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China CDC weekly 2019年第3期1卷 38-42页

作者： Lei Zhou Xin Wang Jiandong Li Rui Song Xiaoping Dong George F.Gao Zijian Feng Public Health Emergency Center Chinese Center for Disease Control and PreventionBeijingChina department of Epidemiology and Biostatistics School of Public HealthPeking University Health Science CenterBeijingChina National Institute for Communicable disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Institute for Viral disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Beijing Ditan Hospital Capital Medical UniversityBeijingChina Global Public Health Center Chinese Center for Disease Control and PreventionBeijingChina State Key Laboratory for Infectious disease Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases(Zhejiang University)National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Chinese Center for disease Control and Prevention BeijingChina

Summary What is already known on this topic?Cases of histoplasmosis have been reported in every continent except Antarctica but are fairly rare in *** prevalence of histoplasmosis has been observed in Central America,Caribbean,and South *** of Histoplasma are acquired through a respiratory route,particularly inhalation of aerosols from disturbed soils enriched with excreta from birds and bats.

关键词： China soils disturbed

First report of human infection by Rhodoplanes sp.,Alphaproteobacteria in China

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Asian Pacific Journal of Tropical Medicine 2011年第3期4卷 248-250页

作者： Zhang LJ Wang GQ Yu HL Wang J Wang SW Jia Y Yu YY Xu JG department of Rickettsiology National Institute of Communicable Disease Control and PreventionChina CDC department of Infectious diseases Peking University First Hospital department of Infectious diseases Peking UniversityFirst Hospital

We isolated a novel strain of Alphaproteobacteria from a patient,who had medical history of chronic rhinitis for more than twenty years and recently experienced local skin abscess and ulcer. He eventually died of multiple organ failure due to multi-antibiotics *** identified the microorganism by 16SrRNA sequencing and found that it belonged to the genus Rhodoplanes. It was named as Rhodoplanes *** *** is resumed that Rhodoplanes *** ZLJ-0 might be an emerging human pathogen involving in unknown febrile conditions and could cause local infection of any tissues or *** diagnosis of febrile patients should be conducted in clinical practice and research on emerging pathogens of Alphaproteobacteria should be performed to determine the epidemiology,clinical symptoms and pathogenic features of these pathogens.

关键词： Rhodoplanes sp. Infection Alphaproteobacteria Isolation Pathogen

Perceptions and Controversies on Cholera in the Traditional Chinese Medicine Field in the Late Qing Dynasty

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Chinese Medicine and Culture 2024年第2期7卷 143-151页

作者： GUO Shiqiang WU Haohuan WU Yinghua The department of History College of Liberal Arts Of Jinan UniversityGuangzhou 510632China Jinan University Library Jinan UniversityGuangzhou 510632China

At the beginning of the initial cholera outbreak in China,Wang Qingren(王清任),after years of clinical trials,became an early representative who discovered the infectious characteristics and observed the course of cholera in the field of traditional Chinesse medicine(TCM).Kou Langao(寇兰皋)and Xu Zimo(徐子默),both medical practitioners,constructed a diagnosis and treatment system for cholera with cold patterns under the theory of *** represented“School of Cholera with Cold Patterns”(SCCP).In the 1860s,with the influence of Wang Shixiong’s(王士雄)studies on the nature of cholera under the theory of epidemic febrile disease,the“School of Cholera with Heated Patterns”(SCHP)prevailed *** two schools complemented each other in theories and contributed to the integrity of TCM in cholera diagnosis and *** reviewing previous literature,books,clinical cases,and historical materials in medical field,this article aims 1)to summarise the influence of TCM on the cognitive development towards cholera in the late Qing dynasty;2)to explore the origin of the controversy between SCCP and SCHP from historical evidence;3)to summarize the historical lessons from the debate over cholera in TCM based on the principle of treatment based on pattern identification,and offer suggestions for the current prevention and treatment of new diseases using TCM.

关键词： Traditional Chinese medicine Cholera School of Cholera with Cold Patterns School of Cholera with Heated Patterns Wang Shixiong Xu Zimo

Procedure and clinical assessments of malariotherapy:recent experience in 20 HIV patients

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Chinese Medical Journal 2003年第7期116卷 1016-1021页

作者：陈小平肖斌权徐慧芳施文钧高凯饶纪礼 department of AIDS Control and Prevention Guangzhou Center for Disease Control and Prevention Guangzhou 510080 China department

