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Chinese Medical Journal 2024年第12期137卷 1486-1488页

作者： Kailiang Wang Yongzhi Shan Penghu Wei Liankun Ren Liang Chen Junming Zhu Guoguang Zhao department of neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China International Neuroscience Institute(China-INI) Clinical Research Center for EpilepsyCapital Medical UniversityBeijing 100053China China National Medical Center for Neurological Diseases Beijing 100053China department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China department of neurosurgery Huashan HospitalFudan UniversityShanghai 200032China department of neurosurgery The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310009China

To the Editor:Recent studies have characterized drugresistant epilepsy(DRE)as essentially a neural network disease.[1]Detection and disconnection of this pathological epileptic connectome or network can greatly improve seizure *** team also proposes the development of the newly emerging branch of epileptic networks neurosurgery(ENN).Responsive neurostimulation(RNS)is an ENN-oriented emerging treatment option without the resection of the seizure-onset zone or epileptic focus and aims to control the seizure or other epileptic manifestations by modulating or disrupting the network’s key nodes(epileptic hubs)in a self-responsive way.

关键词： epilepsy stimulation drug

Post-acute ischemic stroke hyperglycemia aggravates destruction of the blood-brain barrier

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Neural Regeneration Research 2024年第6期19卷 1344-1350页

作者： Tianqi Xu Jianhong Yang Yao Xu Xiaofeng Wang Xiang Gao Jie Sun Chenhui Zhou Yi Huang department of Neurology The First Affiliated Hospital of Ningbo University department of General Surgery The First Affiliated Hospital of Ningbo University department of neurosurgery The First Affiliated Hospital of Ningbo University Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province

Post-acute ischemic stroke hyperglycemia increases the risk of hemorrhagic transformation, which is associated with blood-brain barrier disruption. Brain microvascular endothelial cells are a major component of the blood-brain barrier. Intercellular mitochondrial transfer has emerged as a novel paradigm for repairing cells with mitochondrial dysfunction. In this study, we first investigated whether mitochondrial transfer exists between brain microvascular endothelial cells, and then investigated the effects of post-acute ischemic stroke hyperglycemia on mitochondrial transfer between brain microvascular endothelial cells. We found that healthy brain microvascular endothelial cells can transfer intact mitochondria to oxygen glucose deprivation-injured brain microvascular endothelial cells. However, post-oxygen glucose deprivation hyperglycemia hindered mitochondrial transfer and exacerbated mitochondrial dysfunction. We established an in vitro brain microvascular endothelial cell model of the blood-brain barrier. We found that post-acute ischemic stroke hyperglycemia reduced the overall energy metabolism levels of brain microvascular endothelial cells and increased permeability of the blood-brain barrier. In a clinical study, we retrospectively analyzed the relationship between post-acute ischemic stroke hyperglycemia and the severity of hemorrhagic transformation. We found that post-acute ischemic stroke hyperglycemia serves as an independent predictor of severe hemorrhagic transformation. These findings suggest that post-acute ischemic stroke hyperglycemia can aggravate disruption of the blood-brain barrier by inhibiting mitochondrial transfer.

关键词： acute ischemic stroke blood-brain barrier brain microvascular endothelial cells mitochondrial transfer stress hyperglycemia

Outcomes after surgical and nonsurgical treatment of pediatric cerebral cavernous malformation

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Pediatric Investigation 2024年第2期8卷 126-134页

作者： Haohao Zhang Qishuai Yu Zhiqi Mao Liang Zhang Xinguang Yu Medical School of Nankai University TianjinChina department of neurosurgery Chinese PLA General HospitalBeijingChina department of neurosurgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Importance:Pediatric cerebral cavernous malformation(CCM)is a rarely encountered vascular *** study on surgical excision and nonsurgical management outcomes of CCM in pediatrics is ***:To determine the demographic characteristics,hemorrhage rate,and long-term outcomes of pediatric patients with ***:A retrospective study of pediatric patients with CCM in Chinese PLA General Hospital was conducted between January 2004 and January *** compared the clinical characteristics,radiological features,and outcomes of the surgical and nonsurgical ***:Seventy-nine children were included,with 69.6%being boys,and the average age was 11.8±5.5 *** annual retrospective hemorrhagic rate was 5.7%per patient per ***-six children(70.9%)underwent surgical excision,and they were more likely to present with seizure symptoms(P=0.011),have a higher proportion of larger lesion size(P=0.008),less likely to have durations≤10 days(P=0.048),and less likely to have supratentorial deep CCM(P=0.014)compared to children who received nonsurgical *** resection was achieved in most surgical cases(55,98.2%).During the 143.9±50.8 months of follow-up,44 patients(78.6%)achieved improvement,12 patients(17.8%)remained the same,and two(3.6%)experienced *** the nonsurgical management group,14 children(60.9%)experienced symptom improvement,eight(34.8%)remained the same,and one(4.3%)worsened,with a re-hemorrhagic risk of 8.7%.Interpretation:Surgical removal of pediatric CCM can eliminate the risk of hemorrhage and lead to satisfactory *** children undergoing nonsurgical management,long-term close monitoring is essential due to the life-long risk of hemorrhage.

