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Procalcitonin as a marker of infection in febrile neutropenia:A systematic review

Modern Chemotherapy 2013年第1期2卷 8-14页

作者： Anders K.Boysen Bettina R.Jensen Laurids Φ.Poulsen Paw Jensen Soren Ladefoged department of oncology Aarhus University HospitalAarhusDenmark department of oncology Aalborg University HospitalAalborgDenmark department of Hematology Aalborg University HospitalAalborgDenmark department of Clinical Biochemistry Aarhus University HospitalAarhusDenmark

Aim: Management of febrile neutropenia is challenged by lacking microbiological and clinical documentation of infection. Procalcitonin is emerging as a new promising biomarker of infection. We aimed to undertake a systematic review evaluating the diagnostic accuracy of procalcitonin as a marker of infection in febrile neutropenia. Methods: We performed a systematic re- view of the literature using the databases MEDLINE, EMBASE and Cochrane Library including a search of the grey literature (e.g. unpublished data, web sides of relevant societies). The methodological quality was assessed using predefined criteria. The relevant data were extracted and analyzed by two authors. Results: The literature search yielded a total of 193 studies of which nine were eligible for inclusion. There was a great variation in the quality of the methodological design. A notable heterogeneity exists regarding the studied populations and the definition of the reference standards. Among the nine included studies the sensitivity ranged from 42% to 72% and the specificity ranged from 64% - 89% at a cut off value ranging from 0.5 - 0.8 ng/ml. The studied endpoint was either microbiologically or clinically documented infection. Four studies found procalcitonin superior to Creactive protein in discriminating infection from the various other causes of fever. Conclusion: Procalcitonin appears to be a promising biomarker and might add new diagnostic information in the management of febrile neutropenia.

关键词： Procalcitonin Febrile Neutropenia

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Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines

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Chinese Journal of Natural Medicines 2014年第12期12卷 881-894页

作者： Ravichandran Senthilkumar CHEN Bao-An CAI Xiao-Hui FU Rong department of Neoplastic Hematologic Disorders (Medical Science Key Subject of Jiangsu Province) Zhongda Hospital Schoool of Medicine Southeast University department of oncology School of Medicine Southeast University State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Carcinogenesis and Intervention China Pharmaceutical University

Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases. It occurs in cultured tumor cell lines, as well as in human cancers. Therefore, it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients. Plant-derived natural products have been used for the treatment of various diseases for thousands of years. This review summarizes the anticancer and multidrug-resistance reversing properties of the extracts and bioactive compounds from traditional medicinal plants in different leukemia cell lines. Further mechanistic studies will pave the road to establish the anticancer potential of plant-derived natural compounds.

关键词： Traditional medicinal plants Leukemia Multidrug resistance(MDR) Reversal multidrug resistance Apoptosis

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Clinical applications of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography in carcinoma of unknown primary

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Chinese Medical Journal 2011年第7期124卷 1010-1014页

作者： HU Man ZHAO Wei ZHANG Pin-liang JU Gui-fang FU Zheng ZHANG Guo-li KONG Li YANG Yan-qin MA Yi-dong YU Jin-ming department of Radiation oncology and Shandong Province Key Laboratory of Radiation oncology Shandong Cancer Hospital Shandong Academy of Medical Sciences Jinan Shandong 250117 China department of Nuclear Medicine Shandong Cancer Hospital Jinan Shandong 250117 China

Background Carcinoma of unknown primary （CUP） encompasses a heterogeneous group of tumors with varying clinical features. The management of patients of CUP remains a clinical challenge. The purpose of this study was to evaluate the clinical applications of integrated 18F-fluorodeoxyglucose positron emission tomography/computed tomography （FDG PET/CT） information in patients with CUP, including detecting the occult primary tumor and effecting on disease therapy.

