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Edaravone combined with Schwann cell transplantation may repair spinal cord injury in rats

Neural Regeneration Research 2015年第2期10卷 230-236页

作者： Shu-quan Zhang Min-fei Wu Zhe Piao Jin Yao Ji-hai Li Xin-gang Wang Jun Liu department of Orthopedics Tianjin Nankai Hospital department of Spine surgery Orthopedic Hospital Second Hospital Clinical Hospital Jilin University department of Burns and Plastic surgery China-Japan Union Hospital Jilin University department of Hand and foot surgery and Reparative & Reconstructive surgery Center Orthopedic Hospital Second Hospital Clinical Hospital Jilin University

Edaravone has been shown to delay neuronal apoptosis, thereby improving nerve function and the microenvironment after spinal cord injury. Edaravone can provide a favorable environment for theAa：eatment of spinal cord injury using Schwann cell transplantation. This study used rat models of complete spinal cord transection at T9. Six hours later, Schwann cells were transplanted in the head and tail ends of the injury site. Simultaneously, edaravone was injected through the caudal vein. Eight weeks later, the PKH-26-1abeled Schwann cells had survived and migrated to the center of the spinal cord injury region in rats after combined treatment with edaravone and Schwann cells. Moreover, the number of PKH-26-1abeled Schwann cells in the rat spinal cord was more than that in rats undergoing Schwann cell transplantation alone or rats without any treatment. Horseradish peroxidase retrograde tracing revealed that the number of horserad- ish peroxidase-positive nerve fibers was greater in rats treated with edaravone combined with Schwann cells than in rats with Schwann cell transplantation alone. The results demonstrated that lower extremity motor function and neurophysiological function were better in rats treated with edaravone and Schwann cells than in rats with Schwann cell transplantation only. These data confirmed that Schwann cell transplantation combined with edaravone injection promoted the regeneration of nerve fibers of rats with spinal cord injury and improved neurological function.

关键词： nerve regeneration spinal cord injury Schwann cells cell transplantation edaravone motor function electrophysiological function neural regeneration

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foot and ankle surgery:Tourniquet placement site to cause as little postoperative pain as possible

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World Journal of Orthopedics 2024年第6期15卷 498-500页

作者： Emerito Carlos Rodriguez-Merchan department of Orthopedic surgery La Paz University Hospital-IdiPazMadrid 28046Spain Osteoarticular surgery Research Hospital La Paz Institute for Health Research-IdiPAZ(La Paz University Hospital-Autonomous University of Madrid)Madrid 28046Spain

There is controversy in the literature on where to place the tourniquet(thigh,calf,ankle)for foot and ankle *** some authors prefer the ankle tourniquet to the calf tourniquet,others state that the surgeon can decide between using the thigh tourniquet or the ankle tourniquet,since there was no difference in postoperative pain between *** to place the tourniquet during foot and ankle surgery to cause the least possible postoperative pain to the patient as a result of the tourniquet is a common question in clinical *** reality is that,unfortunately,there is no consensus on this *** the only possible way to answer this question would be to conduct a comparative study with sufficient statistical power to reach scientifically sound *** does not seem easy to carry out such a study,but it would be important to be able to answer the question posed in the title of this Editorial once and for all.

关键词： surgery foot ankle Tourniquet Site Postoperative pain

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Clinical Versus Doppler Based Assessment in Determining Amputation Level in Diabetic foot Gangrene;A Prospective Cross-Sectional Study at Atbuth, Bauchi

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Open Journal of Orthopedics 2024年第8期14卷 366-373页

作者： Shaphat Shuaibu Ibrahim Stephen Yusuf Abubakar Musa Shirama Yakubu Bababa Yusuf Aliyu Salihu Makama Baje Salihu Bukar Shehu department of Orthoepaedics and Trauma Abubakar Tafawa-Balewa University Teaching Hospital Bauchi Nigeria department of Radiology Abubakar Tafawa-Balewa University Teaching Hospital Bauchi Nigeria department of surgery Abubakar Tafawa-Balewa University Teaching Hospital Bauchi Nigeria

