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World Journal of Gastrointestinal Surgery 2022年第4期14卷 304-314页

作者： Qi-Ying Song Xiong-Guang Li Li-Yu Zhang Di Wu Shuo Li Ben-Long Zhang Zi-Yao Xu Ri-Li-Ge Wu Xin Guo Xin-Xin Wang Medical School of Chinese People’s Liberation Army Chinese People’s Liberation Army General HospitalBeijing 100853China School of Medicine Nankai UniversityTianjin 300071China Medical Big Data Research Center Chinese PLA General HospitalBeijing 100853China Air Force Medical University Xijing Hospital Xi’an 710000Shaanxi ProvinceChina department of General Surgery Chinese People’s Liberation Army General HospitalBeijing 100853China

BACKGROUND The studies of laparoscopic-assisted transhiatal gastrectomy(LTG) in patients with Siewert type Ⅱ adenocarcinoma of the esophagogastric junction(AEG) are *** To compare the surgical efficiency of LTG with the open transhiatal gastrectomy(OTG) for patients with Siewert type Ⅱ *** We retrospectively evaluated a total of 578 patients with Siewert type Ⅱ AEG who have undergone LTG or OTG at the First Medical Center of the Chinese People’s Liberation Army General Hospital from January 2014 to December 2019. The short-term and long-term outcomes were compared between the LTG(n = 382) and OTG(n = 196) *** Compared with the OTG group, the LTG group had a longer operative time but less blood loss, shorter length of abdominal incision and an increased number of harvested lymph nodes(P oncology safety. In addition, patients with advanced stage AEG may benefit more from LTG in the long-term outcomes.

关键词： Adenocarcinoma of the esophagogastric junction Siewert type II Laparoscopic-assisted transhiatal gastrectomy Open transhiatal gastrectomy

Pulmonary hamartoma:a clinic-pathologic study of 206 consecutive cases focusing on different histologic variants

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中华胸部外科电子杂志 2022年第3期9卷 133-139页

作者： Laura Melocchi Alberto Cavazza Maria Sirolli Elisa Albertini Sofia Melotti Tommaso Bizzarro Arianna Oberti Fabio Davoli Giulio Rossi Pathology Unit Department of OncologyFondazione Poliambulanza Hospital InstituteBresciaItaly Pathology Unit Azienda USL/IRCCS di Reggio EmiliaReggio EmiliaItaly Pathology Unit Santa Maria delle Croci Teaching HospitalAzienda USL of RomagnaRavennaItaly Resident of the School of Specialization in Anatomic Pathology“A.M.Mancini” University of BolognaBolognaItaly Operative Unit of Pathologic Anatomy Azienda USL of RomagnaInfermi HospitalRiminiItaly Specialty School of Pathologic Anatomy University of BresciaBresciaItaly General and Thoracic Surgery Unit IRCCS Istituto Ortopedico RizzoliBolognaItaly department of Thoracic Surgery Azienda USL of RomagnaSanta Maria delle Croci Teaching HospitalRavennaItaly

Background:Pulmonary hamartoma(PH)is the most common benign pulmonary tumor usually presenting as a solitary,well-demarcated nodule composed of mature cartilage and adipose *** unusual histologic variants are challenging on clinic-radiologic and pathologic ***:We collected a multicentric,retrospective,consecutive series of 206 PH with clinical characteristics and histologic ***:Clinical data were in line with the literature demonstrating a male prevalence(2:1)and a median age of 61.6 *** median size of the nodule was 17.8 *** performed,SUVmax>2.5 at FDC-PET was evidenced in 4%of cases(5 out of 119)and was significantly associated with undifferentiated/myxoid *** histology showing chondroid or chondro-lipomatous PH was quoted in 186 cases(90%),while leiomyomatous and undifferentiated/myxoid variants were recorded in 20 cases(10%).The high rate of unusual variants on pathology is possibly related to a selection bias due to external consultations or surgical excision of the lesions lacking classic features at imaging ***:About 10% of PH may show unusual histology and SUVmax>2.5 at FDC-PET in 4%.These uncommon findings may challenge the correct recognition,raising some concerns in terms of differential diagnosis with several other mesenchymal tumors in the *** features should be kept in mind to achieve a correct diagnosis and avoid unnecessary invasive treatments.

