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World Journal of emergency medicine 2025年第1期16卷 78-81页

作者： Zhi’ang Li Peifang Li Yiling Jiang Jianjun Zhu Jianliang Zhu Zhiping Xu Lijun Liu department of emergency and intensive care medicine the Second Affiliated Hospital of Soochow UniversitySuzhou 215004China

Mechanical ventilation is a specialized oxygen therapy and life support technology with significant importance for critically ill patients. In fact, 40%–66% of patients in the intensive care unit(ICU) require mechanical ventilation.^([1,2]) However, the mechanical ventilation can lead to ventilatorassociated lung injury(VALI),^([3]) ultimately resulting in difficulties in weaning from mechanical ventilation,prolonged hospital stays, and even increased mortality.

关键词： specialized ventilation ultimately

NIR driven catalytic enhanced acute lung injury therapy by using polydopamine@Co nanozyme via scavenging ROS

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Chinese Chemical Letters 2025年第2期36卷 337-343页

作者： Xiaoshuai Wu Bailei Wang Yichen Li Xiaoxuan Guan Mingjing Yin Wenquan Lv Yin Chen Fei Lu Tao Qin Huyang Gao Weiqian Jin Yifu Huang Cuiping Li Ming Gao Junyu Lu intensive care Unit The Second Affiliated Hospital of Guangxi Medical University department of Critical care medicine The Ninth Affiliated Hospital of Guangxi Medical University Life Sciences Institute Guangxi Medical University department of emergency The First Affiliated Hospital of Guangxi Medical University College & Hospital of Stomatology Guangxi Medical University Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction Guangxi Medical University

Acute lung injury(ALI) was characterized by excessive reactive oxygen species(ROS) levels and inflammatory response in the lung. Scavenging ROS could inhibit the excessive inflammatory response, further treating ALI. Herein, we designed a novel nanozyme(P@Co) comprised of polydopamine(PDA) nanoparticles(NPs) loading with ultra-small Co, combining with near infrared(NIR) irradiation, which could efficiently scavenge intracellular ROS and suppress inflammatory responses against ALI. For lipopolysaccharide(LPS) induced macrophages, P@Co + NIR presented excellent antioxidant and anti-inflammatory capacities through lowering intracellular ROS levels, decreasing the expression levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α) as well as inducing macrophage M2 directional polarization. Significantly, it displayed the outstanding activities of lowering acute lung inflammation, relieving diffuse alveolar damage, and up-regulating heat shock protein 70(HSP70) expression, resulting in synergistic enhanced ALI therapy effect. It offers a novel strategy for the clinical treatment of ROS related diseases.

关键词： Acute lung injury M2 directional polarization Nanozyme NIR driven ROS scavenging

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin Huang Jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina department of emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of emergency medicine FuzhouFujian ProvinceChina The Second department of intensive care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

Therapeutic strategies and prognostic challenges in linitis plastica

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World Journal of Experimental medicine 2025年第1期15卷 1-5页

作者： Grigorios Christodoulidis Sara Eirini Agko Konstantinos Eleftherios Koumarelas Marina Nektaria Kouliou department of General Surgery University Hospital of LarissaLarissa 41110Greece intensive care Unit Asklepios Paulinen Clinic WiesbadenWiesbaden 65197Germany department of emergency medicine General Hospital of LarissaLarissa 41221Greece

Gastric cancer ranks fifth as the most common cancer and third as the leading cause of death *** factors include advancing age,low-fiber diets,high salt intake and Helicobacter pylori *** relies on histological examination following endoscopic biopsy with staging accomplished through various imaging *** gastric cancer is primarily managed via endoscopic resection,while non-early operable cases typically undergo *** cases are addressed through sequential chemotherapy lines,with initial treatment usually comprising a platinum and fluoropyrimidine *** plastica(LP)is a rare,aggressive form of gastric cancer characterized by diffuse infiltration of the gastric wall,resulting in poor outcomes even after curative *** absence of a standardized definition contributes to uncertainty regarding the precise incidence of these *** is often diagnosed at advanced stages,with a reported median survival rate of approximately 4%-29%,despite“curative resection”.Its distinctive biological behavior includes perineural invasion,nodal metastasis,and peritoneal *** bleak prognosis for LP patients partly stems from delayed diagnosis and its aggressive biological nature,posing significant challenges for clinical ***,no specialized treatment strategy exists for LP,and clinical approaches typically align with those used for general gastric cancer *** resection is the primary treatment,but the optimal surgical approach remains *** studies have investigated the efficacy of neoadjuvant chemotherapy and radiotherapy in improving survival outcomes for LP ***,controversies persist regarding the role of adjuvant chemotherapy and postoperative *** requires a multidisciplinary approach and personalized treatment strategies tailored to each patient’s *** research is needed to elucidate optimal therapeutic interventions and

