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Protein-nucleic acid hybrid nanostructures for molecular diagnostic applications

Nano research 2024年第10期17卷 9003-9014页

作者： Noah R.Sundah Yuxuan Seah Auginia Natalia Xiaoyan Chen Panida Cen Yu Liu Huilin Shao Institute for health Innovation and Technology National University of SingaporeSingapore 117599Singapore department of Biomedical Engineering College of Design and EngineeringNational University of SingaporeSingapore 117583Singapore Integrative Sciences and Engineering Programme NUS Graduate SchoolNational University of SingaporeSingapore 119077Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnology and ResearchSingapore 138673Singapore department of Surgery Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore

Molecular diagnostic technologies empower new clinical opportunities in precision ***,existing approaches face limitations with respect to performance,operation and *** molecules including proteins and nucleic acids are being increasingly adopted as tools in the development of new molecular diagnostic *** particular,leveraging their complementary properties—the functional diversity of proteins and the precision programmability of nucleic acids—a wide range of protein–nucleic acid hybrid nanostructures have been *** hybrid structures take diverse forms,ranging from one-dimensional to three-dimensional hybrids,as static assemblies to dynamic machines,and possess myriad functions to recognize target biomarkers,encode vast information and execute catalytic *** by recent advances in this area of molecular nanotechnology,we review the state-of-art design and application of various types of protein–nucleic acid hybrid nanostructures for molecular diagnostics,and present an outlook on the challenges and opportunities for emerging pre-clinical and clinical applications,highlighting the promise for earlier detection,more refined diagnosis and highly tailored treatment decision that ultimately lead to improved patient outcomes.

关键词： molecular nanotechnology DNA-protein hybrid molecular diagnostics precision medicine

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Associations of short-term ambient temperature exposure with lung function in middle-aged and elderly people:A longitudinal study in China

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Eco-Environment & health 2024年第2期3卷 165-173页

作者： Weihong Qiu Bin Wang Xiaobing Feng Heng He Lieyang Fan Zi Yea Xiuquan Nie Ge Mua Wei Liu Dongming Wang Min Zhou Weihong Chen department of Occupational and Environmental health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China department of epidemiology and health Statistics School of Public HealthFujian Medical UniversityFuzhou 350122China

The short-term associations of ambient temperature exposure with lung function in middle-aged and elderly Chinese remain *** study included 19,128 participants from the Dongfeng-Tongji cohort's first(2013)and second(2018)*** lung function for each subject was determined between April and December 2013 and re-assessed in 2018,with three parameters(forced vital capacity[FVC],forced expiratory volume in 1 s[FEV1],and peak expiratory flow[PEF])*** China Meteorological Data Sharing Service Center provided temperature data during the study *** the two follow-ups,a total of 25,511 records(average age:first,64.57;second,65.80)were evaluated,including 10,604 males(41.57%).The inversely J-shaped associations between moving average temperatures(lag01–lag07)and FVC,FEV1,and PEF were observed,and the optimum temperatures at lag04 were 16.5C,18.7C,and 16.2C,*** lag04,every 1C increase in temperature was associated with 14.07 mL,9.78 mL,and 62.72 mL/s increase in FVC,FEV1,and PEF in the lowtemperature zone(

关键词： Ambient temperature Lung function Middle-aged and elderly people Vulnerable groups Linear mixed-effects model Generalized additive mixed model

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Prioritization of risk genes in colorectal cancer by integrative analysis of multi-omics data and gene networks

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Science China(Life Sciences) 2024年第1期67卷 132-148页

作者： Ming Zhang Xiaoyang Wang Nan Yang Xu Zhu Zequn Lu Yimin Cai Bin Li Ying Zhu Xiangpan Li Yongchang Wei Shaokai Zhang Jianbo Tian Xiaoping Miao department of epidemiology and Biostatistics School of Public HealthDepartment of Gastrointestinal OncologyZhongnan Hospital of Wuhan UniversityDepartment of Radiation OncologyRenmin Hospital of Wuhan UniversityTaiKang Center for Life and Medical SciencesWuhan UniversityWuhan 430071China research Center of Public health Renmin hospital of Wuhan UniversityWuhan UniversityWuhan 430060China department of Cancer epidemiology The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalHenan Engineering Research Center of Cancer Prevention and ControlHenan International Joint Laboratory of Cancer PreventionZhengzhou 450008China department of Gastrointestinal Surgery Renmin Hospital of Wuhan UniversityWuhan 430060China department of Radiation Oncology Renmin Hospital of Wuhan UniversityWuhan 430060China department of Gastrointestinal Oncology Hubei Cancer Clinical Study CenterZhongnan Hospital of Wuhan UniversityWuhan 430062China department of epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430073China Jiangsu Collaborative Innovation Center for Cancer Personalized medicine Nanjing Medical UniversityNanjing 211166China