关键词： Pediatric Cerebral cavernous malformation Surgery Hemorrhage

Classification and treatment strategy for Moyamoya disease-related aneurysms

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Chinese Neurosurgical Journal 2024年第1期10卷 1-7页

作者： Yangchun Hu Xiaojian Wang Chao Li Liang Zhao Jing Luo Lei Ye Baochun Cheng department of neurosurgery The First Affiliated Hospital of Anhui Medical UniversityJixi 218Hefei 230022People’s Republic of China

Background Moyamoya disease(MMD)is a cerebrovascular disorder characterized by progressive unilateral or bilateral stenosis of the distal internal carotid *** hemodynamic features in MMD patients alter,the comorbidity of intracranial aneurysm(IA)is sometimes observed *** aim to investigate clinical characteristics and therapeutic strategies for the comorbidity of Moyamoya disease with intracranial aneurysms(MMD-IA).Methods A total of 13 MMD-IA patients were recruited in this study and were manifested to be intracranial *** reviewed the surgical technique notes for all *** According to the locations of an aneurysm,MMD-IA could be divided into several categories:(1)MMD-IA at a circle of Willis—aneurysms usually located at the trunk of Willis circle;(2)MMD-IA at collateral anastomosis—aneurysms located at the distal end of collateral anastomosis;and(3)MMA-IA at basal ganglia *** this report,aneurysms in 10 patients located at Willis circle,2 at the pericallosal artery,and 1 at the basal ganglia *** them,endovascular embolism was performed among 5 *** clipping was conducted among 7 patients.A patient with an aneurysm at the basal ganglia region just accepted revascularization *** the treatments were ***-up studies,ranging from 6 to 24 months,demonstrated all patients received satisfactory curative *** Diverse clinical presentations could be observed among MMD-IA *** neurosurgical treatments should be chosen according to the locations of the aneurysm.

关键词： Moyamoya disease Aneurysm Clipping Revascularization Endovascular embolism

The secondary injury cascade after spinal cord injury: an analysis of local cytokine/chemokine regulation

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Neural Regeneration Research 2024年第6期19卷 1308-1317页

作者： Daniel J.Hellenbrand Charles M.Quinn Zachariah J.Piper Ryan T.Elder Raveena R.Mishra Taylor L.Marti Phoebe M.Omuro Rylie M.Roddick Jae Sung Lee William L.Murphy Amgad S.Hanna department of neurosurgery University of Wisconsin-Madison School of Medicine and Public Health department of Biomedical Engineering University of Wisconsin-Madison department of Orthopedics and Rehabilitation University of Wisconsin-Madison department of Materials Science and Engineering University of Wisconsin-Madison Forward BIO Institute University of Wisconsin-Madison

After spinal cord injury, there is an extensive infiltration of immune cells, which exacerbates the injury and leads to further neural degeneration. Therefore, a major aim of current research involves targeting the immune response as a treatment for spinal cord injury. Although much research has been performed analyzing the complex inflammatory process following spinal cord injury, there remain major discrepancies within previous literature regarding the timeline of local cytokine regulation. The objectives of this study were to establish an overview of the timeline of cytokine regulation for 2 weeks after spinal cord injury, identify sexual dimorphisms in terms of cytokine levels, and determine local cytokines that significantly change based on the severity of spinal cord injury. Rats were inflicted with either a mild contusion, moderate contusion, severe contusion, or complete transection, 7 mm of spinal cord centered on the injury was harvested at varying times post-injury, and tissue homogenates were analyzed with a Cytokine/Chemokine 27-Plex assay. Results demonstrated pro-inflammatory cytokines including tumor necrosis factor α, interleukin-1β, and interleukin-6 were all upregulated after spinal cord injury, but returned to uninjured levels within approximately 24 hours post-injury, while chemokines including monocyte chemoattractant protein-1 remained upregulated for days post-injury. In contrast, several anti-inflammatory cytokines and growth factors including interleukin-10 and vascular endothelial growth factor were downregulated by 7 days post-injury. After spinal cord injury, tissue inhibitor of metalloproteinase-1, which specifically affects astrocytes involved in glial scar development, increased more than all other cytokines tested, reaching 26.9-fold higher than uninjured rats. After a mild injury, 11 cytokines demonstrated sexual dimorphisms; however, after a severe contusion only leptin levels were different between female and male rats. In conclus