关键词： Hamartoma lung WHO histology immunohistochemistry incidence imaging

Update in mortality in GH-treated patients

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中国神经肿瘤杂志 2013年第4期11卷 258-258页

作者： Erfurth EM department of Endocrinology Sk?ne University Hospital

During GH therapy for 2.3-9.6 years,male adult-onset GH-deficient patients with a diagnosis of a nonfunctioning adenoma have no increased all-cause ***,women with adult-onset GH deficiency(GHD)are still at slightly higher *** general improvement in mortality is due to a more contemporary regimen of cardiovascular drugs,a refinement of surgical procedures,besides the introduction of GH therapy improved hormone replacement regimens with lowered glucocorticoid replacement,updated approaches of sex steroids for women,and less use of cranial *** underlying disease is the most important predictor for mortality:eg,a craniopharyngioma,malignant causes of hypopituitarism,previous Cushing's disease,and the presence of diabetes insipidus/

关键词： GH Update in mortality in GH-treated patients

Giant Pituitary Adenomas:surgical Outcomes of 50 Cases Operated on by the Endonasal Endoscopic Approach

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中国神经肿瘤杂志 2013年第4期11卷 229-229页

作者： Gondim JA Almeida JP Albuquerque LA Gomes EF Schops M department of Neurosurgery Hospital Geral de Fortaleza

OBJECTIVE:To present our experience with the surgical management of giant pituitary adenomas in a series of 50 cases operated on by an endoscopic endonasal ***:A retrospective data analysis of all patients who underwent transsphenoidal endonasal endoscopic surgery at the General Hospital of Fortaleza,Brazil,between January 1998 and November 2011was *** who presented with pituitary adenomas larger than 4 cm were included in the *** of factors related 1o the choice of the operative approach,hormonal and visual status,extent of resection,tumor control rates,clinical outcome,and complications were ***:Fifty cases(10.41%)matched our inclusion *** tumors were present in 42 patients(84%);among functioning adenomas,five patients(10%)had growth hormone-secreting adenomas,and three patients(6%)had *** removal of the tumor occurred in 19 cases(38%),near-total removal in 9 cases(18%),and partial removal in 22 cases(44%).Postoperative cerebrospinal fluid leaks occurred in four cases(8%).Postoperative diabetes insipidus was present in 10%and new anterior pituitary insufficiency affecting one axis or more than one axis was observed in 22%and 14%,*** presence of Knosp score≥3 was associated with subtotal *** harboring hormonally active adenomas were submitted to adjuvant medical therapy fur long-term clinical *** improved in 38 patients(76%),with only one case of visual deterioration ***:Transsphenoidal endoscopic endonasal surgery may provide effective treatment for patients with giant adenomas when performed by a surgical team that specializes in pituitary *** cases in which total resectiun by the endoscopic approach may be associated with important complications,we advocate the use of partial resections followed by adjuvant drug therapy or *** cases of progressive enlargement of residual lesions,a second endoscopic deb

关键词：手术治疗垂体腺瘤视镜鼻巨型数据分析内镜患者

在有并发症和无并发症的胆结石患者中疼痛的发作存在特定的模式且多数患者伴有消化不良:一项前瞻性研究结果

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世界核心医学期刊文摘（胃肠病学分册） 2006年第6期2卷 57-58页

作者： Berhane T. Vetrhus M. Hausken T. 赵菊辉(译) 陈云茹(校) department of Surgery Rogaland Central Hospital P.O.B. 8100 NO-4068 Stavanger Norway 不详

Objective. The cardinal indication for surgical treatment of gallstones is pain attacks. However, following cholecystectomy, 20%of patients remain symptomatic. It is unclear to what extent post-cholecystectomy symptoms can be ascribed to persistence of preoperative symptoms or to new pathology. The pain and digestive pattern in gallstone patients has not been defined in a recent setting with ultrasonography as the diagnostic method. The aim of this study was to characterize a pain pattern that is typical for gallstone disease and to describe the extent of associated dyspepsia. Material and methods. A total of 220 patients with symptomatic gallstone disease including complicated disease (acute cholecystitis and common bile duct stones) were interviewed using detailed questionnaires to disclose pain patterns and symptoms of indigestion. Results. All patients had pain in the right upper quadrant (RUQ) including the upper midline epigastrium. The pain was localized to the right subcostal area in 20%and to the upper epigastrium in 14%, and in the rest (66%) it was more evenly distributed. An area of maximal pain could be defined in 90%. Maximal pain was located under the costal arch in 51%of patients and in the epigastrium in 41%, but in 3%behind the sternum and in 5%in the back. The pain was referred to the back in 63%of the patients. The mean visual analogue scale (VAS) score was very high: 90 mm on a 0-100 scale. A pattern of incipient or low-grade warning pain with a subsequent relatively steady state until subsiding in the same fashion was present in 90%of the patients. An urge to walk around was experienced by 71%. Pain attacks usually occurred in the late evening or at night (77%), with 85%of the attacks lasting for more than one hour and almost never less than half an hour. Sixty-six percent of the patients were intolerant to at least one kind of food, but only 48%to fatty foods. Symptoms of functional indigestion (gastroesophageal reflux, dyspepsia or irritable

