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Cell thickness dependence of electrically tunable infrared reflectors based on polymer stabilized cholesteric liquid crystals

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Science China Materials 2018年第5期61卷 745-751页

作者： Xiaowen Hu Laurens T. de Haan Hitesh Khandelwal Albertus P.H.J. Schenning Li Nian Guofu Zhou SCNU-TUE Joint Laboratory of Device Integrated Responsive Materials （DIRM） National Center for International Research on Green Optoelectronics South China Normal University No 378 West Waihuan Road Guangzhou Higher Education Mega Center Guangzhou 510006 China Laboratory of Functional Organic Materials ＆ Devices Department of Chemical Engineering and Chemistry Eindhoven University of Technology P. O. Box 513 5600 MB Eindhoven The Netherlands Institute of Electronic Paper Displays and Guangdong Provincial Key Laboratory of Optical Information Materials and Technology South China Academy of Advanced Optoelectronics South China Normal University Guangzhou 510006 China Shenzhen Guohua Optoelectronics Tech. Co. Ltd. Shenzhen 518110 China

We reported here the fabrication of the elec- trically tunable infrared （IR） reflectors based on the polymer stabilized cholesteric liquid crystal （PSCLC） with negative dielectric anisotropy. A systematic study of the influence of cell gap on the electrically tunable reflection bandwidth was performed. When a direct current （DC） electric field was ap- plied, the reflection bandwidth red shifted in the cells with small cell gap, whereas the bandwidth broadening was ob- served in the cells with large cell gap. It is therefore reasonable to deduct that the reflection is dictated by the pitch gradient steepness which strongly relies on the cell thickness. The re- sults reveal that for making PSCLC based IR reflector windows with electrically induced bandwidth broadening, a minimal cell gap thickness is required. The resulted IR reflectors pos- sess a short native switching time and long-term operation stability, and are potentially applicable as smart energy saving windows in buildings and automobiles.

关键词： cholesteric cell gap polymer network electric reg-ulating infrared reflector

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黑钨矿的氧扩散动力学

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资源调查与环境 2006年第3期27卷 178-187页

作者：钱雅倩 WANG Jian-hua 郭吉保南京地质矿产研究所江苏南京210016 department of Terrestrial Magnetism Carnegie Insitution of Washington Washington DC 20015 USA 国土资源部同位素地质重点实验室北京100037

在水压100MPa，温度500～800℃和富^18O水的热液条件下，开展了黑钨矿氧扩散动力学的实验研究。并由离子探针质谱测定平行于c轴和垂直于c轴的黑钨矿氧同位素扩散剖面。经实验研究获得了黑钨矿氧扩散的Arrenius关系。黑钨矿平行于c轴氧... 详细信息

在水压100MPa，温度500～800℃和富^18O水的热液条件下，开展了黑钨矿氧扩散动力学的实验研究。并由离子探针质谱测定平行于c轴和垂直于c轴的黑钨矿氧同位素扩散剖面。经实验研究获得了黑钨矿氧扩散的Arrenius关系。黑钨矿平行于c轴氧扩散的指数前因子D0为1．15×10^-6cm^2／s，扩散活化能Q为171．4±7．4kJ／mol；垂直于c轴的氧扩散的指数前因子D0为8．51×10^-7cm^2／s，扩散活化能Q为170．8±7．8kJ／mol。黑钨矿的氧扩散无明显方向性。黑钨矿的氧扩散交换封闭温度低于透辉石、角闪石和金红石，高于钙长石，与磁铁矿十分接近。

关键词：黑钨矿氧扩散动力学离子探针实验研究

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无镍高氮奥氏体不锈钢的脆韧转变

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热处理 2014年第5期29卷 63-66页

作者： M.Tanaka T.Onomoto T.Tsuchiyama K.Higashida 顾剑锋 department of Materials Science and Engineering Kyushu University744 MotookaNishi-kuFukuoka 819-0395Japan Fukuoka Industrial Technology Center Mechanics and Electronics Research Institute3-6-1NorimatsuYahatanishi-kuKitakyushu 807-0831Japan 上海交通大学

研究了无镍高氮奥氏体不锈钢的脆韧转变(BDT)。在176 K、273 K和336 K进行的落锤试验结果表明,尽管Fe-25Cr-1.1N(质量分数,%)是面心立方结构的奥氏体合金钢,但仍展现出显著的脆韧转变现象。对冲击试验试样的塑性变形观察表明,BDT是由于... 详细信息

