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Cerbera odollam fruit extracts enhance anti-cancer activity of sorafenib in HCT116 and HepG2 cells

Chinese Herbal Medicines 2025年第1期17卷 108-126页

作者： Supawadee Parhira Orakot Simanurak Khemmachat Pansooksan Julintorn Somran Apirath Wangteeraprasert Zhihong Jiang Liping Bai Pranee Nangngam Dumrongsak Pekthong Piyarat Srisawang department of Pharmaceutical Technology Faculty of Pharmaceutical Sciences Naresuan University Center of Excellence for Innovation in Chemistry Naresuan University Center of Excellence for Environmental Health and Toxicology Faculty of Pharmaceutical Sciences Naresuan University department of Physiology Faculty of Medical Science Naresuan University department of Pharmaceutical Chemistry and Pharmacognosy Faculty of Pharmaceutical Sciences Naresuan University department of Pathology Faculty of Medicine Naresuan University department of Medicine Faculty of Medicine Naresuan University State Key Laboratory of Quality Research in Chinese Medicine Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease Macau Institute for Applied Research in Medicine and Health Macau University of Science and Technology department of Biology Faculty of Science Naresuan University department of Pharmacy Practice Faculty of Pharmaceutical Sciences Naresuan University Center of Excellence in Medical biotechnology Faculty of Medical Science Naresuan University

Objective:While higher therapeutic doses of toxic cardiac glycosides derived from Cerbera odollam are frequently employed in cases of suicide or homicide,ongoing research is investigating the potential anticancer properties of low-concentration extracts obtained from the fruits of *** present study aimed to determine the enhanced anticancer effects and minimize potential side effects of combining extracts from *** fruits from Thailand with sorafenib against HCT116 and HepG2 ***:The dried powder of fresh green fruits of *** was fractionated,and its phytochemical contents,including total cardiac glycosides,phenolics,flavonoids,and triterpenoids,were *** cytotoxic effects of these fractions were evaluated against HCT116 and HepG2 cells using the MTT *** fractions showing the most significant response in HCT116 and HepG2 cells were subsequently combined with sorafenib to examine their synergistic *** induction,cell cycle progression,and mitochondrial membrane potential（MMP） were then *** underlying mechanism of the apoptotic effect was further investigated by analyzing reactive oxygen species（ROS） generation and the expression levels of antioxidant ***:Phytochemical analysis showed that ***-ethyl acetate fraction（COEtOAc） was rich in cardiac glycosides,phenolics,and flavonoids,while the dichloromethane fraction（CODCM） contained high levels of triterpenoids and *** 24 h treatment,HCT116 showed the most significant response to COEtOAc,while HepG2 responded well to CODCM with IC50values of（42.04±16.94） μg/mL and（123.75±14.21） μg/m L,***,COEtOAc（20 μg/mL） or CODCM（30 μg/mL）,both administered at sub-IC50concentrations,were combined with sorafenib at 6 μmol/L for HCT116 cells and2 μmol/L for HepG2 cells,incubated for 24 *** combination resulted in a significant suppression in cell viability by approximately 50%.The combination of treatments marked

关键词： apoptosis Cerbera odollam Gaertn. HCT116 HepG2 reactive oxygen species sorafenib

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Pentaploidization allows introgression of Aegilops tauschii into tetraploid wheat

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The crop Journal 2025年第1期13卷 227-232页

作者： Fan Yang Zehou Liu Hongshen Wan Sujie Yang Ning Yang Hongxia Ding Yun Jiang Junyan Feng Jie Zhang Ying Wang Xing Fan Yonghong Zhou Jun Li Wuyun Yang crop Research Institute Sichuan Academy of Agricultural SciencesChengdu 610066SichuanChina biotechnology and Nuclear Technology Research Institute Sichuan Academy of Agricultural SciencesChengdu 610066SichuanChina Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina College of Agronomy Sichuan Agricultural UniversityChengdu 611130SichuanChina

Pentaploid hybrids produced from crosses between hexaploid and tetraploid wheats combine the genetic variation of both *** a synthetic hexaploid wheat LM/AT23 with its AB-genome donor,the durum wheat LM,and selfing the pentaploid hybrids to the F7 generation yielded mostly euploid tetraploids and a few *** special derivatives of tetraploid were isolated,including a 4D(4B)substitution line with large panicles and high resistance to stripe rust and a 2DS.2AL translocation line with non-waxy *** discovery of small D-genome introgressions in the A and B genomes suggested that pentaploidization can be used to induce homoeologous *** introgression of D genome from Aegilops tauschii to the AB genomes might promote the development of super tetraploid wheat with hexaploid biological characteristics(especially stress resistance)and quality functions and the functional study of the introduced chromosomes or fragments.

