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Expression and Characterization of a Novelλ-Carrageenase Cgl150A_Wa from Wenyingzhuangia aestuarii

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Journal of Ocean university of China 2024年第1期23卷 209-215页

作者： SUN Yuhao CAO Siqi ZHANG Yuying XUE Changhu XIAO Hang CHANG Yaoguang College of food science and Engineering Ocean University of ChinaQingdao 266003China Marine Life Research Center Laoshan National LaboratoryQingdao 266237China department of food science University of Massachusetts AmherstMA 01003United States

λ-Carrageenan is a highly sulfated polysaccharide alternating of 1,4-O-α-D-galactopyranose-2,6-sulfate(D2S,6S)and 1,3-O-β-D-galactopyranose-2-sulfate(G2S).λ-Carrageenases are desirable tools forλ-carrageenan *** on the genome mining,a novelλ-carrageenase Cgl150A_Wa was cloned from the bacterium Wenyingzhuangia aestuarii and expressed in Escherichia ***150A_Wa was an endo-acting enzyme and exhibited its maximum activity at 30℃and pH *** employing a glycomics strategy that combined ultra-performance liquid chromatography-mass spectrometry analysis and glycoinformatics,Cgl150A_Wa was proven to degradeλ-carrageenan octaose and hexaose,and the major hydrolysis product of Cgl150A_Wa wasλ-carrageenan *** addition to the typicalλ-carrageenan motifs,the active center of Cgl150A_Wa might tolerate desulfatedλ-carrageenan ***150A_Wa is a potential biotechnological tool for preparingλ-carrageenan oligosaccharides and structural investigation.

关键词： carrageenan λ-carrageenase LC-MS oligosaccharide GH150

The modulatory effect of oolong tea polyphenols on intestinal flora and hypothalamus gene expression in a circadian rhythm disturbance mouse model

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food science and Human Wellness 2024年第2期13卷 748-764页

作者： Ruonan Yan Chi-Tang Ho Yanan Liu Shengnan Zhan Zufang Wu Xin Zhang department of food science and Engineering Ningbo UniversityNingbo 315211China department of food science Rutgers UniversityNew BrunswickNew Jersey 08901USA

The interaction between host circadian rhythm and gut microbes through the gut-brain axis provides new clues for tea polyphenols to improve host *** present research showed that oolong tea polyphenols(OTP)improved the structural disorder of the intestinal flora caused by continuous darkness,thereby modulating the production of metabolites related to pyruvate metabolism,glycolysis/gluconeogenesis,and tryptophan metabolism to alleviate the steady-state *** fecal microbiota transplantation from the OTP group,the single-cell transcriptomic analysis revealed that OTP significantly increased the number of hypothalamus cell clusters,up-regulated the number of astrocytes and fibroblasts,and enhanced the expression of circadian rhythm genes Cry2,Per3,Bhlhe41,Nr1d1,Nr1d2,Dbp and Rorb in hypothalamic *** results confirmed that OTP can actively improve the intestinal environmental state as well as internal/peripheral circadian rhythm disorders and cognitive impairment,with potential prebiotic functional characteristics to notably contribute to host health.

关键词： Gut microbiota Circadian rhythm Oolong tea polyphenols Single-cell sequencing Metabolism

Polyphenol components in black chokeberry(Aronia melanocarpa)as clinically proven diseases control factors——an overview

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food science and Human Wellness 2024年第3期13卷 1152-1167页

作者： Ningxuan Gao Chi Shu Yuehua Wang Jinlong Tian Yuxi Lang Chenyu Jin Xingyue Cui Hanqian Jiang Shi’an Liu Zhiying Li Wei Chen Hao Xu Bin Li department of food science College of FoodShenyang Agricultural UniversityShenyang 110161China department of food science and Nutrition College of Biosystems Engineering and Food ScienceZhejiang UniversityHangzhou 310058China Chaoyang Beihe food Co. Ltd.Chaoyang 122100China

The black chokeberry is rich in polyphenols,including flavonoids with anthocyanins,flavanols and lavonols as the main components and a variety of phenolic acids represented by chlorogenic *** of these polyphenols,black chokeberry has the effect of preventing and adjuvant therapy *** study summarized the current research results on the types and contents of functional components in black chokeberry,and analyzed their digestion,absorption and metabolism in human *** this basis,the disease control functions that have been proved effective in clinical research were reviewed and *** studies showed that black chokeberry have good prevention and adjuvant therapy effects on hyperlipidemia,hypertension,diabetes and *** there are different functional components in black chokeberry,its prevention and treatment of the same disease can come from multiple pathways,which provides a more reliable effectiveness for the disease control of different populations.

