检索结果-南通市图书馆

Neural Regeneration Research 2015年第12期10卷 2004-2010页

作者： Bei Zhang Qiang He Ying-ying Li Ce Li Yu-long Bai Yong-shan Hu Feng Zhang department of rehabilitation Medicine Huashan HospitalFudan University State Key Laboratory of Medical Neurobiology Fudan University department of rehabilitation the Third Hospital of Hebei Medical University

motor function impairment is a common outcome of ***-induced movement therapy（CIMT）involving intensive use of the impaired limb while restraining the unaffected limb is widely used to overcome the effects of＇learned non-use＇and improve limb function after ***,the underlying mechanism of CIMT remains *** the present study,rats were randomly divided into a middle cerebral artery occlusion（model）group,a CIMT＋model（CIMT）group,or a sham *** of the affected limb by plaster cast was performed in the CIMT and sham *** with the model group,CIMT significantly improved the forelimb functional performance in *** western blot assay,the expression of phosphorylated extracellular regulated protein kinase in the bilateral cortex and hippocampi of cerebral ischemic rats in the CIMT group was significantly lower than that in the model group,and was similar to sham group *** data suggest that functional recovery after CIMT may be related to decreased expression of phosphorylated extracellular regulated protein kinase in the bilateral cortex and hippocampi.

关键词： nerve regeneration constraint-induced movement therapy mitogen-activated proteinkinase signaling system brain ischemia locomotion recovery cortex hippocampus middle cerebralartery occlusion foot fault test balance beam walking rats NSFC grants neural regeneration

Different types of drug abusers prefrontal cortex activation patterns and based on machine-learning classification

在线全文

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2022年第2期15卷 83-92页

作者： Banghua Yang Xuelin Gu Shouwei Gao Lin Feng Yan Ding Xu Wen Wang School of Mechanical and Electrical Engineering and Automation Shanghai University Shanghai 200444P.R.China Shanghai Drug rehabilitation Administration Bureau Shanghai 200080 P.R.China department of Radiology&functional and Molecular Imaging Key Lab of Shaanxi Province Tangdu Hospital Fourth Military Medical University Xi'anShaanxi 710038P.R.China Engineering Research Center of Traditional Chinese Medicine Intelligent rehabilitation Ministry of Education ShanghaiP.R.China Shanghai Intelligent Engineering Technology Research Center for Addiction and rehabilitation Minhang District 200240 ShanghaiP.R.China

Drug addiction can cause abnormal brain activation changes,which are the root cause of drug craving and brain function *** study enrolled drug abusers to determine the effects of different drugs on brain activation.A functional near-infrared spectroscopy(fNIRS)device was used for the *** study was designed with an experimental paradigm that included the induction of resting and drug addiction *** collected the fNIRS data of 30 drug users,including 10 who used heroin,10 who used Methamphetamine,and 10 who used mixed ***,using Statistical Analysis,the study analyzed the activations of eight functional areas of the left and right hemispheres of the prefrontal cortex of drug addicts who respectively used heroin,Methamphetamine,and mixed drugs,including Left/Right-Dorsolateral prefrontal cortex(L/R-DLPFC),Left/Right-Ventrolateral prefrontal cortex(L/R-VLPFC),Left/Right-Fronto-polar prefrontal cortex(L/R-FPC),and Left/Right Orbitofrontal Cortex(L/R-OFC).Second,referencing the degrees of activation of oxyhaemoglobin concentration(HbO2),the study made an analysis and got the specific activation patterns of each group of the ***,after taking out data which are related to the addicts who recorded high degrees of activation among the three groups of addicts,and which had the same channel numbers,the paper classified the different drug abusers using the data as the input data for Convolutional Neural Networks(CNNs).The average three-class accuracy is 67.13%.It is of great significance for the analysis of brain function errors and personalized rehabilitation.

关键词： Drug addiction fNIRS machine-learning di®erent drug users brain regions activation

Heat shock factor 1 promotes neurite outgrowth and suppresses inflammation in the severed spinal cord of geckos

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第9期18卷 2011-2018页

作者： Bing-Qiang He Ai-Cheng Li Yu-Xuan Hou Hui Li Xing-Yuan Zhang Hui-Fei Hao Hong-Hua Song Ri-Xin Cai Ying-Jie Wang Yue Zhou Yong-Jun Wang Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationMedical School of Nantong UniversityNantongJiangsu ProvinceChina department of rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