Objective To demonstrate the side effects of malariotherapy and to explore safe procedures in conduct of malariotherapy for human immunodeficiency virus (HIV) infected patients Methods Twenty HIV/ acquired immunodeficiency syndrome (AIDS) patients were selected for the study of malariotherapy and were intravenously infected with Plasmodia vivax to induce therapeutic malaria Malaria was terminated with chloroquine after 10-20 malarial febrile episodes Clinical assessments were made before (baseline), during (malarial phase) and after (post) termination of malaria The density of Plasmodia in peripheral blood from the HIV/AIDS patients were compared to that from HIV negative naturally infected malarial patients who donated the blood for the therapeutically induced malaria CD 4 cell baseline levels were correlated to the severity of malarial symptoms and parasitemia Results There were no significant differences of Plasmodium density between the HIV/AIDS patients injected with P vivax and the HIV negative blood donors However, it was found that the HIV positive patients had milder malarial symptoms and parasitemia with progressively lower CD 4 cell baseline levels All patients developed every day or every other day fever episodes with headache and shaking chill These symptoms were well tolerated with the aid of anti pyretic medications Spleen and liver enlargement were seen in 15 of 20 and 4 of 20 patients respectively Transitory liver effects with increase of serum glutamic pyruvic transaminase were seen in 2 of 20 during malarial phase Most patients experienced mild to medium anemia and 6 of 20 patients developed thrombocytopenia during malarial phase All these side effects disappeared after termination of malaria or within one month thereafter No complications occurred in these patients Conclusions Therapeutically induced acute vivax malaria was well tolerated in 20 HIV positive subjects who represented a range of CD 4 cel

关键词： malariotherapy human immunodeficiency virus· acquired immunodeficiency syndrome side effect

Usefulness of metagenomic next-generation sequencing in adenovirus 7-induced acute respiratory distress syndrome:A case report

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World Journal of Clinical Cases 2021年第21期9卷 6067-6072页

作者： Xiao-Juan Zhang Jia-Yin Zheng Xin Li Ying-Jian Liang Zhi-Dan Zhang department of Intensive Care Unit The First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina department of Infectious disease The First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Direct metagenomic next-generation sequencing(mNGS)of clinical samples is an effective method for the molecular diagnosis of ***,its role in the diagnosis of patients with acute respiratory distress syndrome(ARDS)of an unknown infectious etiology remains *** SUMMARY A 33-year-old man was admitted to our center for a cough and febrile *** after admission,the patient was diagnosed with ARDS and treated in the intensive care ***,chest computed tomography features suggested an *** was performed and the results were indicative of an infection caused by adenovirus type *** patient recovered after receiving appropriate *** mNGS is a promising tool for the diagnosis of ARDS caused by infectious ***,further studies are required to develop strategies for incorporating mNGS into the current diagnostic process for the disease.

关键词： Acute respiratory distress syndrome Metagenomic next-generation sequencing Adenovirus Case report

Effect of Yishen Qiqiao Fang on dopamine content in serum and cerebrospinal fluid of patients in persistent vegetative statec

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Neural Regeneration Research 2007年第7期2卷 412-415页

作者： Guangkui Feng Tao Liu Zhaoqing Xi Fujun Lin Peidong Wang Lichun Zhang Chunping Wu Hulong Ma Chong Liu Lianyungang Hospital of Traditional Chinese Medicine Lianyungang 222004 Jiangsu Province China department of Seasonal febrile diseases Nanjing University of Traditional Chinese Medicine Nanjing 210029 Jiangsu Province China department of Emergency Jiangsu College of Traditional Chinese Medicine Nanjing 210029 Jiangsu Province China First Clinical Medical College Nanjing University of Traditional Chinese Medicine Nanjing 210029 Jiangsu Province China department of Neurology Nanjing Zijin Hospital Nanjing 210029 Jiangsu Province China

BACKGROUND： It has been demonstrated that the attack of persistent vegetative state is associated with the damaged neuron, which produces dopamine, and nervous pathway, the reduce of dopamine or malfunction of dopamine.OBJECTIVE： To observe the effect of self-made traditional Chinese medicine （TCM） Yishen Qiqiao Fang,which has the functions of supplementing qi and nourishing blood, resolving phlegm by promoting blood circulation, restoring consciousness and inducing resuscitation, on the contents of dopamine in serum and cerebrospinal fluid of patients in persistent vegetative state.DESIGN： An open randomized controlled clinical trial.SETTINGS： Nanjing University of Traditional Chinese Medicine, Nanjing Zijin Hospital.PARTICIPANTS： Thirty-eight inpatients of persistent vegetative state were selected from the department of Neurology, Nanjing Zijin Hospital from August 2005 to November 2006. The patients were diagnosed according to the diagnostic standards set by the summary of a meeting for specialists in Nanjing. Informed contents were obtained from their relatives. According to the order of admission, the enrolled patients were divided into control group （n =20） and TCM treated group （n =20）.METHODS： In the control group, the patients were treated with routine treatments for the symptoms. In the TCM treated group, the patients were treated with Yishen Qiqiao Fang besides the same treatments in the control group. TCM dispensing granules： each bag of mongolian milkvetch root, Chinese angelica and peach seed equaled to 10 g crude drug respectively; each bag of grassleaf sweetflag rhizome and dahurian angelica root equaled to 6 g crude drug respectively; Musk 0.05 g. The daily dosage for adults： 4 bags of mongolian milkvetch root, 2 bags of Chinese angelica, 0.05 g musk, 1 bag of peach seed, 2 bags of grassleaf sweetflag rhizome and 2 bags of dahurian angelica root, which should be given though nasal feeding or gastrostogavage before breakfast and supper ever