关键词： Black chokeberry Hyperlipidemia Hypertension Diabetes Inflammation

3D electromagnetic modelling for high-temperature superconducting dynamo flux pumps using T-A formulation

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High Voltage 2024年第2期9卷 367-379页

作者： Luning Hao Fangliang Dong Jintao Hu Qi Wang Haigening Wei Ismail Patel Adil Shah Yuyang Wu Tim Coombs department of Engineering University of CambridgeCambridgeUK Plasma science and Fusion Center Massachusetts Institute of TechnologyCambridgeMassachusettsUSA

A high-temperature superconducting(HTS)dynamo flux pump can inject DC currents into closed-loop HTS magnets without *** enables the realisation of current-lead-free or even through-wall charging systems for high-field applications such as nuclear magnetic resonance/magnetic resonance imaging(MRI)magnets,fusion reactors and *** have proposed many simulation models to understand the working principle of HTS dynamos,few of which are in 3D because of converging ***,the influences of many key 3D parameters in the HTS dynamo are scarcely *** authors propose an efficient 3D modelling method of the HTS dynamo based on the T-A *** rotating magnets are modelled by a ring-shaped permanent magnet with space-time-variant remanent flux density to avoid moving ***,together with the T-A formulation,makes the 3D model efficient and *** accuracy of the model is verified by the experimental instantaneous and time-integrated dynamic *** this model,the authors present systematic case studies to thoroughly explore the influences of the key parameters of a dynamo flux pump on the dynamic voltage and *** proposed modelling method and results could significantly benefit the design and optimisation of HTS dynamos for high-field magnets.

关键词： formulation magnets pump

Fabrication， characterization， antihypertensive effect and potential mechanisms of a novel angiotensin I-converting enzyme inhibitory peptide derived from garlic by-products

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food science and Human Wellness 2024年

作者： Lu Xiang Zhenjia Zheng Yongqiu Qi Haihua Chen Zhichang Qiu Xuguang Qiao Key Laboratory of food Nutrition and Health in Universities of Shandong， College of food science and Engineering， Shandong Agricultural university College of food science and Engineering， Qingdao Agricultural university department of food science， university of massachusetts 102 Holdsworth Way， Amherst， Massachusetts 01003， United States

The valorisation of vegetable by-products is a promising strategy to combat climate change and achieve global carbon neutrality goals. This study aimed to exploit the high-value utilization of garlic by-products and to investigate the antihypertensive effects and potential mechanisms of the resulting angiotensin-converting enzyme （ACE）1inhibitory peptides. After protein extraction， enzymatic hydrolysis， and activity-directed fractionation， a potent and highly stable ACE inhibitory peptide (IC50value: 31.38 μmol/L) was obtained， which was identified as VWAS and acted as a competitive inhibitor. VWAS stably bound to key residues in the ACE active center mainly through hydrogen bonding interactions and effectively lowered blood pressure in spontaneously hypertensive rats via alleviating renal and cardiac injuries， improving endothelial dysfunction， and regulating the renal renin-angiotensin system， antioxidant system， and anti-inflammatory system. These findings suggested that garlic protein-derived peptide （VWAS） was a desirable candidate for antihypertensive functional foods and provided guidance for the high-value utilization of garlic by-products.

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Piperine regulates the circadian rhythms of hepatic clock gene expressions and gut microbiota in high-fat diet-induced obese rats

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food science and Human Wellness 2024年第3期13卷 1617-1627页

作者： Weiyun Zhang Chi-Tang Ho Wenlian Wei Jie Xiao Muwen Lu Guangdong Provincial Key Laboratory of Nutraceuticals and Functional foods College of Food ScienceSouth China Agricultural UniversityGuangzhou 510642China department of food science Rutgers UniversityNew Brunswick 08901USA

The interplay between the host circadian clock and microbiota has significant influences on host metabolism processes,and circadian desynchrony triggered by high-fat diet(HFD)is closely related to metabolic *** this study,the modulatory effects of piperine(PIP)on lipid metabolism homeostasis,gut microbiota community and circadian rhythm of hepatic clock gene expressions in obese rats were *** Sprague-Dawley(SD)rats were fed with normal diet(ND),HFD and HFD supplemented with PIP,*** 9 weeks,rats were sacrificed with tissue and fecal samples collected for circadian *** showed that chronic PIP administration ameliorated the obesity-induced alterations in lipid metabolism and dysregulation of hepatic clock gene expressions in obese *** gut microbial communities studied through 16S rRNA sequencing showed that PIP ameliorated the imbalanced nicrobiota and recovered the circadian rhythm of Lactobacillaceae,Desulfovibrionaceae,Paraprevotellaceae,and *** fecal metabolic profiles indicated that 3-dehydroshikimate,cytidine and lithocholyltaurine were altered,which were involved in the amino acid and fatty acid metabolism *** findings could provide theoretical basis for PIP to work as functional food to alleviate the lipid metabolism disorder,circadian rhythm misalignment,and gut microbiota dysbiosis with wide applications in the food and pharmaceutic industries.

