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Polyphenol components in black chokeberry(Aronia melanocarpa)as clinically proven diseases control factors——an overview

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food science and Human Wellness 2024年第3期13卷 1152-1167页

作者： Ningxuan Gao Chi Shu Yuehua Wang Jinlong Tian Yuxi Lang Chenyu Jin Xingyue Cui Hanqian Jiang Shi’an Liu Zhiying Li Wei Chen Hao Xu Bin Li department of food science College of FoodShenyang Agricultural UniversityShenyang 110161China department of food science and Nutrition College of Biosystems Engineering and Food ScienceZhejiang UniversityHangzhou 310058China Chaoyang Beihe food Co. Ltd.Chaoyang 122100China

The black chokeberry is rich in polyphenols,including flavonoids with anthocyanins,flavanols and lavonols as the main components and a variety of phenolic acids represented by chlorogenic *** of these polyphenols,black chokeberry has the effect of preventing and adjuvant therapy *** study summarized the current research results on the types and contents of functional components in black chokeberry,and analyzed their digestion,absorption and metabolism in human *** this basis,the disease control functions that have been proved effective in clinical research were reviewed and *** studies showed that black chokeberry have good prevention and adjuvant therapy effects on hyperlipidemia,hypertension,diabetes and *** there are different functional components in black chokeberry,its prevention and treatment of the same disease can come from multiple pathways,which provides a more reliable effectiveness for the disease control of different populations.

关键词： Black chokeberry Hyperlipidemia Hypertension Diabetes Inflammation

A novel strain of Levilactobacillus brevis PDD-5 isolated from salty vegetables has beneficial effects on hyperuricemia through anti-inflammation and improvement of kidney damage

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food science and Human Wellness 2024年第2期13卷 898-908页

作者： Jue Xu Maolin Tu Xiankang Fan Yuxing Guo Tao Zhang Xiaoqun Zeng Zhendong Cai Zhen Wu Daodong Pan State Key Laboratory for Managing Biotic and Chemical Threats to the quality and Safety of Agro-products Ningbo UniversityNingbo 315211China Key Laboratory of Animal Protein food Deep Processing Technology of Zhejiang Province College of Food and Pharmaceutical SciencesNingbo UniversityNingbo 315211China department of food science and Technology School of Food Science and Pharmaceutical EngineeringNanjing Normal UniversityNanjing 210023China

Hyperuricemia is a metabolic disorder caused by abnormal purine metabolism,resulting in abnormally high serum uric *** this study,a novel Levilactobacillus brevis PDD-5 isolated from salty vegetables was verified with the function of alleviating *** relevant effects of *** PDD-5 in lowering uric acid were analyzed by in vitro and in vivo *** results showed that the *** PDD-5 has(68.86±15.46)%of inosine uptake capacity and(95.75±3.30)%of guanosine uptake capacity in *** administration of *** PDD-5 to hyperuricemia rats reduced uric acid,creatinine,and urea nitrogen in serum,as well as decreased inosine and guanosine levels in the intestinal contents of *** of relevant markers in the kidney by ELISA kits revealed that *** PDD-5 alleviated oxidative stress and ***,the gene expression of uric acid transporter 1(URAT1)and glucose transporter 9(GLUT9)was down-regulated,and the gene expression of organic anion transporter 1(OAT1)was up-regulated after treatment with *** *** blot analysis showed that *** PDD-5 alleviated hyperuricemia-induced kidney injury through the NLRP3 *** se findings suggest that *** PDD-5 can lower uric acid,repair kidney damage,and also has the potential to prevent uric acid nephropathy.

关键词： Lactic acid bacteria Purine nucleoside Hyperuricemia Uric acid nephropathy

The modulatory effect of oolong tea polyphenols on intestinal flora and hypothalamus gene expression in a circadian rhythm disturbance mouse model

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food science and Human Wellness 2024年第2期13卷 748-764页

作者： Ruonan Yan Chi-Tang Ho Yanan Liu Shengnan Zhan Zufang Wu Xin Zhang department of food science and Engineering Ningbo UniversityNingbo 315211China department of food science Rutgers UniversityNew BrunswickNew Jersey 08901USA