关键词： carcinoma of unknown primary 18F-fluorodeoxyglucose positron emission tomography/computed tomography

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The Impact of Pretransplant Disease Characteristics on the Outcome of Autologous Stem Cell Transplantation for Neuroblastoma with High-Risk Features: A Retrospective Model from a Limited Resources Country

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Journal of Cancer Therapy 2019年第6期10卷 422-432页

作者： Ahmed Elhemaly Mahmoud Hammad Mohamed Saad Zaghloul Maged Elshafie Naglaa Elkinaae Mohamed Khaled Alaa El-Haddad department of Pediatric oncology National Cancer InstituteCairo UniversityCairoEgypt department of Pediatric oncology Children’s Cancer Hospital EgyptCairoEgypt department of Radiation oncology National Cancer InstituteCairo UniversityCairoEgypt department of Radiation oncology Children’s Cancer Hospital EgyptCairo UniversityCairoEgypt department of Surgical oncology National Cancer InstituteCairo UniversityCairoEgypt department of Surgical oncology Children’s Cancer Hospital EgyptCairoEgypt department of Pathology National Cancer InstituteCairo UniversityCairoEgypt department of Pathology Children’s Cancer Hospital EgyptCairoEgypt department of Research Children’s Cancer Hospital EgyptCairoEgypt

High-risk neuroblastoma still has poor survival outcome. Improvement of outcome is attributed to the consolidation of chemotherapy by autologous bone marrow transplant. Further improvement of the outcome by tandem autologous transplant is followed by immune therapy. We aimed with this study to correlate initial disease characteristics with the outcome of transplanted high-risk neuroblastoma. A retrospective analysis was done for 73 transplanted patients. Patients were treated in Children’s Cancer Hospital Egypt from July 2012 to July 2015. Seventy patients received Busulphan/Melphalan conditioning. The 3-year overall survival (OS) and event-free survival (EFS) was 63.3% and 51.3%, respectively. Disease stage did not impact the OS and EFS, P = 0.54 and 0.62 respectively. Status of MYCN did not reflect statistically on outcome for tumors with amplified compared to nonamplified (EFS, 49% and 63.1%, respectively). Response after induction chemotherapy pointed that patients who had objective response (complete response, very good partial response and partial response) were better compared to those with less response with EFS and OS of 53.3% and 64.2% compared to 49.3% and 63.5%, respectively, which may indicate that chemo-sensitive tumors have better outcome. By the end of the study, twenty-seven patients relapsed, out of them 25 patients died. Pretransplant risk features for neuroblastoma was nullified by autologous stem cell transplant. The modest outcome observed, highlights some limitations that need to be sorted out in countries with limited resources. The introduction of immune therapy and tandem transplant is needed to achieve a better outcome, yet it adds to more financial burden.

关键词： Neuroblastoma Limited-Resource Autologous Bone Marrow Transplant Busulphan Melphalan

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Effects of lighting conditions and accommodation on the three-dimensional position of Visian implantable collamer lens

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Eye and Vision 2024年第3期10卷 31-40页

作者： Lingling Niu Zhe Zhang Huamao Miao Jing Zhao Xiaoying Wang Ji C.He Xingtao Zhou department of Ophthalmology and Optometry Eye&ENT HospitalFudan UniversityShanghaiChina NHC Key Laboratory of Myopia(Fudan University) ShanghaiChina Key Laboratory of Myopia Chinese Academy of Medical SciencesShanghaiChina Shanghai Research Center of Ophthalmology and Optometry ShanghaiChina New England College of Optometry MABostonUSA

Background To investigate the effects of lighting conditions and accommodation on the three-dimensional position of Visian implantable collamer lens(ICL V4c).Methods This observational study recruited 62 eyes of 31 myopia patients underwent ICL V4c *** segment optical coherence tomography(AS-OCT)assessed the anterior chamber depth(ACD),ACD-ICL(distance from the corneal endothelium to anterior surface of the ICL V4c),vault(distance between the posterior ICL V4c surface and anterior crystalline lens surface),and crystalline lens tilt under various lighting conditions and accommodation relative to the corneal topographic axis at one year after ICL V4c *** was defined as the scotopic condition,which was also the non-accommodative stimulus *** ICL V4c tilt was analyzed using *** significance level was set at Pent(P=0.063).Crystalline lens under various lighting conditions and accommodation exhibited similar *** vertical tilt of ICL V4c was significantly larger under photopic conditions than the baseline(P=0.038).The horizontal and total tilts were significantly decreased during accommodation(P=0.043 and 0.013,respectively).Conclusions The axial position of ICL V4c in the anterior chamber was stable under various lighting *** conditions and accommodation may influence vertical,horizontal and total tilts of ICL V4c.

