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花生壳多酚提取物抗糖尿病活性的评价（英文）

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2018年第10期19卷 764-775页

作者： Xiao-meng SUN Hai-qing YE Jing-bo LIU Lei WU Ding-bo LIN Ya-li YU Feng GAO department of food Science and Engineering College of Food Science and Engineering Jilin University Department of Food Quality and Safety College of Food Science and Engineering Jilin University department of Nutritional Sciences Oklahoma State University

目的:评估花生壳多酚提取物的抗糖尿病活性。创新点:明确了花生壳多酚的抗糖尿病活性。方法:通过高脂饮食/链脲霉素(HFD/STZ)诱导产生糖尿病小鼠。将糖尿病小鼠随机分为四组:二甲双胍组、花生壳多酚高、中、低剂量组(分别为200、100和50... 详细信息

目的:评估花生壳多酚提取物的抗糖尿病活性。创新点:明确了花生壳多酚的抗糖尿病活性。方法:通过高脂饮食/链脲霉素(HFD/STZ)诱导产生糖尿病小鼠。将糖尿病小鼠随机分为四组:二甲双胍组、花生壳多酚高、中、低剂量组(分别为200、100和50mg/kg);同时设置正常对照组及糖尿病对照组。二甲双胍及花生壳多酚每日口服一次,剂量为每天10 ml/kg体重,持续4周;考察不同剂量的花生壳多酚对糖尿病小鼠的体重、饮食、饮水,空腹血糖、血清总胆固醇、血脂、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇,及血液中超氧化物歧化酶、谷胱甘肽、丙二醛、肝糖原水平的影响;并对小鼠的肝脏、肾脏和胰岛组织进行组织学分析。结论:花生壳多酚具有一定的降血糖作用,可作为潜在的食物补充剂应用于糖尿病患者的饮食管理中。

关键词：花生壳多酚提取物抗糖尿病活性链脲佐菌素

Prospects of sea buckthorn(Hippophae rhamnoides L.) polysaccharides: preparation， structural characterization， and bioactivities diversity

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food Science and Human Wellness 2024年

作者： Shuyuan Shi Ruiyun Wu Zixin Han Yu Sun Pinglan Li Fazheng Ren Nan Shang Key Laboratory of Precision Nutrition and food quality College of food Science and Nutritional Engineering China Agricultural University Key Laboratory of Precision Nutrition and food quality department of Nutrition and Healthy China Agricultural University College of Engineering China Agricultural University

Sea buckthorn (Hippophae rhamnoides L.) is a natural homologous substance of medicine and food. Polysaccharide， as one of its primary active components， has very superior biological activity and can be used as a dietary supplement for functional foods， with good commercial prospects. Although initial progress has been made in the study of sea buckthorn polysaccharides， related studies have been fragmented and lacked systematic and generalization. This manuscript presents a critical analysis and systematic summary of the extraction and purification methods， structural characterization and physicochemical properties， biological activity and potential mechanisms， and structure-activity relationships of sea buckthorn polysaccharides. Accumulating evidence has indicated that sea buckthorn polysaccharides， which were widely prepared by water extraction and column chromatography purifications， exhibited exhibit superior biological activities in vitro and in vivo， including antioxidant， immunomodulatory， anti-inflammatory， hepatorenal protective， antibacterial， antiviral， and prebiotic activities. After analysis， it was concluded that there is a correlation between the relevant activities of sea buckthorn polysaccharides and that the structure of sea buckthorn polysaccharides has a great influence on their biological activity. We reviewed the challenges and limitations of sea buckthorn polysaccharides， summarized the critical aspects， and provided suggestions for potential breakthroughs in the research and application of sea buckthorn polysaccharide.