关键词： Pentaploid hybridization Interspecific hybridization Alien introgression Homoeologous recombination Aegilops tauschii

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Decellularized amniotic membrane promotes the anti-inflammatory response of macrophages via PI3K/AKT/HIF-1α pathway

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Chinese Chemical Letters 2025年第1期36卷 403-407页

作者： Xiongbo Song Jinwen Xiao Juan Wu Li Sun Long Chen department of Orthopedics Guizhou Provincial People’s HospitalGuiyang 550000China The Lab of Tissue Engineering and Translational Medicine College of MedicineGuizhou UniversityGuiyang 550000China Wuhan Kangchuang biotechnology Wuhan 430074China

Macrophages undergo dynamic transitions between M1 and M2 states,exerting profound influences on both inflammatory and regenerative *** biocompatible and wound-healing properties of decellularized amniotic membrane(d AM)make it a subject of exploration for its potential impact on the anti-inflammatory response of *** findings unequivocally demonstrate that d AM promotes anti-inflammatory M2 polarization of macrophage,with its cytokine-rich content posited as a potential *** application of RNA sequencing unveils differential gene expression,implicating the hypoxia inducible factor-1α(HIF-1α)signaling pathway in this intricate *** investigation further demonstrates that d AM facilitates anti-inflammatory M2 polarization of macrophage through the upregulation of epidermal growth factor(EGF),which,in turn,activates the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)pathway and stabilizes HIF-1α.This cascade results in a noteworthy augmentation of anti-inflammatory gene *** study significantly contributes to advancing our comprehension of d AM's immunomodulatory role in tissue repair,thereby suggesting promising therapeutic potential.

关键词： Macrophage Decellularized amniotic membrane Anti-inflammatory response Hypoxia inducible factor-1α Epidermal growth factor

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Synergistic effect of nitrocellulose coating on structural and reactivity stabilization of ammonium nitrate oxidizer

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Defence Technology(防务技术) 2025年第1期43卷 35-43页

作者： Amir Abdelaziz Djalal Trache Ahmed Fouzi Tarchoun Hani Boukeciat Yash Pal Sourbh Thakur Weiqiang Pang Thomas M.Klapötke Energetic Materials Laboratory(EMLab) Teaching and Research Unit of Energetic ProcessesEcole Militaire PolytechniqueBP 17 Bordj El-BahriAlgiers 16046Algeria School of Aeronautical science Hindustan Institute of Technology and ScienceChennai 603103India department of Organic Chemistry Bioorganic Chemistry and BiotechnologySilesian University of TechnologyB.Krzywoustego 4Gliwice 44–100Poland Xi'an Modern Chemistry Research Institute 168 Zhangba Rd.EastXi'an 710065China Energetic Materials Research Department of ChemistryLudwig-Maximilian UniversityMunich Butenandtstrasse 5-13(D)Munich D-81377Germany

The present work aims to stabilize the room temperature allotropic transition of ammonium nitrate(AN)particles utilizing a microencapsulation technique,which involves solvent/non-solvent in which nitrocellulose(NC)has been employed as a coating *** SEM micrographs revealed distinct features of both pure AN and NC,contrasting with the irregular granular surface topography of the coated AN particles,demonstrating the adherence of NC on the AN *** analysis via infrared spectroscopy(IR)demonstrated a successful association of AN and NC,with slight shifts observed in IR bands indicating interfacial *** X-ray Diffraction(PXRD)analysis further elucidated the structural changes induced by the coating process,revealing that the NC coating altered the crystallization pattern of its pure *** analysis demonstrates distinct profiles for pure and coated AN,for which the coated sample exhibits a temperature increase and an enthalpy decrease of the room temperature allotropic transition by 6℃,and 36%,***,the presence of NC coating alters the intermolecular forces within the composite system,leading to a reduction in melting enthalpy of coated AN by~39%compared to pure *** thermal decomposition analysis shows a two-step thermolysis process for coated AN,with a significant increase in the released heat by about 78%accompanied by an increase in the activation barrier of NC and AN thermolysis,demonstrating a stabilized reactivity of the AN-NC *** findings highlight the synergistic effect of NC coating on AN particles,which contributed to a structural and reactive stabilization of both AN and NC,proving the potential application of NC-coated AN as a strategically advantageous oxidizer in composite solid propellant formulations.