关键词：胆结石患者疼痛模式消化不良并发症前瞻性研究不良症状胆囊切除术后胆囊切除后胆总管结石

信迪利单抗对比安慰剂联合化疗用于局部晚期或转移性食管鳞癌的一线治疗(ORIENT-15):一项多中心、随机、双盲、Ⅲ期临床研究

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英国医学杂志中文版 2022年第8期25卷 431-443页

作者：鲁智豪王军业束永前刘连科孔莉杨磊汪步海孙国贵姬颖华曹国春刘虎崔同建李娜邱文生李高峰侯新芳罗辉薛丽英张艳桥岳文彬刘峥王秀问高社干潘跃银 Marie-Pierre Galais Aziz Zaanan 马卓李昊宇王岩沈琳 ORIENT-研究团队北京大学肿瘤医院胃肠肿瘤科济宁医学院附属医院肿瘤科南京医科大学第一附属医院肿瘤内科山东省肿瘤防治研究院(山东第一医科大学和山东省医学科学院)、特需病房南通市肿瘤医院肿瘤内科苏北人民医院(扬州大学附属医院)肿瘤内科唐山市人民医院放化科新乡医学院第一附属医院肿瘤内科江苏省肿瘤医院(南京医科大学)肿瘤科安徽省肿瘤医院(中国科学技术大学)肿瘤内科福建省立医院肿瘤科遂宁市中心医院肿瘤内科青岛大学附属医院肿瘤内科云南省肿瘤医院胸外科二病区河南省肿瘤医院肿瘤内科江西省肿瘤医院胸部肿瘤放疗科二病区内蒙古自治区人民医院肿瘤内科哈尔滨医科大学附属肿瘤医院消化肿瘤科二病区濮阳市油田总医院肿瘤内科邯郸市中心医院肿瘤内科三病区山东大学齐鲁医院肿瘤科河南科技大学第一附属医院肿瘤科安徽省立医院肿瘤化疗科 department of Medical oncology Centre François BaclesseCaenFrance department of Gastroenterology and digestive oncology Hôpital Européen Georges PompidouParisFrance 信达生物制药有限公司肿瘤学医学科学与策略部信达生物制药有限公司统计部北京大学肿瘤医院恶性肿瘤发病机制及转化研究教育部重点实验室不详

目的评价信迪利单抗对比安慰剂联合化疗(顺铂加紫杉醇或顺铂加5-氟尿嘧啶)作为不可切除的局部晚期、复发或转移性食管鳞癌一线治疗的效果。设计多中心、随机、双盲、Ⅲ期临床研究。背景2018年12月14日至2021年4月9日,国内66家研究中心,... 详细信息

目的评价信迪利单抗对比安慰剂联合化疗(顺铂加紫杉醇或顺铂加5-氟尿嘧啶)作为不可切除的局部晚期、复发或转移性食管鳞癌一线治疗的效果。设计多中心、随机、双盲、Ⅲ期临床研究。背景2018年12月14日至2021年4月9日,国内66家研究中心,国外13家研究中心。受试者659例未曾接受过系统性治疗的成年(≥18岁)晚期或转移性食管鳞癌患者。干预受试者按1∶1的比例随机分组,每3周接受1次信迪利单抗或安慰剂(体重60 kg者200 mg)与顺铂75 mg/m2和紫杉醇175 mg/m2的联合治疗。本研究经修订,允许研究者选择顺铂联合紫杉醇或顺铂联合5-氟尿嘧啶(800 mg/m2,第1~5天连续输注给药)化疗方案。主要结局指标所有患者和程序性细胞死亡配体1(PD-L1)表达联合阳性评分≥10的患者总生存期。结果659例患者随机分配至信迪利单抗(n=327)或安慰剂(n=332)联合化疗组。659例患者中有616例(93%)接受了信迪利单抗或安慰剂与顺铂和紫杉醇联合治疗,有43例(7%)接受了信迪利单抗或安慰剂与顺铂和5-氟尿嘧啶联合治疗。期中分析显示,在所有患者(中位总生存期16.7 vs 12.5个月,风险比0.63,95%可信区间0.51~0.78;P<0.001)和联合阳性评分≥10的患者(17.2 vs 13.6个月,0.64,0.48~0.85;P=0.002)中,信迪利单抗联合化疗组的总生存期均优于安慰剂联合化疗组。与安慰剂联合化疗相比,信迪利单抗联合化疗显著延长了所有患者(7.2 vs 5.7个月,0.56,0.46~0.68;P<0.001)和联合阳性评分≥10患者(8.3 vs 6.4个月,0.58,0.45~0.75;P<0.001)的无进展生存期。信迪利单抗联合化疗组出现治疗相关不良事件的患者人数为321/327例(98%),安慰剂联合化疗组为326/332例(98%)。在信迪利单抗联合化疗组和安慰剂联合化疗组中,3级及以上治疗相关不良事件的发生率分别为60%(196/327)和55%(181/332)。结论与安慰剂相比,信迪利单抗联合顺铂加紫杉醇作为一线治疗显著改善了晚期或转移性食管鳞癌患者的总生存期和无进展生存期。信迪利单抗联合顺铂加5-氟尿嘧啶也显示出类似的获益。临床试验注册*** NCT03748134。

