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Elevation of the glycated albumin to glycated hemoglobin ratio during the progression of hepatitis C virus related liver fibrosis

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World Journal of Hepatology 2012年第1期4卷 11-17页

作者： Nobuhiro Aizawa Hirayuki Enomoto Hiroyasu Imanishi Masaki Saito Yoshinori Iwata Hironori Tanaka Naoto Ikeda Yoshiyuki Sakai Tomoyuki Takashima Takashi Iwai Ei-ichiro Moriwaki Soji Shimomura Hiroko Iijima Hideji Nakamura Shuhei Nishiguchi Division of Hepatobiliary and Pancreatic Disease Department of Internal Medicine Hyogo College of Medicine department of gasteroenterology Nissay Hospital

AIM: To analyze the relationship between the glycated albumin (GA) to glycated hemoglobin (HbA1c) ratio and the histological grading of liver ***: The study retrospectively included consecutive hepatitis C virus positive chronic liver disease patients (n = 142) who had undergone percutaneous liver biopsy between January 2008 and March 2010 at our institution. The ratios of GA/HbA1c were calculated in all patients to investigate the relationship with the degree of the liver fibrosis. The values of the aspartate aminotransferase-to-platelet ratio index (APRI), an excellent marker for the evaluation of liver fibrosis, were also calculated. In addition, we combined the ratio of GA/HbA1c and the APRI in order to improve our ability to detect the presence of significant liver fibrosis. RESULTS: Sixty-one (43%) patients had either no fibrosis or minimal fibrosis (METAVIR score: F0-F1), while 25 (17%) had intermediate fibrosis (F2). Fifty-six (39%) patients had severe fibrosis (F3-F4) and 27 of them had cirrhosis (F4). The mean values of the GA/HbA1c increased with the progression of the fibrosis (F0-1: 2.83 ± 0.24, F2: 2.85 ± 0.24, F3: 2.92 ± 0.35, F4: 3.14 ± 0.54). There was a significant dif- ference between the F0-F1 vs F4, F2 vs F4, and F3 vs F4 groups (P 3.0) was as follows: its sensitivity

关键词： Glycated albumin Glycated hemoglobin Liver fibrosis Liver biopsy Hepatitis C virus

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Antiviral Effects of Stichopus japonicus Acid Mucopolysaccharide on Hepatitis B Virus Transgenic Mice

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Journal of Ocean University of China 2016年第4期15卷 719-725页

作者： XIN Yongning LI Wei LU Linlin ZHOU Li David W Victor XUAN Shiying Qingdao Municipal Hospital Qingdao 266071 P. R. China department of gasteroenterology Qingdao No.6 People's Hospital Qingdao 266033 P. R. China Taiyuan Infectious Diseases Hospital Taiyuan 030000 P. R. China Hepatology & Transplant Medicine Department of Medicine Houston Methodist Hospital Houston USA

Hepatitis B virus(HBV) is a significant global pathogen and efficient cure for HBV patients is still a challenging goal. We previously reported that acidic mucopolysaccharide from stichopus japonicus selenka(SJAMP) could inhibit HBs Ag and HBe Ag expression in vitro. However, the potential anti-HBV effects of SJAMP in vivo have not yet been explored. In this study, we show that SJAMP exhibits potent anti-HBV activity in HBV transgenic mice in a dose-dependent manner. Specifically, sixty HBV transgenic male BALB/c mice were randomly selected to receive the treatment of PBS, low dose SJAMP(30 mg kg^(-1)), middle dose SJAMP(40 mg kg^(-1)), high dose SJAMP(50 mg kg^(-1)) and IFN(45 IU kg^(-1)) for 30 d. SJAMP treatment suppressed serum HBV-DNA, and liver HBs Ag and HBc Ag levels in HBV-transgenic mice. The present study highlights the potential application of SJAMP in HBV therapy.