Genome-wide association studies(GWASs)have identified over 140 colorectal cancer(CRC)-associated loci;however,target genes at the majority of loci and underlying molecular mechanisms are poorly ***,we utilized a Bayesian approach,integrative risk gene selector(iRIGS),to prioritize risk genes at CRC GWAS loci by integrating multi-omics *** a result,a total of 105 high-confidence risk genes(HRGs)were identified,which exhibited strong gene dependencies for CRC and enrichment in the biological processes implicated in *** the 105 HRGs,CEBPB,located at the 20q13.13 locus,acted as a transcription factor playing critical roles in *** subsequent assays indicated the tumor promoter function of CEBPB that facilitated CRC cell proliferation by regulating multiple oncogenic pathways such as MAPK,PI3K-Akt,and Ras ***,by integrating a fine-mapping analysis and three independent case-control studies in Chinese populations consisting of 8,039 cases and 12,775 controls,we elucidated that rs1810503,a putative functional variant regulating CEBPB,was associated with CRC risk(OR=0.90,95%CI=0.86–0.93,P=1.07×10^(−7)).The association between rs1810503 and CRC risk was further validated in three additional multi-ancestry populations consisting of 24,254 cases and 58,741 ***,the rs1810503 A to T allele change weakened the enhancer activity in an allele-specific manner to decrease CEBPB expression via longrange promoter-enhancer interactions,mediated by the transcription factor,REST,and thus decreased CRC *** summary,our study provides a genetic resource and a generalizable strategy for CRC etiology investigation,and highlights the biological implications of CEBPB in CRC tumorigenesis,shedding new light on the etiology of CRC.

关键词： susceptibility genes gene screening models multi-omics GWAS CEBPB long-range promoter-enhancer interactions

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Changes in Adipose Tissue and Circulating Concentrations of Persistent Organic Pollutants in Midlife Women

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Environment & health 2024年第4期2卷 243-252页

作者： Amelia Grant-Alfieri Amila Devasurendra Stuart Batterman Carrie Karvonen-Gutierrez Sung Kyun Park department of Environmental health Sciences University of Michigan School of Public HealthAnn ArborMichigan 48109United States department of epidemiology University of Michigan School of Public HealthAnn ArborMichigan 48109United States

Polychlorinated biphenyls(PCBs)and organochlorine pesticides(OCPs)are persistent organic pollutants(POPs)that bioaccumulate in adipose *** investigated the relationship between change in central adiposity and changes in circulating concentrations of POPs over a 12-year period during the *** concentrations of 34 PCBs and 19 OCPs were measured at four time points(1999/2000,2002/03,2005/06,2009/11)in a cohort of midlife women,the Study of Women’s health Across the *** mixed models were used to test the association between a change in waist circumference and a change in serum POP ***-five women contributed 181 PCB ***-nine women contributed 151 OCP *** adjustment for covariates(study site,race and ethnicity,age at baseline,parity),a one-inch(2.54 cm)increase in the change in waist circumference between visits was associated with a 4.9%decrease in the change in serum concentration of PCB 194(95%CI:−8.0%,−1.6%).No associations were observed for other PCB congeners or the presence of *** increase in the difference in waist circumference over time was not associated with a change in the difference in serum concentrations of PCBs and OCPs except for PCB 194,possibly due to the high lipophilicity.

关键词： persistent organic pollutants PCBs pesticides adipose tissue women midlife

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Comparing role of ATP between acute pain in neuromyelitis optica spectrum disorder and peripheral neuropathic pain

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Neural Regeneration research 2025年第1期20卷 184-185页

作者： Teruyuki Ishikura Tatsusada Okuno department of Molecular Neuroscience Graduate School of MedicineOsaka UniversityOsakaJapan department of Neurology Osaka University Graduate School of MedicineOsaka UniversityOsakaJapan

In this article, we present our previous research, which highlighted adenosine triphosphate(ATP) as the cause of neuropathic pain during the acute phase of neuromyelitis optica spectrum disorder(NMOSD). In NMOSD pathology, damageassociated molecular patterns(DAMPs), including ATP, are released from damaged astrocytes, triggering the activation of innate immune cells. ATP is a central mediator of acute pain in NMOSD.

