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Transmucosal Bleomycin for Tongue Lymphatic Malformations

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International Journal of Otolaryngology and head & neck surgery 2015年第2期4卷 81-85页

作者： Eric W. Cerrati Teresa M. O David Binetter Yelena Bernstein Milton Waner department of Otolaryngology New York University New York USA Vascular Birthmark Institute of New York Lenox Hill and Manhattan Eye Ear and Throat Hospitals New York USA

Purpose: Bleomycin is an antibiotic medication that inhibits the synthesis of DNA, RNA, and proteins and is now used in a variety of medical conditions including vascular anomalies. The aim of this study was to evaluate the clinical efficacy of transmucosal intralesional injection of bleomycin in the management of tongue lymphatic malformations. Method: A single institutional case series was presented on patients with recalcitrant lymphatic malformations of the tongue who were treated with bleomycin. Age at the time of injection, gender, number of treatments, amount of bleomycin injected per session, post-injection complications, pre- and post-injection symptoms, and anatomic extent of the lymphatic malformation were all recorded and analyzed. Results: Five patients received transmucosal bleomycin and were followed over a 10-month period. The patients included 4 females and 1 male, aged from 3.25 to 36 years (average 13.52 years). Four patients had one treatment while 1 required two treatments. A total of 1 to 6 units were injected per session. Overall reduction in size of the lymphatic malformation and improvement in all symptoms were observed in the patients by day 14. Average follow-up was 9 to 12 months. Conclusion: Intralesional injection of bleomycin is an effective treatment modality in patients with lymphatic malformations of the tongue.

关键词： Bleomycin Sclerotherapy Lymphatic Malformation Tongue

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大鼠多通道人工耳蜗植入模型的建立

临床耳鼻咽喉头颈外科杂志 2008年第13期22卷 603-605页

作者：卢伟徐瑾 Shepherd R K 郑州大学附属第一医院耳鼻咽喉科郑州450052 The Bionic Ear Institute Australia department of Otolaryngology University of MelbourneAustralia

目的:建立多通道人工耳蜗植入的大鼠动物模型。方法:5只正常听力的Hooded Wister大鼠经药物致聋后,采用在前期研究中所创立的新手术步骤,在鼓阶内植入多通道电极。对双极电刺激诱发的听性脑干反应(EABRs)进行分析,对耳蜗组织学切片进行... 详细信息

目的:建立多通道人工耳蜗植入的大鼠动物模型。方法:5只正常听力的Hooded Wister大鼠经药物致聋后,采用在前期研究中所创立的新手术步骤,在鼓阶内植入多通道电极。对双极电刺激诱发的听性脑干反应(EABRs)进行分析,对耳蜗组织学切片进行评价。结果:在电极植入后,顺利描记到正常EABRs波形,从而确认了有效的人工耳蜗功能状态。组织学观察表明,电极植入后的大鼠耳蜗内未见组织结构的严重损伤。结论:本文介绍的大鼠多通道人工耳蜗植入法有效、安全,所建立的大鼠动物模型为进行多通道人工耳蜗植入研究提供了一个新的途径;也为其他小啮齿动物(如沙鼠和小鼠)的实验性耳显微外科研究提供了思路。

关键词：人工耳蜗植入大鼠耳蜗听性脑干反应

Targeting cancer stem cells in squamous cell carcinoma

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Precision Clinical Medicine 2019年第3期2卷 152-165页

作者： Demeng Chen Cun-Yu Wang Laboratory of Molecular Signaling Division of Oral Biology and MedicineSchool of DentistryUCLALos AngelesCA 90095USA department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUCLALos AngelesCA 90095USA Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center UCLALos AngelesCA 90095USA

head and neck squamous cell carcinoma(HNSCC)is a highly aggressive tumor and the sixth most common cancer *** treatment strategies for HNSCC are surgery,radiotherapy,chemotherapy,immunotherapy or combinatorial ***,the overall 5-year survival rate of HNSCC patients remains at about 50%.Cancer stem cells(CSCs),a small population among tumor cells,are able to self-renew and differentiate into different tumor cell types in a hierarchical manner,similar to normal *** HNSCC,CSCs are proposed to be responsible for tumor initiation,progression,metastasis,drug resistance,and *** this review,we discuss the molecular and cellular characteristics of CSCs in *** summarize current approaches used in the literature for identification of HNSCC CSCs,and mechanisms required for CSC *** also highlight the role of CSCs in treatment failure and therapeutic targeting options for eliminating CSCs in HNSCC.

