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Mitophagy in intracerebral hemorrhage:a new target for therapeutic intervention

Neural Regeneration Research 2024年第2期19卷 316-323页

作者： Yiyang Chen Wenxuan Tang Xinqi Huang Yumei An Jiawen Li Shengye Yuan Haiyan Shan Mingyang Zhang Institute of forensic Sciences Suzhou Medical CollegeSoochow UniversitySuzhouJiangsu ProvinceChina Shanghai Key Lab of forensic Medicine Key Lab of Forensic ScienceMinistry of Justice(Academy of Forensic Science)ShanghaiChina department of Obstetrics and Gynecology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhouJiangsu ProvinceChina

Intracerebral hemorrhage is a life-threatening condition with a high fatality rate and severe ***,there is currently no treatment available for intracerebral hemorrhage,unlike for other stroke *** studies have indicated that mitochondrial dysfunction and mitophagy likely relate to the pathophysiology of intracerebral ***,or selective autophagy of mitochondria,is an essential pathway to preserve mitochondrial homeostasis by clearing up damaged *** markedly contributes to the reduction of secondary brain injury caused by mitochondrial dysfunction after intracerebral *** review provides an overview of the mitochondrial dysfunction that occurs after intracerebral hemorrhage and the underlying mechanisms regarding how mitophagy regulates it,and discusses the new direction of therapeutic strategies targeting mitophagy for intracerebral hemorrhage,aiming to determine the close connection between mitophagy and intracerebral hemorrhage and identify new therapies to modulate mitophagy after intracerebral *** conclusion,although only a small number of drugs modulating mitophagy in intracerebral hemorrhage have been found thus far,most of which are in the preclinical stage and require further investigation,mitophagy is still a very valid and promising therapeutic target for intracerebral hemorrhage in the long run.

关键词： intracerebral hemorrhage mitochondrial dysfunction mitophagy neuroinflammation neuroprotection reactive oxygen species secondary brain injury therapeutic target

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The role of snapin in regulation of brain homeostasis

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Neural Regeneration Research 2024年第8期19卷 1696-1701页

作者： Jiawen Li Xinqi Huang Yumei An Xueshi Chen Yiyang Chen Mingyuan Xu Haiyan Shan Mingyang Zhang Shanghai Key Lab of forensic Medicine Key Lab of Forensic ScienceMinistry of JusticeChina(Academy of Forensic Science)ShanghaiChina Institute of forensic Sciences Suzhou Medical CollegeSoochow UniversitySuzhouJiangsu ProvinceChina department of Obstetrics and Gynecology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhouJiangsu ProvinceChina

Brain homeostasis refe rs to the normal working state of the brain in a certain period,which is impo rtant for overall health and normal life ***,there is a lack of effective treatment methods for the adverse consequences caused by brain homeostasis *** is a protein that assists in the formation of neuronal synapses and plays a crucial role in the normal growth and development of ***,many researchers have reported the association between snapin and neurologic and psychiatric disorders,demonstrating that snapin can improve brain *** manifestations of brain disease often involve imbalances in brain homeostasis and may lead to neurological and behavioral *** article aims to explo re the role of snapin in restoring brain homeostasis after injury or diseases,highlighting its significance in maintaining brain homeostasis and treating brain ***,it comprehensively discusses the implications of snapin in other extracerebral diseases such as diabetes and viral infections,with the objective of determining the clinical potential of snapin in maintaining brain homeostasis.

关键词： brain homeostasis diabetes neurological diseases snapin traumatic brain injury vesicle fusion

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Death from Fat Embolism after Lipectomy in a Patient with Madelung’s Disease

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Journal of forensic Science and Medicine 2024年第2期10卷 148-151页

作者： Xing-An Yang Teng-Fei Yang Fu Zhang Jiang-Wei Kong Zi-Lin Meng Xin-Biao Liao Pei-Yu Liang Dong-Ri Li department of forensic Pathology School of Forensic MedicineSouthern Medical UniversityGuangzhouGuangdongChina Guangdong Public Security department Forensic Pathology LabGuangzhouGuangdongChina