关键词： Implantable collamer lens Anterior segment optical coherence tomography Myopia Tilt

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Distribution and characteristics of telocytes as nurse cells in the architectural organization of engineered heart tissues

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Science China(Life Sciences) 2014年第2期57卷 241-247页

作者： ZHOU Jin WANG Yan ZHU Ping SUN HongYu MOU YongChao DUAN CuiMi YAO AnNing LV ShuangHong WANG ChangYong department of Advanced Interdisciplinary Studies Institute of Basic Medical Sciences and Tissue Engineering Research CenterAcademy of Military Medical Sciences The First department of Cardiology South Building The General Hospital of People's Liberation Army Laboratory of oncology Affiliated Hospital of Academy of Military Medical Sciences

Interstitial Cajal-like cells are a distinct type of interstitial cell with a wide distribution in mammalian organs and tissues,and have been given the name"telocytes".Recent studies have demonstrated the potential roles of telocytes in heart development,renewal,and ***,further research on the functions of telocytes is limited by the complicated in vivo *** study was designed to construct engineered heart tissue(EHT)as a three-dimensional model in vitro to better understand the role of telocytes in the architectural organization of the *** were constructed by seeding neonatal cardiomyocytes in collagen/Matrigel scaffolds followed by culture under persistent static *** in EHTs were identified by histology,toluidine blue staining,immunofluorescence,and transmission electron *** results from histology and toluidine blue staining demonstrated widespread putative telocytes with compact toluidine blue-stained nuclei,which were located around *** from the cell bodies showed a characteristic dichotomous branching pattern and formed networks in *** revealed positive staining of telocytes for CD34 and vimentin with typical moniliform prolongations.A series of electron microscopy images further showed that typical telocytes embraced the cardiomyocytes with their long prolongations and exhibited a marked appearance of nursing cardiomyocytes during the construction of *** finding highlights the great importance of telocytes in the architectural organization of *** also suggests that EHT is an appropriate physical and pathological model system in vitro to study the roles of telocytes during heart development and regeneration.

关键词： telocytes collagen/matrigel scaffolds engineered heart tissues reconstruction

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Clinical characteristics and prognosis of non-small cell lung cancer patients with liver metastasis:A population-based study

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World Journal of Clinical Cases 2022年第30期10卷 10882-10895页

作者： Jun-Feng Wang Hong-Di Lu Ying Wang Rui Zhang Xiang Li Sheng Wang The First department of Thoracic oncology Jilin Province Tumor HospitalChangchun 130021Jilin ProvinceChina Big Data Center for Clinical Research Jilin Province Tumor HospitalChangchun 130021Jilin ProvinceChina

BACKGROUND The presence of liver metastasis(LM) is an independent prognostic factor for shorter survival in non-small cell lung cancer(NSCLC) *** median overall survival of patients with involvement of the liver is less than 5 *** present,identifying prognostic factors and constructing survival prediction nomogram for NSCLC patients with LM(NSCLC-LM) are highly *** To build a forecasting model to predict the survival time of NSCLC-LM *** Data on NSCLC-LM patients were collected from the Surveillance,Epidemiology,and End Results database between 2010 and *** analysis was used to estimate the incidence trend of ***-Meier curves were constructed to assess survival *** regression was applied to select the independent prognostic predictors of cancer-specific survival(CSS).A nomogram was established and its prognostic performance was *** The age-adjusted incidence of NSCLC-LM increased from 22.7 per 1000000 in 2010to 25.2 in 2013,and then declined to 22.1 in *** to the multivariable Cox regression analysis of the training set,age,marital status,sex,race,histological type,T stage,metastatic pattern,and whether the patient received chemotherapy or not were identified as independent prognostic factors for CSS(P ent performance to predict the individual CSS of NSCLC-LM patients.

关键词： Non-small cell lung cancer Liver metastasis Nomogram Risk classification system

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Radiation therapy for patients with brain metastases from non-small cell lung cancer without driven gene mutation

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Chinese Medical Journal 2020年第19期133卷 2359-2361页

作者： Pei-Jie Li Jie Luo Guang-E Liu Da-Hai Liu Sha-Sha Shen Xin-Juan Li Hu Ma department of oncology The Second Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou 563000China.