The interaction between host circadian rhythm and gut microbes through the gut-brain axis provides new clues for tea polyphenols to improve host *** present research showed that oolong tea polyphenols(OTP)improved the structural disorder of the intestinal flora caused by continuous darkness,thereby modulating the production of metabolites related to pyruvate metabolism,glycolysis/gluconeogenesis,and tryptophan metabolism to alleviate the steady-state *** fecal microbiota transplantation from the OTP group,the single-cell transcriptomic analysis revealed that OTP significantly increased the number of hypothalamus cell clusters,up-regulated the number of astrocytes and fibroblasts,and enhanced the expression of circadian rhythm genes Cry2,Per3,Bhlhe41,Nr1d1,Nr1d2,Dbp and Rorb in hypothalamic *** results confirmed that OTP can actively improve the intestinal environmental state as well as internal/peripheral circadian rhythm disorders and cognitive impairment,with potential prebiotic functional characteristics to notably contribute to host health.

关键词： Gut microbiota Circadian rhythm Oolong tea polyphenols Single-cell sequencing Metabolism

Prospects of sea buckthorn(Hippophae rhamnoides L.) polysaccharides: preparation， structural characterization， and bioactivities diversity

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food science and Human Wellness 2024年

作者： Shuyuan Shi Ruiyun Wu Zixin Han Yu Sun Pinglan Li Fazheng Ren Nan Shang Key Laboratory of Precision Nutrition and food quality College of food science and Nutritional Engineering China Agricultural University Key Laboratory of Precision Nutrition and food quality department of Nutrition and Healthy China Agricultural University College of Engineering China Agricultural University

Sea buckthorn (Hippophae rhamnoides L.) is a natural homologous substance of medicine and food. Polysaccharide， as one of its primary active components， has very superior biological activity and can be used as a dietary supplement for functional foods， with good commercial prospects. Although initial progress has been made in the study of sea buckthorn polysaccharides， related studies have been fragmented and lacked systematic and generalization. This manuscript presents a critical analysis and systematic summary of the extraction and purification methods， structural characterization and physicochemical properties， biological activity and potential mechanisms， and structure-activity relationships of sea buckthorn polysaccharides. Accumulating evidence has indicated that sea buckthorn polysaccharides， which were widely prepared by water extraction and column chromatography purifications， exhibited exhibit superior biological activities in vitro and in vivo， including antioxidant， immunomodulatory， anti-inflammatory， hepatorenal protective， antibacterial， antiviral， and prebiotic activities. After analysis， it was concluded that there is a correlation between the relevant activities of sea buckthorn polysaccharides and that the structure of sea buckthorn polysaccharides has a great influence on their biological activity. We reviewed the challenges and limitations of sea buckthorn polysaccharides， summarized the critical aspects， and provided suggestions for potential breakthroughs in the research and application of sea buckthorn polysaccharide.

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Sleep Promotion by 3-Hydroxy-4-Iminobutyric Acid in Walnut Diaphragma juglandis Fructus

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Research 2024年第2期6卷 613-627页

作者： Jian Ji Yongli Ye Lina Sheng Jiadi Sun Qianqian Hong Chang Liu Jun Ding Shuxiang Geng Deping Xu Yinzhi Zhang Xiulan Sun State Key Laboratory of food science and Technology School of Food Science and TechnologyNational Engineering Research Center for Functional FoodSynergetic Innovation Center of Food Safety and Quality ControlJiangnan UniversityLihu Avenue 1800WuxiJiangsu 214100P.R.China College of food science and Pharmacy Xinjang Agricultural UniversityNo.311 Nongda Dong RoadUrumqiXinjangUygur Autonomous Region 830052P.R.China department of Chemistry Wuhan UniversityWuhanHubei 430072P.R.China Yunnan Academy of Forestry and Grassland KunmingYunnan 650201P.R.China

Insufficient sleep can produce a multitude of deleterious repercussions on various domains of human ***,the walnut(Juglans mandshurica)confers numerous salutary biological activities pertaining to ***,the sedative and hypnotic capacities of walnut's functional constituents remain *** this investigation,we analyzed the sedative and hypnotic components of the walnut Diaphragma juglandis fructus and innovatively discovered a compound,defined as 3-hydroxy-4-iminobutyric acid(HIBA),which disrupts motor activity and enhances sleep duration by regulating the neurotransmitters(GABA,DA,etc.)within the brain and serum of ***,a metabolomics approach of the serum,basal ganglia,hypothalamus,and hippocampus as well as the gut microbiota was undertaken to unravel the underlying molecular mechanisms of sleep *** data reveal that HIBA can regulate the metabolism of basal ganglia(sphingolipids,acylcarnitines,etc.),possibly in relation to HIBA's influence on the gut microbiome(Muribaculum,Bacteroides,Lactobacillus,etc.).Therefore,we introduce a novel natural product,HIBA,and explicate the modulation of sleep promotion in mice based on the microbiota-gut-brain *** study contributes fresh insights toward natural product-based sleep research.

