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Chinese Journal of Natural Medicines 2018年第3期16卷 203-209页

作者： Hyung Seo Hwang Joong Hyun Shim department of Oriental cosmetic science Semyung University

Caesalpinia sappan L., belonging to the family Leguminosae, is a medicinal plant that is distributed in Southeast Asia. The dried heartwood of this plant is used as a traditional ingredient of food, red dyes, and folk medicines in the treatment of diarrhea, dysentery, tuberculosis, skin infections, and inflammation. Brazilin is the major active compound, which has exhibited various pharmacological effects, including anti-platelet activity, anti-hepatotoxicity, induction of immunological tolerance, and anti-inflammatory and antioxidant activities. The present study aimed to evaluate the antioxidant activity and expression of antioxidant enzymes of C. sappan L. extract and its major compound, brazilin, in human epidermal keratinocytes exposed to UVA irradiation. Our results indicated that C. sappan L. extract reduced UVA-induced H2 O2 production via GPX7 activation. Moreover, brazilin exhibited antioxidant effects that were similar to those of C. sappan L. via glutathione peroxidase 7(GPX7), suggesting that C. sappan L. extract and its natural compound represent potential treatments for oxidative stress-induced photoaging of skin.

关键词： Caesalpinia sappan L. Brazilin 紫外 GPX7 抗氧化

Hair growth-promotion effects and antioxidant activity of the banana flower extract HappyAngel^(■):double-blind, placebo-controlled trial

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Food science and Human Wellness 2023年第5期12卷 1917-1923页

作者： Chia-Hua Liang Yung-Hsiang Lin Yung-Kai Lin Chi-Fu Chiang Department of Cosmetic Science and Institute of Cosmetic Science Chia Nan University of Pharmacy and ScienceTainan 71710China Research&Design Center TCI CO.Ltd.Taipei 114722China institute of Food Safety and Risk Management Department of Food ScienceTaiwan Ocean UniversityKeelung 202301China Graduate institute of Biomedical Engineering Chung Hsing UniversityTaichung 202301China

Banana flowers contain various bioactive components, including several antioxidants with anti-inflammatory effects. However, it is unclear whether they can reduce and prevent hair loss. This study examines the effect of banana flower extracts on preventing hair loss and strengthening hair roots. The banana flower extract(HappyAngel^(■))was used to treat human hair follicle dermal papilla cells(HFDPCs)and the expression of reactive oxygen species(ROS), dihydrotestosterone(DHT), and hair-related genes(SRD5A1, SRD5A2, AR, and KROX20)were monitored. Fifty subjects were divided into a placebo group and a banana flower group. The experimental group consumed banana flower extract daily for twelve weeks and then underwent hair testing, hair-related genes analysis, collection of hair loss, and questionnaires. The results showed that the banana flower extract significantly increased hair cell growth and decreased the expression of ROS, DHT, and hair follicle growth inhibition-related SRD5A1, SRD5A2, and AR genes, and significantly increased the expression of hair growth-related KROX20 gene in HFDPCs. Consuming banana flower extract for twelve weeks increased the hair root diameter and reduced hair loss and scalp redness compared to the placebo group. Thus, banana flower extract(HappyAngel^(■))can stimulate hair growth and inhibit the activation of hair loss genes.

关键词： Banana flower Dihydrotestosterone Hair loss ROS Follicle dermal papilla cells

Code Transform Model Producing High-Performance Program

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Computer Modeling in Engineering & sciences 2021年第10期129卷 253-277页

作者： Bao Rong Chang Hsiu-Fen Tsai Po-Wen Su department of Computer science and Information Engineering National University of KaohsiungKaohsiungTaiwan department of Fragrance and cosmetic science Kaohsiung Medical UniversityKaohsiungTaiwan

This paper introduces a novel transform method to produce the newly generated programs through code transform model called the second generation of Generative Pre-trained Transformer(GPT-2)reasonably,improving the program execution performance significantly.Besides,a theoretical estimation in statistics has given the minimum number of generated programs as required,which guarantees to find the best one within them.The proposed approach can help the voice assistant machine resolve the problem of inefficient execution of application code.In addition to GPT-2,this study develops the variational Simhash algorithm to check the code similarity between sample program and newly generated program,and conceives the piecewise longest common subsequence algorithm to examine the execution’s conformity from the two programs mentioned above.The code similarity check deducts the redundant generated programs,and the output conformity check finds the best-performing generative program.In addition to texts,the proposed approach can also prove the other media,including images,sounds,and movies.As a result,the newly generated program outperforms the sample program significantly because the number of code lines reduces 27.21%,and the program execution time shortens 24.62%.