关键词： Ammonium nitrate Nitrocellulose Stabilization Coating Thermolysis kinetics

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Nanoplastics and nano-ZnO facilitate Cd accumulation in zebrafish larvae via a distinct pathway: Revelation by LA-ICP-MS imaging

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Chinese Chemical Letters 2025年第2期36卷 436-440页

作者： Pengyu Chen Beibei Chen Man He Yuxi Zhou Lei Lei Jian Han Bingsheng Zhou Ligang Hu Bin Hu department of Chemistry Wuhan University State Key Laboratory of Freshwater Ecology and biotechnology Institute of Hydrobiology Chinese Academy of Sciences State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

The interaction between nanoparticles （NPs） and pollutants affects their bioavailability and ***,the processes by which NPs and pollutants change in vivo have rarely been ***,using laser ablation-inductively coupled plasma-mass spectrometry （LA-ICP–MS）,we found that both nanoplastics and ZnO NPs caused more Cd to accumulate in zebrafish larvae,but with distinct *** could adsorb Cd2+and transfer it into the larvae through the“Trojan horse”*** coexposure of nanoplastics and Cd2+caused Cd to accumulate in the abdomen where the nanoplastics were located without dissociation,showing a lower toxic effect than Cd2+exposure *** NPs weakly adsorbed Cd2+,but they increased the Zn and Cd contents in larvae by enhancing the expression of metal *** coexposure of ZnO and Cd2+evenly distributed Cd in the larvae,revealing a more severe toxic effect than Cd2+exposure *** results demonstrated the changing bioavailability and toxicity of Cd induced by different *** also shows the vital role LA-ICP-MS plays in revealing the relationship between toxicity and *** addition,the long-term effect of bioavailability on heavy metal toxicity and nanosafety deserves further investigation.

关键词： Cadmium Combined effect LA-ICP-MS Nanoplastics Zebrafish larvae ZnO nanoparticles

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Reconstruction characteristics of gut microbiota from patients with type 1 diabetes affect the phenotypic reproducibility of glucose metabolism in mice

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science China(Life sciences) 2025年第1期68卷 176-188页

作者： Zhiyi Wang Mengxue Gong Yuanyuan Fang Huijuan Yuan Chenhong Zhang State Key Laboratory of Microbial Metabolism School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China department of Endocrinology Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhou 450003China

The human microbiota-associated(HMA)mice model,especially the germ-free(GF)-humanized mice,has been widely used to probe the causal relationships between gut microbiota and human diseases such as type 1 diabetes(T1D).However,most studies have not clarified the extent to which the reconstruction of the human donor microbiota in recipient mice correlates with corresponding phenotypic *** this study,we transplanted fecal microbiota from five patients with T1D and four healthy people into GF mice,and microbiota from each donor were transplanted into 10 *** with similar microbiota structure to the donor exhibited better phenotypic *** characteristics of the microbial community assembly of donors also influenced the phenotypic reproducibility in mice,and individuals with a higher proportion of stochastic processes showed more severe *** enriched in patients with T1D had a stronger colonization potential in mice with impaired glucose metabolism,and microbiota functional features related to T1D were better reproduced in these *** indicates that assembly traits and colonization efficacy of microbiota influence phenotypic reproducibility in GF-humanized *** findings provide important insights for using HMA mice models to explore links between gut microbiota and human diseases.

