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CRABP2 regulates infiltration of cancer-associated fibroblasts and immune response in melanoma

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Oncology Research 2024年第2期32卷 261-272页

作者： SHUANGSHUANG ZENG XI CHEN QIAOLI YI ABHIMANYU THAKUR HUI YANG YUANLIANG YAN SHAO LIU department of Pharmacy Xiangya HospitalCentral South UniversityChangsha410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha410008China Pritzker School of Molecular engineering Ben May Department for Cancer ResearchUniversity of ChicagoChicagoILUSA department of Pathology The Second Affiliated Hospital of Shandong First Medical UniversityTaian271000China

Finding biomarkers for immunotherapy is an urgent issue in cancer *** retinoic acid-binding protein 2(CRABP2)is a controversial factor in the occurrence and development of human ***,there is limited research on the relationship between CRABP2 and immunotherapy *** study found that negative correlations of CRABP2 and immune checkpoint markers(PD-1,PD-L1,and CTLA-4)were observed in breast invasive carcinoma(BRCA),skin cutaneous melanoma(SKCM),stomach adenocarcinoma(STAD)and testicular germ cell tumors(TGCT).In particular,in SKCM patients who were treated with PD-1 inhibitors,high levels of CRABP2 predicted poor ***,CRABP2 expression was elevated in cancer-associated fibroblasts(CAFs)at the single-cell *** expression of CRABP2 was positively correlated with markers of CAFs,such as MFAP5,PDPN,ITGA11,PDGFRα/βand THY1 in *** validate the tumor-promoting effect of CRABP2 in vivo,SKCM xenograft mice models with CRABP2 overexpression have been *** models showed an increase in tumor weight and *** analysis indicated that CRABP2 may be involved in immunerelated pathways of SKCM,such as extracellular matrix(ECM)receptor interaction and epithelial-mesenchymal transition(EMT).The study suggests that CRABP2 may regulate immunotherapy in SKCM patients by influencing infiltration of *** conclusion,this study provides new insights into the role of CRABP2 in immunotherapy *** findings suggest that CRABP2 may be a promising biomarker for PD-1 inhibitors in SKCM *** research is needed to confirm these findings and to explore the clinical implications of CRABP2 in immunotherapy.

关键词： CRABP2 Melanoma PD-1 Cancer-associated fibroblasts Immune infiltration

A strained π-extended[10]cycloparaphenylene carbon nanoring

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Chinese Chemical Letters 2024年第5期35卷 171-174页

作者： Kang Wei Jiayu Li Wen Zhang Bing Yuan Ming-De Li Pingwu Du Key Laboratory of Precision and Intelligent Chemistry Anhui Laboratory of Advanced Photon Science and TechnologyDepartment of Materials Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou UniversityShantou 515063China

Herein,we report the facile synthesis of a highly strained hexabenzocoronene-containing carbon nanoring,cyclo[4]-paraphenylene[2]-2,11-hexabenzocoronenylene([4,2]CPHBC),as the segment of a[10,10]single-walled carbon nanotube([10,10]SWNT).[4,2]CPHBC was synthesized based on the platinummediated assembly of diborylbiphenyl and diborylhexabenzocoronene,forming a tetranuclear platinum complex,followed by reductive *** nanoring molecule was confirmed by NMR and HRMS,and its photophysical properties were studied using steady-state and time-resolved ***,the selective supramolecular host-guest interaction between[4,2]CPHBC and C_(60) was also investigated.

关键词： CPP Hexabenzocoronene Fullerene Supramolecular chemistry

Does young feces make the elderly live better? Application of fecal microbiota transplantation in healthy aging

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BIOCELL 2024年第6期48卷 873-887页

作者： YUANYUAN LIAO XINSI LI QIAN LI YIZHONG WANG XIUJUN TAN TING GONG department of Endodontics Stomatological Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences ChongqingChina Chongqing Municipal Key Laboratory of Oral Biomedical engineering of Higher Education ChongqingChina department of Research&Development Zhejiang Charioteer Pharmaceutical Co.Ltd.TaizhouChina department of Implantology Stomatological Hospital of Chongqing Medical UniversityChongqingChina

As we are facing an aging society,anti-aging strategies have been pursued to reduce the negative impacts of aging and increase the health span of human *** microbiota has become a key factor in the anti-aging *** of gut microbiota by fecal microbiota transplantation(FMT)to prevent frailty and unhealthy aging has been a hot topic of *** narrative review summarizes the beneﬁts of FMT for health span and lifespan,brains,eyes,productive systems,bones,and *** mechanisms of FMT in improving healthy aging are *** increased beneﬁcial bacteria and decreased pathological bacteria decreased gut permeability and systemic inﬂammation,increased short-chain fatty acid(SCFA)and SCFA-producing bacteria,and other factors are listed as mechanisms of FMT to improve healthy *** points that need to be considered to ensure the optimal outcomes of FMT are also discussed,such as recipients’age,sex,genetic background,and gut microbiota after *** thisﬁeld is still in its infancy,it has shown that FMT has great potential to improve healthy aging.