A 56-year-old man with a long history of alcoholism and a palpable raised mass about 23 cm×12 cm in size on his neck was diagnosed with Madelung’s disease(MD);the patient also had *** day 1,he underwent neck lipoma tissue resection and suddenly had dyspnea 9 h after the operation,which was followed by cardiac *** heart rate resuscitation,he developed a heartbeat,but he remained in a coma and died 9 days after the *** obvious pathological tracheal compression from a hematoma was observed while evaluating the patient’s neck on *** microscopy,the patient had an extensive pulmonary fat embolism,partial alveolar septal rupture and hemorrhage,and fat particles,and there was extensive infiltration of macrophages,which had phagocytosed fat particles,in the alveolar *** was also evidence of pulmonary infection and hypoxic-ischemic *** cause of death was postoperative pulmonary fat embolism resulting in pneumonia and central nervous system *** is the first report of a patient with MD who died of a fatal pulmonary fat embolism after neck lipoma tissue *** experts and clinicians should pay sufficient attention to this case.

关键词： forensic pathology madelung’s disease pulmonary fat embolism

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Injection of a Self-propelled Polymer into a Small Circular Cavity

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Chinese Journal of Polymer Science 2024年第6期42卷 886-894页

作者： Chao Wang Yan-Li Zhou Xiao Yang Fan Wu Meng-Bo Luo department of physics Taizhou UniversityTaizhou318000China department of physics Zhejiang UniversityHangzhou310027China

The injection of a polymer chain into a small circular cavity under tangential self-propelled force is studied by using Langevin dynamics *** indicate that the injection dynamics of the active polymer shows strong correlation with the polymer conformation inside the cavity depending on the polymer rigidity(k_(b)).The injection timeτvaries nonmonotonously with increasing k_(b),and reaches its minimum at k_(b)^(*).When k_(b) is small(k_(b)≪k_(b)^(*)),the polymer is nearly random coil in the cavity,and spends a long time at the final stage of the injection process due to the large repulsion between monomers inside the *** k_(b) is moderate(k_(b)∼k_(b)^(*)),the part of polymer inside the cavity forms spiral configuration under the tangential active force,and the whole polymer moves synchronously with a constant velocity during the injection process,leading to a small injection *** k_(b) is large(k_(b)≫k_(b)^(*)),the polymer is nearly straight at the initial stage of the injection process,and takes a long time to bend itself,leading to a large injection time.

关键词： Active Polymer Injection Dynamics Simulation

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Are hydrides under high-pressure-high-temperature superconductors?

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National Science Review 2024年第7期11卷 9-12页

作者： J.E.Hirsch department of physics University of California

Contrary to the current consensus, I argue that the existing evidence for high-temperature superconductivity in hydrides under high pressure is not compelling. I suggest that the focus of the field should urgently shift to establish unequivocally experimentally whether or not superconductivity in pressurized hydrides exists, instead of continuing to search for new materials that might show elusive signals of unproven superconductivity at ever higher temperatures. The implications of a negative finding for the theoretical understanding of superconductivity are discussed.

关键词： Hydrides

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Effects of Rattling Behavior of K and Cd Atoms along Different Directions in Anisotropic KCdAs on Lattice Thermal Transport and Thermoelectric Properties

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Energy & Environmental Materials 2024年第6期7卷 388-398页

作者： Yue Wang Yinchang Zhao Jun Ni Zhenhong Dai department of physics Yantai UniversityYantai 264005China State Key Laboratory of Low-Dimensional Quantum physics Department of PhysicsTsinghua UniversityBeijing 100084China

We employ advanced first principles methodology,merging self-consistent phonon theory and the Boltzmann transport equation,to comprehensively explore the thermal transport and thermoelectric properties of ***,the study accounts for the impact of quartic anharmonicity on phonon group velocities in the pursuit of lattice thermal conductivity and investigates 3ph and 4ph scattering processes on phonon *** various methodologies,including examining atomic vibrational modes and analyzing 3ph and 4ph scattering processes,the article unveils microphysical mechanisms contributing to the lowκL within *** features include significant anisotropy in Cd atoms,pronounced anharmonicity in K atoms,and relative vibrations in non-equivalent As atomic *** atoms,situated between As layers,exhibit rattling modes and strong lattice anharmonicity,contributing to the observed lowκ*** flat bands near the valence band maximum translate into high PF,aligning with ultralowκL for exceptional thermoelectric *** optimal temperature and carrier concentration doping,outstanding ZT values are achieved:4.25(a(b)-axis,p-type,3×10^(19)cm^(−3),500 K),0.90(c-axis,p-type,5×10^(20)cm^(−3),700 K),1.61(a(b)-axis,n-type,2×10^(18)cm^(−3),700 K),and 3.06(c-axis,n-type,9×10^(17)cm^(−3),700 K).