关键词： pain acute pathology

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Therapeutic potential of stem cells in subarachnoid hemorrhage

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Neural Regeneration research 2025年第4期20卷 936-945页

作者： Hideki Kanamaru Hidenori Suzuki department of Neurosurgery Mie University Graduate School of MedicineTsuJapan

Aneurysm rupture can result in subarachnoid hemorrhage,a condition with potentially severe consequences,such as disability and *** the acute stage,early brain injury manifests as intracranial pressure elevation,global cerebral ischemia,acute hydrocephalus,and direct blood–brain contact due to aneurysm *** may subsequently cause delayed cerebral infarction,often with cerebral vasospasm,significantly affecting patient *** complications such as brain volume loss and chronic hydrocephalus can further impact *** the mechanisms of subarachnoid hemorrhage-induced brain injury is paramount for identifying effective *** cell therapy,with its multipotent differentiation capacity and anti-inflammatory effects,has emerged as a promising approach for treating previously deemed incurable *** review focuses on the potential application of stem cells in subarachnoid hemorrhage pathology and explores their role in neurogenesis and as a therapeutic intervention in preclinical and clinical subarachnoid hemorrhage studies.

关键词： delayed cerebral ischemia early brain injury matricellular protein neurogenesis stem cell therapy subarachnoid hemorrhage

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Global,Regional,and National Trends Analysis in Incidence of Genital Herpes Among the Population Aged 15-49 Years—Worldwide,1990-2021

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China CDC weekly 2024年第40期6卷 1033-1037页

作者： Guiying Cao Jue Liu Min Liu Wannian Liang department of epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Key Laboratory of epidemiology of Major Diseases Ministry of EducationPeking UniversityBeijingChina Vanke school of Public health Tsinghua UniversityBeijingChina Institute for healthy China Tsinghua UniversityBeijingChina

What is already known on this topic?Genital herpes infection is a chronic condition that can cause recurrent symptoms,significantly affecting both quality of life and sexual ***,there is currently no available data on the global trends and regional variations in the incidence of genital herpes among individuals of reproductive *** is added by this report?From 1990 to 2021,there was a 51.97%increase in global incident cases of genital herpes among individuals aged 15-49 *** incidence rates also rose in low-middle socio-demographic index region,South Asia,Southern Sub-Saharan Africa,and Central *** these regions,countries in Southern Sub-Saharan Africa experienced the highest burden of genital herpes among individuals aged 15-49 *** are the implications for public health practice?Given the rise in global incident cases and incidence rates in some regions among individuals of reproductive age from 1990 to 2021,it is imperative to prioritize the implementation of preventive strategies and interventions for genital herpes *** includes a significant focus on the development of vaccines.

关键词： Incidence Population incidence

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Life's essential 8 and risk of subclinical atherosclerosis progression: a prospective cohort study

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Journal of Geriatric Cardiology 2024年第7期21卷 751-759页

作者： Shi-Yu ZHOU Fang-Chao LIU Shu-Feng CHEN Jian-Xin LI Jie CAO Ke-Yong HUANG Zheng-Hao TANG Feng-Chao LIANG Dong-Sheng HU Lian-Cheng ZHAO Ying LI Jian-Feng HUANG Xiang-Feng LU Bin LU Dong-Feng GU department of epidemiology&Key Laboratory of Cardiovascular epidemiology State Key Laboratory of Cardiovas-cular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina school of Public health and Emergency Management School of Medi-cineSouthern University of Science and TechnologyShenzhenChina department of epidemiology and health Stat-istics School of Public HealthZhengzhou UniversityZhengzhouChina department of Biostatistics and Epidemi-ology School of Public HealthShenzhen University Health Science CenterShenzhenChina department of Radi-ology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina

