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Role of peripheral amyloid-β aggregates in Alzheimer’s disease: mechanistic, diagnostic, and therapeutic implications

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Neural Regeneration Research 2025年第4期20卷 1087-1089页

作者： Nazaret Gamez Rodrigo Morales department of Neurology The University of Texas Health Science Center at HoustonHoustonTXUSA Centro Integrativo de Biologia y Quimica aplicada(CIBQA) Universidad Bernardo O’HigginsSantiagoChile

Compelling evidence demonstrates that the levels of peripheral amyloid-β(Aβ)fluctuate in Alzheimer’s disease(AD)***,Aβdeposits have been identified in peripheral ***,the relevance of peripheral Aβ(misfolded or not)in pathological situations,and the temporal appearance of these pathological fluctuations,are not well *** presence of misfolded Aβin peripheral compartments raises concerns on potential inter-individual transmissions considering the well-reported prion-like properties of this disease-associated *** latter is supported by multiple reports demonstrating that Aβmisfolding can be transmitted between humans and experimental animals through multiple routes of *** this mini-review,we discuss the potential implications of peripheral,disease-associated Aβin disease mechanisms,as well as in diagnostic and therapeutic approaches.

关键词： therapeutic amyloid latter

ClBBM and ClPLT2 function redundantly during both male and female gametophytes development in watermelon

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Horticultural Plant Journal 2025年第1期11卷 323-335页

作者： Qiyan Liu Dongfen Han Jinfan Chen Jie Wang Denghu Cheng Xiner Chen Jiao Jiang Shujuan Tian Jiafa Wang Man Liu Haizheng Xiong Li Yuan State Key Laboratory of Crop Stress Biology for Arid Areas College of HorticultureNorthwest A&F UniversityYanglingShaanxi 712100China department of Horticulture University of ArkansasFayettevilleAR 72701USA

As a prerequisite for sexual reproduction,gametophyte development is an interesting process involving cell proliferation,differentiation and *** has been extensively explored in model plants,but the regulatory mechanism of gametophyte development largely remains unknown in Cucurbitaceae *** present study,we have shown that watermelon ClBBM and ClPLT2,two AP2/ERf transcription factors,participated in both male and female gametophyte *** and Clplt2 single mutants resembled wild-type phenotypes in both vegetative and reproductive *** Clbbm/Clplt2 double mutant showed partial pollen abortion and bore less seeds comparing to *** results indicated that the abnormal pollen grains were caused by premature tapetum degeneration,and reduced seed-set was due to faulty embryo sac *** and ClPLT2 were expressed in fG4 embryo sacs,and their transcripts were also detectable in the tapetum and microspore of stage 9 anthers,which was consistent with developmental stages of defective phenotypes observed in double *** expression of genes essential for tapetum development,ClATM1,ClAMS,ClMS1 and ClMS188,was decreased in Clbbm/Clplt2 double ***,the transcriptome analysis indicated that ClBBM and ClPLT2 participated in tapetum and pollen wall development by regulate cell cycle,transmembrane transport,glucan and cellulose metabolic ***,ClBBM and ClPLT2 were functionally redundant in regulating gametophyte development in watermelon,and their functions differ from their homologous genes in model plant Arabidopsis.

关键词： Watermelon Gametophyte Male sterility Seedless

Structural designs and mechanism insights into electrocatalytic oxidation of 5-hydroxymethylfurfural

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Journal of Energy Chemistry 2025年第1期100卷 792-814页

作者： Jing Lei Huijie Zhang Jian Yang Jia Ran Jiqiang Ning Haiyan Wang Yong Hu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Department of ChemistryZhejiang Normal UniversityJinhua 321004ZhejiangChina Jinhua Advanced Research Institute Jinhua 321019ZhejiangChina department of Optical Science and Engineering Fudan UniversityShanghai 200438China College of Chemistry and Materials Engineering Zhejiang A&F UniversityHangzhou 311300ZhejiangChina

Biomass conversion offers an efficient approach to alleviate the energy and environmental *** oxidation of 5-hydroxymethylfurfural(HMf)has attracted tremendous attention in the latest few years for the mild synthesis conditions and high conversion efficiency to obtain 2,5-furan dicarboxylic acid(fDCA),but there still remain problems such as limited yield,short cycle life,and ambiguous reaction *** many reviews highlighting a variety of electrocatalysts for electrochemical oxidation of HMf,a detailed discussion of the structural modulation of catalyst and the underlying catalytic mechanism is still *** herein provide a comprehensive summary of the recent development of electrochemical oxidation of HMf to fDCA,particularly focusing on the mechanism studies as well as the advanced strategies developed to regulate the structure and optimize the performance of the electrocatalysts,including heterointerface construction,defect engineering,single-atom engineering,and in situ *** characterization techniques and theoretical calculation methods for mechanism and active site studies are elaborated,and challenges and future directions of electrochemical oxidation of HMf are also *** review will provide guidance for designing advanced catalysts and deepening the understanding of the reaction mechanism beneath electrochemical oxidation of HMf to fDCA.