研究了无镍高氮奥氏体不锈钢的脆韧转变(BDT)。在176 K、273 K和336 K进行的落锤试验结果表明,尽管Fe-25Cr-1.1N(质量分数,%)是面心立方结构的奥氏体合金钢,但仍展现出显著的脆韧转变现象。对冲击试验试样的塑性变形观察表明,BDT是由于低温下差的延展性所致,这与铁素体钢的情况是一致的。为了测量BDT的激活能,利用4点弯曲试验研究了应变速率与BDT温度的关系。研究发现,BDT温度与应变速率之间的依赖关系不显著,且BDT温度对应变率的Arrhenius曲线表明Fe-25Cr-1.1N钢BDT的激活能比低碳铁素体钢的高得多。从滑移位错与溶质氮原子发生交互作用导致低温下位错可动性降低这一角度,本文探讨了高氮钢特有的BDT及其高激活能的本质原因。

关键词：脆韧转变位错断裂激活能位错迁移率

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苯二氮■类药物:获益、风险、合理使用

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中国药物依赖性杂志 2019年第3期28卷 163-171页

作者：索琳王佳孙丽丽刘剑锋李静应急总医院药学部北京100028 应急总医院干部医疗科北京100028 天津医科大学总医院空港医院临床心理科天津300308 department of Pharmacology and Toxicology University at BuffaloBuffaloNYUSA14203

苯二氮类药物(Benzodiazepines,BZDs)在临床上被广泛使用,具有抗焦虑、镇静催眠、抗惊厥、肌肉松弛和诱导麻醉的作用,不合理的使用会产生认知功能损害、记忆损害、跌倒、骨折、增加交通事故的发生、痴呆、死亡,及依赖或滥用等风险。... 详细信息

苯二氮类药物(Benzodiazepines,BZDs)在临床上被广泛使用,具有抗焦虑、镇静催眠、抗惊厥、肌肉松弛和诱导麻醉的作用,不合理的使用会产生认知功能损害、记忆损害、跌倒、骨折、增加交通事故的发生、痴呆、死亡,及依赖或滥用等风险。尽管指南建议BZDs不作为治疗失眠与焦虑症的首选药物,并且只能在短期内使用,但是此类药物仍被长期使用,尤其是老年人。本文对BZDs的特性、用药获益、用药风险、长期使用的情况进行综述,旨在促进此类药物在临床中的合理使用,减少用药风险。

关键词：苯二氮类药物用药获益用药风险合理使用

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阿片类药物替代疗法:安全性和滥用倾向的比较研究

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中国药物依赖性杂志 2009年第4期18卷 357-357页

作者： Sharon L WALSH Center on Drug and Alcohol Research Department of Behavioral Science and PsychiatryUniversity of Kentucky

阿片类药物维持疗法是治疗阿片、海洛因和阿片类制剂依赖的有效方法。美沙酮和丁丙诺啡是世界范围内最常用于替代治疗的阿片类药物,纳曲酮作为一种阿片受体的拮抗剂用于阻断治疗。研究数据显示维持疗法比脱毒疗法疗效更好,但是,存在长... 详细信息

阿片类药物维持疗法是治疗阿片、海洛因和阿片类制剂依赖的有效方法。美沙酮和丁丙诺啡是世界范围内最常用于替代治疗的阿片类药物,纳曲酮作为一种阿片受体的拮抗剂用于阻断治疗。研究数据显示维持疗法比脱毒疗法疗效更好,但是,存在长期用药剂量的安全性问题,包括对药物的直接反应和滥用风险。对美沙酮和丁丙诺啡(单独使用或与纳曲酮合用)的研究揭示了剂量与效应的关系,以及最佳的用药方案。研究数据提示,在呼吸抑制(过量)和对心血管的直接作用方面丁丙诺啡较美沙酮风险更低。丁丙诺啡,作为一种部分激动剂,可能比美沙酮或者海洛因等完全激动剂的滥用倾向更小。本文提供的数据说明在阿片依赖的个体上丁丙诺啡的滥用风险较美沙酮的更低。最近的数据提示,在阿片依赖和非依赖的使用者中,丁丙诺啡/纳曲酮合用的滥用潜力低于丁丙诺啡单独使用。

关键词：阿片替代治疗安全性滥用倾向

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源于制鞋工业的固体废料处理(续)(英文)

