检索结果-南通市图书馆

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

引用

Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for disease control and Prevention GuiyangGuizhou ProvinceChina department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and control of Endemic and Ethnic Regional diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Introduction of Zika virus in Bangladesh:An impending public health threat

引用

Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 925-928页

作者： A.K.M.Muraduzzaman Sharmin Sultana Tahmina Shirin Selina Khatun MdTarikul Islam Mahmudur Rahman department of Virology Institute of EpidemiologyDisease Control&Research(IEDCR)DhakaBangladesh department of epidemiology Institute of EpidemiologyDisease Control&Research(IEDCR)DhakaBangladesh Laboratory of Genetics and Genomics Institute for Developing Science and Health InitiativesDhakaBangladesh Institute of epidemiology Disease Control&Research(IEDCR)DhakaBangladesh

Objective: To explore the presence of Zika virus(ZIKV) in Bangladesh and to understand the associated risk ***: A retrospective sero-surveillance was performed on stored serum samples of dengue surveillance conducted from 2013 to 2016. Real time RT-PCR was performed on randomly selected acute serum samples to detect the Zika virus nucleic ***: Of 200 samples screened, one was found positive for ZIKV by real time RTPCR and further confirmed by genome sequencing. The case was a 65 years old male from a metropolitan city of Bangladesh who had no history of travel outside *** analysis of partial E gene sequences from Bangladeshi isolates demonstrated a close relationship with ZIKV from Brazil and current South American strains clustering within a monophyletic clade distinct from African ***: Presence of ZIKV raises serious public health concerns in Bangladesh owing to its association with congenital anomalies/neurological-manifestations. We,therefore, recommend every suspected viral fever patient, particularly pregnant women be screened for ZIKV infection to rule out yet another emerging infection in Bangladesh.

关键词： Zika virus Bangladesh Public health impact

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association between measles antibodies in vaccinated and naturally infected mothers with protective antibodies and the occurrence of measles in their children:A cross-sectional study in the Bavi district of Hanoi

引用

Asian Pacific Journal of Tropical Medicine 2019年第9期12卷 404-408页

作者： Cam Nhat Nguyen Quynh Ngoc Nguyen Than Huu Dao Le Thi Quynh Mai Infectious disease Prevention und control department Center for Disease ControlHonoiVietnom Virology department National Institute of Hygiene and EpidemiologyHanoiVietnam

Objective:To determine the concentration and rate of decay of maternal IgG antibodies against measles prevalence in infants of vaccinated or naturally infected mothers and study initial measles immunization occurs in nine-month-old ***:In total,401 pregnant women and the same number of their subsequent newborns were recruited in the Bavi district of Hanoi in 2016-2017;they were divided into two groups:Older women(born before 1985,n=201)and younger women(born after 1990,n=200).Samples were collected at five time-points;week 36 of pregnancy,birth(cord),and 3,6,and 9 months after ***-specific IgG antibody levels were ***:In total,77.06% of the 401 pregnant women were seropositive for measles-specific IgG antibodies.A significantly greater proportion of mothers aged 30 and older(88.06%)and their newborn(93.53%)were seropositive compared to the mothers aged 25 and younger(66.00%),and their newborn(72.00%)(P<0.001).The infants of older mothers had significantly higher geometric mean titres(GMT)of measles IgG antibodies than the infants of younger mothers(P<0.001)at all time-points of the study *** proportion of measles IgG antibodies together with GMT decreased from 82.97%(506.96)at the age of three months to 23.19%(45.22)at the age of nine ***:This study provides a profile of maternal antibodies against measles in Vietnamese infants and investigates the early susceptibility to measles in both the infants of vaccinated mothers and mothers with naturally acquired *** data suggest that determining the appropriate age for measles vaccination is paramount for the elimination of measles in Vietnam.

关键词： Infant Measles Seropositive National Expanded Program of Immunization Vietnam

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Developing a Subjective Evaluation Scale for Assessing the Built Environments of China’s Hygienic City Initiative

引用

Biomedical and Environmental Sciences 2021年第5期34卷 372-378页

作者： ZHENG Wen Jing YAO Hong Yan LIU Jian Jun YU Shi Cheng Office of epidemiology Chinese Center for Disease Control and PreventionBeijing 102206China Chinese Center for disease control and Prevention Beijing 102206China

Objective To develop a preliminary subjective evaluation scale for assessing the built environments of China’s Hygienic City Initiative and to evaluate its reliability and *** The initial items of the scale were determined based on a review of policy documents and consultations with experts. The final items of the scale were confirmed through individual interviews with residents combined with the discretetrend method, critical ratio method, correlation coefficient method, and factor analysis method. Then, the dimensions of the scale were determined using exploratory factor analysis(EFA). The Cronbach’s α coefficient, split-half reliability coefficient, and confirmatory factor analysis(CFA) were used to assess the reliability and validity of the *** A scale containing five dimensions with 22 items was established, including urban lifestyle,governance, basic functions, environmental sanitation, and amenities. The Cronbach’s α coefficient of the scale was 0.876, and the split-half reliability coefficient was 0.796. The CFA results indicate that each inspection level was within the standard *** The preliminarily subjective evaluation scale for assessing the built environments of China’s Hygienic City Initiative demonstrates a high level of reliability and validity. Additional empirical studies should be carried out to further verify the value of the scale in terms of practical application.

