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Reconstruction of Tibial Nonossifying Fibroma Accompanying with Undetected Ewing＆#39;s Sarcoma by Ilizarov Method

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Chinese Medical Journal 2017年第21期130卷 2639-2640页

作者： Xue-Hui Liu Ge Sun Chang-Gui Tong Zhi-Hong Tong Hai-Dong Liang department of Hand and foot Microsurgery The Second Hospital of Dalian Medical University Dalian Liaoning 116023 China department of Thoracic surgery The Second Hospital of Dalian Medical University Dalian Liaoning 116023 China

The clinical behavior of nonossifying fibroma （NOF） appears to be a benign lesion without recurrence or canceration.[1] Ewing＇s sarcoma （ES） is usually regarded as a differential diagnosis of NOF.[2] There has not been any report on NOF and ES appearing in the same position simultaneously. Here, we first report a case that the simultaneous onset of two entities was mistaken for the development of NOF into ES. A17-year-old boy referred to hospital in October 2010 for a durative ache in his right knee after an injury during football training. Initial radiographs revealed a low-density area with sclerotic margin on the proximal part of the right tibia. Computed tomography （CT） scan showed a radiolucent, eccentric, and cortically based lesion in the posterolateral metaphysis of the right tibia. Then, the patient underwent magnetic resonance imaging （MRI）, in which a lesion revealed long mixed signs on T1-weighted imaging （T1WI） and short signs on T2WI accompanied with bone contusion around it. These reports suggested that the eccentric area could be an osteoid osteoma or a NOF. A percutaneous biopsy of the right proximal tibia lesion was performed, and then NOF was pathologically confirmed. Hence, curettage and bone grafting were performed.

关键词： Ewing's Sarcoma Ilizarov Method Nonossifying Fibroma

Effect of lentiviral vector-mediated overexpression of hypoxia-inducible factor 1 alpha delivered by pluronic F-127 hydrogel on brachial plexus avulsion in rats

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Neural Regeneration Research 2019年第6期14卷 1069-1078页

作者： Tao Wang Li-Ni Zeng Zhe Zhu Yu-Hui Wang Lu Ding Wei-Bin Luo Xiao-Min Zhang Zhi-Wei He Hong-Fu Wu Institute of Stem Cells and Regenerative Medicine Department of PhysiologyGuangdong Medical University department of surgery the Third Hospital of Guangdong Medical University (Longjiang Hospital of Shunde District) Hand & foot surgery and Reparative & Reconstruction surgery Center the Second Hospital of Jilin University department of Scientific Research Center the Seventh Affiliated HospitalSun Yat-Sen University

Brachial plexus avulsion often results in massive motor neuron death and severe functional deficits of target muscles. However, no satisfactory treatment is currently available. Hypoxia-inducible factor 1α is a critical molecule targeting several genes associated with ischemia-hypoxia damage and angiogenesis. In this study, a rat model of brachial plexus avulsion-reimplantation was established, in which C5–7 ventral nerve roots were avulsed and only the C6 root reimplanted. Different implants were immediately injected using a microsyringe into the avulsion-reimplantation site of the C6 root post-brachial plexus avulsion. Rats were randomly divided into five groups: phosphate-buffered saline, negative control of lentivirus, hypoxia-inducible factor 1α(hypoxia-inducible factor 1α overexpression lentivirus), gel(pluronic F-127 hydrogel), and gel + hypoxia-inducible factor 1α(pluronic F-127 hydrogel + hypoxia-inducible factor 1α overexpression lentivirus). The Terzis grooming test was performed to assess recovery of motor function. Scores were higher in the hypoxia-inducible factor 1α and gel +hypoxia-inducible factor 1α groups(in particular the gel + hypoxia-inducible factor 1α group) compared with the phosphate-buffered saline group. Electrophysiology, fluorogold retrograde tracing, and immunofluorescent staining were further performed to investigate neural pathway reconstruction and changes of neurons, motor endplates, and angiogenesis. Compared with the phosphate-buffered saline group, action potential latency of musculocutaneous nerves was markedly shortened in the hypoxia-inducible factor 1α and gel + hypoxia-inducible factor1α groups. Meanwhile, the number of fluorogold-positive cells and ChAT-positive neurons, neovascular area(labeled by CD31 around av ulsed sites in ipsilateral spinal cord segments), and the number of motor endplates in biceps brachii(identified by α-bungarotoxin) were all visibly increased, as well as the morphology of motor endplate in biceps