The low intrinsic growth capacity of neurons and an injury-induced inhibitory milieu are major contributo rs to the failure of sensory and motor functional recovery following spinal cord *** shock transcription factor 1(HSF1),a master regulator of the heat shock response,plays neurogenetic and neuroprotective roles in the damaged or diseased central nervous ***,the underlying mechanism has not been fully *** the present study,we used a gecko model of spontaneous nerve regeneration to investigate the potential roles of gecko HSF1(gHSF1) in the regulation of neurite outgrowth and inflammatory inhibition of macrophages following spinal cord ***1 expression in neurons and microglia at the lesion site increased dramatically immediately after tail ***1 ove rexpression in gecko primary neuro ns significantly promoted axonal growth by suppressing the expression of suppressor of cytokine signaling-3,and fa cilitated neuro nal survival via activation of the mitogen-activated extracellular signal-regulated kinase/extracellular regulated protein kinases and phosphatidylinositol 3-kinase/protein kinase B ***,gHSF1 efficiently inhibited the macrophagemediated inflammatory response by inactivating 1kappa B-alpha/NF-kappaB *** findings show that HSF1 plays dual roles in promoting axonal regrowth and inhibiting leukocyte inflammation,and provide new avenues of investigation for promoting spinal co rd injury repair in mammals.

关键词： apoptosis gecko heat shock factor 1 inflammation neuron regeneration spinal cord suppressor of cytokine signaling-3

Medial reorganization of motor function in corona radiata following middle cerebral artery infarction A case report

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2009年第9期4卷 668-671页

作者： Sung Ho Jang department of Physical Medicine & rehabilitation Yeungnam University College of Medicine

Peri-lesional reorganization is one of the motor recovery mechanisms following stroke. A 23-year-old female who presented with complete paralysis of the right extremities at the onset of infarct in the left middle cerebral artery territory was included. She slowly recovered some function, and could extend the affected knee with resistance after 9 months. Diffusion tensor tractography, functional MRI, and transcranial magnetic stimulation testing were performed at 7 years after onset. Results showed that diffusion tensor tractography of the affected （left） hemisphere passed through the medial corona radiata at, or around, the wall of the lateral ventricle. The contralateral primary sensorimotor cortex was activated during affected knee movements. The motor-evoked potential, which was obtained from the affected leg, exhibited corticospinal tract characteristics. Results indicated that motor function of the affected leg recovered via the corticospinal tract, which descended through the corona radiata medial to the infarct. The motor function of the affected leg was reorganized to the medial corona radiata following infarct to the middle cerebral artery territory.

关键词： functional magnetic resonance imaging stroke cortical reorganization motor recovery diffusion tensor tractography transcranial maanetic stimulation

Corticospinal tract recovery in a patient with traumatic transtentorial herniation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2013年第5期8卷 469-473页

作者： Sang Seok Yeo Sung Ho Jang department of Physical Medicine and rehabilitation College of Medicine Yeungnam University

Transtentorial herniation is one of the causes of motor weakness in traumatic brain injury. In this study, we report on a patient who underwent decompressive craniectomy due to traumatic intracerebral hemorrhage. Brain CT images taken after surgery showed intracerebral hemorrhage in the left fronto-temporal lobe and left transtentorial herniation. The patient presented with severe paralysis of the right extremities at the time of intracerebral hemorrhage onset, but the limb motor function recovered partially at 6 months after onset and to nearly normal level at 27 months. Through diffusion tensor tractography, the left corticospinal tract was disrupted below the cerebral peduncle at 1 month after onset and the disrupted left corticospinal tract was reconstructed at 27 months. These findings suggest that recovery of limb motor function in a patient with traumatic transtentorial herniation can come to be true by recovery of corticospinal tract.

关键词： neural regeneration neuroimaging diffusion tensor imaging diffusion tensor tractography ttanscranial magnetic stimulation traumatic brain injury intracerebral hemorrhage transtentorfa herniation corticospinal tract motor paralysis neuroimaing grants-supported paper photographs-containing paper neuroregeneration

rehabilitation of anterior pituitary dysfunction combined with extrapontine myelinolysis: A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2019年第24期7卷 4420-4425页

作者： Ming-Xuan Yang Xue-Nong Chen department of rehabilitation Affiliated Hospital of Zunyi Medical University