关键词： Linitis plastica Surgery Chemotherapy Radiotherapy Treatment strategies Gastric cancer

Chinese clinical practice consensus for device-supported treatment in adults with post-cardiac arrest syndrome(2024 Edition)

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World Journal of emergency medicine 2025年第1期16卷 3-9页

作者： Chuanbao Li Shengchuan Cao Yue Zheng Mengzhi Zong Haitao Zhang Xuezhong Yu Feng Xu Yuguo Chen the Chinese Clinical Practice Consensus for Device-supported Treatment in Adults with Post-cardiac Arrest Syndrome Work group department of emergency medicine Chest Pain CenterShandong Provincial Clinical Research Center for Emergency and Critical Care MedicineQilu Hospital of Shandong UniversityJinan 250012China department of Critical care medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China State Key Laboratory of Complex Severe and Rare Diseases Emergency DepartmentPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China 不详

During cardiac arrest (CA),severe ischemia and hypoxia occur in tissues and organs of the entire body,inflammatory cytokines are released,and ischemiareperfusion injury occurs after the return of spontaneous circulation (ROSC),leading to multiple organ dysfunction in the body;this condition is called post-CA syndrome(PCAS).^([1])According to the BASeline Investigation of Out-of-Hospital Cardiac Arrest (BASIC-OHCA) study,the crude incidence of emergency medical service (EMS)-assessed OHCA was 95.7 per 100,000 individuals,and only1.2%of those individuals survived to hospital discharge or30 d after being resuscitated by the EMS in China.

关键词： cardiac organs return

Advances and challenges in diagnosing and managing adult autoimmune enteropathy

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World Journal of Gastroenterology 2025年第2期31卷 128-131页

作者： Grigorios Christodoulidis Sara E Agko Marina N Kouliou Konstantinos E Koumarelas Dimitris Zacharoulis department of General Surgery University Hospital of LarissaLarissa 41110Greece department of intensive care Unit Asklepios Paulinen Clinic WiesbadenWiesbaden 65197Germany department of emergency medicine General Hospital of LarissaLarissa 41221Greece department of Surgery University Hospital of LarissaLarissa 41334Greece

Autoimmune enteropathy(AIE)is a rare immune mediated disorder primarily affecting children,characterized by chronic diarrhea,malabsorption,vomiting,weight loss and villous *** has also been observed in adults presenting diagnostic and treatment challenges due to its overlap with other gastrointestinal disorders such as celiac *** diagnostic criteria for AIE include small bowel villous atrophy,lack of response to dietary restrictions,presence of anti-enterocyte antibodies,and predisposition to autoimmunity without severe *** criteria emphasize characteristic histological findings and exclusion of other causes of villous *** is associated with various autoimmune disorders and can present with overlapping features with Celiac disease,including villous atrophy but without significant intraepithelial *** primarily involves immunosuppression using corticosteroids,calcineurin inhibitors,and anti-tumor necrosis factor therapy,alongside nutri-tional *** the challenges,understanding AIE’s diverse manifest-ations and improving diagnostic criteria are essential for effective management and improved patient *** research is needed to elucidate the pathogenesis,disease progression and long-term outcomes of AIE.

关键词： Autoimmune enteropathy Diagnosis Prognosis Adult autoimmune enter-opathy and challenges Autoimmune enteropathy and treatment Autoimmune enteropathy and diagnostic criteria Pathophysiology of autoimmune enteropathy

Inferior vena cava invasion by double-J stent

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World Journal of emergency medicine 2025年第1期16卷 97-98页

作者： Huiming Zhong Shanxiang Xu Mao Zhang Yiping Feng department of emergency medicine the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China Key Laboratory of the Diagnosis and Treatment of Severe Trauma and Burn of Zhejiang Province Hangzhou 310009China Zhejiang Province Clinical Research Center for emergency and Critical care medicine Hangzhou 310009China Research Institute of emergency medicine Zhejiang UniversityHangzhou 310009China

The double-J stent (DJS), first reported by Zimskind et al^([1])in 1967, is a commonly used therapeutic tool in urology. DJS is primarily used to maintain urine flow from the kidney to the bladder and to restore the continuity of the urinary tract in various urological conditions.^([2]) The DJS placement is typically performed under cystoscopic or fluoroscopic *** complications include dysuria, urinary frequency,hematuria, bacteriuria, stent fragmentation, and stone formation.^([3]) Most of these complications can be managed with supportive medical care.

