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Presence of CCK-A, B receptors and effect of gastrin and cholecystokinin on growth of pancreatobiliary cancer cell lines

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World Journal of Gastroenterology 2005年第6期11卷 803-809页

作者： Jin-Young Jang Sun-Whe Kim Ja-Lok Ku Yong-Hyun Park Jae-Gahb Park department of surgery

AIM: To investigate the effects of gastrin and cholecystokinin (CCK) and their specific antagonists on the growth of pancreatic and biliary tract cancer cell lines. METHODS: Five pancreatic and 6 biliary cancer cell lines with 2 conrtol cells were used in this study. Cell proliferation study was done using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) test and direct cell count method. Reverse transcription-polymerase chain reaction (RT-PCR) and slot blot hybridization were performed to examine and quantify the expression of hormonal receptors in these cell lines. RESULTS: SNU-308 showed a growth stimulating effect by gastrin-17, as did SNU-478 by both gastrin-17 and CCK-8. The trophic effect of these two hormones was completely blocked by specific antagonists (L-365, 260 for gastrin and L-364, 718 for CCK). Other cell lines did not respond to gastrin or CCK. In RT-PCR, the presence of CCK-A receptor and CCK-B/gastrin receptor mRNA was detected in all biliary and pancreatic cancer cell lines. In slot blot hybridization, compared to the cell lines which did not respond to hormones, those that responded to hormones showed high expression of receptor mRNA. CONCLUSION: Gastrin and CCK exert a trophic action on some of the biliary tract cancers.

关键词： Bile duct cancer Gallbladder cancer Pancreatic cancer Gastrin Cholecystokinin

Intestinal autotransplantation:the next level of complexity in locally advanced pancreatic cancer

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Hepatobiliary surgery and Nutrition 2023年第4期12卷 604-606页

作者： Artur Rebelo Jorg Kleeff department of Visceral Vascular and Endocrine SurgeryUniversity Hospital Halle(Saale)Martin-Luther-University Halle-WittenbergHalleGermany

Pancreatic ductal adenocarcinoma(PDAC)remains a devastating disease,and selecting patients who might benefit from complex arterial resection continues to be a ***,in the era of modern multimodal treatments,surgery for pancreatic cancer has become increasingly *** chemotherapy regimens such as modified-FOLFIRINOX(mFOLFIRINOX)and nab-paclitaxel/gemcitabine are effective in a significant proportion of patients.

关键词： Pancreatic cancer with intestinal autotransplantation locally advanced arterial resection

Hepatocellular carcinoma presenting as an extrahepatic mass:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2241-2252页

作者： Wei Kelly Wu Krutika Patel Chandrasekhar Padmanabhan Kamran Idrees department of surgery Vanderbilt University Medical CenterNashvilleTN 37232United States department of Pathology Microbiology and ImmunologyVanderbilt University Medical CenterNashvilleTN 37232United States Division of Surgical Oncology and endocrine surgery Department of SurgeryVanderbilt University Medical CenterNashvilleTN 37232United States

BACKGROUND Hepatocellular carcinoma(HCC)is a primary liver tumor generally diagnosed based on radiographic *** disease is typically associated with increased tumor diameter,multifocality,and vascular *** report a case of a patient who presented with extrahepatic HCC metastasis to a portocaval lymph node with occult hepatic primary on computed tomography(CT).We review the literature for cases of extrahepatic HCC presentation without known hepatic lesions and discuss strategies to differentiate between metastatic and ectopic *** SUMMARY A 67-year-old male with remotely treated hepatis C was referred for evaluation of an enlarging portocaval,mixed cystic-solid *** CT evaluations demonstrated steatosis,but no cirrhosis or liver *** ultrasound demonstrated a normal-appearing pancreas,biliary tree,and *** needle aspiration yielded atypical *** differential diagnosis included duodenal or pancreatic cyst,lymphoproliferative cyst,stromal or mesenchymal lesions,nodal involvement from gastrointestinal or hematologic malignancy,or duodenal gastrointestinal stromal *** review by a multidisciplinary tumor board,the patient underwent open surgical resection of a 5.2 cm×5.5 cm retroperitoneal mass with pathology consistent with moderately-differentiated *** resonance imaging(MRI)subsequently demonstrated a 1.2 cm segment VIII hepatic lesion with late arterial enhancement,fatty sparing,and intrinsic T1 *** fetoprotein was 23.3 ng/*** patient was diagnosed with HCC with portocaval nodal ***:We surveyed the literature for HCC presenting as extrahepatic masses without history of concurrent or prior intrahepatic *** identified 18 cases of extrahepatic HCC ultimately found to represent metastatic lesions,and 30 cases of extrahepatic HCC found to be primary,ectopic *** Hepatocellular carcinoma can seldomly present with extrahepatic metastasis in the setting of