Background: Amputation is defined as the surgical removal of a limb or part of a limb through the bone. If the amputation is done above or below the knee, they are termed major while minor amputations involve the partial removal of foot including forefoot resections, ray amputation of the digits or parts of the digits. Significant number of patients with diabetic foot ulcers end with amputations. In the past the amputation level was decided by clinical assessment alone, such as physical examination using color, temperature, peripheral pulses and wound bleeding during surgical procedure. The use of Doppler ultrasound to measure arterial blood pressure at the proposed amputation site has been advocated as a predictor of amputation success. An optimal choice of the level of amputation can reduce amputation complications. Methodology: A Prospective comparative randomized cross-sectional study carried out between 1st January 2022 and 1st January 2024 in ATBUTH, Bauchi amongst patients with diabetic foot Wagener stage IV and V scheduled for amputation. Outcome measures of wound break down, flap necrosis and re-amputation were assessed amongst the clinical based level assessment group and the doppler based level assessment group. Results: A total of 171 patients were recruited into the study. Males 103 and 68 are females, giving a male to female ratio of 1.5:1. mean age 47 years. There were 84 patients in the clinical based level assessment group and 87 patients in the doppler based level assessment. Conclusion: Diabetes mellitus foot disease is a significant risk factor for non-traumatic lower limb amputation and doppler level assessment is superior to clinical level in determining amputation level among diabetic patients scheduled for amputation. P-value 0.003.

关键词： Diabetics Amputation foot Gangrene Doppler Clinical

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Non-surgical treatment of diabetic foot ulcers on the dorsum of the foot with polydeoxyribonucleotide injection:Two case reports

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World Journal of Clinical Cases 2024年第20期12卷 4446-4451页

作者： Yooseok Ha Jeong-Hee Kim Jiyoung Kim Hyeokjae Kwon department of Plastic and Reconstructive surgery Chungnam National University HospitalDaejeon 35015South Korea College of Nursing Woosuk UniversityWanju-gun 55338South Korea

BACKGROUND Diabetic foot ulcers are caused by a variety of factors,including peripheral neuropathy,peripheral arterial disease,impaired wound healing mechanisms,and repetitive *** with diabetic foot ulcer on the dorsum of the foot are often treated ***,the right non-surgical therapy must be chosen if surgical choices are contraindicated or if the patient prefers conservative treatment over *** SUMMARY The purpose of this case report is to highlight the efficacy of polydeoxyribonucleotide(PDRN)injection as a non-surgical treatment option for diabetic foot ulcers on the dorsum of the foot,particularly in patients who choose against surgical *** case report presents two cases of diabetic foot ulcers located on the dorsum of the foot that were successfully treated with PDRN injection as a non-surgical *** If the patient declines surgery for diabetic ulcers with Wagner grade II or below,PDRN injection can be effective if necrotic tissue is removed and the wound bed kept clean.

关键词： Diabetic foot Wound healing Regenerative medicine Polydeoxyribonucleotides Case report

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Portraying Diabetic foot Ulcers: Comparative Evaluation of Diabetic foot Infections versus Diabetic foot Ulcers

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Advances in Infectious Diseases 2024年第2期14卷 297-309页

作者： Jamal Wadi Al Ramahi Leen Sharqawi Sarah AL-Najafi Eman Awwad Haya M. Al-Obaidi Abdel Hafez Mohammad Sara Nofal Dina Riyadh Al-Janabi Ibrahim Zuhair Hamza Jamal Al-Masaeid Mohammed Al-Ithawi Dina Rasheed Bellal O. Al-Far Osama Al-Izi Qutaiba Al-Bustanji School of Medicine The University of Jordan Amman Jordan department of the Internal Medicine The Specialty Hospital Amman Jordan department of Pharmacy The Specialty Hospital Amman Jordan department of the Medical Al Khalidi Hospital Amman Jordan department of Pharmacy Jordan Hospital Amman Jordan department of Internal Medicine Jordan Hospital Amman Jordan department of General surgery Jordan Hospital Amman Jordan

Background: Confusion often arises in caring for diabetic foot infections and ulcers, especially with antimicrobials;we aim to shed light on this entity and alert healthcare workers to its stewardship. Methods: Records were reviewed between February 2016 and September 2023. Data for patients diagnosed with diabetes and foot ulcers, infected or not, were examined following ICD 9 search terms. Records for patients were included if they were prediabetic/diabetic adults with foot ulcers, more than 18 years old, and on antidiabetic treatment. Patients were excluded if they insulin resistant, with normal HgbA1c levels, wheel-chair dependent, bed-bound, non-diabetic patients, diabetic patients who had vascular lower limb surgery earlier to ulcers, diabetic patients who had aortocoronary bypass, deep venous thrombosis within six months, malignancy, and severe clinical depression. A modified IWGDF/IDSA guidelines definitions for DFI and DFU was considered. Statistical analysis was done using R programming. Statistical methods were employed as appropriate, and a significant P-value was considered for P Results: Most characteristics were well balanced between DFI and DFU, on imaging osteomyelitis and tissue swelling were significantly more in DFI. Endovascular radiological procedures showed angiograms to be considerably more in DFI, while angioplasty was more in DFU, in addition to smoking. Bacteremia was uncommon, and swab cultures were mostly polymicrobial in both ulcers;no clear association with blood bacteria was detected with the polymicrobial growth, though few were concordant. Antimicrobials prescribed for both ulcers were not statistically different except for carbapenems, which were more in DFI (P Conclusion: Attention should be paid to best practices while caring for diabetic ulcers. These include swab culture interpretations, the use of antimicrobials, and plan management according to DFI or DFU to utilize either local care or combination with antimicrobials.

