable Adsorption and Desorption of Hydrogen Atoms on Single-Walled Carbon Nanotubes

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Chinese Physics Letters 2002年第10期19卷 1498-1500页

作者： Zhao Ming-Wen Xia Yue-Yuan Ma Yu-Chen Ying Min-Ju Liu Xiang-Dong Mei Liang-Mo department of Physics Shandong University Ji'nan 250100 department of Optoelectronics Shandong University Ji'nan 250100

Chemical adsorption and desorption of hydrogen atoms on single-walled carbon nanotubes (SWNTs) are investigated by using molecular dynamics simulations. It is found that the adsorption and desorption energy of hydrogen atoms depend on the hydrogen coverage and the diameter of the SWNTs. Hydrogen-adsorption geometry at the coverage of 1.0 is more energetically stable. The adsorption energy decreases with the increasing diameter of the armchair tubes. The adsorption and desorption energy of hydrogen atoms can be modified reversibly by externally radial deformation. The averaged C-H bond energy on the high curvature sites of the deformed tube increases with increasing radial deformation, while that on the low curvature sites decreases.

关键词： Molecular dynamics

Optical Nutation Effect in the Three-Level System Driven by a Coherent Microwave Field

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Chinese Physics Letters 1997年第8期14卷 589-592页

作者： CAO Zhuo-liang GUO Guang-can department of Physics Anhui UniversityHefei 230039 department of Physics University of Science and Technology of ChinaHefei 230026

In this paper,a coherent transient effect-optical nutation in Bloch form is studied semiclassically in the three-level atomic system driven by a coherent microwave *** amplitude of the optical nutation signal field is *** is found that the signal field,related to the microwave,is the overlap of two slow oscillations instead of one.

关键词： field. microwave coherent

Casimir Energy in Hartle-Hawking State

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Chinese Physics Letters 2008年第8期25卷 2791-2794页

作者：方恒忠朱建阳 department of Physics China University of Petroleum Dongying 257061 department of Physics Beijing Normal University Beijing 100875

We calculate the Casimir effect at finite temperature in Minkowski spacetime by using statistical method, the approximate expressions of the Casimir effect in the low and high temperature limits are also discussed. Then employing some general properties of the renormalized stress tensor, we obtain the Casimir energy stress tensor in Hattie-Hawking state.

关键词： CURVED SPACETIME QUANTUM FIELD

L(1, 2)-edge-labelings for lattices

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Applied Mathematics(A Journal of Chinese Universities) 2014年第2期29卷 230-240页

作者： HE Dan LIN Wen-song department of Mathematics Southeast University

For a graph G and two positive integers j and k, an m-L（j, k）-edge-labeling of G is an assignment on the edges to the set {0, 1, 2,..., m}, such that adjacent edges which receive labels differ at least by j, and edges which are distance two apart receive labels differ at least by k. The λj,k-number of G is the minimum m such that an m-L（j, k）-edge-labeling is admitted by G. In this article, the L（1, 2）-edge-labeling for the hexagonal lattice, the square lattice and the triangular lattice are studied, and the bounds for λj,k-numbers of these graphs are obtained.

关键词： L(j k)-edge-labeling line graph triangular lattice square lattice hexagonal lattice.