关键词： Extrahepatic Metastasis Portocaval Lymph node Case report

A Japanese multi-institutional randomized controlled trial(ND-Trial)

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Hepatobiliary surgery and Nutrition 2021年第2期10卷 226-228页

作者： Stylianos Tzedakis David Fuks department of Digestive PancreaticHepato-biliary and Endocrine SurgeryCochin HospitalAPHPParisFrance University of Paris ParisFrance

We read with great interest the recently(Annals of surgery,Feb,2021)published article by Arita and collaborators(1)about the clinical impact of a no-drain policy in liver *** aforementioned study(ND-trial)is the first multi-institutional randomized controlled trial(RCT)assessing the impact of a drain placement after liver resection on the severe postoperative complication rate.

关键词： surgery randomized clinical

Comment on:Failure to rescue in patients with distal pancreatectomy:a nationwide analysis of 10,632 patients

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Hepatobiliary surgery and Nutrition 2021年第2期10卷 229-231页

作者： Ugo Marchese David Fuks Stephanie Truant Mehdi El Amrani department of Digestive Hepatobiliary and Endocrine SurgeryParis UniversityCochin HospitalAP-HP75014 ParisFrance department of Digestive surgery and Transplantation Lille UniversityCHRU de LilleLilleFrance

We read with great interest the article recently published by Lequeu et al.(1)based on the French national administrative prospective database for hospital care(PMSI:Programme de Médicalisation des Systèmes d’Information)containing all discharge reports from both private and public hospitals in *** series aimed at evaluating the influence of hospital volume on failure to rescue after distal pancreatectomy(DP)with or without splenectomy by open and minimally invasive *** number of deaths among patients who experienced major postoperative complication,failure to rescue(FTR)represents the inability for a center to manage these complications and to avoid postoperative ***,FTR appears to be a relevant indicator of quality of care after surgical procedures related to postoperative morbidity and its management.

关键词： patients nationwide

Changes of duplex parameters and splenic size in liver transplant recipients during a long period of observation

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World Journal of Gastroenterology 2005年第43期11卷 6787-6791页

作者： Bita Boozari Michael Gebel Mathias J Bahr Michael P Manns Christian P Strassburg Joerg S Bleck J Klempnauer Bjoern Nashan department of Gastroenterology department of Visceral and Transplant surgery department of Transplant surgery

AIM: To assess the changes of portal and arterial velocities, resistance index, spleen and liver size during a long observation period (13.7 years) after orthotopic liver transplantation (OLT).METHODS: Two hundred and sixty patients were recruited retrospectively for this study and divided into groups with defined time intervals after OLT. The cross-sectional changes of portal and arterial velocities,resistance index, spleen and liver size between the defined time intervals were studied. The complications detected by ultrasound were compared to gold standard ***: The mean values for liver size were all within the normal range. The splenic size decreased between the time intervals 100 and 1 000 d after OLT (t;P＜0.01).While portal and arterial flow velocities decreased up to 5.5 years (t; portal velocity P＜0.01, maximal systolic velocity P=0.05, maximal end diastolic velocity P＜0.01),RI increased during this interval (t:P＜0.01). Higher RIvalues were found in older patients (r = 0.24, P＜0.001).CONCLUSION: The arterial and portal velocities show adaptation processes continuing over the course of many years after OLT and are reported for the first time. The vascular complications detected by ultrasound occur mostly up to 100 d after OLT.

关键词： Ultrasound Color Doppler Liver transplantation Monitoring

Prognostic analysis of surgical treatment of peripheral cholangiocarcinoma: Two decades of experience at Chang Gung Memorial Hospital

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World Journal of Gastroenterology 2005年第12期11卷 1779-1784页

作者： Yi-Yin Jan Chun-Nan Yeh Ta-Sen Yeh Tse-Ching Chen department of surgery department of Pathology