关键词： nerve regeneration peripheral nerve injury brachial plexus avulsion hypoxia ischemia hypoxia-inducible factor 1αoverexpression pluronic F-127 motor neurons axonal regeneration angiogenesis neural regeneration

Hybrid pedestrian positioning system using wearable inertial sensors and ultrasonic ranging

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Defence Technology（防务技术） 2024年第3期33卷 327-338页

作者： Lin Qi Yu Liu Chuanshun Gao Tao Feng Yue Yu School of Communication and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong Kong 999077China

Pedestrian positioning system(PPS)using wearable inertial sensors has wide applications towards various emerging fields such as smart healthcare,emergency rescue,soldier positioning,*** performance of traditional PPS is limited by the cumulative error of inertial sensors,complex motion modes of pedestrians,and the low robustness of the multi-sensor collaboration *** paper presents a hybrid pedestrian positioning system using the combination of wearable inertial sensors and ultrasonic ranging(H-PPS).A robust two nodes integration structure is developed to adaptively combine the motion data acquired from the single waist-mounted and foot-mounted node,and enhanced by a novel ellipsoid constraint *** addition,a deep-learning-based walking speed estimator is proposed by considering all the motion features provided by different nodes,which effectively reduces the cumulative error originating from inertial ***,a comprehensive data and model dual-driven model is presented to effectively combine the motion data provided by different sensor nodes and walking speed estimator,and multi-level constraints are extracted to further improve the performance of the overall *** results indicate that the proposed H-PPS significantly improves the performance of the single PPS and outperforms existing algorithms in accuracy index under complex indoor scenarios.

关键词： Pedestrian positioning system Wearable inertial sensors Ultrasonic ranging Deep-learning Data and model dual-driven

Recurrence of intratendinous ganglion due to incomplete excision of satellite lesion in the extensor digitorum brevis tendon: A case report

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World Journal of Clinical Cases 2022年第36期10卷 13373-13380页

作者： Jeong Jin Park Hyun Gyu Seok Hongfei Yan Chul Hyun Park department of Orthopaedic surgery Yeungnam University HospitalDaeguKoreaDaegu 42415South Korea department of Orthopaedic surgery College of MedicineYeungnam UniversityDaegu 42415South Korea

BACKGROUND Intratendious ganglions are rare lesions, especially on the foot and ankle. Although several studies have presented the intratendinous ganglion of the foot and ankle, there are only few reported cases, and no cases of recurrence or secondary surgery have been *** SUMMARY We present the case of a 32-year-old man with an intratendinous ganglion of the second extensor digitorum brevis(EDB) tendon that recurred after ganglion excision. Magnetic resonance imaging(MRI) performed before the first surgery was reviewed to analyze the causes of the recurrence. We confirmed that there was a lack of satellite detection. After recurrence, MRI revealed an extratendinous lesion, tenosynovitis, and intratendinous ganglion of the second EDB tendon. Since the second EDB tendon can compensate for the extrinsic muscle, en bloc resection was performed alone. In addition, meticulous excision and synovectomy were performed for extra-tendinous lesions and tenosynovitis, respectively. The patient returned to daily life without any functional problems or *** If removal of the affected tendon is not fatal, en bloc resection should first be considered to prevent incomplete excision and intraoperative leakage. When planning surgical excision, it is necessary to evaluate the presence of satellite lesions along the course of the affected tendon.

