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The Use of Dried Blood Spot Samples in Screening Drugs of Abuse

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Pharmacology & Pharmacy 2013年第2期4卷 152-159页

作者： Rizwana Quraishi Raka Jain Atul Ambekar National Drug dependence Treatment Centre Department of Psychiatry All India Institute of Medical Sciences New Delhi India

The present article will provide an overview of use of dried blood sampling method for analysis of drug of abuse. Relatively short half life and instability in blood, calls for alternative sampling method for determination of drugs of abuse. Dried blood spot (DBS) method has many advantages over the conventional sampling methods. The available method for DBS sample collection, storage and transport are described here. The techniques involved in and the factors that may influence the accuracy and reproducibility of the DBS methods for determination of drugs of abuse are presented. The DBS sampling has the potential to be a useful technique to detect drugs of abuse. The use of DBS for any drug should be judged against the potential error involved with the method.

关键词： Dried Blood Spots Drugs of Abuse Screening Review

Gut microbiota modulating intestinal stem cell differentiation

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World Journal of Stem Cells 2024年第6期16卷 619-622页

作者： Lin He Chen Zhu Xiang-Feng Zhou Shu-E Zeng Le Zhang Kuan Li department of Alcohol and Drug dependence Treatment The Mental Hospital of Yunnan ProvinceKunming 650224Yunnan ProvinceChina department of Physical Education Kunming Medical UniversityKunming 650500Yunnan ProvinceChina department of Geriatric Psychiatry The Mental Hospital of Yunnan ProvinceKunming 650224Yunnan ProvinceChina Sleep Medicine Center The Mental Hospital of Yunnan ProvinceKunming 650224Yunnan ProvinceChina

Proliferation and differentiation of intestinal stem cell(ISC)to replace damaged gut mucosal epithelial cells in inflammatory states is a critical step in ameliorating gut ***,when this disordered proliferation continues,it induces the ISC to enter a cancerous *** gut microbiota on the free surface of the gut mucosal barrier is able to interact with ISC on a sustained ***-biota metabolites are able to regulate the proliferation of gut stem and progenitor cells through transcription factors,while in steady state,differentiated colono-cytes are able to break down such metabolites,thereby protecting stem cells at the gut *** the future,the gut flora and its metabolites mediating the regulation of ISC differentiation will be a potential treatment for enteropathies.

关键词： Intestinal stem cells Gut microbiota Gut stem niche Microenvironment Probiotics

Effects of protein synthesis inhibitors on the behavioral sensitization induced by a single morphine exposure in mice

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中国药理通讯 2008年第3期25卷 40-41页

作者： Juan Luo Jian-Hui Liang department of Neuropharmacology National Institute on Drug Dependence Peking University 38 Xueyuan Road Beijing 100191 PR China

Prevalence and risk factors of cardiovascular diseases and psychological distress among female scientists and technicians

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第12期23卷 1057-1064页

作者： Lijun ZHANG Yanping BAO Guo LI Shuhui TAO Meiyan LIU department of Psycho-Cardiology Beijing Anzhen HospitalCapital Medical UniversityBejing 100029China National Institute on Drug dependence and Beijing Key Laboratory of Drug dependence Peking UniversityBeijing 100191China School of Public Health Peking UniversityBejing 100191China Henan Medical School Henan UniversityKaifeng 475001China

This study aimed to explore the prevalence and risk factors of cardiovascular disease(CVD)and psychological distress among female scientists and technicians in ***,we included scientists and technicians from representative research institutions,medical institutions,colleges,universities,and businesses in China,and the data were collected from July 1,2019 to March 31,2021 via online *** parameters evaluated in this study included age,sex,marital status,educational background,monthly income,sleep hours,sleep problems,smoking,alcohol consumption,work-related stress,work burnout,cardiovascular symptoms,CVD,family history,and depressive and anxiety symptoms.A total of 14530 scientists and technicians were included,comprising 7144 men and 7386 *** found 34.9%men and 16.6%women with CVD,35.1%men and 21.4%women with depressive symptoms,28.7%men and 13.8%women with anxiety symptoms,and 22.0%men and9.5%women with CVD combined with depressive or anxiety *** study focused on the details of *** women(age≤35 years)had the highest prevalence of depressive symptoms(24.9%),anxiety symptoms(16.2%),and comorbidity(11.2%).It was established that,despite traditional risk factors,unmanageable work burnout,depressive symptoms,and anxiety symptoms were associated with a higher risk of CVD in women;insomnia,overwhelming work stress,unmanageable work burnout,and CVD were linked to a higher risk of depressive symptoms and anxiety;insomnia,overwhelming work stress,and unmanageable work burnout were related to CVD combined with depressive or anxiety symptoms.A bidirectional relationship was noted between CVD and depression or anxiety in female scientists and technicians,and insomnia and overwhelming work stress were positively associated with *** is suggested that effective measures should be taken to protect female scientists and technicians from CVD and psychological distress.