关键词： cancer stem cells head and neck squamous cell carcinoma lymph node metastasis resistance

Injection medialization laryngoplasty improves dysphagia in patients with unilateral vocal fold immobility

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World Journal of Otorhinolaryngology-head and neck surgery 2018年第2期4卷 126-129页

作者： Mursalin M. Anis Zainulabideen Memon Coastal Ear Nose and Throat Neptune NJ USA department of Otolaryngology University of Miami Miami FL USA Jersey Shore University Medical Center Neptune NJ USA

Objective: To assess patient reported swallowing outcomes before and after injec-tion medialization laryngoplasty in patients with unilateral vocal fold immobility (UVFI). Methods: Case series with chart review of patients with UVFI who underwent injection media-lization laryngoplasty at a community laryngology practice by a single clinician between October 2015 and December 2017. Patient-reported validated surveys of swallowing impair-ment, Eating Assessment Tool (EAT-10), demographics, etiology and duration of symptoms were recorded before and after injection. A paired t test was done on EAT-10 surveys before and after IML to assess for statistical significance. Results: Twenty-one patients with UVFI and glottic insufficiency underwent IML between October 2015 and December 2017. Nineteen of 21 patients (90％) presented with dysphagia (EAT-10 ≥ 3). 76％ of patients with dysphagia reported improvement in swallowing function af-ter IML. The EAT-10 scores of UVFI patients with dysphagia before and after IML were 17.0 ± 14.0 and 4.2 ± 9.6, respectively (p = 0.004). Conclusions: Nearly all patients with UVFI and glottic insufficiency report associated dysphagia. Three fourths of these patients perceive improvement in their swallowing function after injection medialization laryngoplasty. Patients with idiopathic UVFI may have a more sus-tained improvement and those with severe preop dysphagia may not benefit. Further research is necessary to refine patient selection and to assess duration of improved swallowing function.

关键词： Unilateral vocal fold immobility Glottic insufficiency Dysphagia Eating assessment tool Injection medialization laryngoplasty

EAST/SeSAME耳聋综合征及内向整流性钾离子通道Kir4.1在内耳中的功能表达

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临床耳鼻咽喉头颈外科杂志 2015年第14期29卷 1318-1322页

作者：陈静赵红波三峡大学医学院解剖与组织胚胎学系湖北宜昌443002 department of Otolaryngology University of Kentucky Medical Center

EAST或者SeSAME耳聋综合征是一种新发现的常染色体隐形遗传病,由KCNJ10基因突变产生。KCNJ10基因编码内向整流性钾离子通道4.1（inwardly rectifying potassium channel 4.1,Kir4.1）的特点是在细胞膜电位超极化情况下电导增加,而去极... 详细信息

EAST或者SeSAME耳聋综合征是一种新发现的常染色体隐形遗传病,由KCNJ10基因突变产生。KCNJ10基因编码内向整流性钾离子通道4.1（inwardly rectifying potassium channel 4.1,Kir4.1）的特点是在细胞膜电位超极化情况下电导增加,而去极化情况下电导降低,

关键词： KCNJ10 耳蜗内电位耳聋 EAST综合征 SeSAME综合征

Lipodystrophy of HIV (LDHIV) in the head and neck: Imaging and Clinical Features

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Endoscopic Management of Recurrent Anterior Skull Base Schwannoma

International Journal of Otolaryngology and head & neck surgery（耳鼻喉） 2012年第2期

作者： Saman Hazany Rafael Rojas Gul Moonis department of Neuroradiology Beth Israel Deaconess Medical Center department of Neuroradiology University of Southern California

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International Journal of Otolaryngology and head & neck surgery 2013年第2期2卷 52-56页

作者： Jivianne T. Lee Lester D. R. Thompson Rohit Garg David B. Keschner Terry Shibuya department of Pathology Woodland Hills Medical Center Southern California Permanente Medical Group Woodland Hills USA Orange County Sinus and Skull Base Institute Southern California Permanente Medical Group Irvine USA

Objectives: Sinonasal schwannomas account for less than 4% of head and neck schwannomas, with the primary treatment modality being surgical excision via external approaches. The aim of this report is to present a rare case of recurrent schwannoma of the ethmoid cavity involving the anterior skull base which was successfully managed with endoscopic resection. Study Design: Case report and review of the literature. Methods: The clinical presentation, radiographic features, histopathologic characteristics, surgical approach, and patient outcome were examined in the context of a literature review. Results: A 43-year-old woman presented with a 9-month history of left facial pain and pressure. She had a prior history of sinonasal schwannoma excision with cerebrospinal fluid (CSF) leak repair via bifrontal craniotomy in 2007. Magnetic resonance imaging (MRI) and nasal endoscopy revealed a left ethmoid mass measuring 2.2 cm × 2.7 cm × 2.4 cm abutting the anterior skull base. The tumor was completely removed using a transnasal endoscopic approach, and the anterior skull base reconstructed with tensor fascia lata graft. Histology of the specimen showed schwannoma, and there has been no evidence of tumor recurrence nor CSF leak after 24 months of follow-up. Conclusion: With continual advances in surgical technique and instrumentation, sinonasal schwannomas have become increasingly more amenable to endoscopic resection even in the case of recurrence and skull base involvement.

