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High-Confidence Computing 2023年第2期3卷 71-82页

作者： Himani Tyagi Rajendra Kumar Santosh Kr Pandey department of Computer Science Jamia Millia IslamiaNew Delhi 110025India department of ec&it MeityNew Delhi 110003India

The Internet of Things is a modern technology that is directed at easing human life by automating most of the things used in daily *** never-ending dependency on the network for communication is attracting adversaries to exploit the vulnerabilities of ***,this technology is facing some serious issues and challenges concerning security and *** issues and challenges are the real motivation behind considering this ***,this survey includes a discussion about security and privacy challenges as well as available solutions for IoT based wireless sensor *** systematic literature review(SLR)focuses particularly on a popular and applicable security approach known as Trust Management System(TMS).Firstly,all aspects of trust management,including trust indicators,trust properties,trust evaluation,trust building,trust models and the importance of those models for security and privacy,trust prediction methodologies,and ultimately trust-based attacks,are covered in this ***,trust management schemes are classified into four groups based on the methodology used for trust-based security solutions in the IoT:cryptography-based,computational and probabilistic-based,information theory-based,and ***,an understanding of the problems and difficulties with current methodologies is given,along with suggestions for further ***,the SLR is concluded by formulating the desirable characteristics of a trust management system in the IoT and proposing a trust model suitable for IoT networks.

关键词： Trust Trust management approaches IoT Security Privacy Reliability Attacks Trust attributes Systematic literature review Cybersecurity

Risk factors for bleeding after endoscopic submucosal dissection for gastric lesions

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World Journal of Gastroenterology 2010年第23期16卷 2913-2917页

作者： Yosuke Tsuji Ken Ohata Takafumi Ito Hideyuki Chiba Tomohiko Ohya Toshiaki Gunji Nobuyuki Matsuhashi department of Gastroenterology Kanto Medical CenterNTT EC department of Endoscopy The Jikei University School of Medicine Center for Preventive Medicine Kanto Medical CenterNTT EC

AIM:To assess risk factors for bleeding after gastric endoscopic submucosal dissection(ESD) and to develop preventive ***:This retrospective study was performed in a tertiary referral center.A total of 328 patients underwent ESD for 398 gastric neoplasms between July 2007 and June *** main outcome was association between post-ESD bleeding and the following:age;sex;comorbidities;daily use of medicine potentially related to gastric injury/bleeding;location,size,and histological depth of lesions;ulceration;experience of operator coagulating the ulcer floor,and duration of *** also determined the relationship between the location of post-ESD bleeding and risk factors for ***:Univariate analysis revealed significant risk factors:tumor location [odds ratio(OR),2.86;95% CI:1.21-6.79,P=0.024],coagulator experience(OR,4.29;95% CI:1.43-12.86,P=0.009),and medicine potentially related to gastric injury/bleeding(OR,2.80;95% CI:1.14-6.90,P=0.039).Multivariate logistic regression analysis confirmed significant,independent risk factors:tumor in lower third of stomach(OR,2.47;95% CI:1.02-5.96,P=0.044),beginner coagulator(OR,3.93;95% CI:1.29-11.9,P=0.016),and medicine(OR,2.76;95% CI:1.09-6.98,P=0.032).We classif ied cases of post-ESD bleeding into two groups(bleeding at the ulcer margin vs bleeding at the center) and found that bleeding at the margin occurred more frequently with beginner coagulators compared with experts(OR,16.00;95% CI:1.22-210.59,P=0.040).CONCLUSION:Beginner coagulators,tumor in the antrum,and medicines were significant risk factors for post-ESD *** at the ulcer margin frequently occurred with beginner operators.

关键词： Bleeding Endoscopic submucosal dissection Ulcer floor Anti-thrombotic drugs Coagulation

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.Lee Ryota L.Matsuoka department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(ec)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ecs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Impact of wind power generating system integration on frequency stabilization in multi-area power system with fuzzy logic controller in deregulated environment

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Frontiers in Energy 2015年第1期9卷 7-21页

作者： Y. K. BHATESHVAR H. D. MATHUR H. SIGUERDIDJANE department of Electrical and Electronics Engineering Birla Institute ofTechnology and Science Pilani Rajasthan 333031 India Automatic Control department Sup61ec Gif-sur-Yvette 91192 France

Among the available options for renewable energy integration in existing power system, wind power is being considered as one of the suited options for future electrical power generation. The major constraint of wind power generating system （WPGS） is that it does not provide inertial support because of power electronic converters between the grid and the WPGS to facilitate frequency stabilization. The proposed control strategy suggests a substantial contribution to system inertia in terms of short-term active power support in a two area restructured power system. The control scheme uses fuzzy logic based design and takes frequency deviation as input to provide quick active power support, which balances the drop in frequency and tie-line power during transient conditions. This paper presents a comprehensive study of the wind power impact with increasing wind power penetration on frequency stabilization in restructured power system scenario. Variation of load conditions are also analyzed in simulation studies for the same power system model with the proposed control scheme. Simula- tion results advocates the justification of control scheme over other schemes.