BACKGROUND Extramedullary myelinolysis is a rare demyelinating disease, often caused by rapid increases in serum sodium concentration in patients with *** manifestations are neuropsychiatric symptoms, limb weakness, and dysarthria. Because of its poor prognosis and high disability rate, it poses a huge burden on the global economy, societies, and families. This article reports rehabilitation in a patient with pituitary dysfunction combined with extramedullary *** SUMMARY A 27-year-old Chinese man developed anorexia, vomiting, and limb weakness and was diagnosed with pituitary insufficiency. He had low serum sodium, slow movement, muscle weakness, and muscle tone abnormalities after sodium supplementation, involuntary limb shaking, ataxia, and dysarthria. According to the symptoms and signs and imaging reports, he was diagnosed with extramedullary myelinolysis. After treatment with hormone therapy and neurotrophic drugs, motor and speech function did not improve, so he was treated in the rehabilitation department for 4 wk. The patient's physical status was improved substantially during his stay at the rehabilitation *** Patients with extramedullary myelinolysis who actively participate in rehabilitation intervention can significantly improve their activities of daily living.

关键词： Anterior pituitary dysfunction Extrapontine myelinolysis rehabilitation motor function Speech function Case report

Effectiveness of oral motor respiratory exercise and vocal intonation therapy on respiratory function and vocal quality in patients with spinal cord injury:a randomized controlled trial

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第2期16卷 375-381页

作者： Xiao-Ying Zhang Yi-Chuan Song Chang-Bin Liu Chuan Qin Song-Huai Liu Jian-Jun Li School of rehabilitation Medicine Capital Medical UniversityBeijingChina China rehabilitation Science Institute BeijingChina Beijing Key Laboratory of Neural Injury and rehabilitation BeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Music Therapy Center Department of PsychologyChina Rehabilitation Research CenterBeijingChina department of rehabilitation Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina department of Spinal and Neural functional Reconstruction China Rehabilitation Research CenterBeijingChina

Singing,as a method of combining respiratory function exercise and vocal intonation therapy,provides a new direction for respiratory function exercise in patients with spinal cord *** randomized controlled trial investigated the effects of oral motor respiratory exercise and vocal intonation therapy on respiratory function and vocal quality in patients with spinal cord *** 31 included patients with spinal cord injury,18 completed the *** 18 patients were randomly assigned to undergo music therapy(intervention group,30 min/d,5 times a week,for a total of 12 weeks;n=9,7 males and 2 females;30.33±11.74 years old)or normal respiratory training(control group,n=9;8 males and 1 female;34.78±11.13 years old).Both patient groups received routine treatment *** and at 6 and 12 weeks after intervention,a standard respiratory function test,a voice test,the ***'s Respiratory Questionnaire,and a quality of life questionnaire were *** results showed that the inspiratory capacity,forced expiratory volume in 1 second,forced vital capacity,maximal mid-expiratory flow rate,sing-loud pressure level,and sustained note length were significantly increased in the intervention group compared with the control *** ***'s Respiratory Questionnaire and quality of life results of patients in the intervention group were significantly superior to those in the control *** findings suggest that oral motor respiratory exercise and vocal intonation therapy,as respiratory training methods in music therapy,are effective and valuable for improving respiratory dysfunction and vocal quality in patients with spinal cord *** study was approved by the Ethics Committee of China rehabilitation Research Center(approval No.2019-78-1)on May 27,2019 and was registered with the Chinese Clinical Trial Registry(registration number:Chi CTR1900026922)on October 26,2019.

关键词： central nervous system clinical trial injury oral motor randomized repair respiratory exercise spinal cord

Difference in cortical activation during use of volar and dorsal hand splints:a functional magnetic resonance imaging study

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2016年第8期11卷 1274-1277页

作者： Sung Ho Jang Woo Hyuk Jang department of Physical Medicine and rehabilitation College of MedicineYeungnam University

There have been no studies reported on the difference in cortical activation during use of volar and dorsal hand *** attempted to investigate the difference in cortical activation in the somatosensory cortical area during use of volar and dorsal hand splints by functional magnetic resonance imaging（f MRI）.We recruited eight healthy volunteers.f MRI was performed while subjects who were fitted with volar or dorsal hand splints performed grasp-release *** of interest were placed on the primary motor cortex（M1）,primary somatosensory cortex（S1）,posterior parietal cortex（PPC）,and secondary somatosensory cortex（S2）.Results of group analysis of f MRI data showed that the total numbers of activated voxels in all ROIs were significantly higher during use of volar hand splint（3,376） compared with that（1,416） during use of dorsal hand *** each ROI,use of volar hand splint induced greater activation in all ROIs（M1：1,748,S1 ：1,455,PPC：23,and S2：150） compared with use of dorsal hand splint（M1：783,S1：625,PPC：0,and S2：8）.The peak activated value was also higher during use of volar hand splint（t-value：17.29） compared with that during use of dorsal hand splint（t-value：13.11）.Taken together,use of volar hand splint induced greater cortical activation relevant to somatosensory function than use of dorsal hand *** result would be important for the physiatrist and therapist to apply appropriate somatosensory input in patients with brain injury.