关键词： gut microbiome human microbiota-associated animal model type 1 diabetes

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Puccinia triticina effector Pt-1234 modulates wheat immunity by targeting transcription factor TaNAC069 via its C subdomain

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The crop Journal 2025年第1期13卷 69-78页

作者： Huaimin Geng Yanjun Zhang Zhen Qin Shen Wang Changshan Liu Zhongchi Cui Daqun Liu Haiyan Wang College of Plant Protection Hebei Agricultural University/Technological Innovation Center for Biological Control of Crop Diseases and Insect Pests of Hebei ProvinceBaoding 071000HebeiChina department of Resource and Environmental Engineering Xingtai Polytechnic CollegeXingtai 054000HebeiChina Institute of Cereal and Oil crops Hebei Academy of Agricultural and Forestry Sciences/Hebei Laboratory of Crop Genetic and BreedingShijiazhuang 050035HebeiChina

The NAC(NAM,ATAF1/2,and CUC2)is a defense-associated transcription factor(TF)family that positively regulates defense responses to pathogen ***069 positively regulates resistance in wheat to Puccinia triticina(Pt).However,the molecular mechanism of its interaction with a Pt effector is not *** found that Pt effector Pt-1234 interacts with TaNAC069 to subvert host immunity during Pt *** real-time PCR analysis showed that expression of Pt-1234 was significantly upregulated during the early stage of Pt ***-mediated cell death assays in wheat showed that the Pt-1234 protein was unable to induce cell death in wheat near-isogenic lines carrying different leaf rust resistance genes,whereas it suppressed BAX-induced cell death in leaves of Nicotiana *** of Pt-1234 by host-induced gene silencing(HIGS)significantly reduced the virulence of Pt in the susceptible wheat variety *** C subdomain of TaNAC069 was responsible for its interaction with Pt-1234,and the E subdomain was required for TaNAC069-mediated defense responses to Pt in *** findings indicate that Pt utilizes Pt-1234 to interact with wheat transcription factor TaNAC069 through its C subdomain,thereby modulating wheat immunity.

关键词： Effectors NAC transcription factor Host-induced gene silencing Puccinia triticina Triticum aestivum

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Phytobiotics in poultry:revolutionizing broiler chicken nutrition with plant‑derived gut health enhancers

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Journal of Animal science and biotechnology 2025年第1期16卷 1-33页

作者： Uchechukwu Edna Obianwuna Xinyu Chang Vivian U.Oleforuh‑Okoleh Patience N.Onu Haijun Zhang Kai Qiu Shugeng Wu National Engineering Research Center of Biological Feed Institute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081China department of Animal science Rivers State UniversityPort HarcourtRivers StateNigeria department of Animal science Ebonyi State UniversityAbakilikiEbonyi StateNigeria.

As the global population continues to expand,the demand for broiler chicken production to supply safe and high-quality meat is *** meet this ever-growing demand,broiler chickens with enhanced growth performance are being developed,but they often face challenges related to oxidative stress,which can adversely affect gut ***,which are plant-derived feed additives known for their antimicrobial,antioxidant,immune-modulating,and growth-promoting properties,have emerged as promising natural alternatives to synthetic *** review consolidates recent advancements in the use of phytobiotics-derived products from leaves,roots,seeds,flowers,and their extracts in broiler diets reared under standard experimental conditions,without the introduction of *** focus is on elucidating the key mechanisms through which phytobiotics improve gut health,includ-ing their effects on gut morphology,integrity,microflora composition,antioxidant capacity,and immune *** review highlights the potential of phytobiotics to revolutionize broiler nutrition by acting as natural enhancers of gut *** findings reveal that phytobiotics significantly improve intestinal health,and boost growth per-formance,offering a sustainable approach to managing to gut *** findings indicate a potential shift in how gut-health related challenges in broilers can be addressed,moving towards natural phytobiotic ***-ever,several challenges *** the dosage of phytobiotics,ensuring consistent performance,and over-coming the limitations related to their extraction and application are key areas requiring further *** review emphasizes the importance of continued research to refine phytobiotic formulations,explore synergistic effects,and incorporate advanced technologies such as AI-driven methods and precision nutrition to tailor feeding strategies more ***,the development of innovative delivery

关键词： Broilers Essential oils Gut health Herbs and spices Phytobiotics Plant extracts