关键词： Newly generated programs GPT-2 predetermined generative programs variational Simhash algorithm piecewise longest common subsequence

Optimizing Big Data Retrieval and Job Scheduling Using Deep Learning Approaches

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Computer Modeling in Engineering & sciences 2023年第2期134卷 783-815页

作者： Bao Rong Chang Hsiu-Fen Tsai Yu-Chieh Lin department of Computer science and Information Engineering National University of KaohsiungKaohsiungTaiwan department of Fragrance and cosmetic science Kaohsiung Medical UniversityKaohsiungTaiwan

Big data analytics in business intelligence do not provide effective data retrieval methods and job scheduling that will cause execution inefficiency and low system throughput.This paper aims to enhance the capability of data retrieval and job scheduling to speed up the operation of big data analytics to overcome inefficiency and low throughput problems.First,integrating stacked sparse autoencoder and Elasticsearch indexing explored fast data searching and distributed indexing,which reduces the search scope of the database and dramatically speeds up data searching.Next,exploiting a deep neural network to predict the approximate execution time of a job gives prioritized job scheduling based on the shortest job first,which reduces the average waiting time of job execution.As a result,the proposed data retrieval approach outperforms the previous method using a deep autoencoder and Solr indexing,significantly improving the speed of data retrieval up to 53%and increasing system throughput by 53%.On the other hand,the proposed job scheduling algorithmdefeats both first-in-first-out andmemory-sensitive heterogeneous early finish time scheduling algorithms,effectively shortening the average waiting time up to 5%and average weighted turnaround time by 19%,respectively.

关键词： Stacked sparse autoencoder Elasticsearch distributed indexing data retrieval deep neural network job scheduling

Implementation of Rapid Code Transformation Process Using Deep Learning Approaches

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Computer Modeling in Engineering & sciences 2023年第7期136卷 107-134页

作者： Bao Rong Chang Hsiu-Fen Tsai Han-Lin Chou department of Computer science and Information Engineering National University of KaohsiungKaohsiung811Taiwan department of Fragrance and cosmetic science Kaohsiung Medical UniversityKaohsiung811Taiwan

Our previous work has introduced the newly generated program using the code transformation model GPT-2,verifying the generated programming codes through simhash(SH)and longest common subsequence(LCS)algo-rithms.However,the entire code transformation process has encountered a time-consuming problem.Therefore,the objective of this study is to speed up the code transformation process signi􀀀cantly.This paper has proposed deep learning approaches for modifying SH using a variational simhash(VSH)algorithm and replacing LCS with a piecewise longest common subsequence(PLCS)algorithm to faster the veri􀀀cation process in the test phase.Besides the code transformation model GPT-2,this study has also introduced MicrosoMASS and Facebook BART for a comparative analysis of their performance.Meanwhile,the explainable AI technique using local interpretable model-agnostic explanations(LIME)can also interpret the decision-making ofAImodels.The experimental results show that VSH can reduce the number of quali􀀀ed programs by 22.11%,and PLCS can reduce the execution time of selected pocket programs by 32.39%.As a result,the proposed approaches can signi􀀀cantly speed up the entire code transformation process by 1.38 times on average compared with our previous work.

关键词： Code transformation model variational simhash piecewise longest common subsequence explainable AI LIME

Preparation and characterization of nanoparticles from quaternized cyclodextrin-grafted chitosan associated with hyaluronic acid for cosmetics

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Asian Journal of Pharmaceutical sciences 2018年第5期13卷 498-504页

作者： Sakhiran Sakulwech Nattaya Lourith Uracha Ruktanonchai Mayuree Kanlayavattanakul School of cosmetic science Mae Fah Luang University Phytocosmetics and Cosmeceuticals Research Group Mae Fah Luang University National Nanotechnology Center National Science and Technology Development Agency