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Comparative acetylome analysis reveals the potential mechanism of high fat diet function in allergic disease

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food Science and Human Wellness 2023年第3期12卷 889-894页

作者： Yanan Sun Ning Liu Huihui Wang Taiqi Qu Fazheng Ren Yixuan Li Key Laboratory of Precision Nutrition and food quality Department of Nutrition and HealthChina Agricultural UniversityBeijing 100193China College of food Science and Engineering Gansu Agricultural UniversityLanzhou 730070China

Modern technological lifestyles promote allergic diseases,especially food allergies.The underlying molecular mechanisms remain to be uncovered.Protein acetylation is one of the most important post-translational modifications,and it is involved in regulating multiple body metabolic processes.This study aimed to clarify the effects of a high-fat diet(HFD)on allergy risk and the underlying mechanisms.Four-week-old male C57 BL/6 J mice were randomly divided into two groups and fed a normal fat diet(NFD)or HFD for 24 weeks.Then,serum lipids were measured,and skeletal muscle was collected for acetylome analysis.Compared with the findings in the NFD group,HFD-fed mice were obese and hyperlipidemic.Acetylome analysis also revealed 32 differentially expressed proteins between the HFD and NFD groups.Among these,eight acetylated proteins were upregulated in the HFD group.In addition,13 and 11 proteins were acetylated only in the HFD group and NFD group,respectively.These proteins were mainly involved in regulating energy metabolism and mitochondrial function.This study provides information regarding the underlying molecular mechanisms by which HFD promotes allergy.

关键词： Allergic disease High fat diet Skeletal muscle Acetylome

Minimization of methabenzthiazuron residues in leaching water using amended soils and photocatalytic treatment with TiO_2 and ZnO

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Journal of Environmental Sciences 2014年第4期26卷 757-764页

作者： Jos Fenoll Pilar Flores Pilar Hellín Joaquín Hern'andez Simón Navarro Department of Food Quality Murcia Institute of Agri-Food Research and Development department of Agricultural Chemistry Geology and Pedology School of Chemistry University of Murcia Campus Universitario de Espinardo

In the present work, potential groundwater pollution by methabenzthiazuron （MTBU） and the effect of three different amendments （composted sheep manure, composted pine bark and spent coffee grounds） on its mobility were investigated under laboratory conditions. The efficiency of ZnO and TiO2 suspensions in the photocatalytic degradation of MTBU in leaching water was also investigated. The relative and cumulative breakthrough curves were obtained from disturbed soil columns. The presence and/or addition of organic matter drastically reduced the movement of the herbicide. On other hand, photocatalytic experiments showed that the addition of ZnO and TiO2 strongly enhances the degradation rate of this herbicide compared with the results of photolytic experiments under artificial light. ZnO appeared to be more effective in MTBU oxidation than TiO2. The results obtained point to the interest of using organic wastes and heterogeneous photocatalysis for reducing the pollution of groundwater by pesticide drainage.

关键词： groundwater pollution organic amendment pesticide movement photocatalytic oxidation semiconductor oxides

Dietary L-proline supplementation ameliorates autism-like behaviors and modulates gut microbiota in the valproic acid-induced mouse model of autism spectrum disorder

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food Science and Human Wellness 2023年

作者： Jingjing Fang Ruixuan Geng Seong-Gook Kang Kunlun Huang Tao Tong College of food Science and Nutritional Engineering 3. China Agricultural University Key Laboratory of Safety Assessment of Genetically Modified Organism (food Safety)， Ministry of Agriculture 6. Beijing Laboratory for food quality and Safety department of food Engineering， Mokpo National University Key Laboratory of Precision Nutrition and food quality， Key Laboratory of Functional Dairy， Ministry of Education

The effective intervention strategy for autism spectrum disorder (ASD) are currently limited. Herein， we attempted to evaluate the potential of L-proline (Pro)， a multifunctional amino acid， in ameliorating autism-like behaviors and clarify the molecular mechanisms involved by using the typical valproic acid (VPA)-induced mouse model of ASD. Pro significantly attenuates repetitive behaviors and social dysfunction in ASD mice. The correlation analysis revealed that the beneficial effects of Pro on autism-like behaviors are related to the modulation of gut microbiota structure and composition. The histological analysis revealed that Pro could reverse the decrease of Nissl-positive cells in the prefrontal cortex (PFC) induced by VPA exposure. RNA sequencing demonstrated that Pro can also alter the PFC transcriptomic profile distinguished by the regulation of genes involved in Parkinson disease， neuroactive ligand-receptor interaction， oxidative phosphorylation， and MAPK signaling pathway. Overall， dietary Pro supplementation may be a promising intervention strategy for ASD.