关键词： metabolism promotion insight

Utilization of pH-driven methods to fortify nanoemulsions with multiple polyphenols

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food science and Human Wellness 2024年第4期13卷 1943-1950页

作者： Hualu Zhou Bingjing Zheng David Julian McClements department of food science and Technology College of Agricultural and Environmental SciencesUniversity of GeorgiaGriffinGA 30223USA Biopolymers and Colloids Laboratory Department of Food ScienceUniversity of MassachusettsAmherstMA 01003USA department of food science&Bioengineering Zhejiang Gongshang UniversityHangzhou 310018China

Simple but effective methods are required to incorporate multiple bioactive polyphenols into delivery systems to increase their dispersibility,stability and *** developed and tested three p Hdriven protocols for creating nanoemulsions loaded with multiple lipophilic *** protocols differed in how the different polyphenols were incorporated into the *** impact of these three methods on the formation,properties,and gastrointestinal fate of nanoemulsions loaded with curcumin,resveratrol,and quercetin was *** three methods produced nanoemulsions with similar initial particle properties:droplet diameters(0.15,0.16,and 0.15μm)and zeta-potentials(–59,–58,and–58 m V),***,the average encapsulation efficiencies(82%,88%,and 61%),gastrointestinal stabilities(83%,97%,and 29%)and bioaccessibilities(77%,90%,and 73%)for curcumin,resveratrol,and quercetin were somewhat *** particular,more quercetin degradation occurred using the approach that held it under alkaline conditions for extended *** general,the p H-driven method provides researchers with a versatile approach of incorporating multiple polyphenols with different characteristics into functional food and beverages using a simple and inexpensive method.

关键词： Polyphenols pH-Driven encapsulation Nanoemulsions Gastrointestinal fate Functional foods

Encapsulated ferric pyrophosphate improves intestinal inflammation and gut flora disorder in suckling rats with iron deficiency anemia

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food science and Human Wellness 2024年

作者： Mengxiao Hu Lili Qiu Rui Song Xiyu Qin Xiaoxue Liu Zidi Tan Rong Liu Xiaoyu Wang College of food science & Nutritional Engineering China Agricultural University Key Laboratory of Precision Nutrition and food quality department of Nutrition and Health China Agricultural University food Laboratory of Zhongyuan Luohe

The prevalence of iron deficiency anemia （IDA） remains high in infants， resulting in growth retardation， neurodevelopmental impairment， immunodeficiency and other irreversible injuries. Efficient and safe iron supplementation for infants has been the goal of recent research. This study aims to investigate the effect of encapsulated ferric pyrophosphate （FePP） on intestinal inflammation and gut microbiota in IDA suckling rats. Newborn Sprague Dawley rats were gavaged with low and high doses of FePP and FeSO4（2 and 10 mg Fe/kg BW， respectively） during postnatal days 2-14. Results showed that FePP supplementation was as effective as FeSO4in promoting growth， alleviating anemia and restoring body iron levels. Both low and high doses of FePP could significantly down-regulate the expression of pro-inflammatory cytokines in the colon to the level similar to that in the Ctrl group （P > 0.05）. However， the high dose of FeSO4did not show a down-regulation effect. Compared with the Ctrl group， IDA caused a disturbance of gut microbiota composition in suckling rats， and FePP could restore this dysbiosis. Besides， FePP was more beneficial than FeSO4in increasing the abundance of beneficial bacteria such as Bacteroides and Akkermansia. Spearman's correlation analysis showed a correlation between gut microbiota and biochemical indicators such as iron status， pro-inflammatory cytokine expression， and oxidative stress level. Overall， these findings suggested that FePP could effectively improve IDA， and is more effective than FeSO4in alleviating intestinal inflammation and regulating gut microbiota， which provides a basis for the application of new iron fortificant in infant formula.

