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Efficacy of ctDNA methylation combined with traditional detection modality to detect liver cancer among high-risk patients:A multicenter diagnostic trial

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Chinese Journal of Cancer Research 2023年第1期35卷 58-65页

作者： Maomao Cao Jufang Shi Changfa Xia He Li Wei Cai Xianyun Qi Chunyun Dai Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China department of prevention and control of chronic noncommunicable diseases Binhai County Center for Disease Control and PreventionBinhai 224521China chronic noncommunicable diseases prevention and Treatment department Yingdong District Center for Disease Control and PreventionFuyang 236142China department for chronic noncommunicable diseases control Sheyang Center for Disease Control and PreventionSheyang 224300China

Objective:Circulating tumor DNA(ctDNA)and alpha-fetoprotein(AFP)plus ultrasound(US)have been considered to have high diagnostic accuracy for cancer detection,however,the efficacy of ctDNA methylation combined with the traditional detection modality of liver cancer has not been tested in a Chinese independent ***:The high-risk individuals aged between 35 and 70 years who were diagnosed with liver cirrhosis or had moderate and severe fatty liver were eligible for *** participants were invited to receive a traditional examination[referring to AFP plus US],and ctDNA methylation,*** sensitivity and specificity of different diagnostic tools were *** logistic regression model was applied to estimate the area under the curve(AUC),which was further validated by 10-fold internal ***:A total of 1,205 individuals were recruited in our study,and 39 participants were diagnosed with liver *** sensitivity of AFP,US,US plus AFP,and the combination of US,AFP,and ctDNA methylation was33.33%,56.41%,66.67%,and 87.18%,*** corresponding specificity of AFP,US,US plus AFP,and the combination of all modalities was 98.20%,99.31%,97.68%,and 97.68%,*** AUCs of AFP,US,US plus AFP,and the combination of AFP,US,and ctDNA methylation were 65.77%,77.86%,82.18%,and92.43%,*** internally validated AUCs of AFP,US,US plus AFP,and the combination of AFP,US,and ctDNA methylation were 67.57%,83.26%,86.54%,and 93.35%,***:The ctDNA methylation is a good complementary to AFP and US for the detection of liver cancer.

关键词： Liver cancer detection ctDNA methylation diagnostic performance

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Pulmonary Heart Disease Associated Mortality—China,2014–2021

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China CDC weekly 2023年第35期5卷 779-784页

作者： Yangyang Xu Zhe Liu Jinlei Qi Lijun Wang Maigeng Zhou Peng Yin National Center for chronic and noncommunicable Disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina

Introduction:Over the latter half of the previous century,pulmonary heart disease(PHD)emerged as a significant public health issue in ***,the current mortality rate is *** the Multiple Cause of Death database,the present study aims to investigate the current state and progression of PHD-associated death in ***:Data from the China National Mortality Surveillance System were used to analyze progression in mortality rates attributable to PHD from 2014 to *** standardize population structure for each year during the investigation period,demographic information from the 2020 census was employed as the reference *** mortality rates(ASMR)were determined based on sex,urban-rural area,and *** identify trends in ASMR,a joinpoint regression analysis was ***:The ASMR of PHD exhibited a marked decrease,falling from 61.68 per 100,000 in 2014 to 28.53 per 100,000 in *** downward trend was observable in both genders,all regions,and both urban and rural *** greatest ASMR values were documented in the western *** observations revealed a higher ASMR in rural areas versus urban ones and in males versus *** deaths predominantly occurred among older individuals,particularly those aged 80 and *** obstructive pulmonary disease(COPD)emerged as the principal underlying cause of death PHD-associated mortalities,accounting for between 87.41%and 93.42%of cases throughout the period 2014–***:There was a declining trend in PHD mortality in China from 2014 to 2021,with COPD accounting for a significant proportion of these *** the high prevalence of COPD and the escalating population aging in China,PHD remains a significant health concern that warrants further attention.

关键词： latter downward urban

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Unintentional Drowning Mortality Among Individuals Under Age 20—China,2013–2021

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China CDC weekly 2023年第47期5卷 1058-1062页

作者： Zi Li Xiao Deng Ye Jin Leilei Duan Pengpeng Ye National Center for chronic and noncommunicable Disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina

ABSTRACT Introduction:This study seeks to elucidate the evolving trend and identify disparities among subgroups in the mortality rate due to unintentional drowning in individuals under the age of 20 from the timeframe... 详细信息

关键词： subgroups China. identif

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Prevalence and Years of Life Lost due to Disability from Dental Caries among Children and Adolescents in Western China,1990-2015

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Biomedical and Environmental Sciences 2017年第10期30卷 701-707页

