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Pharmacology & Pharmacy 2021年第5期12卷 100-108页

作者： Cheyenne Moffett Katherine J. Kost Austen Thompson Michael H. Ossipov Joseph V. Pergolizzi Jr. Sumiyo Umeda-Raffa Robert B. Raffa Tally M. Largent-Milnes Todd Vanderah department of Pharmacology and Comprehensive Pain and Addiction Center University of Arizona Tucson AZ USA NEMA Inc. Naples FL USA Neumentum Inc. Morristown NJ USA Enalare Therapeutics Naples FL USA Pharmaceutical Sciences (Form. Faculty) Hokkaido University of Science Hokkaido Japan School of Pharmacy (Prof Em.) Temple University Philadelphia PA USA College of Pharmacy (Adjunct) University of Arizona Tucson AZ USA

The benzodiazepines were introduced into medical practice during the 1960s. At the time, they represented a safer alternative to extant therapies used for anxiety, such as the barbiturates. However, on September 23, 2020, the United States FDA indicated that more is needed to be known about the initiation, continuation, and discontinuation of the use of these widely-used drugs with publication of the announcement “to address the serious risks of abuse, addiction, physical dependence, and withdrawal reactions, the U.S. Food and Drug Administration (FDA) is requiring the Boxed Warning be updated for all benzodiazepine medicines.” Because for many years, there has been a sparsity of research on these drugs, relevant information is unfortunately lacking at this critical time. It is therefore valuable to (re)establish animal models and begin to collect relevant data. We here use a model of conditioned place

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Multifunctionality and Thresholds of Alpine Grassland on the Tibetan Plateau

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Journal of Resources and Ecology 2020年第3期11卷 263-271页

作者： SONG Minghua LI Meng HUO Jiajuan WU Liang ZHANG Xianzhou Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of ScienceBeijing 100101China department of Ecology School of Ecology and EnvironmentInner Mongolia UniversityHohhot 010021China Center for World Geography and Resources Research Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China

Ecosystems can simultaneously provide multiple functions and services. Knowledge on the combinations of such multi-dimensional functions is critical for accurately assessing the carrying capacity and implementing sustainable management. However, accurately quantify the multifunctionality of ecosystems remains challenging due to the dependence and close association among individual functions. Here, we quantified spatial patterns in the multifunctionality of alpine grassland on the Tibetan Plateau by integrating four important individual functions based on data collected from a field survey and remote sensing NDVI. After mapping the spatial pattern of multifunctionality, we extracted multifunctionality values across four types of grassland along the northern Tibet Plateau transect. Effects of climate and grazing intensity on the multifunctionality were differentiated. Our results showed that the highest values of multifunctionality occurred in the alpine meadow. Low values of multifunctionality were comparable in different types of grassland. Annual precipitation explained the large variation of multifunctionality across the different types of grassland in the transect, which showed a significantly positive effect on the multifunctionality. Grazing intensity further explained the rest of the variation in the multifunctionality(residuals), which showed a shift from neutral or positive to negative effects on multifunctionality across the different types of grassland. The consistently rapid declines of belowground biomass, SOC, and species richness resulted in the collapse of the multifunctionality as bare ground cover amounted to 75%, which corresponded to a multifunctionality value of 0.233. Our results are the first to show the spatial pattern of grassland multifunctionality. The rapid decline of the multifunctionality suggests that a collapse in the multifunctionality can occur after the vegetation cover decreases to 25%, which is also accompanied by rapid losses of

关键词： individual functions multifunctionality grazing intensity alpine grassland vegetation cover

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CORRELATION BETWEEN THE ELASTIC AND THE VIBRONIC BEHAVIOR OF NANOSTRUCTURED TITANIA AND THEIR PRESSURE,SIZE,AND TEMPERATURE dependence

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Journal of Advanced Dielectrics 2011年第4期1卷 407-416页

作者： X.J.LIU L.K.PAN Z.SUN Y.M.CHEN X.X.YANG L.W.YANG Z.F.ZHOU CHANG Q.SUN Engineering Research Center for Nanophotonics&Advanced Instrument Ministry of Education Department of Physics East China Normal University Shanghai 200062P.R.China Institute for Quantum Engineering and Micro-Nano Energy Technology Key Laboratory of Low-Dimensional Materials and Application Technology and Faculty of Materials and Optoelectronic Physics Xiangtan University Hunan 411105P.R.China School of Electrical and Electronic Engineering Nanyang Technological University Singapore 639798 Singapore