关键词： serotonin cerebrospinal fluid dopamine

Co-infections with Babesia microti and Plasmodium parasites along the China-Myanmar border

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Infectious diseases of Poverty 2013年第1期2卷 188-194页

作者： Xia Zhou Sheng-Guo Li Shen-Bo Chen Jia-Zhi Wang Bin Xu He-Jun Zhou Hong-Xiang Zhu Ge Jun-Hu Chen Wei Hu National Institute of Parasitic diseases Chinese Center for Disease Control and PreventionWHO Collaborating Centre for MalariaSchistosomiasis and FilariasisKey Laboratory of Parasite&Vector Biology Ministry of HealthShanghai 200025China department of Parasitology Medical College of Soochow UniversityNo.199 Renai RoadSuzhou 215123China Tengchong Center for disease Control and prevention Yunnan province 679100China department of Microbiology and Microbial Engineering School of Life ScienceFudan UniversityShanghai 200433China

Background:Babesiosis is an emerging health risk in several parts of the ***,little is known about the prevalence of Babesia in malaria-endemic *** area along the China-Myanmar border in Yunnan is a main endemic area of malaria in ***,however,human infection with Babesia microti(***)is not recognized in this region,and its profile of co-infection is not yet ***:To understand its profile of co-infections with ***,our investigation was undertaken in the malaria-endemic area along the China-Myanmar border in Yunnan between April 2012 and June *** parasite species,including ***,Plasmodium falciparum(***),***,and ***,were identified among 449 suspected febrile persons detected by nested polymerase chain reaction(PCR)assay based on small subunit ribosomal ribonucleic acid(RNA)genes of *** and Plasmodium ***:Of all the collected samples from febrile patients,mono-infection with ***,***,***,and *** accounted for 1.8%(8/449),9.8%(44/449),2.9%(13/449),and 0.2%(1/449),*** rate of mixed infections of *** with *** or *** are both 0.2%(1/449),and mixed infections of *** and *** accounted for 1.1%(5/449).Conclusions:This report supports the hypothesis that babesiosis caused by *** is emerging along the China-Myanmar border in the Yunnan province,***,but it was ignored because of low parasitemia or mixed infection with Plasmodium *** sensitive and specific diagnosis methods are needed to find the rapid response mechanism of emergency for babesiosis and malaria co-prevalence areas.

关键词： Babesia Plasmodium Co-infection China-Myanmar border

Recent progress on chikungunya virus research

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Virologica Sinica 2017年第6期32卷 441-453页

作者： Wenxi An Ningning Ge Yilin Cao Jin Sun Xia Jin Viral disease and Vaccine Translational Research Unit CAS Key Laboratory of Molecular Virology andImmunology Institut Pasteur of Shanghai Chinese Academy of Sciences department of Biochemistry and Molecular Biology Pennsylvania State University State College College of Pharmaceutical Sciences Jilin University

Chikungunya virus(CHIKV) is an arbovirus transmitted by Aedes mosquitos in tropical and subtropical regions across the world. After decades of sporadic outbreaks, it re-emerged in Africa,Asia, India Ocean and America suddenly, causing major regional epidemics recently and becoming a notable global health problem. Infection by CHIKV results in a spectrum of clinical diseases including an acute self-limiting febrile illness in most individuals, a chronic phase of recurrent join pain in a proportion of patients, and long-term arthralgia for months to years for the unfortunate few. No specific anti-viral drugs or licensed vaccines for CHIKV are available so far. A better understanding of virus-host interactions is essential for the development of therapeutics and vaccines. To this end, we reviewed the existing knowledge on CHIKV's epidemiology, clinical presentation, molecular virology, diagnostic approaches, host immune response, vaccine development, and available animal models. Such a comprehensive overview, we believe, will shed lights on the promises and challenges in CHIKV vaccine development.

