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Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/ OAK and CHOICE-01 trials

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science China(Life sciences) 2025年第1期68卷 249-262页

作者： Jinliang Wang Wenyong Zhou Yu Xu Jianchun Duan Qiaoxia Zhou Guoqiang Wang Leo Li Chunwei Xu Wenxian Wang Shangli Cai Zhijie Wang Jie Wang department of Oncology The Fifth Medical Center of Chinese PLA General HospitalBeijing 100091China department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Burning Rock Biotech Guangzhou 510300China CAMS Key Laboratoryof Translational Research on Lungcancer State Key Laboratoryof Molecular OncologyDepartmentof Medical OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Institute of Basic Medicine and cancer(IBMC) Chinese Academy of SciencesHangzhou 310000China department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Hangzhou 310022China

In non-small cell lung cancers,the non-squamous and squamous subtypes(nsqNSCLC and sqNSCLC)exhibit disparities in pathophysiology,tumor immunology,and potential genomic correlates affecting responses to immune checkpoint inhibitor(ICI)-based *** our inhouse training cohort(n=85),the presence of the LRP1B deleterious mutation(LRP1B-del)was associated with longer and shorter progression-free survival(PFS)on ICIs alone in nsqNSCLCs and sqNSCLCs,respectively(Pinteraction=0.008).These results were validated using a larger public ICI cohort(n=208,Pinteractionchemotherapy than from chemotherapy alone(Pinteraction=0.008).This multi-cohort study delineates the antithetical impacts of LRP1Bdel in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy *** findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs,emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

关键词： non-squamous NSCLC squamous NSCLC LRP1B deleterious mutations predictive biomarker immune checkpoint inhibitor

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Clinicopathological and molecular features of HR+/HER2- breast cancer patients with distinct endocrine resistance patterns

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Chinese Journal of cancer Research 2025年第01期 48-72页

作者： Siwei Zhang Han Wang Hang Zhang Qingyuan Zhuang Xiaohui Zhu Yi Xiao Yizhou Jiang Key Laboratory of Breast cancer in Shanghai Department of Breast Surgery Fudan University Shanghai Cancer Center department of Oncology Shanghai Medical College Fudan University

Objective: Recurrence continues to be a pivotal challenge among hormone receptor-positive（HR+）/human epidermal growth factor receptor 2-negative（HER2-） breast cancers. In the international consensus guidelines,HR+/HER2-breast cancer relapse patterns are divided into three distinct types: primary resistant, secondary resistant, and endocrine sensitive. However, owing to the lack of cohorts with treatment and follow-up data, the heterogeneity among different recurrence patterns remains uncharted. Current treatments still lack ***: This analysis included data from a large-scale multiomics study of a HR+/HER2-breast cancer cohort（n=314）. Through the analysis of transcriptomics（n=312）, proteomics（n=124）, whole-exome sequencing（n=290）,metabolomics（n=217）, and digital pathology（n=228） data, we explored distinctive molecular features and identified putative therapeutic targets for patients experiencing ***: We explored distinct clinicopathological characteristics, biological heterogeneity, and potential therapeutic strategies for recurrence. Based on a shared relapse signature, we stratified patients into high-and lowrecurrence-risk groups. Patients with different relapse patterns presented unique molecular features in primary tumors. Specifically, receptor tyrosine kinase（RTK） pathway activation in the primary resistant group suggested the utility of RTK inhibitors, whereas mammalian target of rapamycin（mTOR） and cell cycle pathway activation in the secondary resistant group highlighted the potential of mTOR and CDK4/6 inhibitors. Interestingly, the endocrine-sensitive group displayed a quiescent state and high genomic instability, suggesting that targeting quiescent cells and using poly-ADP-ribose polymerase（PARP） inhibitors could be effective ***: These findings illuminate the clinicopathological and molecular landscape of HR+/HER2-breast cancer patients with distinct recurrence patterns, highlighting potential targeted the

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Improved treatment of colorectal liver metastases by early response evaluation and regimen adjustment: a prospective study of clinical functional MR-based modeling

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cancer Biology & Medicine 2025年第02期 166-176页