Hyaluronic acid(HA, 20–50 kDa) is a hydrophilic macromolecule with anti-wrinkle effects and moisturizing properties. However, its high molecular weight prevents it from penetrating into the deeper layers of the skin and, thus, limits its benefits to topical effects. Thus, the objective of this study is to prepare nanoparticles of quaternized cyclodextrin-grafted chitosan(QCD-g-CS) associated with HA in different molar ratios of QCD-g-CS and HA. The conjugation of the carboxylic moieties of HA and the amides of QCD-g-CS was confirmed by Fourier-transform infrared spectroscopy. Thus, the system was optimized to create nanoparticles with a small size(235.63 ± 21.89 nm), narrow polydispersity index(0.13 ± 0.02), and zeta potential of 16.07 ± 0.65 m V. The association efficiency and loading efficiency were determined by ultra-performance liquid chromatography as 86.77 ± 0.69% and 10.85 ± 0.09%, respectively. The spherical morphology of the obtained nanoparticles was confirmed by transmission electron microscopy. Moreover, the in-vitro hydrating ability was significantly higher( P cosmetics.

关键词： Hyaluronic acid QCD-g-CS Polymeric nanoparticles Ionic gelation Delivery system

Compared Evaluation of Botulinum Toxin A and a cosmetic Antiperspirant in the Treatment of Focal Axillary Hyperhidrosis

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Journal of cosmetics, Dermatological sciences and Applications 2013年第3期3卷 190-196页

作者： Meike Streker Stefanie Lübberding Martina Kerscher cosmetic science Department of Chemistry University of Hamburg Hamburg Germany

Background: Primary focal hyperhidrosis can significantly reduce quality of life. Therefore a lot of treatment options in a range of conservative, physical and surgical techniques are available. Objective: To assess the efficacy of an antiperspirant containing aluminum chloride compared to a Botulinumtoxin A treatment for patients with primary focal hyperhidrosis. Methods and material: In this randomized, single-center, half-side trail, a clinical score was done by patients and physician to evaluate the severity of hyperhidrosis. Gravimetric tests were performed to gather the amount of sweat per unit of time. Furthermore the efficacy was determined using a four point questionnaire. Skin irritation was assessed by measuring pH value and transepidermal water loss. Results: A total of 22 patients were enrolled. Two weeks after baseline the hyperhidrosis level was significantly reduced (BTX-A: ﹣92.9%, AL: 66.7%). In addition both treatment options induced a significant reduction of sweat production (BTX-A: ﹣80.8%, AL: 68.8%). Please change in: Patients evaluated good resp, very good efficacy for both treatment options at day 28. pH value and TEWL never left physiological range. Conclusion: Both botulinum toxin A treatment and an antiperspirant containing aluminum chloride in the evaluated galenic formulation are an effective and safe treatment option for axillary focal hyperhidrosis.

关键词： Hyperhidrosis Aluminum Chloride Botulinum Toxin Antiperspirant Sweating

阴离子对鼠尾草提取物中Ni盐前体绿色合成的NiO纳米粒子磁性和结构性能的影响

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无机化学学报 2024年第2期40卷 451-462页

作者： Kubra Zenkin Aslihan Dalmaz Mesut Ozdincer Sefa Durmus department of Chemistry Graduate Education InstituteDuzce UniversityDuzce 81620Türkiye department of Natural and Herbal Products/cosmetic Products Graduate Education InstituteDuzce UniversityDuzce 81620Türkiye department of Composite-Materials Graduate Education InstituteDuzce UniversityDuzce 81620Türkiye department of Chemistry Faculty of Art and ScienceDuzce UniversityDuzce 81620Türkiye

采用绿色合成方法,将鼠尾草提取物用作还原和封端剂合成氧化镍纳米颗粒(NiO NPs)。此外,使用各种前驱体合成了NiO NPs,并使用扫描电子显微镜对其形貌进行了分析。利用傅里叶变换红外光谱和粉末X射线衍射(PXRD)对NiO NPs的结构进行了表征... 详细信息

采用绿色合成方法,将鼠尾草提取物用作还原和封端剂合成氧化镍纳米颗粒(NiO NPs)。此外,使用各种前驱体合成了NiO NPs,并使用扫描电子显微镜对其形貌进行了分析。利用傅里叶变换红外光谱和粉末X射线衍射(PXRD)对NiO NPs的结构进行了表征,使用振动样品磁强计测量了它们的磁性。PXRD研究表明,所有合成的NiO NPs都表现出具有高结晶度的面心立方相,并且形成了具有高纯度相的NiO。磁化研究结果表明,3种镍盐(乙酸盐、氯化物和硫酸盐)前驱体合成的NiO NPs分别表现出超顺磁、软铁磁和顺磁行为。