关键词： chikungunya virus(CHIKV) epidemiology molecular virology host immune response vaccine development

Role of urine studies in asymptomatic febrile neutropenic patients presenting to the emergency department

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World Journal of Emergency Medicine 2021年第2期12卷 99-104页

作者： Hady Zgheib Aline El Zakhem Cynthia Wakil Mohamad Ali Cheaito Rola Cheaito Antoine Finianos Ralphe Bou Chebl Rima Kaddoura Nader Al Souky Imad El Majzoub department of Emergency Medicine American University of Beirut Medical CenterBeirut 11-0236Lebanon department of Internal Medicine American University of Beirut Medical CenterBeirut 11-0236Lebanon

BACKGROUND: The role of urine studies in the detection of urinary tract infection(UTI) in febrile neutropenic patients with urinary symptoms(having a urinary catheter or having a positive urine analysis) is inarguable. However, the evidence is scarce regarding the indication for urine studies in asymptomatic(i.e., without urinary symptoms) patients with febrile neutropenia(FN) presenting to the emergency department(ED). The aim of this study is to evaluate the need for obtaining urine studies in asymptomatic febrile neutropenic ***: This was a retrospective cohort study conducted on adult cancer patients who presented to the ED with FN and had no urinary symptoms. We included all ED presentations of eligible patients between January 2013 and September 2018. Student's t-test and Wilcoxon rank-sum test were used for continuous data, while Chi-square and Fisher's exact tests were used for categorical data. Participants were divided into two groups based on their urine culture(UC) results: negative and positive UCs. Two cut-offs were used for positive UC results: ≥10~5 cfu/m L and ≥10~4 cfu/m ***: We included 284 patients in our study. The age of our patient population was 48.5±18.5 years. More than two-thirds(68.7%) of patients had severe neutropenia, while only 3.9% and 9.9% of the patients had positive UCs at ≥10~5 cfu/m L and ≥10~4 cfu/m L, respectively. UCs were expectedly positive in most patients with urinalysis(UA) abnormalities. However, 27.3% and 32.1% of patients with positive UCs at ≥10~5 cfu/m L and ≥10~4 cfu/m L respectively had a normal UA. CONCLUSIONS: In our study, the incidence of UTI in adult febrile neutropenic cancer patients who present to the ED without urinary symptoms is low. Consequently, routine urine testing may not be warranted in this population, as it adds unnecessary financial burdens on the patients and delays timely management.

关键词： Adult Cancer Emergency department febrile neutropenia Urine testing

Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients

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Chinese Medical Journal 2020年第9期133卷 1039-1043页

作者： Yun Ling Shui-Bao Xu Yi-Xiao Lin Di Tian Zhao-Qin Zhu Fa-Hui Dai Fan Wu Zhi-Gang Song Wei Huang Jun Chen Bi-Jie Hu Sheng Wang En-Qiang Mao Lei Zhu Wen-Hong Zhang Hong-Zhou Lu department of Infectious disease Shanghai Public Health Clinical CenterShanghai 201508China department of Infectious disease and Immunology Shanghai Public Health Clinical CenterShanghai 201508China department of Hepatology Shanghai Public Health Clinical CenterShanghai 201508China department of Infectious disease Zhongshan HospitalFudan UniversityShanghai 200032China department of Critical Care Medicine Shanghai Tenth People’s HospitalTongji UniversityShanghai 200072China department of Emergency Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China department of Pulmonology Zhongshan HospitalFudan UniversityShanghai 200032China department of Infectious disease Huashan HospitalFudan UniversityShanghai 200041China Shanghai Medical College of Fudan University Shanghai 200032China

Background:A patient’s infectivity is determined by the presence of the virus in different body fluids,secretions,and *** persistence and clearance of viral RNA from different specimens of patients with 2019 novel coronavirus disease(COVID-19)remain *** study analyzed the clearance time and factors influencing 2019 novel coronavirus(2019-nCoV)RNA in different samples from patients with COVID-19,providing further evidence to improve the management of patients during ***:The clinical data and laboratory test results of convalescent patients with COVID-19 who were admitted to from January 20,2020 to February 10,2020 were collected *** reverse transcription polymerase chain reaction(RT-PCR)results for patients’oropharyngeal swab,stool,urine,and serum samples were collected and *** patients refer to recovered non-febrile patients without respiratory symptoms who had two successive(minimum 24 h sampling interval)negative RT-PCR results for viral RNA from oropharyngeal *** effects of cluster of differentiation 4(CD4)+T lymphocytes,inflammatory indicators,and glucocorticoid treatment on viral nucleic acid clearance were ***:In the 292 confirmed cases,66 patients recovered after treatment and were included in our *** total,28(42.4%)women and 38 men(57.6%)with a median age of 44.0(34.0-62.0)years were *** in-hospital treatment,patients’inflammatory indicators decreased with improved clinical *** median time from the onset of symptoms to first negative RT-PCR results for oropharyngeal swabs in convalescent patients was 9.5(6.0-11.0)*** February 10,2020,11 convalescent patients(16.7%)still tested positive for viral RNA from stool specimens and the other 55 patients’stool specimens were negative for 2019-nCoV following a median duration of 11.0(9.0-16.0)days after symptom *** these 55 patients,43 had a longer duration until stool specimens were negative f

关键词： COVID-19 2019-nCoV Nucleic acid detection Glucocorticoid