作者： Wenhua Li Huan Zhang Zhe Gong Yue Li Zhiyu Chen Xiaodong Zhu Mingzhu Huang Zhe Zhang Chenchen Wang Lixin Qiu Qirong Geng Jinjia Chang Xiaoying Zhao Xuedan Sheng Wen Zhang Tong Tong Weijian Guo department of Medical Oncology Fudan University Shanghai Cancer Center department of Oncology Shanghai Medical College Fudan University department of Radiology Fudan University Shanghai Cancer Center department of Radiation Oncology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences

Objective: The aim of the study was to evaluate the feasibility of functional MR in predicting the clinical response to chemotherapy in patients with colorectal liver metastases(CLM).Methods: A total of 196 eligible patients were enrolled in the study between August 2016 and January 2023. Functional MR was performed at baseline and after one cycle of chemotherapy. The diffusion kurtosis radiomic texture features were extracted and a signature model was built using the R package. The initial 100 cases were designated as the training set, the following 48 cases were designated as the validation set, and the final 48 cases were designated as the intervention validation ***: Good performance for the response prediction(AUC = 0.818 in the training set and 0.755 in the validation set) was demonstrated. The objective response rates(ORRs) in the high-risk subgroup were significantly lower than the low-risk subgroup in the training and validation sets. Worse progression-free survival and overall survival rates were noted in the high-risk population. In the intervention set 22.9%(11/48) of the chemotherapy regimens for patients were changed in response to the model-predicted results and the ORR reached 77.1%(37/48), which was significantly higher than the training and validation sets [47.97%(71/148); P = 0.000].Conclusions: A functional MR signature effectively predicted the chemotherapy response and long-term survival. The adjustment of the regimen guided by the model significantly improved the ORR.

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Advances in neoadjuvant therapy for resectable intrahepatic cholangiocarcinoma: An invited commentary

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Oncology and Translational Medicine 2025年第1期11卷 1-4页

作者： Ruyu Han Peipei Song Wei Tang Tianqiang Song Lu Chen Tianjin Medical University cancer Institute and Hospital National Clinical Research Center for CancerNational Key Laboratory of Druggability Evaluation and Systematic Translational MedicineTianjin Key Laboratory of Digestive CancerTianjin’s Clinical Research Center for CancerTianjinChina department of Hepatobiliary cancer Liver Cancer Research CenterTianjin Medical University Cancer Institute and HospitalTianjinChina National Center for Global Health and Medicine TokyoJapan

Intrahepatic cholangiocarcinoma(ICC)poses a significant threat to human health owing to its high malignancy rate and poor ***-gery is the most effective treatment option for ***,the prognosis remains unfavorable even after surgical ***,neo-adjuvant therapy has emerged as a potential treatment option for patients with *** therapy can improve patient prognosis by reducing the tumor size and eliminating tiny lesions that are not visible to the naked ***,specific treatment options for neoad-juvant therapy are *** review summarizes the studies on neoadjuvant therapy for ICC in the last decade,including chemotherapy,radiotherapy,interventional therapy,targeted therapy,and immunotherapy,with the aim of providing suggestions for the selection of clinical treatment options for patients with *** reports suggest that chemotherapy is the most effective neoadjuvant treatment ***-ever,radiotherapy and interventional therapies require further investigation to obtain conclusive *** targeted thera-pies and immunotherapies have been studied less extensively,several ongoing clinical trials are investigating these promising approaches.

关键词： Intrahepatic cholangiocarcinoma Resectable Neoadjuvant therapy

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High Expression of INF2 Predicts Poor Prognosis and Promotes Hepatocellular Carcinoma Progression

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生物化学与生物物理进展 2025年第1期52卷 194-208页

作者： WANG Hai-Biao LIN Man YE Fu-Sang SHI Jia-Xin LI Hong YE Meng WANG Jie department of Hepatobiliary and Pancreatic Surgery Ningbo Medical Center of LiHuiLi HospitalNingbo 315040China department of Radiotherapy and chemotherapy The First Affiliated Hospital of Ningbo UniversityNingbo 315010China department of Biochemistry and Molecular Biology Zhejiang Key Laboratory of PathophysiologyScience Health Center of Ningbo UniversityNingbo 315211China department of Pathology Ningbo Clinical Pathology Diagnosis CenterNingbo 315021China