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Exposure to Emerging and Legacy Polyfluoroalkyl Substances in the Sixth Total Diet Study-China,2016-2019

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China CDC weekly 2022年第9期4卷 168-171,I0003,I0004页

作者： Yuxin Wang Xueyan Gao Jiaying Liu Bing Lyu Jingguang Li Yunfeng Zhao Yongning Wu NHC Key Laboratory of food Safety Risk Assessment Chinese Academy of Medical Science Research Unit(No.2019RU014)China National Center for Food Safety Risk AssessmentBeijingChina Key Laboratory of Precision Nutrition and food quality Department of Nutrition and HealthChina Agricultural UniversityBeijingChina

Summary What is already known about this topic?Perfluoroalkyl substances(PFASs)are persistent organic pollutants,which have multi-organ toxicity and potential health risk to humans.What is added by this report?The most commonly detected PFASs in the Sixth China Total Diet Study(TDS)samples were perfluorooctanesulfonate(PFOS),perfluorooctanoic acid(PFOA),perfluoroundecanoic acid(PFUdA),perfluorodecanoic acid(PFDA),perfluorononanoic acid(PFNA),and 9-chlorohexadecafluoro-3-oxanonane-1-sulfonate(6:2 Cl-PFESA).The mean estimated weekly intakes(EWIs)of PFOA,PFOS,and 6:2 Cl-PFESA in the Sixth TDS were 2.17,2.72,and 2.75 ng/kg body weight per week,respectively.What are the implications for public health practice?The PFASs levels in some food category and dietary exposure still need to be continuously monitored,especially for 6:2 Cl-PFESA.

关键词： intake Total continuously

α-Ionone protects against UVB-induced photoaging in epidermal keratinocytes

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Chinese Herbal Medicines 2023年第1期15卷 132-138页

作者： Ruixuan Geng Seong-Gook Kang Kunlun Huang Tao Tong Key Laboratory of Precision Nutrition and food quality Key Laboratory of Functional DairyMinistry of EducationCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China department of food Engineering Mokpo National University61 DorimriChungkyemyonMuangunJeonnam 534-729Korea Key Laboratory of Safety Assessment of Genetically Modified Organism(food Safety) Ministry of AgricultureBeijing 100083China Beijing Laboratory for food quality and Safety Beijing 100083China

Objective: To evaluate whether α-ionone, an aromatic compound mainly found in raspberries, carrots,roasted almonds, fruits, and herbs, inhibits UVB-mediated photoaging and barrier dysfunction in a human epidermal keratinocyte cell line(HaCaT cells).Methods: The anti-photoaging effect of α-ionone was evaluated by detecting the expression of barrierrelated genes and matrix metalloproteinases(MMPs) in HaCaT cells. The levels of reactive oxygen species,oxidation product, antioxidant enzyme, and inflammatory factors were further analysed to underline the protective effect of α-ionone on epidermal photoaging.Results: It was found that α-ionone attenuated UVB-induced barrier dysfunction by reversing keratin 1and filaggrin in HaCaT cells. α-Ionone also reduced the protein amount of MMP-1 and mRNA expression of MMP-1 and MMP-3 in UVB-irradiated HaCaT cells, implying protective effects on extracellular matrix.Furthermore, HaCaT cells exposed to α-ionone showed significant decreases in interleukin(IL)-1β, IL-6,IL-8, and tumor necrosis factor-α as compared to UVB-irradiated HaCaT cells. α-Ionone treatment significantly inhibited the UVB-induced intracellular reactive oxygen species increase and malondialdehyde accumulation. Therefore, the beneficial effects of α-ionone on inhibiting MMPs secretion and barrier damage may be related to attenuated inflammation and oxidative stress.Conclusion: Our results highlight the protective effects of α-ionone on epidermal photoaging and promote its clinic application as a potential natural anti-photodamage agent in future.