关键词： astrocytes chemokines cytokines inflammation macrophages microglia secondary damage spinal cord injury

MPZL1 as an HGF/MET signaling amplifier promotes cell migration and invasion in glioblastoma

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Genes & Diseases 2024年第5期11卷 70-73页

作者： Haimin Song Bowen Ni Xuetao Peng Weijuan Xu Shaochun Yang Runwei Yang Ziyu Wang Kaishu Li Rui Lin Yunxiao Zhang Jinglin Guo Kezhi Wu Guangwei Shi Jichao Sun Chunming He Yawei Liu department of neurosurgery The First Affiliated Hospital of Gannan Medical UniversityGanzhouJiangxi 341000China department of neurosurgery&Medical Research Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)FoshanGuangdong 528300China Medical Research Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)FoshanGuangdong 528300China Bidding and Procurement Office Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)FoshanGuangdong 528300China department of neurosurgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China department of neurosurgery The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuanGuangdong 511518China department of neurosurgery The First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong 515041China department of Geriatrics Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenGuangdong 518020China

The extremely poor prognosis of patients is largely due to hepatocyte growth factor(HGF)/MET signaling,which promotes migration and invasion of glioblastoma(IDH wildtype;GBM;WHO grade 4).1,2 Clinical trials targeting MET,the only receptor of HGF,have yielded unimpressive results in GBM.3,4 Here we found that HGF induced strong chemotaxis on GBM cells,but MET expression was extremely ***,therefore,used single-cell RNA sequencing(scRNA-seq)coupled with label-free proteome profiling to identify membrane proteins associated with HGF/MET signaling amplification in GBM and to provide a novel modulator,MPZL1,for HGF/MET-targeted therapy.

关键词： invasion prognosis Clinical

Preparation of Laser Cladding Coating Undercooling Cu-based Alloy and Co on Non-equilibrium Solidification Structure

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 463-472页

作者：田徐铭 CAO Shichao HOU Kai HOU Xiaopeng WANG Hongfu 张煜 department of Outpatient Xinzhou People’s HospitalXinzhou 034099China School of Mechanical Engineering North University of ChinaTaiyuan 030051China department of neurosurgery Xinzhou People’s HospitalXinzhou 034099China department of Orthopedics Xinzhou People’s HospitalXinzhou 034099China

The effect of the gradient content of Co element on the solidification process of Cu-based alloy under deep under cooling conditions was *** non-equilibrium solidification structure of the under cooled alloy samples were *** is found that the rapidly solidified alloy has undergone twice grain refinement during the undercooling *** and significance of the maximum undercooling refinement structure of Cu60Ni35Co5 at T=253 K were ***-density defects were observed,such as dislocations,stacking faults networks,and twinning *** standard FCC diffraction pattern represents that it is still a single-phase *** on the metallographic diagram,EBSD and TEM data analysis,it is illustrated that the occurrence of grain refinement under high undercooling is due to stress induced *** addition,the laser cladding technology is used to coat Co-based alloy(Stellite12) coating on 304 stainless steel substrate;the microstructure of the coating cross-section was *** was found that the microstructure of the cross-section is presented as columnar crystals,planar crystals,and disordered growth direction,so that the coating has better hardness and wear *** electrochemical corrosion of the substrate and coating,it can be seen that the Co and Cr elements present in the coating are more likely to form a dense passivation film,which improved the corrosion resistance of the coating.

关键词： non-equilibrium solidification structure undercooling recrystallization laser cladding coating

Intra-arterial tenecteplase during thrombectomy for acute stroke(BRETIS-TNK II):rationale and design

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Stroke & Vascular Neurology 2024年第1期9卷 59-65页

作者： Zi-Ai Zhao Jing Qiu Wei Li Thanh Nguyen Shouchun Wang Huaizhang Shi Ming Wei Feng Wang Di Li Hui-Sheng Chen department of Neurology General Hospital of Northern Theater CommandShenyangLiaoning ProvinceChina Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA department of Neurology First Affiliated Hospital of Jilin UniversityChangchunJilinChina department of neurosurgery First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina department of neurosurgery Tianjin Huanhu HospitalTianjinTianjinChina department of Interventional Therapy First Affiliated Hospital of Dalian Medical UniversityDalianChina Neurological Intervention department Dalian Municipal Central HospitalDalianLiaoningChina