关键词： anharmonic lattice dynamics electron transport characteristics first principles calculation lattice thermal transport octahedron thermoelectric properties

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Consistency between domain wall oscillation modes and spin wave modes in nanostrips

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Chinese physics B 2024年第6期33卷 511-516页

作者：董新伟吴振江 department of physics and Institute of Theoretical physics and Astrophysics Xiamen UniversityXiamen 361005China

Investigations on domain wall(DW) and spin wave(SW) modes in a series of nanostrips with different widths and thicknesses have been carried out using micromagnetic simulation. The simulation results show that the frequencies of SW modes and the corresponding DW modes are consistent with each other if they have the same node number along the width direction. This consistency is more pronounced in wide and thin nanostrips, favoring the DW motion driven by *** analysis of the moving behavior of a DW driven by SWs is also carried out. The average DW speed can reach a larger value of ~ 140 m/s under two different SW sources. We argue that this study is very meaningful for the potential application of DW motion driven by SWs.

关键词： micromagnetic simulation domain wall spin wave

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On the half-quantized Hall conductance of massive surface electrons in magnetic topological insulator films

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Science China(physics,Mechanics & Astronomy) 2024年第6期67卷 127-136页

作者： Rui Chen Shun-Qing Shen department of physics The University of Hong KongHong Kong 999077China department of physics Hubei UniversityWuhan 430062China

In topological insulators,massive surface states resulting from local symmetry breaking were thought to exhibit a half-quantized Hall conductance,obtained from the low-energy effective model in an infinite Brillouin *** a lattice model,the surface band is composed of a combination of surface states and bulk *** massive surface states alone may not be enough to support an exact one-half quantized surface Hall conductance in a finite Brillouin zone and the whole surface band always gives an integer quantized Hall conductance as enforced by the TKNN *** explore this,we investigate the band structures of a lattice model describing the magnetic topological insulator film that supports the axion insulator,Chern insulator,and semi-magnetic topological insulator *** reveal that the gapped and gapless surface bands in the three phases are characterized by an integer-quantized Hall conductance and a half-quantized Hall conductance,*** propose an effective model to describe the three phases and show that the low-energy dispersion of the surface bands inherits from the surface Dirac *** gapped surface band manifests a nearly half-quantized Hall conductance at low energy near the center of Brillouin zone,but is compensated by another nearly half-quantized Hall conductance at high energy near the boundary of Brillouin zone because a single band can only have an integer-quantized Hall *** gapless band hosts a zero Hall conductance at low energy but is compensated by another half-quantized Hall conductance at high energy,and thus the half-quantized Hall conductance can only originate from the gapless ***,we calculate the layer-resolved Hall conductance of the *** conclusion suggests that the individual gapped surface band alone does not support the half-quantized surface Hall effect in a lattice model.

关键词： magnetic topological insulator Dirac equation half-quantized Hall conductance

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Prospects and challenges in electrochemical nitrogen activation for ammonia synthesis

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Science China Chemistry 2024年第11期67卷 3510-3514页

作者： Xianbiao Fu Ib Chorkendorff department of physics Technical University of Denmark

“The fixation of atmospheric nitrogen stands as one of the profound discoveries awaiting the ingenuity of chemists,”proclaimed William Crookes in his 1898 speech [1]. This statement swiftly surged like a colossal wa... 详细信息

关键词： REDUCTION EFFICIENCY N-2

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The combined effects of quantum and strong coupling on the nonlinear collective excitation in quantum dusty plasmas

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Communications in Theoretical physics 2024年第10期76卷 137-142页

作者： Chengkai Li Youyou Kang Yunliang Wang department of physics School of Mathematics and Physics University of Science and Technology Beijing

The quantum hydrodynamic model for electrons and ions and the generalized hydrodynamic model for the strongly coupled dust particles are proposed in the strongly coupled quantum dusty plasma, where the combined quantum effects of quantum diffraction, quantum statistic pressure,as well as electron exchange and correlation effects are all considered in the quantum hydrodynamic model. The shear and bulk viscosity effects are included in the viscoelastic relaxation, which leads to the decay of the dust-ion-acoustic waves. The approximate time-dependent solitary solution is obtained by the momentum conservation law in the presence of viscosity.

关键词： dusty plasma quantum plasma strongly coupled plasma

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