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food-derived bio-functional peptides for the management of hyperuricemia and associated mechanism

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food science and Human Wellness 2024年第4期13卷 1767-1786页

作者： Yanxin Wang Mingxia Ma Yumeng Huang Siqing Fan Jie Peng Shiming Li Xiurong Su Yanbo Wang Chenyang Lu State Key Laboratory for Managing Biotic and Chemical Threats to the quality and Safety of Agro-Products and School of Marine science Ningbo UniversityNingbo 315211China School of food and Health Beijing Technology and Business UniversityBeijing 100048China department of food science Rutgers UniversityNew BrunswickNJ 08901USA College of Life sciences Huanggang Normal UniversityHuanggang 438000China food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China

Hyperuricemia,a metabolic disorder related to uric acid metabolism dysregulation,has become a common metabolic disease worldwide,due to changes in lifestyle and dietary *** recent years,owing to their high activity and few adverse effects,food-derived active peptides used as functional foods against hyperuricemia have attracted increasing *** article aims to focus on the challenge associated with peptide-specific preparation methods development,functional components identification,action mechanism(s)clarification,and bioavailability *** current review proposed recent advances in producing the food-derived peptides with high anti-hyperuricemia activity by protein source screening and matched enzymatic hydrolysis condition adjusting,increased the knowledge about strategies to search antihyperuricemia peptides with definite structure,and emphasized the necessity of combining computer-aided approaches and activity *** addition,novel action mechanism mediated by gut microbiota was discussed,providing different insights from classical ***,considering that little attention was paid previously on the structure-activity relationships of anti-hyperuricemia peptides,we collected the sequences from published studies and make a preliminary summary about the structure-activity relationships,which in turn provided guides for enzymatic hydrolysis optimization and bioavailability ***,this article could promote the development,application and commercialization of food-derived anti-hyperuricemia peptides in the future.

关键词： Hyperuricemia Peptide Enzyme hydrolysis Mechanism Structure-activity relationship Bioavailability

Dietary Lipid Intervention in the Prevention of Brain Aging

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Engineering 2024年第6期37卷 128-137页

作者： Wei Xiong Bing Fang Xiaoyu Wang Ming Zhang Min Du Jiazeng Sun Juan Chen Yixuan Li Changhao Sun Xingen Lei Xue Zhang Fazheng Ren Key Laboratory of Precision Nutrition and food quality Department of Nutrition and HealthChina Agricultural UniversityBeijing 100083China Key Laboratory of Functional Dairy Co-Constructed by the Ministry of Education and Beijing MunicipalityCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China School of food science and Chemical Engineering Beijing Technology and Business UniversityBeijing 100048China department of Animal science Washington State UniversityPullmanWA 99164USA department of Nutrition and food Hygiene School of Public HealthHarbin Medical UniversityHarbin 150028China department of Animal science Cornell UniversityIthacaNY 14853USA National Health Commission(NHC)and Chinese Academy of Medical sciences(CAMS)Key Laboratory of Molecular Probe and Targeted Theranostics Harbin Medical UniversityHarbin 150028China

As people live longer,the burden of aging-related brain diseases,especially dementia,is *** aging increases the risk of cognitive impairment,which manifests as a progressive loss of neuron function caused by the impairment of synaptic plasticity via disrupting lipid ***,supplemental dietary lipids have the potential to prevent brain *** review summarizes the important roles of dietary lipids in brain function from both structure and mechanism *** and animal studies have provided evidence of the functions of polyunsaturated fatty acids(PUFAs)in brain *** results of interventions indicate that phospholipids—including phosphatidylcholine,phosphatidylserine,and plasmalogen—are efficient in alleviating cognitive impairment during aging,with plasmalogen exhibiting higher efficacy than *** is a recognized nutrient used in clinical trials due to its special vinyl ether bonds and abundance in the postsynaptic membrane of *** research should determine the dose-dependent effects of plasmalogen in alleviating brain-aging diseases and should develop extraction and storage procedures for its clinical application.

关键词： Brain aging Nutritional intervention Phospholipids Phosphatidylcholine Phosphatidylserine Plasmalogen