关键词： nerve regeneration functional MRI hand splint somatosensory function dorsal hand splint volar hand splint neural regeneration

motor recovery via aberrant pyramidal tract in a patient with traumatic brain injury A diffusion tensor tractography study

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2013年第1期8卷 90-94页

作者： Sang Seok Yeo Sung Ho Jang department of Physical Medicine and rehabilitation College of Medicine Yeungnam University

The aberrant pyramidal tract is the collateral pathway of the pyramidal tract through the medial lemniscus in the brainstem. A 21-year-old man presented with right hemiparesis due to a traumatic intracerebral hemorrhage in the left corona radiata. His motor function recovered almost to the normal state at 10 months after onset. Through diffusion tensor tractography, the pyramidal tract in the affected （left） hemisphere showed discontinuation at the pontine level at 13 months after onset. An aberrant pyramidal tract was observed, which originated from the primary motor cortex and the supplementary motor area and descended through the corona radiata, then through the posterior limb of the internal capsule and the medial lemniscus pathway from the midbrain to the pons, finally entered into the pyramidal tract area at the pontomedullary junction, it suggests that the motor functions of the right extremities in this patient had recovered by this aberrant pyramidal tract.

关键词： neural regeneration neuroimaging diffusion tensor imaging diffusion tensor tractography transcranial magnetic stimulation pyramidal tract aberrant pyramidal tract motor paralysis motorrecovery traumatic brain injury head trauma intracerebral hemorrhage grant-supported paper photographs-containing paper neuroregeneration

PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis

在线全文

学校读者我要写书评

暂无评论

Bone Research 2022年第2期10卷 378-393页

作者： Wenhao Jiang Yunyun Jin Shiwei Zhang Yi Ding Konglin Huo Junjie Yang Lei Zhao Baoning Nian Tao PZhong Weiqiang Lu Hankun Zhang Xu Cao Karan Mehul Shah Ning Wang Mingyao Liu Jian Luo Yangzhi rehabilitation Hospital(Sunshine rehabilitation Centre) Tongji University School of MedicineShanghaiPR China Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghaiPR China departments of Orthopaedic Surgery and Biomedical Engineering and Institute of Cell Engineering The Johns Hopkins University School of MedicineBaltimoreMDUSA department of Oncology and Metabolism The University of SheffieldSheffieldUK

Prostaglandin E2(PGE2), a major cyclooxygenase-2(COX-2) product, is highly secreted by the osteoblast lineage in the subchondral bone tissue of osteoarthritis(OA) patients. However, NSAIDs, including COX-2 inhibitors, have severe side effects during OA treatment. Therefore, the identification of novel drug targets of PGE2 signaling in OA progression is urgently needed. Osteoclasts play a critical role in subchondral bone homeostasis and OA-related pain. However, the mechanisms by which PGE2 regulates osteoclast function and subsequently subchondral bone homeostasis are largely unknown. Here, we show that PGE2 acts via EP4 receptors on osteoclasts during the progression of OA and OA-related pain. Our data show that while PGE2 mediates migration and osteoclastogenesis via its EP2 and EP4 receptors, tissue-specific knockout of only the EP4 receptor in osteoclasts(EP4 Lys M) reduced disease progression and osteophyte formation in a murine model of OA. Furthermore, OA-related pain was alleviated in the EP4 Lys M mice, with reduced Netrin-1 secretion and CGRP-positive sensory innervation of the subchondral bone. The expression of plateletderived growth factor-BB(PDGF-BB) was also lower in the EP4 Lys Mmice, which resulted in reduced type H blood vessel formation in subchondral bone. Importantly, we identified a novel potent EP4 antagonist, HL-43, which showed in vitro and in vivo effects consistent with those observed in the EP4 Lys Mmice. Finally, we showed that the Gαs/PI3 K/AKT/MAPK signaling pathway is downstream of EP4 activation via PGE2 in osteoclasts. Together, our data demonstrate that PGE2/EP4 signaling in osteoclasts mediates angiogenesis and sensory neuron innervation in subchondral bone, promoting OA progression and pain, and that inhibition of EP4 with HL-43 has therapeutic potential in OA.

关键词： osteoclast homeostasis PGE2