关键词： Diabetic foot Ulcers Diabetic Limb Amputation Antimicrobials Stewardship Broad-Spectrum Antimicrobials in Diabetic foot Ulcers

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Effect of lentiviral vector-mediated overexpression of hypoxia-inducible factor 1 alpha delivered by pluronic F-127 hydrogel on brachial plexus avulsion in rats

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Neural Regeneration Research 2019年第6期14卷 1069-1078页

作者： Tao Wang Li-Ni Zeng Zhe Zhu Yu-Hui Wang Lu Ding Wei-Bin Luo Xiao-Min Zhang Zhi-Wei He Hong-Fu Wu Institute of Stem Cells and Regenerative Medicine Department of PhysiologyGuangdong Medical University department of surgery the Third Hospital of Guangdong Medical University (Longjiang Hospital of Shunde District) Hand & foot surgery and Reparative & Reconstruction surgery Center the Second Hospital of Jilin University department of Scientific Research Center the Seventh Affiliated HospitalSun Yat-Sen University

Brachial plexus avulsion often results in massive motor neuron death and severe functional deficits of target muscles. However, no satisfactory treatment is currently available. Hypoxia-inducible factor 1α is a critical molecule targeting several genes associated with ischemia-hypoxia damage and angiogenesis. In this study, a rat model of brachial plexus avulsion-reimplantation was established, in which C5–7 ventral nerve roots were avulsed and only the C6 root reimplanted. Different implants were immediately injected using a microsyringe into the avulsion-reimplantation site of the C6 root post-brachial plexus avulsion. Rats were randomly divided into five groups: phosphate-buffered saline, negative control of lentivirus, hypoxia-inducible factor 1α(hypoxia-inducible factor 1α overexpression lentivirus), gel(pluronic F-127 hydrogel), and gel + hypoxia-inducible factor 1α(pluronic F-127 hydrogel + hypoxia-inducible factor 1α overexpression lentivirus). The Terzis grooming test was performed to assess recovery of motor function. Scores were higher in the hypoxia-inducible factor 1α and gel +hypoxia-inducible factor 1α groups(in particular the gel + hypoxia-inducible factor 1α group) compared with the phosphate-buffered saline group. Electrophysiology, fluorogold retrograde tracing, and immunofluorescent staining were further performed to investigate neural pathway reconstruction and changes of neurons, motor endplates, and angiogenesis. Compared with the phosphate-buffered saline group, action potential latency of musculocutaneous nerves was markedly shortened in the hypoxia-inducible factor 1α and gel + hypoxia-inducible factor1α groups. Meanwhile, the number of fluorogold-positive cells and ChAT-positive neurons, neovascular area(labeled by CD31 around av ulsed sites in ipsilateral spinal cord segments), and the number of motor endplates in biceps brachii(identified by α-bungarotoxin) were all visibly increased, as well as the morphology of motor endplate in biceps

关键词： nerve regeneration peripheral nerve injury brachial plexus avulsion hypoxia ischemia hypoxia-inducible factor 1αoverexpression pluronic F-127 motor neurons axonal regeneration angiogenesis neural regeneration

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Delayed reconstruction of lateral complex structures of the ankle

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World Journal of Orthopedics 2011年第4期2卷 31-36页

作者： Gordon L Slater Alejandro E Pino Martin O’Malley Sports foot and ankle surgery Edgecliff Sydney NSW 2027Australia Hospital for Special surgery Department of Foot and Ankle Surgery535 E 70 St.New YorkNY 10021United States Hospital for Special surgery Department of Foot and Ankle Surgery535 E 70th St.New YorkNY 10021United States

Lateral ankle instability is one of the most common and well-recognized conditions presenting to foot and ankle *** may exist as an isolated entity or in conjunction with other concomitant pathology,making it important to appropriately diagnose and identify other conditions that may need to be addressed as part of *** associated conditions may be a source of chronic pain,even when the instability has been appropriately treated,or may lead to failure of treatment by predisposing the patient to ankle inversion *** primary goal of this editorial is to provide a brief summary of the common techniques used in the delayed reconstruction of lateral ankle ligamentous injuries and present a method we have successfully employed for over 15 *** will also briefly discuss the diagnosis and treatment of the more common associated conditions,which are important to identify to achieve satisfactory results for the *** present the outcomes of 250 consecutive reconstructions performed over the last 10 years and describe our operative technique for addressing lateral ankle ligamentous injuries.