Correlation bet ween the elastic and the vibronic behavior of TiO_(2) and their responses to thevariation of crystal size,applied pressure,and measuring temperature has been investig ated basedon the bond order-length-strength correlation *** reproduction of themeasurements clarified that.(i)the elastic modulus(B)and the Raman shifts(△ω)are stronglycorrelated and we can know either one of the B or the △ω from the other;(i)the under-coordination induced cohesive energy loss and the energy density gain in the surface up to skindepth determines the size effect;(ii)bond expansion and bond weakening due to thermalvibration originat es the thermally softened elastic modulus and the Raman shifts;and(iv)bondcompression and bond strengthening results in the mechanically stiffened elastic modulus and theRaman *** the developed premise,one can predict the changing trends of the concernedproperties with derivatives of quantitative information of the atomic cohesive energy,bindingenergy density,Debye tempera ture,and nonlinear compressibility of the specimen.

关键词： TiO_(2)nanostructures elasticity Ramanshift pressure temperature

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非对称核物质不可压缩系数的微观计算(英文)

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原子核物理评论 2011年第4期28卷 396-403页

作者：曹高清左维李建洋甘胜鑫 U. Lombardo 中国科学院近代物理研究所甘肃兰州730000 中国科学院研究生院北京100049 department of Physics and Astrophysics Catania UniversityVia Santa Sofia 64I-9g123and INFN-LNSVia Santa Sofia 44I-95123 CataniaItaly

在带微观三体力的Brueckner-Hartree-Fock方法下研究了非对称核物质的不可压缩系数,得到了不可压缩系数的同位旋以及密度依赖,并做了进一步的讨论。在一定密度下,不可压缩系数作为同位旋非对称度的函数随同位旋单调递增。预测了非对称... 详细信息

在带微观三体力的Brueckner-Hartree-Fock方法下研究了非对称核物质的不可压缩系数,得到了不可压缩系数的同位旋以及密度依赖,并做了进一步的讨论。在一定密度下,不可压缩系数作为同位旋非对称度的函数随同位旋单调递增。预测了非对称核物质在平衡态的同位旋依赖性质并与其他理论方法做了比较。

关键词：不可压缩系数非对称核物质核状态方程 Brueckner-Hartree-Fock方法

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Alkyl chain length-regulated in situ intelligent nano-assemblies with AIE-active photosensitizers for photodynamic cancer therapy

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Asian Journal of Pharmaceutical Sciences 2024年第6期 86-102页

作者： Lingyi Shen Qilong Zhang Yongchao Yao Yali Huang Zhichang Zheng Ming Li Hong Xu Lin Tan Xukun Liao Binyi Xia Lin Li Carl Redshaw Yang Bai Chengli Yang School of Basic Medicine Guizhou Medical University department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University department of Pharmacy The Affiliated Hospital of Guizhou Medical University Chemistry School of Natural SciencesUniversity of Hull Clinical Research Center The Affiliated Hospital of Guizhou Medical University

Photodynamic therapy （PDT） brings new hope for the treatment of breast cancer due to few side effects and highly effective cell killing;however,the low bioavailability of traditiona photosensitizers （PSs） and their dependence on oxygen severely limits their application Aggregation-induced emission （AIE） PSs can dramatically facilitate the photosensitization effect,which can have positive impacts on tumor ***-date,most AIE PSs lack tumor targeting capability and possess poor cell delivery,resulting in their use in large quantities that are harmful to healthy *** this study,a series of AIE PSs based on pyridinium-substituted triphenylamine salts （TTPAs 1–6） with different alkyl chain lengths are *** reveal that TTPAs 1–6 promote the generation of type I and II ROS including?OH *** particular,the membrane permeability and targeting of TTPAs4-6 bearing C8-C10 side-chains are higher than TTPAs 1-3 bearing shorter alkyl chains Additionally,they can assemble with albumin,thereby forming nanoparticles （TTPA 4–6NPs） in situ in blood,which significantly facilitates mitochondrial-targeting and strong ROS generation ***,the TTPA 4–6 NPs are pH-responsive,allowing for increased accumulation or endocytosis of the tumor and enhancing the imaging or therapeutic effect Therefore,the in vivo distributions of TTPA 4–6 NPs are visually enriched in tumor sites and exhibited excellent PDT *** work demonstrates a novel strategy for AIE PDT and has the potential to play an essential role in clinical applications using nano-delivery systems.