关键词：绿色合成 NiO纳米粒子鼠尾草阴离子效应磁性行为

Effects of microenvironment and biological behavior on the paracrine function of stem cells

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Genes & Diseases 2024年第1期11卷 135-147页

作者： Zhixin Xue Yunjun Liao Ye Li The department of Plastic and cosmetic Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Mesenchymal stem cells(MSCs),the most well-studied cell type in the field of stem cell therapy,have multi-lineage differentiation and self-renewal potential.MsC-based thera-pies have been used to treat diverse diseases because of their ability to potently repair tissue and locally restore function.An increasing body of evidence demonstrates that paracrine func-tion is central to the effects of MsC-based therapy.Growth factors,cytokines,chemokines,extracellular matrix components,and extracellular vehicles all contribute to the beneficial ef-fects of MSCs on tissue regeneration and repair.The paracrine substances secreted by MSCs change depending on the tissue microenvironment and biological behavior.In this review,we discuss the bioactive substances secreted by MsCs depending on the microenvironment and biological behavior and their regulatory mechanisms,which explain their potential to treat human diseases,to provide new ideas for further research and clinical cell-free therapy.

关键词： Bioactive behavior Mesenchymal stem cells Microenvironment Paracrine Secretome

Exosomes from circ-Astn1-modified adipose-derived mesenchymal stem cells enhance wound healing through miR-138-5p/SIRT1/FOXO1 axis regulation

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World Journal of Stem Cells 2023年第5期15卷 476-489页

作者： Zhi Wang Cheng Feng Hao Liu Tian Meng Wei-Qing Huang Ke-Xin Song You-Bin Wang department of Plastic and cosmetic Surgery Peking Union Medical College HospitalBeijing 100730China

BACKGROUND Wound healing impairment is a dysfunction induced by hyperglycemia and its effect on endothelial precursor cells(EPCs)in type 2 diabetes mellitus.There is increasing evidence showing that exosomes(Exos)derived from adipose-derived mesenchymal stem cells(ADSCs)exhibit the potential to improve endothelial cell function along with wound healing.However,the potential therapeutic mechanism by which ADSC Exos contribute to wound healing in diabetic mice remains unclear.AIM To reveal the potential therapeutic mechanism of ADSC Exos in wound healing in diabetic mice.METHODS Exos from ADSCs and fibroblasts were used for high-throughput RNA sequencing(RNA-Seq).ADSC-Exo-mediated healing of full-thickness skin wounds in a diabetic mouse model was investigated.We employed EPCs to investigate the therapeutic function of Exos in cell damage and dysfunction caused by high glucose(HG).We utilized a luciferase reporter(LR)assay to analyze interactions among circular RNA astrotactin 1(circ-Astn1),sirtuin(SIRT)and miR-138-5p.A diabetic mouse model was used to verify the therapeutic effect of circ-Astn1 on Exo-mediated wound healing.RESULTS High-throughput RNA-Seq analysis showed that circ-Astn1 expression was increased in ADSC Exos compared with Exos from fibroblasts.Exos containing high concentrations of circ-Astn1 had enhanced therapeutic effects in restoring EPC function under HG conditions by promoting SIRT1 expression.Circ-Astn1 expression enhanced SIRT1 expression through miR-138-5p adsorption,which was validated by the LR assay along with bioinformatics analyses.Exos containing high concentrations of circ-Astn1 had better therapeutic effects on wound healing in vivo compared to wild-type ADSC Exos.Immunofluorescence and immunohistochemical investigations suggested that circ-Astn1 enhanced angiopoiesis through Exo treatment of wounded skin as well as by suppressing apoptosis through promotion of SIRT1 and decreased forkhead box O1 expression.CONCLUSION Circ-Astn1 promotes the therapeutic effect of ADSC-Exos and thus

关键词： Adipose-derived mesenchymal stem cells Circular RNA astrotactin 1 Diabetic Exosomes Angiogenesis