关键词： Electrochemical oxidation of 5- hydroxymethylfurfural 2,5-furan dicarboxylic acid Structural design Mechanism Electrocatalysts

Identifiability and sloppiness of structured systems with a matrix fraction description using finite frequency responses

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Science China(Information Sciences) 2025年第2期68卷 200-215页

作者： Yunxiang MA Tong ZHOU department of Automation Tsinghua University department of Automation and BNRist Tsinghua University

This paper investigates the identifiability of structured systems with a matrix fraction description and attacks practical difficulties in estimating parameters under finite frequency responses. The numerator and denominator polynomial matrices depend affinely on system parameters, which can represent a broad range of systems, especially circuits and mechanical systems. Except for assuming that the denominator matrix is invertible, no further assumptions are adopted. A criterion is provided for validating this assumption utilizing graph theories and matroids. A sufficient and necessary criterion for global identifiability based on the rank of a numerical matrix is given and can be recursively verified with each frequency point,which is computationally attractive for large-scale systems. for an identifiable system, an ellipsoid approximation is obtained for the set of parameters whose corresponding system frequency responses deviate within a specific range from those of the system at a specific parameter value. Using this approximation, explicit expressions for absolute and relative sloppiness have been derived, which can be used to quantify the difficulty of identifying system parameters. Comparisons with the well-known fisher information matrix have also been performed through a mechanical system, revealing significant differences in quantifying parameter estimation hardness.

关键词： identifiability sloppiness structured system matrix fraction graph theory matroid

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Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN T.ASGHAR Z.ABBAS department of Mathematics Division of Science and TechnologyUniversity of Education department of Mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both fick's and fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词： analytical solution Cattaneo-Christov heat and mass flux chemical reaction gyrotactic microorganism hybrid nanofluid O368 oscillating curved stretchable sheet

Reconstruction of pile-up events using a one-dimensional convolutional autoencoder for the NEDA detector array

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Nuclear Science and Techniques 2025年第2期36卷 62-70页

作者： J.M.Deltoro G.Jaworski A.Goasduff V.González A.Gadea M.Palacz J.J.Valiente-Dobón J.Nyberg S.Casans A.E.Navarro-Antón E.Sanchis G.de Angelis A.Boujrad S.Coudert T.Dupasquier S.Ertürk O.Stezowski R.Wadsworth department of Electronic Engineering University of ValenciaBurjassotValenciaSpain Heavy Ion Laboratory University of Warsaw02-093 WarsawPoland Istituto Nazionale di fisica Nucleare Laboratori Nazionali di LegnaroLegnaroItaly Instituto de física Corpuscular CSIC-Universidad de Valencia46980 PaternaValenciaSpain department of Physics and Astronomy Uppsala UniversityUppsalaSweden GANIL CEA/DRF-CNRS/IN2P3Bvd.Henri Becquerel14076 CaenFrance CNRS IN2P3IPN LyonUniversitéLyon 169622 VilleurbanneFrance department of Physics Nigde Omer Halisdemir University51240 NigdeTurkey department of Physics University of YorkHeslingtonYork YO105DDUK

Pulse pile-up is a problem in nuclear spectroscopy and nuclear reaction studies that occurs when two pulses overlap and distort each other,degrading the quality of energy and timing *** methods have been used for pile-up rejection,both digital and analogue,but some pile-up events may contain pulses of interest and need to be *** paper proposes a new method for reconstructing pile-up events acquired with a neutron detector array(NEDA)using an one-dimensional convolutional autoencoder(1D-CAE).The datasets for training and testing the 1D-CAE are created from data acquired from the *** new pile-up signal reconstruction method is evaluated from the point of view of how similar the reconstructed signals are to the original ***,it is analysed considering the result of the neutron-gamma discrimination based on charge comparison,comparing the result obtained from original and reconstructed signals.