关键词： two area power system automatic generationcontrol wind power generating system (WPGS) deregu-lated environment fuzzy logic controller (FLC)

Balloon overtube-guided colorectal endoscopic submucosal dissection

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World Journal of Gastroenterology 2009年第48期15卷 6086-6090页

作者： Tomohiko Ohya Ken Ohata Kazuki Sumiyama Yousuke Tsuji Ikuro Koba Nobuyuki Matsuhashi Hisao Tajiri department of Endoscopy The Jikei University School of Medicine Division of Gastroenterology Kanto Medical Center NTT EC Division of Gastroenterology and Hepatology Yamaga Chou Hospital department of Endoscopy Department of Gastroenterology and HepatologyThe Jikei University School of Medicine

AIM:To evaluate the usefulness of a balloon overtube to assist colorectal endoscopic submucosal dissection(ESD)using a ***:The results of 45 consecutive patients who underwent colorectal ESD were analyzed in a single tertiary endoscopy *** preoperative evaluation of access to the lesion,difficulties were experienced in the positioning and stabilization of a gastroscope in 15 patients who were thus assigned to the balloonguided ESD group.A balloon overtube was placed with a gastroscope to provide an endoscopic channel to the lesion in cases with preoperatively identified difficulties related to *** ESD was performed following standard procedures.A submucosal fluid bleb was created with hyaluronic acid solution.A circumferential mucosal incision was made to marginate the *** isolated lesion was finally excised from the deeper layers with repetitive electrosurgical dissections with needle *** success of colorectal ESD,procedural feasibility,and procedure-related complications were the main outcomes and ***:The overall en bloc excision rate of colorectal ESD during this study at our institution was 95.6%.En bloc excision of the lesion was successfully achieved in 13 of the 15 patients(86.7%)in the balloon overtube-guided colorectal ESD group,which was comparable to the results of the standard ESD group with better accessibility to the lesion(30/30,100%,not statistically significant).CONCLUSION:Use of a balloon overtube can improve access to the lesion and facilitate scope manipulation for colorectal ESD.

关键词： Balloon overtube Colorectal neoplasm Early colorectal cancer En bloc tumor excision Endoscopic submucosal dissection Laterally spreading tumor

Evaluation of the mechanisms of damage to flexible ureteroscopes and suggestions for ureteroscope preservation

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Asian Journal of Andrology 2005年第4期7卷 433-438,页

作者： P.Sooriakumaran R.Kaba H.O.Andrews N.P.N.Buchholz department of Urology Royal Surrey County HospitalGuildfordGU2 7XXUK department of Urology St Bartholomew's HospitalLondon EC1A 7BEUK

Aim： To investigate the causes and costs of flexible ureteroscope damage, and to develop recommendations to limit damage. Methods： The authors analysed repair figures and possible causes of damage to 35 instruments sent for repair to a leading UK supplier over a 1-year period, and calculated cost figures for maintenance of the instruments as opposed to repair and replacement costs. Results： All damages were handling-induced and therefore did not fall under the manufacturer＇s warranty： 28 % were damaged by misfiring of the laser inside the instrument; 72 %, mainly crushing and stripping of the ureteroscope shaft tube, were likely to have occurred during out-of-surgery handling, washing and disinfection. Seventeen （4 %） instruments were not repaired and consequently taken out of service due to the extensive costs involved. Eighteen （51%） ureteroscopes were repaired at an average cost of 10 833 USD. Conclusion： Damages to flexible ureteroscopes bear considerable costs. Most damages occur during handling between surgical procedures. Thorough adherence to handling procedures, and courses for theater staff and surgeons on handling flexible instruments may help to reduce these damages and prove a cost-saving investment. The authors provide a list of recommended procedural measures that may help to prevent such damages.

关键词： ureteroscopes manufacturer's assessment durability instrument handling

Review of the dynamic stiffness method for free-vibration analysis of beams

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Transportation Safety and Environment 2019年第2期1卷 106-116页

作者： J.R.Banerjee department of Mechanical Engineering and Aeronautics School of MathematicsComputer Science and EngineeringCityUniversity of LondonLondonEC1V 0HBUnited Kingdom

The application of the dynamic stiffness method(DSM)for free-vibration analysis of beams is surveyed in this *** historical development of the DSM,which has taken place in several stages,is discussed in detail with reference to the free-vibration problems of *** particular,the suitability of the DSM in solving the free-vibration problems of beams through the application of the well-known Wittrick–Williams algorithm as a solution technique is *** literature concerning homogeneous isotropic metallic beams,for which the DSM is well established,is reviewed first,after which,with the rapid and ongoing emergence of advanced composite materials,the development of the DSM in solving the free-vibration problems of anisotropic beams is *** free-vibration analysis of functionally graded beams using the DSM is also *** survey covers the DSM application for free-vibration analysis of a wide range of beams,including sandwich beams,rotating beams,twisted beams,moving beams and bending-torsion coupled beams,amongst *** aspects of the contributions made by the author and his research team are also ***,the future potential of the DSM in solving complex engineering problems is projected.