关键词： Transgenic transgenic pathogen challenging suppressed potent highlights brown manner inhibit

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Enhanced endoscopic ultrasound imaging for pancreatic lesions: The road to artificial intelligence

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World Journal of Gastroenterology 2022年第29期28卷 3814-3824页

作者： Marco Spadaccini Glenn Koleth James Emmanuel Kareem Khalaf Antonio Facciorusso Fabio Grizzi Cesare Hassan Matteo Colombo Benedetto Mangiavillano Alessandro Fugazza Andrea Anderloni Silvia Carrara Alessandro Repici Digestive Endoscopy Unit Division of GastroenterologyHumanitas Research Hospital and UniversityMilan 20800Italy department of Gastroenterology and Hepatology Queen ElizabethKota Kinabalu 88200SabahMalaysia Section of Gastroenterology Department of Medical SciencesUniversity of FoggiaFoggia 71122Italy department of Immunology and Inflammation Humanitas Clinical and Research HospitalRozzano 20089Italy Digestive Endoscopy Unit Division of GasteroenterologyHumanitas Mater DominiCastellanza 21053Italy

Early detection of pancreatic cancer has long eluded clinicians because of its insidious nature and *** metastatic or locally invasive when symptomatic,most patients are deemed *** those who are symptomatic,multi-modal imaging modalities evaluate and confirm pancreatic ductal *** asymptomatic patients,detected pancreatic lesions can be either solid or *** clinical implications of identifying small asymptomatic solid pancreatic lesions(SPLs)of<2 cm are tantamount to a better *** accurate detection of SPLs undoubtedly promotes higher life expectancy when resected early,driving the development of existing imaging tools while promoting more comprehensive screening *** imaging tool that has matured in its reiterations and received many image-enhancing adjuncts is endoscopic ultrasound(EUS).It carries significant importance when risk stratifying cystic lesions and has substantial diagnostic value when combined with fine needle aspiration/biopsy(FNA/FNB).Adjuncts to EUS imaging include contrast-enhanced harmonic EUS and EUS-elastography,both having improved the specificity of FNA and *** review intends to compile all existing enhancement modalities and explore ongoing research around the most promising of all adjuncts in the field of EUS imaging,artificial intelligence.

关键词： Pancreatic ductal adenocarcinoma Pancreatic cancer Endoscopic ultrasound Contrast-enhanced endoscopic ultrasound Endoscopic ultrasound contrast agents Endoscopic ultrasound elastography Artificial intelligence Fractal analysis Endoscopy Imaging

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Current medical treatment of estrogen receptor-positive breast cancer

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World Journal of Biological Chemistry 2015年第3期6卷 231-239页

作者： Franco Lumachi Davide A Santeufemia Stefano MM Basso department of Surgery Oncology and Gasteroenterology University of Padua School of Medicine Medical Oncology City Hospital Surgery 1 S.Maria degli Angeli Hospital

Approximately 80% of breast cancers(BC) are estrogen receptor(ER)-positive and thus endocrine therapy(ET) should be considered complementary to surgery in the majority of patients. The advantages of oophorectomy, adrenalectomy and hypophysectomy in women with advanced BC have been demonstrated many years ago, and currently ET consist of(1) ovarian function suppression(OFS), usually obtained using gonadotropinreleasing hormone agonists(Gn RHa);(2) selective estrogen receptor modulators or down-regulators(SERMs or SERDs); and(3) aromatase inhibitors(AIs), or a combination of two or more drugs. For patients aged less than 50 years and ER+ BC, there is no conclusive evidence that the combination of OFS and SERMs(i.e., tamoxifen) or chemotherapy is superior to OFS alone. Tamoxifen users exhibit a reduced risk of BC, both invasive and in situ, especially during the first 5 years of therapy, and extending the treatment to 10 years further reduced the risk of recurrences. SERDs(i.e., fulvestrant) are especially useful in the neoadjuvant treatment of advanced BC, alone or in combination with either cytotoxic agents or AIs. There are two types of AIs: type Ⅰ are permanent steroidal inhibitors of aromatase, while type Ⅱ are reversible nonsteroidal inhibitors. Several studies demonstrated the superiority of the third-generation AIs(i.e., anastrozole and letrozole) compared with tamoxifen, and adjuvant therapy with AIs reduces the recurrence risk especially in patients with advanced BC. Unfortunately, some cancers are or became ET-resistant, and thus other drugs have been suggested in combination with SERMs or AIs, including cyclin-dependent kinase 4/6 inhibitors(palbociclib) and mammalian target of rapamycin(m TOR) inhibitors, such as everolimus. Further studies are required to confirm their real usefulness.

关键词： Breast cancer Endocrine therapy Gn RHagonists Ovarian function suppression Tamoxifen Selective estrogen receptor modulator Aromatase inhibitors

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