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Polaron-assisted nonadiabatic dynamics in protonated TiO_(2) with surface water molecule

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ChemPhysMater 2023年第4期2卷 331-336页

作者： Zhongfei Xu Chuanjia Tong Rutong Si Gilberto Teobaldi Limin Liu The Key Laboratory of Resources and Environmental System Optimization Ministry of EducationCollege of Environmental Science and EngineeringNorth China Electric Power UniversityBeijing 102206China School of Physics and Electronics Central South UniversityChangsha 410083China Beijing Computational Science Research Center Beijing 100193China The Abdus Salam International Centre for Theoretical Physics Trieste 34151Italy Scientific Computing department Science and Technology Facilities Council UK Research and Innovation(STFC-UKRI)Rutherford Appleton LaboratoryHarwell CampusDidcot OX110QXUnited Kingdom School of Chemistry University of SouthamptonHighfieldSouthampton SO171BJUnited Kingdom School of Physics Beihang UniversityBeijing 100191China

We investigated the polaron-assisted nonadiabatic dynamics in protonated TiO_(2),as well as the polaron-H_(2)O coupling and its effects on the relaxation of photogenerated *** observed that different polaron hopping regimes result in varied nonadiabatic couplings and relaxations of excited electrons from the conduction band minimum to the gap states of protonated TiO_(2),with a weak dependence on the actual trapping site of the ***-adsorbed H_(2)O molecules can attract polarons toward the adsorbed Ti sites,with the coupling between H_(2)O and the polaron being inversely proportional to their *** findings suggest that the lifetime of the photogenerated charge carriers can be extended by reducing the polaron-H_(2)O distances,with expected benefits to the efficiency of the reduced TiO 2 samples for photocatalytic applications.

关键词： Protonated Polaron-H_(2)O coupling Nonadiabatic molecule dynamics Lifetime Anatase

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Does the spatial arrangement of urban landscape matter?Examples of urban warming and cooling in Phoenix and Las Vegas

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Ecosystem Health and Sustainability 2015年第4期1卷 13-28页

作者： Soe Win Myint Baojuan Zheng Emily Talen Chao Fan Shai Kaplan Ariane Middel Martin Smith Huei-Ping Huang Anthony Brazel School of Geographical Sciences and Urban Planning Arizona State University975 South Myrtle AvenueTempeArizona 85287 USA Geospatial Sciences Center of Excellence South Dakota State University1021 Medary AvenueWecota Hall 115Box 506BBrookingsSouth Dakota 57007 USA department of Geography and Environmental Development Ben-Gurion University of the NegevP.O.Box 653Beer-Sheva 8410501 Israel School of Sustainability Arizona State UniversityWrigley Hall800 Cady Mall 108TempeArizona 85281 USA School for Engineering of Matter Transportand EnergyArizona State University501 East Tyler MallP.O.Box 876106TempeArizona 85287 USA

This study examines the impact of spatial landscape configuration(e.g.,clustered,dispersed)on land-surface temperatures(LST)over Phoenix,Arizona,and Las Vegas,Nevada,*** classified detailed land-cover types via object-based image analysis(OBIA)using Geoeye-1 at 3-m resolution(Las Vegas)and QuickBird at 2.4-m resolution(Phoenix).Spatial autocorrelation(local Moran’s I)was then used to test for spatial dependence and to determine how clustered or dispersed points were ***,we used Advanced Spaceborne Thermal Emission and Reflection Radiometer(ASTER)data acquired over Phoenix(daytime on 10 June and nighttime on 17 October 2011)and Las Vegas(daytime on 6 July and nighttime on 27 August 2005)to examine day-and nighttime LST with regard to the spatial arrangement of anthropogenic and vegetation *** Moran’s I values of each land-cover type were spatially correlated to surface *** spatial configuration of grass and trees shows strong negative correlations with LST,implying that clustered vegetation lowers surface temperatures more *** contrast,clustered spatial arrangements of anthropogenic land-cover types,especially impervious surfaces and open soil,elevate *** findings suggest that city planners and managers should,where possible,incorporate clustered grass and trees to disperse unmanaged soil and paved surfaces,and fill open unmanaged soil with *** findings are in line with national efforts to augment and strengthen green infrastructure,complete streets,parking management,and transit-oriented development practices,and reduce sprawling,unwalkable housing development.