关键词： dynamic stiffness method Wittrick-Williams algorithm free-vibration analysis

Modeling the impact of climate change on sediment transport and morphology in coupled watershed-coast systems:A case study using an integrated approach

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International Journal of Sediment Research 2014年第3期29卷 304-315页

作者： Achilleas G.SAMARAS Christopher G KOUTITAS Research Fellow CIRI-ECFluid Dynamics Research UnitUniversity of BolognaVia del Lazzaretto 15/5Bologna 40131Italy department of Civil Engineering Aristotle University of ThessalonikiUniversity Campus

Climate change is an issue of major concern *** impact on the natural and human environment is studied intensively,as the expected shift in climate will be significant in the next few *** experience shows that the effects will be critical in coastal areas,resulting in erosion and inundation phenomena *** addition to that,coastal areas are subject to "pressures" from upstream watersheds in terms of water quality and sediment *** present paper studies the impact of climate change on sediment transport and morphology in the aforementioned coupled *** study regards a sandy coast and its upstream watershed in Chalkidiki,North Greece;it is based on:(a)an integrated approach for the quantitative correlation of the two through numerical modeling,developed by the authors,and(b)a calibrated application of the relevant models Soil and Water Assessment Tool(SWAT)and PELNCON-M,applied to the watershed and the coastal zone,*** examined climate change scenarios focus on a shift of the rainfall distribution towards fewer and more extreme rainfall events,and an increased frequency of occurrence of extreme wave *** indicate the significance of climatic pressures in wide-scale sediment dynamics,and are deemed to provide a useful perspective for researchers and policy planners involved in the study of coastal morphology evolution in a changing climate.

关键词： Climate change Sediment transport Coastal morphology Integrated approach Numerical modeling

Cyberattack Ramifications, The Hidden Cost of a Security Breach

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Journal of Information Security 2024年第2期15卷 87-105页

作者： Meysam Tahmasebi department of Cybersecurity EC-Council University Albuquerque USA

In this in-depth exploration, I delve into the complex implications and costs of cybersecurity breaches. Venturing beyond just the immediate repercussions, the research unearths both the overt and concealed long-term consequences that businesses encounter. This study integrates findings from various research, including quantitative reports, drawing upon real-world incidents faced by both small and large enterprises. This investigation emphasizes the profound intangible costs, such as trade name devaluation and potential damage to brand reputation, which can persist long after the breach. By collating insights from industry experts and a myriad of research, the study provides a comprehensive perspective on the profound, multi-dimensional impacts of cybersecurity incidents. The overarching aim is to underscore the often-underestimated scope and depth of these breaches, emphasizing the entire timeline post-incident and the urgent need for fortified preventative and reactive measures in the digital domain.

关键词： Artificial Intelligence (AI) Business Continuity Case Studies Copyright Cost-Benefit Analysis Credit Rating Cyberwarfare Cybersecurity Breaches Data Breaches Denial Of Service (DOS) Devaluation Of Trade Name Disaster Recovery Distributed Denial of Service (DDOS) Identity Theft Increased Cost to Raise Debt Insurance Premium Intellectual Property Operational Disruption Patent Post-Breach Customer Protection Recovery Point Objective (RPO) Recovery Time Objective (RTO) Regulatory Compliance Risk Assessment Service Level Agreement Stuxnet Trade Secret

The role of modern immunotherapy in metastatic urothelial cancer:mini review

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 150-159页

作者： Francesca Jackson-Spence Charlotte Toms Yu-Hsuen Yang Leo Jurascheck Julia Choy Lucy Flanders Bernadett Szabados Thomas Powles Barts Cancer Institute Queen Mary University of LondonLondon EC1M 6BQUK department of Medical Oncology St Bartholomew’s HospitalBarts Health NHS TrustLondon EC1A 7BEUK

The approval of immune checkpoint inhibitors(ICIs)has changed the treatment landscape in many aspects of urothelial cancer(UC),in both non-muscle-invasive bladder cancer and muscle-invasive bladder cancer and has introduced the concept of long-term remission for some patients in the metastatic ***-line chemotherapy remains superior at achieving initial control of disease compared to front-line immune ***,long-term durable responses are limited by chemotherapy *** maintenance approach,sequencing chemotherapy with ICIs,could be considered a best of both worlds approach,achieving initial control with chemotherapy,which is maintained in some individuals with ***,outcomes for patients with metastatic UC remain *** are three steps to improving outcomes for these patients;the first is to develop better drugs and combinations of therapies,the second is the development of novel biomarkers and techniques to better select patients for treatment,and the third area of development is to give the drugs in the most optimal setting.

关键词： Metastatic urothelial cancer bladder cancer immune therapy immune checkpoint inhibitors biomarkers