关键词： Female scientist and technician Depressive symptom Anxiety Insomnia Cardiovascular disease(CVD)

Comparative Effectiveness of Mobile Health-Based Comprehensive Smoking Cessation Modalities and Traditional Clinic-Delivered Treatments—Beijing Municipality,China,May 2022 to April 2024

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China CDC weekly 2024年第22期6卷 516-521页

作者： Shuilian Chu Hang Jing Di Zhang Yuan Cao Yunliang Qian Xiurong Liu Lin Xiao Zhaohui Tong Lirong Liang department of Research on Tobacco dependence Therapies Beijing Institute of Respiratory Medicine and Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina Beijing Center for Disease Prevention and Control BeijingChina Tobacco Control Office Chinese Center for Disease Control and PreventionBeijingChina department of Respiratory and Critical Care Medicine Beijing Institute of Respiratory Medicine and Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina

What is already known about this topic?Most Chinese smokers have not accessed professional help due to a lack of sufficient smoking cessation *** health(mHealth)can mitigate obstacles related to time and transportation,thereby providing effective support for smokers seeking to *** is added by this report?This study offers real-world evidence supporting the effectiveness of mHealth-based comprehensive smoking cessation *** findings indicate that these modalities can significantly enhance abstinence rates,albeit to a lesser extent compared to traditional clinicbased *** to the intervention was identified as a critical factor influencing the effectiveness of smoking cessation *** are the implications for public health practice?The mHealth-based comprehensive smoking cessation modalities,with or without mailing cessation medications,present a promising approach to enhancing access to and utilization of smoking cessation *** strategy addresses the significant challenge of limited smoking cessation resources in China.

关键词： smoke Health thereby

Effectiveness and Acceptability of a Comprehensive Mobile Health-Based Modality for Smoking Cessation-Beijing Municipality,China,2022

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China CDC weekly 2023年第21期5卷 464-468页

Summary What is already known on this topic?Mobile health interventions have been demonstrated to be effective in aiding smoking cessation among ***,research on this topic remains limited in *** is added by this report?Following two months of utilizing the services of a comprehensive mobile health(mHealth)-based modality(“Way to Quit”modality)which integrated three online interventions through the WeChat application,29.1%of participating smokers successfully quit *** who used a greater number of online services were more likely to cease *** services were scored highly for satisfaction among *** are the implications for public health practice?This study presents a practical and feasible method to assist Chinese smokers in quitting *** results of this research suggest a promising direction for enhancing the accessibility and utilization of smoking cessation ***,these findings serve as a critical reference for addressing the obstacles faced by smoking cessation services in China.

关键词： smoke services utilizing

Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

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Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li Hong Zhou Zhihao Ren Cheng Xu Chengkuo Lee department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

Asymptotic false discovery control of the Benjamini-Hochberg procedure for pairwise comparisons

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Science China Mathematics 2025年第1期 223-252页

作者： Weidong Liu Dennis Leung Qi-Man Shao School of Mathematical Sciences Shanghai Jiao Tong University School of Mathematics and Statistics University of Melbourne department of Statistics and Data Science SICMSouthern University of Science and Technology

In a one-way analysis-of-variance(ANOVA) model,the number of pairwise comparisons can become large even with a moderate number of *** by this,we consider a regime with a growing number of groups and prove that,when testing pairwise comparisons,the Benjamini-Hochberg(BH) procedure can asymptotically control false discoveries,despite the fact that the involved t-statistics do not exhibit the wellknown positive dependence structure required for exact false discovery rate(FDR) *** Tukey's perspective that the difference between the means of any two groups cannot be exactly zero,our main result provides control over the directional false discovery rate and directional false discovery proportion.A key technical contribution of our work is demonstrating that the dependence among the t-statistics is sufficiently weak to establish the convergence result typically required for asymptotic FDR *** analysis does not rely on conventional assumptions such as normality,variance homogeneity,or a balanced design,thereby offering a theoretical foundation for applications in more general settings.

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Synthesis and biological evaluation of a lipopeptide-based methamphetamine vaccine

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Chinese Chemical Letters 2021年第4期32卷 1575-1579页

作者： Fan Liao Hanxuan Wang Yuankun Dao Kai Yuan Jiazhen Lu Jie Shi Ying Han Suwei Dong Lin Lu Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Beijing 100191China National Institute on Drug dependence and Beijing Key Laboratory of Drug dependence Peking UniversityBeijing 100191China State Key Laboratory of Natural and Biomimetic Drugs and Department of Chemical BiologySchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovem Institute for Brain Research Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China School of Basic Medicine Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

We describe an application of carrier protein-free strategy in constructing a fully synthetic methamphetamine(METH)vaccine that contains three components:Toll-like receptor 2 ligand,Th2 epitope,and METH *** immunological evaluation in mice revealed high titers of METH-specific antibodies induced by the construct and the activation of humoral immunity that would be beneficial for neutralization and clearance of the METH *** ral experiments indicated that the synthetic vaccine attenuated the acquisition of METH-induced conditioned place preference and inhibited the initiation and expression of METH-induced locomotor *** results demonstrate that the lipopeptide-based vaccine has invo ked an immune response and showed the potential of preventing the rewarding and psychoactive effects of METH.

关键词： METH vaccine Carrier protein-free Fully synthesis Lipopeptide Behavioral model