Background Our recent pilot study suggests intra-arterial tenecteplase(TNK)during the first pass of endovascular treatment(EVT)seems safe,may increase first-pass reperfusion and good outcome in acute ischaemic stroke(AIS)patients with large-vessel occlusion(LVO).Aims To determine the efficacy and safety of intra-arterial TNK administration during EVT in AIS-LVO patients presenting up to 24 hours from symptom *** size estimates A maximum of 380 patients are required to test the superiority hypothesis with 80%power according to a two-side 0.05 level of significance,stratified by age,gender,baseline systolic blood pressure,prestroke modified Rankin Scale(mRS),baseline National Institute of Health stroke scale,baseline ASPECTS,time from onset to groin puncture,intravenous thrombolysis before EVT,stroke territory and stroke *** Intra-arterial TNK during thrombectomy for acute stroke(BRETIS-TNK II)study is a prospective,randomised,adaptive enrichment,open-label,blinded end point,multicentre *** AIS-LVO patients are randomly assigned into the experimental group and control group with a ratio of 1:*** experimental group will be treated with intra-arterial infusion of TNK during *** control group will be treated with standard *** The primary end point is a favourable outcome,defined as an mRS score of 0–2 at 90 *** primary safety end point is symptomatic intracranial haemorrhage within 48 hours,which is defined as an increase in the National Institutes of Health Stroke Scale score of≥4 points as a result of the intracranial *** The results of BRETIS-TNK II will provide evidence for the efficacy and safety of intra-arterial TNK administration during EVT in AIS patients with LVO.

关键词： rational stratified TNK

Transcranial direct current stimulation efficacy in trigeminal neuralgia

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World Journal of Clinical Cases 2024年第5期12卷 1036-1038页

作者： Theodoros Fasilis Stylianos Gatzonis Panayiotis Patrikelis Stefanos Korfias Athanasia Alexoudi 1^(st) department of neurosurgery National and Kapodistrian University of AthensAthens 10676Greece department of Neurology Neurological Institute of AthensAthens 10676Greece

Trigeminal neuralgia is a severe,disabling pain and its deafferentation remains a challenge for health *** direct current stimulation is a non-invasive stimulation technique which finds new utility in managing ***-fore,the introduction of alternative,non-invasive,safe,and effective methods should be considered in treating patients with trigeminal neuralgia unresponsive to conventional treatment.

关键词： Trigeminal neuralgia Patient-controlled intravenous analgesia Neuromodulation Transcranial direct current stimulation

Astrocytic calcium waves:unveiling their roles in sleep and arousal modulation

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Neural Regeneration Research 2024年第5期19卷 984-987页

作者： Erxi Wu Dan Qi Damir Nizamutdinov Jason H.Huang department of neurosurgery and Neuroscience Institute Baylor Scott&White HealthTempleTXUSA Texas A&M University School of Medicine TempleTXUSA Texas A&M University School of Pharmacy College StationTXUSA LIVESTRONG Cancer Institutes and department of Oncology Dell Medical Schoolthe University of Texas at AustinAustinTXUSA department of neurosurgery Baylor College of MedicineTempleTXUSA

Neuron-astrocyte interactions are vital for the brain’s *** astrocyte activities is crucial for comprehending the complex neural network,particularly the population-level functions of neurons in different cortical states and associated behaviors in *** on animal sleep and wakefulness have revealed distinct cortical synchrony patterns between ***,outnumbering neurons by nearly fivefold,support and regulate neuronal and synaptic *** research on astrocyte activation during cortical state transitions has emphasized the influence of norepinephrine as a neurotransmitter and calcium waves as key components of ion channel *** summary focuses on a few recent studies investigating astrocyte-neuron interactions in mouse models during sleep,wakefulness,and arousal levels,exploring the involvement of noradrenaline signaling,ion channels,and glutamatergic signaling in different cortical *** findings highlight the significant impact of astrocytes on large-scale neuronal networks,influencing brain activity and *** astrocytic signaling pathways shows promise for treating sleep disorders and arousal *** research is needed to understand astrocytic calcium signaling in different brain regions and its implications for dysregulated brain states,requiring future human studies to comprehensively investigate neuron-astrocyte interactions and pave the way for therapeutic interventions in sleep-and arousal-related disorders.

关键词： arousal astrocyte calcium waves locus coeruleus neuron-astrocyte interaction norepinephrine sleep wakefulness