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皮革科学与工程 2007年第3期17卷 3-7页

作者： P.Mokrejs D.Janacova K.Kolomaznik M.Mladek F.Langmaier V.Vasek Tomas Bata University Faculty of TechnologyDepartment of Protein and Leathernam.TGM 275762 72 ZlinThe Czech Republic Tomas Bata University Faculty of Applied InformaticsInstitute of Processing Control and Applied Computer ScienceNad Stranemi 4511760 05 ZlinThe Czech Republic

4 RESULTS Results of factor experiments 23,i.e.2 levels for 3 experimental factors(temperature in 1st stage of hydrolysis,pH of reaction mixture in 3rd stage of hydrolysis and duration of 3rd stage of hydrolysis) are presented in *** analysis of hydrolysate or of remaining chrome cake it is obvious that yield of nitrogen in hydrolysate,in dependence on fluctuating reaction conditions,ranged in quite narrow limits 58%-65%.

关键词：制鞋工业固体皮革水解影响因素

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神经外科夹闭和血管内弹簧圈栓塞治疗2143例颅内动脉瘤破裂患者的国际蛛网膜下腔动脉瘤试验(ISAT):一项对生存情况、依赖性、癫痫发作、再出血、亚组和动脉瘤阻塞影响的随机对比试验

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世界核心医学期刊文摘（神经病学分册） 2006年第3期2卷 4-4页

作者： Molyneux A.J. Kerr R.S. 郭俊 Nuffield department of Surgery University of Oxford Oxford Radcliffe Hospitals Oxford United Kingdom

Background: Two types of treatment are being used for patients with ruptured intracranilal aneurysms: endovascular detachable-coil treatment or craniotomy and clipping. We undertook a randomised, multicentre trial to compare these treatments in patients who were suitable for either treatment because the relative saf ety and efficacy of these approaches had not been established. Here we present c linical outcomes 1 year after treatment. Methods: 2143 patients with ruptured in tracranial aneurysms, who were admitted to 42 neurosurgical centres, mainly in t he UK and Europe, took part in the trial. They were randomly assigned to neurosu rgical clipping (n=1070) or endovascular coiling (n=1073). The primary outcome w as death or dependence at 1 year (defined by a modified Rankin scale of 3-6). S econdary outcomes included rebleeding from the treated aneurysm and risk of seiz ures. Long-term follow up continues. Analysis was in accordance with the random ised treatment. Findings: We report the 1-year outcomes for 1063 of 1073 patien ts allocated to endovascular treatment, and 1055 of 1070 patients allocated to n eurosurgical treatment. 250 (23.5%) of 1063 patients allocated to endovascular treatment were dead or dependent at 1 year, compared with 326 (30.9%) of 1055 p atients allocated to neurosurgery, an absolute risk reduction of 7.4%(95%CI 3. 6-11.2, p=0.0001). The early survival advantage was maintained for up to 7 year s and was significant (log rank p=0.03). The risk of epilepsy was substantially lower in patients allocated to endovascular treatment, but the risk of late rebl eeding was higher. Interpretation: In patients with ruptured intracranial aneury sms suitable for both treatments, endovascular coiling is more likely to result in independent survival at 1 year than neurosurgical clipping; the survival bene fit continues for at least 7 years. The risk of late rebleeding is low, but is m ore common after endovascular coiling than after neurosurgical clipping.

关键词：膜下腔神经外科再出血 ISAT 弹簧圈栓塞生存情况亚组对比试验预后指标发病风险

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Recent progress of ferroptosis in cancers and drug discovery

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Asian Journal of Pharmaceutical Sciences 2024年第4期 22-42页

作者： Xiang Wang Xinxin Ren Xu Lin Qi Li Yingqiong Zhang Jun Deng Binxin Chen Guoqing Ru Ying Luo Nengming Lin department of Pharmacy Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province Affiliated Hangzhou First People’s Hospital School of Medicine Westlake University department of Pathology Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital Hangzhou Medical College) Key Laboratory of Endocrine Gland Diseases of Zhejiang Province Zhejiang Provincial People’s Hospital (Affiliated People’s HospitalHangzhou Medical College) Clinical Research Center for Cancer of Zhejiang Province Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital Hangzhou Medical College) department of Thoracic Surgery The First Affiliated Hospital Zhejiang University School of Medicine Cancer Center Zhejiang University Westlake Laboratory of Life Sciences and Biomedicine of Zhejiang Province