关键词： Subjective built environment China’s Hygienic City Reliability and validity Scale

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Changes in Notified Incidence of Pulmonary Tuberculosis in China,2005–2020

引用

Biomedical and Environmental Sciences 2023年第2期36卷 117-126页

作者： DONG Zhe YAO Hong Yan YU Shi Cheng HUANG Fei LIU Jian Jun ZHAO Yan Lin WANG Qi Qi epidemiology Office Chinese Center for Disease Control and PreventionBeijing 102206China

Objective To evaluate the trend of notified incidence of pulmonary tuberculosis(PTB)in China at different periods by population and region and to explore the effect of TB prevention and control in recent *** Using pooled data on TB cases reported by the TB Information Management Reporting System(TBIMS)from 2005 to 2020,we calculated the annual percentage change(APC)using the Joinpoint regression *** From 2005 to 2020,a total of 16.2 million cases of PTB were reported in China,with an average notified incidence of 75.5 per 100,000 *** age standardization rate(ASR)continued to decline from 116.9(/100,000)in 2005 to 47.6(/100,000)in 2020,with an average annual decrease of5.6%[APC=-5.6,95%confidence interval(CI):-7.0 to-4.2].The smallest decline occurred in2011–2018(APC=-3.4,95%CI:-4.6 to-2.3)and the largest decrease in 2018–2020(APC=-9.2,95%CI:-16.4 to-1.3).From 2005 to 2020,the ASR in males(159.8 per 100,000 in 2005,72.0 per 100,000 in2020)was higher than that in females(62.2 per 100,000 in 2005,32.3 per 100,000 in 2020),with an average annual decline of 6.0%for male and 4.9%for *** average notified incidence was the highest among older adults(65 years and over)(182.3/100,000),with an average annual decline of6.4%;children(0–14 years)were the lowest(4.8/100,000),with an average annual decline of 7.3%,but a significant increase of 3.3%between 2014 and 2020(APC=3.3,95%CI:1.4 to 5.2);middle-aged(35–64years)decreased by 5.8%;and youth(15–34 years)decreased by an average annual rate of 4.2%.The average ASR in rural areas(81.3/100,000)is higher than that in urban areas(76.1/100,000).The average annual decline in rural areas was 4.5%and 6.3%in urban *** China had the highest average ASR(103.2/100,000),with an average annual decline of 5.9%,while North China had the lowest(56.5/100,000),with an average annual decline of 5.9%.The average ASR in the southwest was 95.3(/100,000),with the smallest annual decline(APC=-4.5,95%CI:-5.5 to

关键词： Tuberculosis Notified incidence Joinpoint regression model Trends China

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Burden of Acute Viral Hepatitis--China,1990−2019

引用

China CDC weekly 2020年第31期2卷 579-586页

作者： Shicheng Yu Qiqi Wang Shujun Wang Jiaojiao Zhang Yuehua Hu Junqi Li Xiaojuan Long Xianglong Xiang Maigeng Zhou Feng Tan Office of epidemiology Chinese Center for Disease Control and PreventionBeijingChina National Center for Chronic and Non-Communicable disease control and Prevention Chinese Center for Disease Control and PreventionBeijingChina department of Academic Publishing Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?The World Health Organization’s(WHO)Global Health Estimates(GHE)reported that acute hepatitis caused 9,213 deaths and 307,720 person years of disability-adjusted life years(DALYs)in 2016,and acute hepatitis B accounted for 85.81%of all DALYs among acute hepatitis types A,B,C,and E in *** is added by this report?In China,the percent changes in years lived with disability(YLDs)due to acute hepatitis A,B,and E in groups aged 50–69 years and 70 years or more and in all age groups for acute hepatitis C were increased from 2000 to *** are the implications for public health practices?Effective vaccines,interventions,and treatments are key approaches to achieve the WHO’s goal of reducing new hepatitis infections by 90%and deaths by 65%between 2016 and 2030.

关键词： acute hepatitis China.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Isolation of Leclercia adecarboxylata Producing Carbapenemases in A Newborn Female

引用

Biomedical and Environmental Sciences 2023年第9期36卷 874-879页

作者： MENG Shuang MIAO Bei Bei LI Jie YIN Jian Wen LIU Ze Liang JIANG Xue Qi GONG Xin Yi LI Juan Chinese Field epidemiology Training Program Chinese Center for Disease Control and PreventionBeijing 102206China State Key Laboratory of Infectious disease Prevention and control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Yunnan Center for disease control and Prevention Kunming 650034YunnanChina

Leclercia adecarboxylata is a Gram-negative bacterium belonging to the Enterobacteriaceae *** our knowledge,this is the first report of a carbapenem-resistant *** strain isolated from a healthy *** *** strain isolated in this study carried four plasmids that may serve as reservoirs for antibiotic resistance *** 2 and 4 did not harbor any antimicrobial resistance *** 3 is a novel plasmid containing three resistance *** bla IMP gene harbored in the strain was most similar to bla IMP-79 at the nucleotide level,with a similarity of 99.4%(737/741).This case highlights the importance of considering *** as a potential cause of infections in children.