Objective INF2 is a member of the formins *** expression and regulation of INF2 have been associated with the progression of various tumors,but the expression and role of INF2 in hepatocellular carcinoma(HCC)remain *** is a highly lethal malignant *** the limitations of traditional treatments,this study explored the expression level,clinical value and potential mechanism of INF2 in HCC in order to seek new therapeutic *** In this study,we used public databases to analyze the expression of INF2 in pan-cancer and HCC,as well as the impact of INF2 expression levels on HCC *** real time polymerase chain reaction(RT-qPCR),Western blot,and immunohistochemistry were used to detect the expression level of INF2 in liver cancer cells and human HCC *** correlation between INF2 expression and clinical pathological features was analyzed using public databases and clinical data of human HCC ***,the effects of INF2 expression on the biological function and Drp1 phosphorylation of liver cancer cells were elucidated through in vitro and in vivo ***,the predictive value and potential mechanism of INF2 in HCC were further analyzed through database and immunohistochemical *** INF2 is aberrantly high expression in HCC samples and the high expression of INF2 is correlated with overall survival,liver cirrhosis and pathological differentiation of HCC *** expression level of INF2 has certain diagnostic value in predicting the prognosis and pathological differentiation of *** vivo and in vitro HCC models,upregulated expression of INF2 triggers the proliferation and migration of the HCC cell,while knockdown of INF2 could counteract this ***2 in liver cancer cells may affect mitochondrial division by inducing Drp1 phosphorylation and mediate immune escape by up-regulating PD-L1 expression,thus promoting tumor *** INF2 is highly expressed in H

关键词： HCC INF2 expression prognosis Drp1

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Phototherapy:progress,challenges,and opportunities

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science China Chemistry 2025年第03期 826-865页

作者： Xi Yuan Jun-Liang Zhou Lin Yuan Jiangli Fan Juyoung Yoon Xiao-Bing Zhang Xiaojun Peng Weihong Tan department of Laboratory Medicine Zhongnan Hospital of Wuhan University Molecular science and Biomedicine Laboratory (MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringAptamer Engineering Center of Hunan ProvinceHunan University Wuhan University Shenzhen Research Institute State Key Laboratory of Fine Chemicals Frontier Science Center for Smart MaterialsDalian University of Technology department of Chemistry and Nanoscience Ewha Womans University

Phototherapy has emerged as a promising modality in modern medicine,attracting significant attention due to its non-invasiveness,exceptional spatiotemporal controllability,and reduced side *** technologies have been developed in phototherapy,encompassing three main approaches:photodynamic therapy,photothermal therapy,and photoactivatable prodrug-based *** this review,we present photosensitizers,photothermal agents,and photoactivatable prodrugs,along with photo-responsive carriers used in ***,we discuss the advantages of phototherapy in combating cancer,infections,and other ***,we highlight the benefits of combining phototherapy with other treatments,as single-mode therapeutic modalities often fail to achieve satisfactory ***,we address the current challenges in developing effective phototherapy agents,particularly regarding their clinical *** believe that advancements in phototherapy will promote non-invasive theranostic techniques for clinical studies.

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Advances in basic and translational research into nasopharyngeal carcinoma

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Oncology and Translational Medicine 2025年第1期11卷 10-16页

作者： Zhe Li Yupei Chen Jun Ma department of Radiation Oncology State Key Laboratory of Oncology in South ChinaGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina

According to the International cancer Research Institute of the World Health Organization data,nasopharyngeal carcinoma(NPC)remains a significant health concern,particularly in regions such as Southeast Asia and southern ***,substantial progress has been made in the field of basic and translational research on NPC,enhancing our understanding of the molecular mechanisms underlying the disease and paving the way for precise therapeutic *** review summarizes the advances in NPC research,focusing on key areas that include radiotherapy and chemotherapy resistance and tumor metastasis,microenvironment,metabolism,microbiome,and ***,future research directions in NPC are discussed to provide valuable insights to advance the field further.