关键词： Intratendinous ganglion Recurrence Surgical excision En bloc resection Case report

Delayed reconstruction of lateral complex structures of the ankle

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World Journal of Orthopedics 2011年第4期2卷 31-36页

作者： Gordon L Slater Alejandro E Pino Martin O’Malley Sports foot and ankle surgery Edgecliff Sydney NSW 2027Australia Hospital for Special surgery Department of Foot and Ankle Surgery535 E 70 St.New YorkNY 10021United States Hospital for Special surgery Department of Foot and Ankle Surgery535 E 70th St.New YorkNY 10021United States

Lateral ankle instability is one of the most common and well-recognized conditions presenting to foot and ankle *** may exist as an isolated entity or in conjunction with other concomitant pathology,making it important to appropriately diagnose and identify other conditions that may need to be addressed as part of *** associated conditions may be a source of chronic pain,even when the instability has been appropriately treated,or may lead to failure of treatment by predisposing the patient to ankle inversion *** primary goal of this editorial is to provide a brief summary of the common techniques used in the delayed reconstruction of lateral ankle ligamentous injuries and present a method we have successfully employed for over 15 *** will also briefly discuss the diagnosis and treatment of the more common associated conditions,which are important to identify to achieve satisfactory results for the *** present the outcomes of 250 consecutive reconstructions performed over the last 10 years and describe our operative technique for addressing lateral ankle ligamentous injuries.

关键词： Lateral ankle ligaments ankle instability ankle ligament reconstruction Anatomic ligament reconstruction ankle sprain

Antioxidant-enriched autologous biogel promoted diabetic wound healing by remodeling inherent posttraumatic inflammatory patterning and restoring compromised microenvironment homeostasis

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Regenerative Biomaterials 2022年第1期9卷 202-218页

作者： Yixi Yang Le Wang Yonglin Zhou Yijun He Shaozhang Lin Yuwei Zeng Yunhe Zhou Wei Li Zaopeng He Qi Zhao Lihao Chen Zijie Li Wenhao Wang Zhi-Yong Zhang Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150P.R.China department of Orthopaedic surgery The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150P.R.China Medical Technology and Related Equipment Laboratory The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150P.R.China Hand and foot surgery&Plastic surgery Affiliated Shunde Hospital of Guangzhou Medical UniversityShunde DistrictFoshanP.R.China

Successful wound healing depends on the reconstruction of proper tissue homeostasis,particularly in the posttraumatic inflammatory tissue *** jeopardizes tissues’immune homeostasis in cutaneous wounds,causing persistent chronic inflammation and cytokine ***,we developed an autologous regeneration factor(ARF)technology to extract the cytokine composite from autologous tissue to restore immune homeostasis and promote wound ***,treatment efficacy was significantly compromised in diabetic ***,we proposed that a combination of melatonin and ARF,which is beneficial for proper immune homeostasis reconstruction,could be an effective treatment for diabetic *** research showed that the utilization of melatonin-mediated ARF biogel(AM gel)promoted diabetic wound regeneration at a more rapid healing ***-Seq analysis showed that AM gel treatment could restore more favorable immune tissue homeostasis with unique inflammatory patterning as a result of the diminished intensity of acute and chronic ***,AM gel could be a novel and promising therapeutic strategy for diabetic wounds in clinical practice through favorable immune homeostatic reconstructions in the tissue microenvironment and proper posttraumatic inflammation patterning.

关键词： autologous regeneration factors wound healing homeostasis tissue microenvironment inflammation patterning

Free tissue transfer for lower extremity trauma in the pediatric patient

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Plastic and Aesthetic Research 2022年第1期9卷 529-538页

作者： Sammy Othman Denis Knobel Division of Plastic and Reconstructive surgery Department of SurgeryNorthwell HealthNew YorkNY 11021USA

Aim:The utilization of free-tissue transfer secondary to traumatic lower extremity defects in the pediatric population is scarcely *** include microsurgeon inexperience,inadequate center resources,and fear of historically described poor surgical *** aim of this study is to investigate more recent articles describing free-flap microsurgical reconstruction for these ***:A systematic review of the literature was conducted through the online databases PubMed,Embase,and Web of Science,examining for articles with at least 20 subjects utilizing free-tissue transfer for soft-tissue defects of the pediatric(aged 18 and younger)lower extremity following traumatic etiology since *** included flap failure,return to the operating room,and functional status,where ***:Seven studies were deemed appropriate for inclusion,with a total of 243 flaps *** vehicle and motorcycle accidents were greater than 75%of total *** defects involved the foot or ankle(65.1%).In total,perforator flaps compromised the majority of flaps(54%),with the most common being the anterolateral thigh,the scapular/parascapular,and deep inferior epigastric *** common perforators included the groin flap,tensor fascia lata,radial forearm,lateral arm,and thoracodorsal perforator ***-based flaps were less common(46%),with the latissimus dorsi and rectus muscle flaps composing the *** most commonly used recipient vessel was the anterior tibialis(49.5%)and posterior tibialis vessels(45.3%).Most studies performed reconstruction within 7-10 days of *** was a cumulative 6.5%flap failure ***:Free tissue transfer for pediatric lower extremity trauma is an important tool that likely leads to powerful *** trends indicate increasing usage of perforator *** study shows that based on existing data,free flap utilization for pediatric patients is an adequate modality for repair,and ma