关键词： Leclercia adecarboxylata Carbapenem-resistant Newborn

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Incidence,Mortality,and DALYs Trends Associated with Esophageal Cancer-China,1990-2019

引用

China CDC weekly 2022年第43期4卷 956-961页

作者： Li Ma Xudong Li Miaomiao Wang Yingying Zhang Jing Wu Yuan He Xueqi Fan Bin Zhang Xiaolong Zhou Office of epidemiology Chinese Center for Disease Control and PreventionBeijingChina National Center for Chronic and Non-Communicable disease control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?Esophageal cancer(EC)is one of the most common malignant tumors in *** new cases and deaths in China account for more than half of the world,and the disease burden of esophageal cancer is *** is added by this report?From 1990 to 2019,the disease burden of EC in China showed a decrease overall;it first increased between 1990 and 2004,but then decreased between 2004 and *** burden of EC in men was much higher than that in *** was an important factor affecting the burden of EC,with disease burden rising rapidly after 40 years *** are the implications for public health practices?The screening,early diagnosis,and treatment for EC should continue to be strengthened in *** and elderly men are high-risk groups of EC and should be a key population for EC prevention and control.

关键词： Esophageal prevention diagnosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Epidemic Characteristics and Spatio-Temporal Patterns of HFRS in Qingdao City,China,2010-2022

引用

Biomedical and Environmental Sciences 2024年第9期37卷 1015-1029页

作者： Ying Li Runze Lu Liyan Dong Litao Sun Zongyi Zhang Yating Zhao Qing Duan Lijie Zhang Fachun Jiang Jing Jia Huilai Ma Chinese Field epidemiology Training Program Chinese Center for Disease Control and PreventionBeijing 100050China National Institute for Viral disease control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Qingdao Municipal Center for disease control and Prevention Qingdao 266024ShandongChina Jiaozhou Center for disease control and Prevention Qingdao 266399ShandongChina Institute for Infectious disease control and Prevention Shandong Center for Disease Control and PreventionJinan 250013ShandongChina Office of epidemiology(Technical Guidance Office for Patriotic Health Work) Chinese Center for Disease Control and PreventionBeijing 102206China

Objective This study investigated the epidemic characteristics and spatio-temporal dynamics of hemorrhagic fever with renal syndrome(HFRS)in Qingdao City,*** Information was collected on HFRS cases in Qingdao City from 2010 to *** epidemiologic,seasonal decomposition,spatial autocorrelation,and spatio-temporal cluster analyses were *** A total of 2,220 patients with HFRS were reported over the study period,with an average annual incidence of 1.89/100,000 and a case fatality rate of 2.52%.The male:female ratio was 2.8:1.75.3%of patients were aged between 16 and 60 years old,75.3%of patients were farmers,and 11.6%had both“three red”and“three pain”*** HFRS epidemic showed two-peak seasonality:the primary fall-winter peak and the minor spring *** HFRS epidemic presented highly spatially heterogeneous,street/township-level hot spots that were mostly distributed in Huangdao,Pingdu,and *** spatio-temporal cluster analysis revealed three cluster areas in Qingdao City that were located in the south of Huangdao District during the fall-winter *** The distribution of HFRS in Qingdao exhibited periodic,seasonal,and regional characteristics,with high spatial clustering *** typical symptoms of“three red”and“three pain”in patients with HFRS were not obvious.

关键词： Hemorrhagic fever with renal syndrome Epidemic characteristics Spatio-temporal distribution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Health Demands of Designated Drivers-Four Cities,China,2019

引用

China CDC weekly 2022年第20期4卷 426-430页

作者： Meng Zhang Qiqi Wang Hongyan Yao Xiao Qi Shicheng Yu Jianjun Liu Office of epidemiology Chinese Center for Disease Control and PreventionBeijingChina Chinese Center for disease control and Prevention BeijingChina

Summary What is already known about this topic?The health status of designated drivers is largely associated with road safety,which is a major public health ***,few studies have focused on the health demands of designated *** is added by this report?This study investigated the health consciousness,first aid knowledge learning,acceptable ways to acquire health knowledge,and willingness to have physical examinations for designated drivers to provide suggestions for improving their health *** are the implications for public health practice?The industry and platform should provide scientific and reasonable guidance on healthy lifestyles for designated drivers and implement physical examinations to monitor their health status.

关键词： designated knowledge consciousness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：