关键词： Nasopharyngeal carcinoma Treatment resistance Tumor biomarkers Tumor microenvironment

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Intra-tumoral bacteria in head and neck cancer: holistic integrative insight

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cancer Biology & Medicine 2025年第02期 113-136页

作者： Yucheng Meng Jiaru Deng Weiwei Deng Zhijun Sun State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of Education Hubei Key Laboratory of Stomatology School & Hospital of Stomatology Frontier Science Center for Immunology and Metabolism Taikang Center for Life and Medical Sciences Wuhan University department of Oral & Maxillofacial Head Neck Oncology School & Hospital of Stomatology Wuhan University

Intra-tumoral bacteria are pivotal in the initiation and progression of head and neck squamous cell carcinoma(HNSCC), exerting a significant influence on tumor cell biology, immune responses, and the tumor microenvironment(TME). Different types and distribution of bacteria threaten the balance of metabolism and the immune environment of tumor cells. Taking advantage of this disrupted homeostasis, intra-tumoral bacteria stimulate the secretion of metabolites or influence specific immune cell types to produce inflammatory or chemokines, thereby influencing the anti-tumor immune response while regulating the level of inflammation and immunosuppression within the TME. Some intra-tumoral bacteria are used as diagnostic and prognostic markers in clinical practice. Based on the unique characteristics of bacteria, the use of engineered bacteria and outer membrane vesicles for drug delivery and biological intervention is a promising new therapeutic strategy. The presence of intra-tumoral bacteria also makes chemoradiotherapy tolerable, resulting in a poor treatment effect. However, due to the immune-related complexity of intra-tumoral bacteria, there may be unexpected effects in immunotherapy. In this review the patterns of intra-tumoral bacteria involvement in HNSCC are discussed, elucidating the dual roles, while exploring the relevance to anti-tumor immune responses in the clinical context and the prospects and limitations of the use of bacteria in targeted therapy.

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Construction of a nomogram prediction model for early postoperative stoma complications of colorectal cancer

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World Journal of Gastrointestinal Surgery 2025年第1期17卷 165-174页

作者： Ming-Qin Ba Wen-Lin Zheng Yu-Ling Zhang Lin-Lin Zhang Jing-Jing Chen Jie Ma Jia-Li Huang department of Gastrointestinal Surgery The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of China(Anhui Provincial Cancer Hospital)Hefei 230031Anhui ProvinceChina

BACKGROUND Postoperative enterostomy is increasing in patients with colorectal cancer,but there is a lack of a model that can predict the probability of early *** To explore the factors influencing early postoperative stoma complications in colorectal cancer patients and to construct a nomogram prediction model for predicting the probability of these *** A retrospective study of 462 patients who underwent postoperative ostomy for colorectal cancer in the Gastrointestinal department of the Anhui Provincial cancer *** patients’basic information,surgical details,pathological results,and preoperative inflammatory and nutritional indicators were *** used univariate and multivariate logistic regression to analyze the risk factors for early postoperative stoma complications in colorectal cancer patients and constructed a nomogram prediction model to predict the probability of these *** Binary logistic regression analysis revealed that diabetes[odds ratio(OR)=3.088,95%confidence interval(CI):1.419-6.719],preoperative radiotherapy and chemotherapy(OR=6.822,95%CI:2.171-21.433),stoma type(OR=2.118,95%CI:1.151-3.898),Nutritional risk screening 2002 score(OR=2.034,95%CI:1.082-3.822)and prognostic nutritional index(OR=0.486,95%CI:0.254-0.927)were risk factors for early stoma complications after colorectal cancer surgery(Pchemotherapy,stoma type,Nutritional risk screening 2002 score and progno

关键词： Colorectal Postoperative Stoma Complications Nomogram

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Computational analyses for cancer biology based on exhaustive experimental backgrounds

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cancer Drug Resistance 2019年第3期2卷 419-427页

作者： Jun Koseki Masamitsu Konno Hideshi Ishii department of Medical Data science Osaka UniversityOsaka565-0871Japan department of frontier science for cancer and chemotherapy Osaka UniversityOsaka565-0871Japan

Antitumor drug therapy plays a very important role in cancer ***,resistance to chemotherapy is a serious *** studies have been conducted to understand and verify the cause of chemoresistance from multiple points of view such as oncogenes,tumor suppressor genes,DNA mutations and repairs,autophagy,cancer stemness,and mitochondrial metabolism and ***,not only medical data from hospitals but also public big data exist on internet ***,the importance of computational science has vastly increased in biological and medical *** statistical or mathematical analyses of these medical data with conventional experiments,many researchers have recently shown that there is a strong relationship between the biological metabolism and chemoresistance for cancer *** example,folate metabolism that mediates one-carbon metabolism and polyamine metabolism have garnered attention regarding their association with *** has been suggested that these metabolisms may be involved in causing resistance to chemotherapy.

关键词： In silico drug design trans-omics analysis computational analyses cancer biology

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