关键词： Reconstructive surgery pediatric trauma pediatric lower extremity microsurgery soft-tissue freetissue transfer

Restoration and protection of brachial plexus injury: hot topics in the last decade

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Neural Regeneration Research 2014年第18期9卷 1723-1728页

作者： Kaizhi Zhang Zheng Lv Jun Liu He Zhu Rui Li Second department of Neurosurgery China-Japan Union Hospital attached to Jilin University Cancer Center the First Hospital affiliated to Jilin University Hand & foot surgery and Reparative & Reconstruction surgery Center the Second Hospital of Jilin University Jilin University Clinic Medical College

Brachial plexus injury is frequently induced by injuries, accidents or birth trauma. Upper limb function may be partially or totally lost after injury, or left permanently disabled. With the de- velopment of various medical technologies, different types of interventions are used, but their effectiveness is wide ranging. Many repair methods have phasic characteristics, i.e., repairs are done in different phases. This study explored research progress and hot topic methods for pro- tection after brachial plexus injury, by analyzing 1,797 articles concerning the repair of brachial plexus injuries, published between 2004 and 2013 and indexed by the Science Citation Index database. Results revealed that there are many methods used to repair brachial plexus injury, and their effects are varied. Intervention methods include nerve transfer surgery, electrical stimula- tion, cell transplantation, neurotrophic factor therapy and drug treatment. Therapeutic methods in this field change according to the hot topic of research.

关键词： nerve regeneration brachial plexus injury repair neuroprotection nerve transfer celltransplantation electroacupuncture neurotrophic factor drugs bibliometrics neural regeneration

Identification of fangchinoline as a broad-spectrum enterovirus inhibitor through reporter virus based high-content screening

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Virologica Sinica 2024年第2期39卷 301-308页

作者： Qiu-Yan Zhang Jia-Qi Li Qi Li Yang Zhang Zhe-Rui Zhang Xiao-Dan Li Hong-Qing Zhang Cheng-Lin Deng Feng-Xia Yang Yi Xu Bo Zhang The Joint Center of Translational Precision Medicine Department of Infections and DiseasesGuangzhou Institute of PediatricsGuangzhou Women and Children's Medical CenterGuangzhou510623China Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan430071China University of Science and Technology of China Department of Life Sciences and MedicineHefei230026China Hunan Normal University School of MedicineChangsha410081China

Hand,foot,and mouth disease(HFMD)is a common pediatric illness mainly caused by enteroviruses,which are important human ***,there are no available antiviral agents for the therapy of enterovirus *** this study,an excellent high-content antiviral screening system utilizing the EV-A71-eGFP reporter virus was *** this screening system,we screened a drug library containing 1042 natural compounds to identify potential EV-A71 ***(FAN),a bis-benzylisoquinoline alkaloid,exhibits potential inhibitory effects against various enteroviruses that cause HFMD,such as EV-A71,CV-A10,CV-B3 and *** investigations revealed that FAN targets the early stage of the enterovirus life *** the selection of FAN-resistant EV-A71 viruses,we demonstrated that the VP1 protein could be a potential target of FAN,as two mutations in VP1(E145G and V258I)resulted in viral resistance to *** research suggests that FAN is an efficient inhibitor of EV-A71 and has the potential to be a broad-spectrum antiviral drug against human enteroviruses.

关键词： Hand,foot,and mouth disease(HFMD) Enterovirus EV-A71 High-content screening Fangchinoline(FAN)