关键词：联合化疗安慰剂顺铂联合一线治疗临床试验注册食管鳞癌程序性细胞死亡可信区间

Natural orifice transluminal endoscopic surgery:The transvaginal route moving forward from cholecystectomy

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World Journal of Gastrointestinal Surgery 2010年第6期2卷 179-186页

作者： Eduardo M Targarona Edgar Mauricio Maldonado Jose Antonio Marzol Franco Marinello department of Surgery Hospital SantpauAutonomous University of Barcelona

The advent of minimally invasive surgery and the advances in endoluminal flexible endoscopy have converged to generate a new concept in digestive surgery,whose acronym natural orifice transluminal endoscopic surgery(NOTES),has become a familiar term in the surgical *** has been performed through the mouth,the bladder,the rectum and the *** these four approaches,the vagina has gained most popularity for several *** is not only readily accessible and easy to decontaminate but it also provides safe entry and simple *** transvaginal approach has been described in the experimental and the clinical setting as an option for cholecystectomy,nephrectomy,splenectomy,segmental gastrectomy,retroperitoneal exploration and bariatric ***,larger series are needed to delineate the exact risks of this approach,and to transcend cultural barriers that impede its wider *** randomized trials will shed light on the definitive role of the vaginal approach in minimal invasive surgery of the future.

关键词： Transvaginal approach Cholecystectomy Nephrectomy Splenectomy Segmental gastrectomy Retroperitoneal exploration Natural orifice transluminal endoscopic surgery Bariatric surgery

Intramedullary spinal cord metastases of malignant melanoma： an autopsy case report and review of the literature

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中国神经肿瘤杂志 2010年第3期8卷 202-202页

作者： Ishii T Terao T Kombze K A be T. department of Neurosurgery Atsugi City Hospital Japan.

Resection of the primary tumor in stage Ⅳ breast cancer

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World Journal of Clinical oncology 2014年第2期5卷 82-85页

作者： Tadahiko Shien Hiroyoshi Doihara department of Breast and Endocrine Surgery Okayama University Hospital

Stage Ⅳ breast cancer refers to breast cancer that has already metastasized to distant regions when initially diagnosed. Treatment for stage Ⅳ is intended to "prolong survival and palliate symptoms". Resection of a primary tumor is considered to be "effective only at alleviating chest symptoms and providing local control" in spite of the advances of imaging examination and medication for breast cancer. Molecular target and endocrine drugs are very effective and useful to tailor-make a treatment strategy according to breast cancer subtypes. Positron emission tomography-computed tomography can detect and diagnose the very small metastases and recurrences which can potentially be cured even if they are distant metastases. Recently, many retrospective studies have reported the survival benefit of surgery for breast cancer patients with metastases and some clinical trials which confirm the surgical prognostic benefit for them have started to enrol patients. The goal of treatment has to be clearly identified:increase the patient's survival time, provide local control or perform histology to determine the cancer's properties. The best evidence is absolutely essential to treat patients who need surgery at the right time. We need to evaluate the treatment strategy, including primary resection for stage Ⅳ breastcancer particularly, and find new evidence by prospective analysis.

关键词： Breast cancer Metastasis Surgery Survival StageⅣ Clinical trial

探討基質金屬蛋白酶於惡性神經膠質瘤之研究(英文)

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探討基質金屬蛋白酶於惡性神經膠質瘤之研究(英文)