关键词： Endoscopic Recurrent Anterior Skull Base Sinonasal Schwannoma

频域信息在感音神经性听力损失患者普通话声调感知中的作用

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中华耳鼻咽喉头颈外科杂志 2012年第2期47卷 122-126页

作者：王硕 Robert Mannell Philip Newall 刘博张华韩德民首都医科大学附属北京同仁医院北京市耳鼻咽喉科研究所耳鼻咽喉头颈科学教育部重点实验室（首都医科大学） 100730 department of Linguistics Macquarie University Hearing Cooperative Research Center Australia department of Linguistics Macquarie University Renwick Centre Royal Institute for Deaf and Blind Children Australia

目的探讨言语频域包络信息和精细结构信息对听力正常和感音神经性听力损失人群汉语普通话声调识别的作用.方法采用线性预测编码技术对具有相同音节但不同声调的单音节字进行频域包络与精细结构的分离,将具有相同音节不同声调的单音节... 详细信息

目的探讨言语频域包络信息和精细结构信息对听力正常和感音神经性听力损失人群汉语普通话声调识别的作用.方法采用线性预测编码技术对具有相同音节但不同声调的单音节字进行频域包络与精细结构的分离,将具有相同音节不同声调的单音节字的频域包络信息进行互换,合成128个新的具有来自于不同声调的频域包络和精细结构信息的“单音节字”.利用这些“单音节字”测试20名听力正常人与48例感音神经性听力损失患者（20例中度、20例中重度及8例重度）的声调感知能力.利用SPSS 15.0软件进行统计分析.结果听力正常受试者99.7％的声调识别基于频域精细结构信息,中度至重度听力损失患者基于频域精细结构感知声调的识别率分别为97.7％,96.3％和83.0％.各组受试者均未依靠频域包络信息识别声调.三组听力损失患者依靠频域精细结构识别声调的能力均与听力正常受试者存在差异（x2=59.2,P＜0.001）.感音神经性听力损失患者利用频域精细结构信息识别声调的能力与其听力损失程度呈负相关关系（r=-0.643,P＜0.001）.结论频域精细结构信息在普通话声调识别中起主要作用,精细结构存在时,频域包络信息对声调识别不起作用.感音神经性听力损失患者利用频域信息感知声调的模式与听力正常人群相似,伴随听力损失程度加重,其利用频域精细结构信息感知声调的能力缓慢降低.

关键词：听觉丧失,感音神经性语音学测听法,言语

人头颈部骨骼肌干细胞的分离培养及生长特性研究

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中华耳鼻咽喉头颈外科杂志 2011年第4期46卷 313-318页

作者：魏燕陈超李源 Andreas E. Albers 中山大学附属三院耳鼻咽喉头颈外科广州510630 department of Hals-Nasen- Ohrenklinik Charit6-Universitatsmedizin Berlin Campus Benjamin Franklin Hindenburgdamm 30 Berlin 12200 Germany

目的体外建立人骨骼肌干细胞的纯化及鉴定方法，并对所分离干细胞的生物学特性进行分析研究。方法分离人头颈部正常骨骼肌组织，采用无血清培养基，悬浮状态培养技术得到人骨骼肌干细胞，体外扩增并观察生长特性。细胞免疫荧光染色和反... 详细信息

目的体外建立人骨骼肌干细胞的纯化及鉴定方法，并对所分离干细胞的生物学特性进行分析研究。方法分离人头颈部正常骨骼肌组织，采用无血清培养基，悬浮状态培养技术得到人骨骼肌干细胞，体外扩增并观察生长特性。细胞免疫荧光染色和反转录聚合酶链反应（RT—PCR）技术鉴定标记物的表达情况，单细胞克隆观察单个细胞生长特性。将分离来的细胞分别转移至采用成平滑肌、成脂、成骨诱导培养基内，观察细胞的生长分化特性，并通过特异性染色予以鉴定。结果悬浮培养条件下，倒置相差显微镜观察示骨骼肌干细胞在培养基内不断增殖形成细胞球。免疫荧光染色示细胞球表达卫星细胞的标记物Pax7及ALDH1，贴壁生长扩增传代后表达肌原细胞标记物Myod及Desmin；RT—PCR检测示表达干细胞标记物0ct3／4，Nanog，Sox2和Pax7；单克隆形成实验显示单个细胞可在悬浮状态下形成新的细胞克隆。骨骼肌细胞在体外可以诱导分化为平滑肌、骨和脂肪细胞。结论在体外可以成功分离、纯化和扩增人骨骼肌干细胞，其具有干细胞的自我更新和多向分化潜能。

关键词：干细胞卫星细胞,骨骼肌细胞分化