关键词： α-ionone epidermal keratinocytes photoaging UVB

Effect of virgin olive oil nanoemulsion combined with ajowan(Carum copticum)essential oil on the quality of lamb loins stored under chilled condition

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food Science and Human Wellness 2022年第4期11卷 904-913页

作者： Sajad Jafarinia Aziz A.Fallah Saied Habibian Dehkordi department of food Hygiene and quality Control Faculty of Veterinary MedicineShahrekord UniversityShahrekord 34141Iran department of Pharmacology Faculty of Veterinary MedicineShahrekord UniversityShahrekord 34141Iran

This survey was conducted to evaluate the impact of virgin olive oil nanoemulsion(ONE) combined with ajowan(Carum copticum) essential oil(AEO) on quality of lamb loin under refrigerated condition. The treatments were control, ONE, ONE + 1% AEO, and ONE + 2% AEO. The treatments caused a delay in growth of mesophilic and psychrotrophic bacteria, Enterobacteriaceae, and lactic acid bacteria during chilled storage. The increasing rate of total volatile nitrogen content, lipid and protein oxidation, metmyoglobin formation, and color deterioration was more retarded in treatment groups. The treatments including ONE + 1% AEO and ONE + 2% AEO were more efficient than ONE alone to delay microbial flora growth, slow down oxidative processes, and improve color in the loins. According to the results of microbial, chemical, and sensory parameters, shelflife of lamb loins was 4 days in control, 8 days in ONE, and at least 16 days in ONE + 1% AEO and ONE + 2% AEO groups. In conclusion, combination of ONE and AEO is appropriate as natural preservative to extend the shelflife of lamb loins stored under chilled condition.

关键词： Olive oil Nanoemulsion Carum copticum Meat Shelf-life

Survival of some food-borne bacteria in kefir produced by microbial levan and pullulan

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food Bioscience 2022年第3期47卷 1082-1089页

作者： Gökhan Gurur Gökmen Jaroslaw Kowalik Duygu Kışla department of food Engineering Faculty of EngineeringEge University35100BornovaIzmirTurkey department of Dairy Science and quality Management Faculty of Food SciencesUniversity of Warmia and Mazury in OlsztynOczapowskiego str.710-719OlsztynPoland

Kefir is a fermented milk product produced by kefir grains traditionally or lyophilized starter culture.Some quality characteristics of kefir produced at 22℃ and 30℃ using kefir grains after addition of microbial levan and pullulan were investigated for 14 days.Additionally,the survival of different Gram-positive and Gram-negative bacteria strains which were inoculated before and after fermentation were investigated during storage.The pH and titratable acidity were in the ranges of 4.67–4.39 and 1.10–0.87%,respectively.The highest exopolysaccharide values(458.3–465.3 mg/kg)were found in the samples produced with the addition of 1%(w/v)of microbial levan at 30℃.Yeast counts were in the ranges of 6.73–5.11 log CFU/mL while the lactobacilli and lactic streptococci counts were in the ranges of 9.64–7.91 and 9.64–8.69 log CFU/mL,respectively.The microbial polysaccharide addition did not show any significant differences in the enumeration of lactic acid bacteria in kefir(p>0.05).All Gram-positive and Gram-negative bacteria grew/survived during fermentation however Listeria monocytogenes was the most susceptible test bacterium to metabolites during storage.The highest reduction in the counts of L.monocytogenes was determined as 2.39 log units after 24 h of fermentation at 30℃ in the samples which were inoculated before fermentation and produced with the addition of pullulan.Kefir samples produced at 30℃ without polysaccharide addition were considered as the best with respect to appearance,taste,consistency and overall acceptability.

关键词： Kefir grain Levan Pullulan food-borne bacteria