关键词： Gut microbiota Healthy aging Lifespan Fecal microbiota transplantation Co-housing Short-chain fatty acid Inﬂammaging

A Stable Fuzzy-Based Computational Model and Control for Inductions Motors

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工程与科学中的计算机建模(英文) 2024年第1期138卷 793-812页

作者： Yongqiu Liu Shaohui Zhong Nasreen Kausar Chunwei Zhang Ardashir Mohammadzadeh Dragan Pamucar School of Mechanical and Electrical engineering Guangdong University of Science&TechnologyDongguan523083China School of Information Hunan Open UniversityChangsha410081China department of Mathematics Faculty of Arts and SciencesYildiz Technical UniversityEsenlerIstanbul34220Turkey Multidisciplinary Center for Infrastructure engineering Shenyang University of TechnologyShenyang110870China Faculty of Organizational Sciences University of BelgradeBelgrade11000Serbia College of engineering Yuan Ze UniversityTaoyuan320315TaiwanChina

In this paper,a stable and adaptive sliding mode control(SMC)method for induction motors is *** the parameters of this system has been one of the existing *** solve this challenge,a new self-tuning type-2 fuzzy neural network calculates and updates the control system parameters with a fast *** to the dynamic changes of the system,in addition to the parameters of the SMC,the parameters of the type-2 fuzzy neural network are also updated *** conditions for guaranteeing the convergence and stability of the control system are *** the simulation part,in order to test the proposed method,several uncertain models and load torque have been ***,the results have been compared to the SMC based on the type-1 fuzzy system,the traditional SMC,and the PI *** average RMSE in different scenarios,for type-2 fuzzy SMC,is 0.0311,for type-1 fuzzy SMC is 0.0497,for traditional SMC is 0.0778,and finally for PI controller is 0.0997.

关键词： Sliding mode control self-tuning type-2 fuzzy systems inductions motor parameters uncertainty

In situ plasmonic & electrochemical fiber-optic sensor for multi-metal-ions detection

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Science China(Information Sciences) 2024年第1期67卷 292-302页

作者： Xiaoling PENG Zhiyong YANG Bo PENG Zhi LI Zhicong REN Xicheng WANG Jiahai LI Zhencheng LI Liang CHEN Daotong YOU Kaiwei LI Jianqing LI Tuan GUO Institute of Photonics Technology Jinan University School of Computer Science and engineering Macau University of Science and Technology Institute for Environmental and Climate Research Jinan University Key Laboratory of Bionic engineering of Ministry of Education Jilin University

High precision and high throughput detection of heavy metal ions is essential for water quality monitoring and ***,we propose a plasmonic & electrochemical dual-mode fiber sensing probe for label-free and real-time detection of multiple ions(Pb2+and Cu2+as examples).This sensor comprises a multimode fiber-single mode fiber reflection probe,the outer surface of which is coated with a gold nanofilm to excite the surface plasmon resonance(SPR) optically and simultaneously serves as an electrochemical working *** traditional electrochemical detection,the enrichment of ions cannot be detected in ***,by utilizing the plasmonic & electrochemical dual-mode detection method,various kinds of metal ions can be deposited onto the gold nanofilm and selectively oxidized during forward potential scanning,and the entire electrochemical process can be monitored by SPR *** experimentally demonstrate that the sensor can simultaneously detect Pb2+and Cu2+in a mixed solution in real-time,providing a linear response over the ion concentration range from 10-12to 10-7M and offering an excellent detection limit(1.69×10-14–5.49×10-13M).The proposed dual-mode fiber sensor has the benefits of remote sensing,compact footprint,and cost-effectiveness and shows excellent potential for water quality risk management in difficult-to-reach environments.

关键词： optical fiber sensor surface plasmon resonance electrochemical measurement ions detection water pollution

Hydrogen Permeation Characteristics of Pd-CuMembrane in Plasma Membrane Reactor

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energy engineering 2024年第2期121卷 259-272页

作者： Muhd Hadi Iskandar Abd Razak Motoki Tsuda YukioHayakawa Shinji Kambara Graduate School of engineering Gifu UniversityGifu501-1193Japan

Hydrogen is an alternative energy source that has the potential to replace fossil *** of the hydrogen applications is as a material for Polymer Electrolyte Membrane Fuel Cells(PEMFC)in fuel cell ***-purity hydrogen can be obtained using a hydrogen separation membrane to prevent unwanted contaminants from potentially harming the PEMFC *** this study,we fabricated a plasma membrane reactor and investigated the permeation performance of a hydrogen separation membrane in a plasma membrane reactor utilizing atmospheric pressure *** result showed the hydrogen permeation rate increasing with time as reactor temperature is increased through joule *** decreasing the gap length of the reactor from 2 to 1 mm,the hydrogen permeation rate increases by up to 40%.The hydrogen permeation rate increases by 30%when pressure is applied to the plasma membrane reactor by up to 100 kPa.