Ferroptosis is a nonapoptotic form of cell death characterized by iron dependence and lipid peroxidation. Ferroptosis is involved in a range of pathological processes, such as cancer. Many studies have confirmed that ferroptosis plays an essential role in inhibiting cancer cell proliferation. In addition, a series of small-molecule compounds have been developed, including erastin, RSL3, and FIN56, which can be used as ferroptosis *** combination of ferroptosis inducers with anticancer drugs can produce a significant synergistic effect in cancer treatment, and patients treated with these combinations exhibit a better prognosis than patients receiving traditional therapy. Therefore, a thorough understanding of the roles of ferroptosis in cancer is of great significance for the treatment of cancer. This review mainly elaborates the molecular biological characteristics and mechanism of ferroptosis, summarizes the function of ferroptosis in cancer development and treatment,illustrates the application of ferroptosis in patient's prognosis prediction and drug discovery, and discusses the prospects of targeting ferroptosis.

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Imaging electrochemiluminescence layer to dissect concentration-dependent light intensity for accurate quantitative analysis

Advanced Sensor and Energy Materials

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Advanced Sensor and Energy Materials 2022年第3期1卷 24-30页

作者： Wen-Xuan Fu Ping Zhou Wei-Liang Guo Bin Su Key Laboratory of Excited-State Materials of Zhejiang Province Institute of Analytical ChemistryDepartment of ChemistryZhejiang UniversityHangzhou 310058China School of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023China

As one of most advanced transduction techniques,electrochemiluminescence(ECL),such as that generated by tris(2,20-bipyridyl)ruthenium(Ru(bpy)32þ),has been extensively used in chemical sensing and analysis,but the reaction mechanism has not been fully *** at gaining insightful mechanistic information on the coreactant system involving(Ru(bpy)32þ)and tri-n-propylamine(TPrA),herein we investigate the variation of thickness of ECL layer(TEL)with the concentration ratio of(Ru(bpy)32þ)to TPrA(cRu/cTPrA)by ECL *** carbon fiber as the working electrode,TEL was observed to grow with the increase of cRu/cTPrA *** conjunction with finite element simulations,the extension of ECL layer was rationalized to be associated with the incremental contribution of so-called“catalytic route”.This route offers an additional channel of generating remote light emission in solution,apart from surface-confined emission produced by the“oxidative-reduction route”.Given the quantitative analysis of coreactant-type analytes is often based on the calibration curve,namely a graph generated by plotting the measured light intensity of a series of standard solutions against their concentrations,the contribution of“catalytic route”particularly at a low concentration of analyte(equivalent to a relatively large cRu/cTPrA)is favorable to the analytical ***,the presence and absence of this route will result in a nonlinear and linear calibration curve,respectively,for example in the detection of TPrA and *** results highlight the microwire-based imaging approach can provide insightful mechanistic information and help unveil the concentration dependence of measured ECL intensity for precise quantitative analysis.

关键词： Reaction mechanism ECL microscopy ECL layer thickness ECL analysis Calibration curve

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线粒体肌病患者的有氧训练与肌肉新陈代谢

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世界核心医学期刊文摘(神经病学分册) 2006年第8期 33-33页

作者： Trenell M.I. Sue C.M. Kemp G.J. 李青波 department of Neurogenetics Kolling Institute for Medical Research Sydney NSW 2065 Australia Dr.

Exercise therapy improves mitochondrial function in patients with mitochondrial myopathy (MM). We undertook this study to determine the metabolic abnormalities that are improved by exercise therapy. This study identified metabolic pathology using 31P- magnetic resonance spectroscopy and magnetic resonance imaging (MRI) in a group of patients with MM compared to a control group matched for age, gender, and physical activity. We also observed the effect of exercise therapy for 12 weeks on muscle metabolism and physical function in the MM group. During muscle activity, there was impaired responsiveness of the mitochondria to changes in cytosolic adenosine diphosphate concentration, increased dependence on anaerobic energy pathways, and an adaptive increase in proton efflux in patients with MM. Following exercise therapy, mitochondrial function and muscle mass improved without any change in proton efflux rate. These metabolic findings were accompanied by improvements in functional ability. We conclude that there are significant metabolic differences between patients with MM and a control population, independent of age, gender, and physical activity. Exercise therapy can assist in improving mitochondrial function in MM patients.

关键词：线粒体肌病运动疗法患者

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