关键词： ASTER daytime temperatures,nighttime temperatures Las Vegas,Nevada,USA local Moran’s I Phoenix,Arizona,USA spatial autocorrelation spatial configuration urban landscape

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钆塞酸二钠增强MRI肝胆期经脾和肌肉校正后的肝脏强化信号的年龄依赖关系

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国际医学放射学杂志 2016年第4期 462-462页

作者： S.Matoori J.M.Froehlich S.Breitenstein A.Doert V.Pozdniakova D.M.Koh 方壮念 department of Radiology Paracelsus Medical University Salzburg

摘要目的研究钆塞酸二钠增强MRI肝胆期非肝硬化病人的年龄与经过参照组织[脾、肾脏、肝脏、竖脊肌(MES)、肝胆管(DHC)]校正的组织信号强度的相关性。方法 2008年11月—2013年6月期间,131例临床病史不相同的病人进行了标准化的钆塞酸二... 详细信息

摘要目的研究钆塞酸二钠增强MRI肝胆期非肝硬化病人的年龄与经过参照组织[脾、肾脏、肝脏、竖脊肌(MES)、肝胆管(DHC)]校正的组织信号强度的相关性。方法 2008年11月—2013年6月期间,131例临床病史不相同的病人进行了标准化的钆塞酸二钠增强3.0 T MRI检查。排除肝硬化

关键词：钆塞酸二钠 MRI 肝脏肝胆

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兴奋剂依赖病人大脑灰质改变及脑-行为关系的性别差异研究

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国际医学放射学杂志 2016年第1期 78-78页

作者： M.F.Regner M.Dalwani D.Yamamoto R.I.Perry J.T.Sakai J.M.Honce 倪玲 department of Radiology University of Colorado School of Medicine

摘要目的通过特定行为学测量的方法,如依赖症状计数、行为方法和冲动,研究性别能否调节长期禁欲的兴奋剂依赖性病人的灰质体积（GMV）,并表征性别如何调节GMV。材料与方法本研究经科罗拉多机构伦理委员会批准并获得病人知情同意书。在... 详细信息

摘要目的通过特定行为学测量的方法,如依赖症状计数、行为方法和冲动,研究性别能否调节长期禁欲的兴奋剂依赖性病人的灰质体积（GMV）,并表征性别如何调节GMV。材料与方法本研究经科罗拉多机构伦理委员会批准并获得病人知情同意书。在该前瞻性、平行组的研究中,127例年龄和性别匹配的被试[68例对照（女28例,男40例）和59例兴奋剂依赖病人（女28例,男31例）]行颅脑3 T扰相梯度回波反转恢复T;W MRI。影像利用基于体素的形态测量软件

关键词：兴奋剂女性病人性别差异差异(心理学)

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Hsp90 Is Involved in the Regulation of Cytosolic =recursor Protein Abundance in Tomato

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Molecular Plant 2015年第2期8卷 228-241页

作者： Bodo Tillmann Sascha Roeth Daniela Bublak Manuel Sommer Ernst H.K. Stelzer Klaus-Dieter Scharf Enrico Schleiff department of Molecular Cell Biology of Plants Goethe-University Max-von-Laue Street 9 60438 Frankfurt am Main Germany Cluster of Excellence 'Macromolecular Complexes' Goethe-University 60438 Frankfurt am Main Germany Center of Membrane Proteomics Goethe University Max-von-Laue Street 9 60438 Frankfurt am Main Germany Buchman Institute for Molecular Life Sciences Goethe University Max-von-Laue Street 15 60438 Frankfurt am Main Germany Institute of Cell Biology Goethe-Universitat Max-von-Laue StraBe 9 60438 Frankfurt am Main Germany

Cytosolic chaperones are involved in the regulation of cellular protein homeostasis in general. Members of the families of heat stress proteins 70 （Hsp70） and 90 （Hsp90） assist the transport of preproteins to organelles such as chloroplasts or mitochondria. In addition, Hsp70 was described to be involved in the degradation of chloroplast preproteins that accumulate in the cytosol. Because a similar function has not been established for Hsp90, we analyzed the influences of Hsp90 and Hsp70 on the protein abundance in the cellular context using an in vivo system based on mesophyll protoplasts. We observed a differential behavior of preproteins with respect to the cytosolic chaperone-dependent regulation. Some preproteins such as pOE33 show a high dependence on Hsp90, whereas the abundance of preproteins such as pSSU is more strongly dependent on Hsp70. The E3 ligase, C-terminus of Hsp70-interacting protein （Chip）, appears to have a more general role in the control of cytosolic protein abundance. We discuss why the different reaction modes are comparable with the cytosolic unfolded protein response.

关键词： Hsp70 Hsp90 chip cytosolic unfolded protein response CPR preprotein degradation

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