关键词： Hydrogen energy hydrogen separation membrane atmospheric pressure plasma

Comprehensive Analysis of Gender Classification Accuracy across Varied Geographic Regions through the Application of Deep Learning Algorithms to Speech Signals

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Computer Systems Science & engineering 2024年第3期48卷 609-625页

作者： Abhishek Singhal Devendra Kumar Sharma department of Electronics and Communication engineering Faculty of Engineering and TechnologySRM Institute of Science and TechnologyDelhi–NCR CampusGhaziabad201204India

This article presents an exhaustive comparative investigation into the accuracy of gender identification across diverse geographical regions,employing a deep learning classification algorithm for speech signal *** this study,speech samples are categorized for both training and testing purposes based on their geographical *** 1 comprises speech samples from speakers outside of India,whereas Category 2 comprises live-recorded speech samples from Indian *** speech samples are likewise classified into four distinct sets,taking into consideration both geographical origin and the language spoken by the ***,the results indicate a noticeable difference in gender identification accuracy among speakers from different geographical *** speakers,utilizing 52 Hindi and 26 English phonemes in their speech,demonstrate a notably higher gender identification accuracy of 85.75%compared to those speakers who predominantly use 26 English phonemes in their conversations when the system is trained using speech samples from Indian *** gender identification accuracy of the proposed model reaches 83.20%when the system is trained using speech samples from speakers outside of *** the analysis of speech signals,Mel Frequency Cepstral Coefficients(MFCCs)serve as relevant features for the speech *** deep learning classification algorithm utilized in this research is based on a Bidirectional Long Short-Term Memory(BiLSTM)architecture within a Recurrent Neural Network(RNN)model.

关键词： Deep learning recurrent neural network voice signal mel frequency cepstral coefficients geographical area gender

Searching for the optimal precondition procedure for mesenchymal stem/stromal cell treatment:Facts and perspectives

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World Journal of Stem Cells 2024年第6期16卷 615-618页

作者： Yu-Dong Zhao Yong-Can Huang Wei-Shi Li department of Orthopedic Peking University Third HospitalBeijing 100191China Shenzhen engineering Laboratory of Orthopaedic Regenerative Technologies Orthopaedic Research CenterPeking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina

Mesenchymal stem/stromal cells are potential optimal cell sources for stem cell therapies,and pretreatment has proven to enhance cell vitality and *** a recent publication,Li et al explored a new combination of pretreatment ***,we present an editorial to comment on their work and provide our view on mesenchymal stem/stromal cell precondition.

关键词： Mesenchymal stem cell Precondition Hypoxia Inflammation

ANovel Non-Isolated Cubic DC-DC Converter with High Voltage Gain for Renewable energy Power Generation System

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energy engineering 2024年第1期121卷 221-241页

作者： Qin Yao Yida Zeng Qingui Jia School of Electrical engineering Southwest Jiaotong UniversityChengdu610036China

In recent years,switched inductor(SL)technology,switched capacitor(SC)technology,and switched inductor-capacitor(SL-SC)technology have been widely applied to optimize and improve DC-DC boost converters,which can effectively enhance voltage gain and reduce device *** address the issue of low output voltage in current renewable energy power generation systems,this study proposes a novel non-isolated cubic high-gain DC-DC converter based on the traditional quadratic DC-DC boost converter by incorporating a SC and a SL-SC ***,the proposed converter’s details are elaborated,including its topology structure,operating mode,voltage gain,device stress,and power ***,a comparative analysis is conducted on the voltage gain and device stress between the proposed converter and other high-gain ***,a closed-loop simulation system is constructed to obtain simulation waveforms of various devices and explore the dynamic ***,an experimental prototype is built,experimental waveforms are obtained,and the experimental dynamic performance and conversion efficiency are *** theoretical analysis’s correctness is verified through simulation and experimental *** proposed converter has advantages such as high voltage gain,low device stress,high conversion efficiency,simple control,and wide input voltage range,achieving a good balance between voltage gain,device stress,and power *** proposed converter is well-suited for renewable energy systems and holds theoretical significance and practical value in renewable energy *** provides an effective solution to the issue of low output voltage in renewable energy power generation systems.

关键词： Cubic DC-DC converter high voltage gain low device stress high efficiency renewable energy