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Skin Slice as a Model for the Investigation of the Role of Mast Cells in Acupuncture Effects

Journal of Acupuncture and Tuina Science 2008年第6期6卷 367-367页

作者：汪丽娜丁光宏顾全保 Wolfgang SCHWARZ Shanghai Research Center for Acupuncture and Meridians Shanghai 201203P.R.China Department of Mechanics and Engineering ScienceFudan UniversityShanghai 200443P.R.China Shanghai Research Center for Acupuncture and Meridians Shanghai 201203P.R.China Max-Planck-Institute for BiophysicsFrankfurt/MainGermany

Objective:To establish a new and better model to investigate the properties of mast cells that couldbe involved in acupuncture process ***:Connective tissue under the corium at thearea of acupuncture point Zusanli(ST 36)from rat was acutely bluntly separated with forceps andscissors,and incubated in bath solution up to several *** cells in slices of that tissue wereirradiated with laser light of 650 nm,and changes in the appearance were observed under *** addition,patch-clamp technique in whole-cell configuration was employed to induce mechano-

关键词：皮肤真皮层针刺疗法柱状细胞

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X-ray detection of ingested non-metallic foreign bodies

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World Journal of Clinical Pediatrics 2014年第2期3卷 14-18页

作者： Miguel Saps John M Rosen Jacob Ecanow Division of Pediatric Gastroenterology Hepatology and NutritionAnn and Robert H Lurie Children’s Hospital of ChicagoNorthwestern Feinberg School of MedicineChicagoIL 60611-2605United States department of Radiology Northshore University Health System University of Chicago Pritzker School of Medicine ChicagoIL 60611-2605United States

AIM: To determine the utility of X-ray in identifying non-metallic foreign body(FB) and assess inter-radiologist agreement in identifying non-metal FB. METHODS: Focus groups of nurses, fellows, and attending physicians were conducted to determine commonly ingested objects suitable for inclusion. Twelve potentially ingested objects(clay, plastic bead, crayon, plastic ring, plastic army figure, glass bead, paperclip, drywall anchor, eraser, Lego?, plastic triangle toy, and barrette) were embedded in a gelatin slab placed on top of a water-equivalent phantom to simulate density of a child's abdomen. The items were selected due to wide availability and appropriate size for accidental pediatric ingestion. Plain radiography of the embedded FBs was obtained. Five experienced radiologists blinded to number and types of objects were asked to identify the FBs. The radiologist was first asked to count thenumber of items that were visible then to identify the shape of each item and describe it to a study investigator who recorded all responses. Overall inter-rater reliability was analyzed using percent agreement and κ coefficient. We calculated P value to assess the probability of error involved in accepting the κ ***: Fourteen objects were radiographed including 12 original objects and 2 duplicates. The model's validity was supported by clear identification of a radiolucent paperclip as a positive control, and lack of identification of plastic beads(negative control) despite repeated inclusion. Each radiologist identified 7-9 of the 14 objects(mean 8, 67%). Six unique objects(50%) were identified by all radiologists and four unique objects(33%) were not identified by any radiologist(plastic bead, LegoTM, plastic triangle toy, and barrette). Identification of objects that were not present, false-positives, occurred 1-2 times per radiologist(mean 1.4). An additional 17% of unique objects were identified by less than half of the radiologists. Agreement between radiologi

关键词： Foreign bodies X-rays Pediatrics Radiographic phantom Diagnostic imaging

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磷酸化-信号转导和转录激活因子3(p-STAT3)(丝氨酸727)联合Ki-67在宫颈上皮内瘤变中的作用

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世界核心医学期刊文摘（妇产科学分册） 2006年第1期2卷 47-47页

作者： Yang S. - F. Yuan S. - S. F. Yeh Y. - T. 张丽娟(译) C. -Y. Chai Department of Pathology Kaohsiung Medical University Chung-Ho Memorial Hospital No. 100 Tzyou 1st Road Kaohsiung 807 Taiwan China 不详

s. Constitutive activation of signal transducer and activator of transcription 3 (STAT3) has been described in many types of cancers. However, the role of phospho- STAT3 (p- STAT3) at serine residue 727 is in large part undetermined. Our purposes of this study were to evaluate the expression patterns of p- STAT3 (ser727) in cervical intraepithelial neoplasia (CIN)- and to explore its possible role in the progression of cervical cancer. Methods. Paraffin-embedded sections from 56 patients including 20 CIN 1, 10 CIN 2, and 26 CIN 3 were collected in this study. Immunohistochemical analysis was performed, and the expression patterns of p- STAT3 (ser727) were categorized by semiquantitative method and further correlated with the CIN histopathologic grade using the χ 2 test with Bonferroni adjustment for multiple comparisons and with the proliferation marker Ki- 67 expression using Fisher’ s Exact Test. Results. The categorized high p- STAT3 (ser727) expression group in nuclei of dysplastic cells was significantly higher in CIN 3 (76.92% ), in comparison with CIN 1/2 (13.33% , P < 0.001). Moreover, both the nuclear and cytoplasmic p- STAT3 (ser727)- expressions were correlated with Ki- 67 nuclear staining (P < 0.001 and < 0.001, respectively). Conclusions. Our result revealed that aberrant expression levels of p- STAT3 (ser727) were significantly correlated with CIN lesion grade and cell proliferation. Evaluation of p- STAT3 (ser727) expression may provide additional prognostic information for the clinical course of the disease and therefore to be developed as a prognostic indicator for cervical cancer.

关键词：宫颈上皮内瘤变 Ki-67表达转录激活因子信号转导丝氨酸磷酸化联合免疫组化分析 Fisher X^2检验

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