关键词： 1D-CAE Autoencoder CAE Convolutional neural network(CNN) Neutron detector Neutron-gamma discrimination(NGD) Machine learning Pulse shape discrimination Pile-up pulse

Pupil apodization for increasing data storage density

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Chinese Optics Letters 2009年第8期7卷 720-723页

作者： Vidal f.Canales Pedro J.Valle Jose E.Oti Manuel P.Cagigal department of física aplicada University of CantabriaLos Castros S/NSantander 39005Spain AOTEK S.COOP. Bo San Andrés 19Arrasate-Mondragón 20500Spain

We introduce a technique for increasing density in optical data storage systems. This technique is based on the use of a superresolving filter at the pupil of a confocal readout system. The main characteristic of this confocal readout system is that the light beam traverses twice through the pupil filter. We describe how to analyze the system performance for general filters, but we focus the study on filters with no focus displacement. Although the storage density attainable depends on the filter characteristics, we show that the storage density can be easily duplicated.

关键词： Pupil apodization for increasing data storage density PSf data

Effect of Baf2 addition on luminescence properties of Er3+/Yb3+ co-doped phosphate glasses

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Journal of Rare Earths 2018年第1期36卷 58-63页

作者： K.Linganna R.Narro-García P.Manasa H.Desirena E.De la Rosa C.K.Jayasankar department of Physics Sri Venkateswara University Advanced Optical Lens Research Center Korea Photonics Technology Institute (KOPTI) Centro de física aplicada y Tecnología Avanzada UNAM Centro de Investigaciones en Optica

Er3+/Yb3+co-doped phosphate glasses（P2O5-Al2O3-BaO-Baf2-K2O-Er2O3-Yb2O3） with varying Baf2content,were prepared by a conventional melt quenching technique and their spectroscopic properties were examined through the Raman, absorption, emission and decay measurements. Raman spectra(350-1400 cm-1) of the Er3+/Yb3+co-doped phosphate glasses with varying Baf2content, were recorded upon laser excitation at 785 nm. Near infrared luminescence spectra were measured in the1400-1600 nm region under 970 nm diode laser excitation and characteristic band was observed at1533 nm corresponding to4Ⅰ13/2→4Ⅰ15/2transition of Er3+ion. The decay curves for the4Ⅰ13/2level of Er3+ion, were measured and the lifetime is found to decrease from 7.94 to 7.70 ms when Baf2content increases from 0 to 8 mol% and then increases up to 7.83 ms with further increase in Baf2content（12 mol%）. The emission *** and figure of merit for the4Ⅰ13/2→4Ⅰ15/2transition of Er3+ion were evaluated and compared to the other host matrices. The upconversion luminescence was measured and intense red emission was observed for all the studied samples.

关键词： Er3+/Yb3+co-doped phosphate glasses Raman spectra Absorption and emission cross-sections Lifetime Rare earths

The dynamic effects of solar eclipses of October 25,2022,and October 14,2023,on GPS-derived total electron content

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Geodesy and Geodynamics 2025年第1期16卷 75-86页

作者： Vishal Chauhan Vishakha Rakesh Singh Shishupal Singh Vikram Singh Om Prakash Singh department of Physics Graphic Era Hill University department of Petroleum Engineering Graphic Era (Deemed to be University) department of Physics St.John's College department of Applied Sciences & Humanities Institute of Engineering & Technology

This study analyzes total electron content(TEC) variations during two solar eclipse events that occurred on October 25, 2022, and October 14, 2023. The solar eclipse of October 25, 2022, was a partial solar eclipse, while the eclipse of October 14, 2023, was an annular solar eclipse. for this study, the data of eight International GNSS Service(IGS) stations from different eclipse coverage zones are used to analyze TEC variations. It is found that the stations located in the maximum eclipse cover zone exhibited notable decreases in TEC values. The minimum variation of about 11.76% in TEC values is observed at the station situating in about 20 percent eclipse cover zone, while it varies from 22% to 38% at the stations falling in about 60 percent eclipse cover zone. The highest variation in TEC values of about 44% is found at the stations in about 80 percent eclipse cover zone. The time of occurrence of maximum depletion in TEC values at each station is in line with their longitudinal sequence. Atmospheric gravity waves(AGWs) are also observed by performing wavelet analysis on TEC data. The global TEC maps visualize and confirm observed TEC variations, providing spatial and temporal insights into the ionospheric response. This analysis highlights the influence of station location and eclipse coverage on the magnitude and spatial distribution of TEC variations.

关键词： Solar eclipse Ionosphere GPS TEC AGW