关键词： urinary invasion bladder

Effect of traumatic brain injury severity on intestinal barrier and gastrointestinal function

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World Journal of emergency medicine 2025年第1期16卷 82-84页

作者： Meifang Cui Xiaoyu Xu Jilu Ye Xuehua Pu Liping Ren intensive care Unit Taizhou People's Hospital Affi liated to Nanjing Medical UniversityTaizhou 225300China intensive care Unit Nanjing Medical UniversityNanjing 210000China

Traumatic brain injury(TBI) is a significant globa public health challenge, with an estimated mortality rate of 13 per 100,000 people in China. Bedsides the immediate neurological consequences,^([1]) TBI is associated with longterm sequelae and an elevated risk of neurodegenerative conditions such as dementia, Parkinson's disease, and epilepsy. Moreover, TBI can induce systemic effects including acute gastrointestinal injury(AGI), contributing to poor patient outcomes.

关键词： gastrointestinal epilepsy elevated

Early prediction cardiac arrest in intensive care units:the value of laboratory indicator trends

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World Journal of emergency medicine 2025年第1期16卷 67-70页

作者： Wentao Sang Jiaxin Ma Xuan Zhang Shuo Wu Chang Pan Jiaqi Zheng Wen Zheng Qiuhuan Yuan Jian Zhang Jingjing Ma Feng Xu department of emergency medicine Qilu HospitalShandong UniversityJinan 250012China Chest Pain Center Qilu HospitalShandong UniversityJinan 250012China Shandong Provincial Clinical Research Center for emergency and Critical care medicine Institute of Emergency and Critical Care Medicine of Shandong UniversityQilu HospitalShandong UniversityJinan 250012China Key Laboratory of emergency and Critical care medicine of Shandong Province Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong ProvinceShandong Provincial Engineering Laboratory for Emergency and Critical Care MedicineQilu HospitalShandong UniversityJinan 250012China Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of EducationChinese Ministry of Health and Chinese Academy of Medical Sciencesthe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineQilu HospitalShandong UniversityJinan 250012China

The incidence of in-hospital cardiac arrest (IHCA) has increased over the past decade,with more than half occurring in intensive care units (ICUs).^([1])ICU cardiac arrest (ICU-CA)presents unique challenges,with worse outcomes than those in monitored wards,highlighting the need for early detection and intervention.^([2])Up to 80%of patients exhibit signs of deterioration hours before IHCA.^([3])Although early warning scores based on vital signs are useful,their eff ectiveness in ICUs is limited due to abnormal physiological parameters.^([4])Laboratory markers,such as sodium,potassium,and lactate,are predictive of poor outcomes,^([5])but static measurements may not capture the patient’s *** in laboratory indicators,such as variability and extremes,may offer better predictive value.^([6])This study aimed to evaluate ICU-CA predictive factors,with a focus on vital signs and trends of laboratory indicators.

关键词： prediction signs arrest

CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NSCLC via the TOLLIP/TLR4-MyD88-NF-κB pathway

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Oncology Research 2025年第1期33卷 133-148页

作者： TAO SUN QINGHUA SONG HUA LIU department of Respiratory and Critical care medicine Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China department of emergency The People’s Hospital of RugaoNantong226500China department of Haematology The People’s Hospital of RugaoNantong226500China

Background:Lung cancer is a life-threatening disease that occurs worldwide,but is especially common in *** crucial role of the tumour microenvironment(TME)in non-small cell lung cancer(NSCLC)has attracted recent ***-associated fibroblasts(CAFs)are the main factors that contribute to the TME function,and CAF exosomes are closely linked to ***:The expression levels of miR-3124-5p and Toll-interacting protein(TOLLIP)were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot *** were isolated and identified from clinical NSCLC *** electron microscopy and Western Blot were used to identify exosomes from these *** in proliferation(CCK-8 and clone formation),migration(wound healing),and invasion(transwell)of NSCLC cells were *** Luciferase reporter test was applied to clarify the binding of miR-3124-5p to *** TOLLIP/TLR4/MyD88/NF-κB pathway proteins were determined using Western blot ***:MiR-3124-5p is overexpressed in clinical tissues and cells of ***-3124-5p was dramatically enriched in CAF-derived *** experiments revealed that CAFs delivered miR-3124-5p into NSCLC cells via exosomes,stimulating cancer cell ***-3124-5p acted as a sponge to negatively regulate TOLLIP expression,which activated the TLR4/MyD88/NF-κB axis to promote the occurrence and development of *** salvage tests were performed to determine whether CAF-exosome-derived miR-3124-5p plays a pro-cancer role in NSCLC by affecting the TOLLIP signalling ***:These results provide an interesting direction for the diagnosis and therapy of NSCLC.

关键词： Non-small cell lung cancer(NSCLC) Cancer-associated fibroblasts(CAFs) Exosomes miR-3124-5p Toll-interacting protein(TOLLIP)