Brain metastasis(BM)of lung cancer is not rare in the course of tumor *** overall survival(OS)of patients diagnosed with BM is only 3.6 months without *** rapid developments in treatment for BM,a median survival time(MST)of approximately 16 months could be achieved.[1]For patients with epidermal growth factor receptor mutations or anaplastic lymphoma kinase gene rearrangements,corresponding agents have been approved for *** patients without driven genes mutation,radiation therapy remains the standard regimen for BM.

关键词： patients lung cancer

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Primary prostate Burkitt's lymphoma resected with holmium laser enucleation of the prostate:A rare case report

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World Journal of Clinical Cases 2023年第18期11卷 4406-4411页

作者： Yu-Fan Wu Xiang Li Jun Ma Dan-Yu Ma Xue-Ming Zeng Qi-Wei Yu Wei-Guo Chen department of Urology Kunshan Hospital of Traditional Chinese MedicineKunshan 215300Jiangsu ProvinceChina department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina department of oncology The Third Affiliated Hospital of Soochow UniversitySuzhou 215300Jiangsu ProvinceChina

BACKGROUND Primary prostate Burkitt's lymphoma is a rare and aggressive condition with a poor *** clinical presentation can be challenging to differentiate from benign prostatic *** the rarity of primary prostate Burkitt's lymphoma,its diagnosis and treatment remain *** SUMMARY This report presents a case of a 57-year-old male with primary prostate Burkitt's lymphoma,initially misdiagnosed as prostatic *** case's operative process,intraoperative findings and postoperative management are discussed in *** Primary prostate lymphoma is difficult to distinguish from other prostate *** laser enucleation of the prostate(HoLEP),a minimally invasive procedure,is crucial in diagnosing and treating this rare *** should remain vigilant and thoroughly combine physical examination,imaging and test results when encountering patients of younger age with small prostate size but a rapid progression of lower urinary tract *** is an essential diagnostic and therapeutic tool in managing primary prostate Burkitt's lymphoma.

关键词： Primary prostate Burkitt's lymphoma Holmium Laser enucleation of the prostate Prostate hyperplasia Case report

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A Fatal Arterio-Tracheal Fistula Post-Tracheostomy: A Case Report in a Sub-Saharan Setting

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International Journal of Otolaryngology and Head & Neck Surgery 2022年第5期11卷 277-282页

作者： Yannick Mossus Douglas Banga Nkomo Serge Rowling’s Ngouatna Lutresse Thome Roger Christian Meva’a Biouélé Leonel Christophe Atanga Adèle-Rose Ngo Nyeki David Mindja Eko François Djomou Alexis Ndjolo ent Surgeon Department of Ophthalmology ENT and Stomatology Faculty of Medicine and Biomedical Sciences of University of Yaoundé Yaoundé Cameroon Thoracic Surgeon Department of Surgery and Specialties Faculty of Medicine and Pharmaceutical Sciences of University of Dschang Dschang Cameroon Anesthesiologist Resuscitator Department of Surgery and Specialties Faculty of Medicine and Biomedical Sciences of University of Yaoundé Yaoundé Cameroon

Fatal bleeding in patients with tracheostomy is an uncommon incident, in the order of 0.1% to 1% of cases. It is secondary in 70% of cases to the innominate artery fistula in the tracheal lumen. The fistula is generally created after the necrosis of tracheal rings. The incriminated factors are the type of cannula used, the site of tracheal opening below the 3rd tracheal ring, tracheal infections and the proximity of the innominate artery to the tracheal axis. The outcome of this incident is fatal in most cases. We report the case of a 59-year-old patient with a tracheostomy on the 11th day of his admission to intensive care for severe head trauma secondary to a road accident. On the 22nd day of his admission, the occurrence of a cataclysmic and fatal haemorrhage through the tracheostomy tube evoked an arterio-tracheal fistula of the innominate artery.

关键词： Arterio-Tracheal Fistula Innominate Artery Tracheostomy Sub-Saharan Setting Case Report

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