关键词： Lateral ankle ligaments ankle instability ankle ligament reconstruction Anatomic ligament reconstruction ankle sprain

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Corrigendum to“3Cpro of FMDV inhibits type II interferon-stimulated JAK-STAT signaling pathway by blocking STAT1 nuclear translocation”[Virol Sin 38(2023)387–397]

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Virologica Sinica 2024年第2期39卷 351-354页

作者： Xiangju Wu Lei Chen Chao Sui Yue Hu Dandan Jiang Fan Yang Laura C.Miller Juntong Li Xiaoyan Cong Nataliia Hrabchenko Changhee Lee Yijun Du Jing Qi Shandong Key Laboratory of Animal Disease Control and Breeding Key Laboratory of Livestock and Poultry Multi-omics of MARAInstitute of Animal Science and Veterinary MedicineInstitute of Crop Germplasm ResourcesShandong Academy of Agricultural SciencesJinan250100China College of Life Science Shandong Normal UniversityJinan250358China State Key Laboratory of Veterinary Etiological Biology National Foot and Mouth Disease Reference LaboratoryKey Laboratory of Animal Virology of Ministry of AgricultureLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou730050China department of Diagnostic Medicine and Pathobiology College of Veterinary MedicineKansas State UniversityManhattanKS66506USA College of Veterinary Medicine and Virus Vaccine Research Center Gyeongsang National UniversityJinju52828Republic of Korea

Due to our negligence,the original version of this article,published online on Mar 14,2023,contained some mistakes in several *** Fig.2D,the positions of the bands for protein 3A and 3B were incorrectly *** has been m... 详细信息

关键词： STAT1 FMDV bands

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Repair of sciatic nerve defects using tissue engineered nerves

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Neural Regeneration Research 2013年第21期8卷 1985-1994页

作者： Caishun Zhang Gang Lv department of Hand and foot surgery First Affiliated Hospital of Liaoning Medical University

In this study, we constructed tissue-engineered nerves with acellular nerve allografts in Sprague-Dawley rats, which were prepared using chemical detergents-enzymatic digestion and mechanical methods, in combination with bone marrow mesenchymal stem cells of Wistar rats cultured in vitro, to repair 15 mm sciatic bone defects in Wistar rats. At postoperative 12 weeks, electrophysiological detection results showed that the conduction velocity of regenerated nerve after repair with tissue-engineered nerves was similar to that after autologous nerve grafting, and was higher than that after repair with acellular nerve allografts. Immunohistochemical staining revealed that motor endplates with acetylcholinesterase-positive nerve fibers were orderly arranged in the middle and superior parts of the gastrocnemius muscle; regenerated nerve tracts and sprouted branches were connected with motor endplates, as shown by acetylcholinesterase histochemistry combined with silver staining. The wet weight ratio of the tibialis anterior muscle at the affected contralateral hind limb was similar to the sciatic nerve after repair with autologous nerve grafts, and higher than that after repair with acellular nerve allografts. The hind limb motor function at the affected side was significantly improved, indicating that acellular nerve allografts combined with bone marrow mesenchymal stem cell bridging could promote functional recovery of rats with sciatic nerve defects.

关键词： neural regeneration peripheral nerve injury tissue engineering artificial nerve sciatic nerve defects bone marrow mesenchymal stem cells nerve scaffold grants-supported paper neuroregeneration

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Posterior malleolar fracture： technique and clinical exerience of the posterolateral approach

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Chinese Journal of Traumatology 2012年第1期15卷 23-26页

作者： HUANGRuo—kun XIE Ming ZHAOJing-jing XIA0 Kai KANWu—sheng department of foot ＆ ankle Pu Ai Hospital Huazhong University of Science and Technology Wuhan 430033China

：Objective：To introduce the posterolateral surgical approach to the posterior malleolar fracture and report its clinical outcomes in 32 ***：This study consisted of 32 cases,22 males and 10 females with the mean age of 48 years（range,21-63years）,suffering from posterior malleolar *** cases were treated with the posterolateral surgical approach to the *** average follow-up period was 28 months （range,24-35 months）.The clinical outcomes of these cases were evaluated on the basis of the Olerud-Molander ankle （OMA）score and plain ***：All cases showed radiological evidence of bony union at *** average OMA score was 82 points; 21 cases had excellent scores（90-100 points）,9 good （61-90 points）,and 2 fair（31-60 points）.The excellent-togood rate was 93.8%.Although most cases did not show any wound dehiscence or necrosis,one patient had a superficial infection which healed after using antibiotic dressing and one had sural cutaneous nerve injury that underwent spontaneous remission without any treatment after three *** addition,one presented with mild symptoms of peroneal tendonitis that disappeared after ***：The posterolateral approach offers an effective technique for fracture reduction and fixation of large posterior malleolar fragments.

关键词： ankle injuries Dislocations Fracturefixation, internal

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