关键词： Piperine Circadian clock Obesity Gut microbiota

Metabolite acetyl-L-carnitine participates in Bifidobacterium animalis F1-7 to ameliorate atherosclerotic inflammation by downregulating theTLR4/NF-κB pathway

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food science and Human Wellness 2024年第2期13卷 813-822页

作者： Xi Liang Zhe Zhang Xiaoying Tian Qingyu Cui Haiyan Lu Maozhen Zhao Tongjie Liu Huaxi Yi Pimin Gong Lanwei Zhang department of Nutrition and food Hygiene School of public healthQingdao UniversityQingdao 266071China College of food science and Engineering Ocean University of ChinaQingdao 266003China

This study aimed to explore the effect of Bifidobacterium animalis F1-7 on the improvement of atherosclerotic *** model ApoE^(-/-)mice were orally administered with *** F1-7 for 12 *** probiotic intervention reduced the plaque areas in aorta and the accumulation of macrophages,and downregulated the expression of toll-like receptor 4(TLR4)/nuclear factorκB(NF-κB)pathway to reduce the levels of inflammatory *** widely-targeted metabolomics analysis showed that acetyl-L-carnitine(ALC)in the intestine of atherosclerotic mice was significantly increased after *** F1-7 *** analysis proved that ALC was associated with atherosclerotic inflammatory *** using oxidized low density lipoprotein induced macrophage foam cells,we further verified that ALC could reduce lipid accumulation and inflammatory response in foam cells by downregulating the TLR4/NF-κB ***,our results revealed that *** F1-7 upregulated the metabolite ALC to downregulate the inflammatory responses,leading to the reduction of plaque accumulation of atherosclerosis.

关键词： Bifidobacterium animalis F1-7 Atherosclerosis Inflammation Metabonomics Acetyl-L-carnitine

Effects of coating formulation on structural changes of turkey nugget during frying:MRI evaluation

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Journal of Future foods 2024年第2期4卷 142-148页

作者： Arash Ghaitaranpour Mohebbat Mohebbi Seyed Amir Oleyaei department of food science and Technology Faculty of AgricultureUrmia UniversityUrmia ***Iran Advanced Frying Research Core Department of Food Science and TechnologyFerdowsi University of MashhadMashhad ***Iran department of food science and Technology Ferdowsi University of MashhadMashhad ***Iran

Application of nondestructive techniques combined with image processing techniques has been increasing in investigating the internal structure of food *** resonance imaging(MRI)is one of these *** aim of this research is to investigate the effect of coating formulation on structural properties of turkey nugget samples(turkey nugget with typical batter,tragacanth-containing batter and tragacanth)by *** revealed that the changes caused by the batter formulation could also be examined using the tomographic *** results also indicated that the brightness of the MRI images of the nugget core and crust decreased during *** core of the nugget with the tragacanth-containing batter was brighter revealing its higher moisture ***,the nugget core was less reduced in this sample compared with the other *** research aimed to present a valuable knowledge about nugget frying pertaining to quality evaluation.

关键词： NuggetDeep fat frying Structural characterization Magnetic resonance imaging(MRI) Image processing

Effects of alcohol on digestion,absorption and metabolism of sea cucumber saponins in healthy mice

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food science and Human Wellness 2024年第1期13卷 137-145页

作者： Wenxian Dang Rong Li Jinyue Yang Changhu Xue Qingrong Huang Yuming Wang Tiantian Zhang College of food science and Engineering Ocean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China department of food science Rutgers State university New BrunswickNJ 08901USA

Sea cucumber saponins have attracted more attention in recent years due to biological *** is a popular practice to soak sea cucumber in Baijiu at home and being applied to industrial manufacturing in ***,knowledge of the effect of alcohol on the absorption and metabolism of sea cucumber saponins is *** effects of alcohol on digestion,absorption and metabolism of sea cucumber saponins in BALB/c mice were investigated after gavage and tail intravenous *** results showed that the content of saponins in serum and liver was significantly higher under the influence of alcohol than that in the control group after oral *** promoted the absorption of sea cucumber saponins prototype as well as inhibited the process of saponins being transformed into deglycositic metabolites in the small ***,sea cucumber saponins remained in circulation for a long time and alcohol slowed down the clearance of sea cucumber saponins under the influence of alcohol after intravenous *** confirmed the feasibility of marinating sea cucumber in Baijiu to improve the efficacy of saponins and provides an important theoretical basis for the utilization of sea cucumber and the development of sea cucumber liquor.

关键词： Holothurin A Echinoside A Alcohol Absorption Metabolism