BACKGROUND Previous studies have demonstrated the benefits of ideal cardiovascular health(CVH) in reducing cardiovascular ***,its role in subclinical atherosclerosis(SA) progression remains *** aim to examine the association of CVH,estimated by the American Heart Association's new Life's Essential 8(LE8),with the progression of *** This prospective cohort study was conducted among 972 asymptomatic Chinese participants and followed up for5.7 *** LE8 score(range,0–100) consisted of blood pressure,lipids,glucose,body mass index,smoking status,diet health,physical activity and sleep health was evaluated in 1998 and 2008–*** of SA was determined by carotid plaque and coronary artery calcification(CAC) in 2008–2009 and 2013–***-binomial regression model was used to estimate the association of LE8 score with SA *** Each 10 points increment in LE8 score was associated with 15.2%(RR:0.848,95% CI:0.797–0.902),17.7%(RR:0.823,95% CI:0.766–0.884) and 12.0%(RR:0.880,95% CI:0.845–0.916) lower risks of carotid plaque,CAC and overall SA progression,*** with participants with non-ideal CVH at both visits,the participants with ideal CVH at both visits had39.1%(RR:0.609,95% CI:0.494–0.752),41.0%(RR:0.590,95% CI:0.456–0.764) and 29.7%(RR:0.703,95% CI:0.598–0.825) lower risks of carotid plaque,CAC and overall SA progression,*** Higher LE8 scores were associated with lower risks of SA ***,long-term maintenance of optimal CVH was more beneficial to prevent SA progression.

关键词： atherosclerosis prospective cardiovascular

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Bayesian estimation of the time-varying reproduction number for pulmonary tuberculosis in Iran:A registry-based study from 2018 to 2022 using new smear-positive cases

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Infectious Disease Modelling 2024年第3期9卷 963-974页

作者： Maryam Rastegar Eisa Nazar Mahshid Nasehi Saeed Sharafi Vahid Fakoor Mohammad Taghi Shakeri department of Biostatistics School of HealthMashhad University of Medical SciencesMashhadIran Orthopedic research Center Mazandaran University of Medical SciencesSariIran Centre for Communicable Diseases Control Ministry of Health and Medical EducationTehranIran department of Statistics Faculty of Mathematical SciencesFerdowsi University of MashhadMashhadIran Social Determinants of health research Center Mashhad University of Medical SciencesMashhadIran department of epidemiology School of Public HealthIran University of Medical SciencesTehran

Introduction Tuberculosis(TB)is one of the most prevalent infectious diseases in the world,causing major public health problems in developing *** rate of TB incidence in Iran was estimated to be 13 per 100,000 in *** study aimed to estimate the reproduction number and serial interval for pulmonary tuberculosis in *** and methods The present national historical cohort study was conducted from March 2018 to March 2022 based on data from the National Tuberculosis and Leprosy Registration Center of Iran's Ministry of health and Medical Education(MOHME).The study included 30,762 tuberculosis cases and 16,165 new smear-positive pulmonary tuberculosis patients in *** estimated the reproduction number of pulmonary tuberculosis in a Bayesian framework,which can incorporate uncertainty in estimating *** analyses were accomplished in R *** The mean age at diagnosis of patients was 52.3±21.2 years,and most patients were in the 35–63 age group(37.1%).Among the data,9121(56.4%)cases were males,and 7044(43.6%)were *** patients,7459(46.1%)had a delayed diagnosis between 1 and 3 ***,3039(18.8%)cases were non-Iranians,and 2978(98%)were *** time-varying reproduction number for pulmonary tuberculosis disease was calculated at an average of 1.06±0.05(95%Crl 0.96–1.15).Conclusions In this study,the incidence and the time-varying reproduction number of pulmonary tuberculosis showed the same *** mean of the time-varying reproduction number indicated that each infected person is causing at least one new infection over time,and the chain of transmission is not being disrupted.

关键词： Reproduction number Bayesian modeling Tuberculosis Iran

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Recent Progress on Water-based Liquid Embolic Agents in Endovascular Treatment

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Chemical research in Chinese Universities 2024年第5期40卷 776-785页

作者： QI Yi FAN Hailong department of Neurosurgery Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo060-8638Japan Institute for Chemical Reaction Design and Discovery(WPI-ICReDD) Hokkaido UniversitySapporo001-0021Japan

Vascular embolization treatment,a minimally invasive surgery for various blood vessel-related conditions,has emerged as a crucial method in treating such as hemorrhage,arteriovenous malformation,aneurysms,and hypervascular *** embolic agents are gaining prominence due to their distinct advantage in infiltrating distal regions,expanding the scope of embolization beyond the reach of solid *** strides in biomaterials and technologies have spurred the development of novel liquid embolic agents,addressing challenges posed by traditional *** mini-review provides a concise overview of the recent progress in water-based liquid embolic agents,highlighting their potential to overcome limitations associated with current embolic *** presenting selected research outcomes,we illuminate advancements that enhance the efficacy of liquid embolic ***,the review outlines essential properties for effective liquid embolic agents,offering insights for future developments in this field.

关键词： Endovascular treatment Lquid embolic agent Hydrogel

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