AIM: To analyze the prognostic factors influencing the overall survival of peripheral cholangiocarcinoma (PCC) patients undergoing surgical treatment during 25 years at a single institution. METHODS: This study retrospectively reviewed prospectively collecting data about 373 patients with historically proven PCC who underwent surgical treatment between 1977 and 2001. RESULTS: Three hundred and seventy-three PCC patients (159 men and 214 women) underwent surgical treatment from 1977 to 2001. Among them, 187 PCC patients underwent hepatectomy and 135 had curative resection (curative resectability rate: 36.2%). The follow-up duration ranged from 1.05 to 167.6 mo (mean/median = 14.1/7.2 mo). Overall cumulative survival rates at 1, 3, and 5 years were 32.5%, 9.2%, and 4.1%, respectively. Univariate log-rank analysis identified the following as adverse influences on overall survival: presence of symptoms, absence of mucobilia, elevated CEA and CA 19-9 levels, non-papillary tumor type, receiving non-hepatectomy, advanced tumor staging, lack of post-operative chemotherapy, and radiotherapy. Meanwhile, multivariate Cox's proportional hazard analysis demonstrated that absence of mucobilia, non-papillary tumor type, advanced tumor staging, non-hepatectomy, and lack of post-operative chemotherapy were the five independent prognostic factors that adversely affected overall survival. CONCLUSION: Favorable overall survival of PCC patients undergoing surgical treatment depends on early tumor stage, presence of mucobilia, papillary tumor type, hepatic resection, and post-operative chemotherapy.

关键词： Prognostic factor Surgical treatment Peripheral cholangiocarcinoma

Synchronous electrogastrographic and manometric study of the stomach as an esophageal substitute

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World Journal of Gastroenterology 2005年第8期11卷 1172-1178页

作者： Ferenc Izbéki Tibor Wittmann Sándor (O|')dor Balázs Botos (A|')ron Altorjay department of Medicine department of surgery

AIM: To investigate the electric and contractile mechanisms involved in the deranged function of the transposed stomach in relation to the course of the symptoms and the changes in contractile and electrical parameters over ***: Twenty-one patients after subtotal esophagectomy and 18 healthy volunteers were *** were compiled by using a questionnaire, and a symptom score was formed. Synchronous electrogastrography and gastric manometry were performed in the fasting state and ***: Eight of the operated patients were symptomfree and 13 had symptoms. The durations of the postoperative periods for the symptomatic (9.1±6.5 mo)and the asymptomatic (28.3±8.8 mo) patients were significantly different. The symptom score correlated negatively with the time that had elapsed since the operation. The percentages of the dominant frequency in the normogastric, bradygastric and tachygastric ranges differed significantly between the controls and the patients.A significant difference was detected between the power ratio of the controls and that of the patients. The occurrence of tachygastria in the symptomatic and the symptom-free patients correlated negatively both with the time that had elapsed and with the symptom score. There was a significant increase in motility index after feeding in the controls, but not in the patients. The contractile activity of the stomach increased both in the controls and in the symptom-free patients. In contrast, in the group of symptomatic patients, the contractile activity decreased postprandially as compared with the fasting ***: The patients' post-operative complaints and symptoms change during the post-operative period and correlate with the parameters of the myoelectric and contractile activities of the stomach. Tachygastria seems to be the major pathogenetic factor involved in the contractile dysfunction.

关键词： Transposed stomach Electrogastrography Gastric manometry Post-operative complaints Contractile dysfunction Tachygastria

Trans-axillary retro-mammary gland route approach of video- assisted breast surgery can perform breast conserving surgery for cancers even in inner side of the breast

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Chinese Medical Journal 2008年第20期121卷 1960-1964页

作者： Koji Yamashita Kazuo Shimizu Division of endocrine surgery Department of Surgery Nippon Medical School Tokyo 113-8602 Japan

Background The endoscopic surgery for inner-side cancer of the breast is usually performed by periareolar approach, but it often makes deformation or malposition of nipple and areola. The trans-axillary approach is favorable without making any injuries on breast skin. Furthermore, we devised a new approach of retro-mammary route without subcutaneous exfoliation, from axillary skin incision, to preserve skin touch sensation.Methods We have performed video-assisted breast surgery （VABS） on 200 patients since December 2001. The newly devised trans-axillary retromammary-route approach （TARM） was performed on 12 patients of early breast cancer. After endoscopic sentinel lymph node biopsy, we lengthened the axillary skin incision to 2.5 cm, and dissected retromammary tissue from superficial pectoral fascia onto major pectoral muscle below the tumor. The working space was made by lifting traction sutures through the gland. We cut the gland vertically at free margin 2 cm apart from the tumor edge, and dissect skin flap over the tumor. The breast reconstruction was done by filling absorbable fiber cotton.Results Traction sutures made it easier to cut the mammary gland vertically. We did not experience any skin damages like burn. All surgical margins were negative. The operation time was needed longer but the blood loss was not different. The postoperative esthetic results were good. The sensory disturbance was minimal. All patients were satisfied with this operation.Conclusion This newly devised TARM approach need no injury on whole breast, and can become a single standard method for breast conserving surgery wherever the cancer situated.

关键词： endoscopic surgery trans-axillary retro-mammary gland breast-conserving surgery aesthetics breast neoplasms