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Effects of dietary Lactobacillus postbiotics and bacitracin on the modulation of mucosaassociated microbiota and pattern recognition receptors affecting immunocompetence of jejunal mucosa in pigs challenged with enterotoxigenic F18^(+)Escherichia coli

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Journal of Animal science and biotechnology 2025年第1期16卷 282-299页

作者： Marcos Elias Duarte Zixiao Deng Sung Woo Kim department of Animal science North Carolina State University116 Polk HallCampus Box 7621RaleighNC 27695USA

Background Enterotoxigenic Escherichia coli(***)is a threat to humans and animals that causes intestinal *** resistance has urged alternatives,including Lactobacillus postbiotics,to mitigate the effects of enterotoxigenic *** Forty-eight newly weaned pigs were allotted to NC:no challenge/no supplement;PC:F18^(+)*** chal-lenge/no supplement;ATB:F18^(+)*** challenge/bacitracin;and LPB:F18^(+)*** challenge/postbiotics and fed diets for 28 *** d 7,pigs were orally inoculated withF18^(+)*** d 28,the mucosa-associated microbiota,immune and oxidative stress status,intestinal morphology,the gene expression of pattern recognition receptors(PRR),and intestinal barrier function were *** were analyzed using the MIXED procedure in SAS *** PC increased(P<0.05)Helicobacter mastomyrinus whereas reduced(P<0.05)Prevotella copri and ***-corea compared to *** LPB increased(P<0.05)*** and Dialister succinatiphilus compared with *** ATB increased(P<0.05)Propionibacterium acnes,Corynebacterium glutamicum,and Sphingomonas pseudosanguinis compared to *** PC tended to reduce(P=0.054)PGLYRP4 and increased(P<0.05)TLR4,CD14,MDA,and crypt cell proliferation compared with *** ATB reduced(P<0.05)NOD1 compared with *** LPB increased(P<0.05)PGLYRP4,and interferon-γand reduced(P<0.05)NOD1 compared with *** ATB and LPB reduced(P<0.05)TNF-αand MDA compared with *** TheF18^(+)*** challenge compromised intestinal *** increased beneficial bacteria show-ing a trend towards increasing the intestinal barrier function,possibly by reducing the expression of PRR ***-tobacillus postbiotics enhanced the immunocompetence of nursery pigs by increasing the expression of interferon-γand PGLYRP4,and by reducing TLR4,NOD1,and CD14.

关键词： Escherichia coli Immunocompetence Intestinal health Pattern recognition receptors Pigs

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AND-logic-gate measurement of bisulfite and viscosity using a dual-lock-and-key fluorescent probe

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science China Chemistry 2025年

作者： Tianyu Liang Shuling Liu Yunhe Jiang Mingyu Tian Chengyan Wu Yang Li Tianruo Shen Xiaofei Sun Keli Zhong Lijun Tang School of Chemistry and Materials Engineering Bohai University Key Laboratory of biotechnology and Bioresources Utilization of Ministry of Education Dalian Minzu University science Mathematics and Technology Cluster Singapore University of Technology and Design

This study presents an innovative dual-lock-and-key fluorescent probe engineered for the simultaneous detection of bisulfite and viscosity. The functionalized probe,(E)-2-(1-ethyl-2-(N-methylquinolinevinyl)quinolin-4(1H)-ylidene)malononitrile(QCQNM), was strategically synthesized by conjugating the quinolylmalononitrile and N-methylquinolinium through an ethylene bridge. Within this construction, the N-methylquinolinium selectively targets bisulfite, while the vinyl moiety serves as a responsive rotor for viscosity. Notably, the presence of either sulfite or viscosity alone cannot elicit significant fluorescent responses from the probe. Conversely, concurrent exposure to both bisulfite and viscosity triggers enhanced fluorescent signals,indicative of an “AND” logic gate characteristic. Quantum chemical calculations were further applied to rationalize the working mechanism of the probe. Additionally, the excellent biocompatibility of this probe in cellular imaging experiments highlights its potential for specific mitochondrial imaging by modulating both exogenous/endogenous bisulfite levels alongside viscosity induced by monensin. This novel approach thereby offers a distinctive analytical tool for monitoring the coexistence of viscosity and bisulfite in specific metabolic and physiological contexts.

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