作者： WANG Zhuo DENG Ying LIU Shi Wei HE Jun JI Kui ZENG Xin Ying YANG Shu Juan XU Xin Yin LUO Yu ZHOU Mai Geng ZHANG Jian Xin West China School of Public Health Sichuan University Sichuan Provincial Center for Disease control and prevention Center for Chronic and Noncommunicable Disease Control and Prevention National Center for chronic and noncommunicable Disease control and prevention Chinese Center for Disease Control and Prevention department of Obstetrics and Gynecology West China Second University HospitalSichuan University

Objective To analyze the prevalence and years lived with disability （YLD） from dental caries among children and adolescents and the time trends over the past two decades in Sichuan province, the largest province in west China. Methods Based on the Global Burden of Disease Study 2015 （GBD2015）, which systematically assessed the epidemiological characteristics of major diseases and their transitions by country and region from 1990 to 2015, we extracted the estimated results for China. We then used the Bayesian meta-regression method to estimate the sex- and age-specific prevalences and YLDs from dental caries among children and adolescents under 15 years old in Sichuan province and compared them with global and national indicators for the same period. Results In 2015, there were almost 6 million cases of dental caries in children and adolescents （aged 〈 15 years） in Sichuan province, accounting for 6% of the total cases in China. For children under 5 years, the prevalence of deciduous caries was 55.9%, and the YLDs value was 10.8 per 100,000, while it was 24.3% and 5.1 per 100,000 respectively among 5- to 14-year-olds; for those aged 5 to 14 years, the prevalence of permanent caries was 21.5%, and the YLDs value was 11.5 per 100,000. From 1990 to 2015, the prevalence of dental caries for children under 5 years increased substantially, by 16.2%, and the YLDs increased by 8.7%. Among those aged 5 to 14 years, the prevalence increased and the YLDs decreased. Conclusion Dental caries remains a huge health burden in Western China. In contrast to the global and national data, the trend has increased rapidly over the past 25 years in this region. This work provides suggestions for the prevention and control for oral health in China with the policy of two-child.

关键词： Children and adolescents Dental caries YLD Disease burden

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Mortality and Causes of Death in Primary and Secondary School Students--China,2018

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China CDC weekly 2020年第13期2卷 199-204页

作者： Wei Wang Yunning Liu Jiangmei Liu Peng Yin Jinlei Qi Jinling You Lijun Wang Maigeng Zhou National Center for chronic and noncommunicable Disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?There were approximately 1.23 million deaths reported among individuals aged 5-19 years worldwide in *** attention has been paid to current mortality among primary and secondary school students aged 6-18 years in *** is added by this report?In 2018,an estimated 28,519 deaths occurred among primary and secondary school students aged 6-18 years in China with an age-standardized mortality rate(ASMR)of 17.66 per 100,*** disparities existed among sexes,age groups,areas,and regions for different causes of ***,road traffic injuries,and leukemia were three leading causes of *** are the implications for public health practice?Government support,legislation enforcement,multisectoral cooperation,and stakeholder engagement should be initiated to reduce premature deaths among primary and secondary school students in China,especially those due to injuries.

关键词： injuries initiated deaths

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Incidence,Prevalence,and Mortality of Four Major chronic Non-communicable diseases—China,1990-2017

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China CDC weekly 2019年第3期1卷 32-37页

作者： Peng Yin Jinlei Qi Yunning Liu Jiangmei Liu Jinling You Lijun Wang Maigeng Zhou National Center for chronic and noncommunicable Disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina

Introduction chronic and non-communicable diseases(NCDs)have become an important public health concern in *** aimed to estimate the incidence,prevalence,and mortality of four major NCDs including cardiovascular disease(CVD),cancer,chronic respiratory diseases(CRD),and diabetes in China during *** The general analytic framework of Global Burden of diseases Study 2017(GBD 2017)was *** from Disease Surveillance Point System,censuses,and Chinese Center for Disease control and prevention Cause-of-Death Reporting System were used for mortality *** surveys,cancer registries,and published studies were used for incidence and prevalence *** In 2017,new cases for CVD,cancer,and diabetes were 13.5,4.6,and 3.3 million,an increase of 120.4%,159.7%,and 57.3%respectively compared with *** were 9.6 million incident cases for CRD in 2017,a 4.9%decrease compared with 1990.A total of 8.1 million people died from cancer,CVD,CRD,and diabetes in China in *** was a substantial decline in age-standardized mortality rate for CRD and a steady but slow decline for CVD and *** 1990-2017,the age-standardized prevalence rate increased by 7.4%,135.2%,and 17.0%for CVD,cancer,and diabetes *** and Implications for Public Health Practice The accumulated prevalence of the four major NCDs are increasing but the age-standardized mortality rate for CVD,cancer,and CRD has been on a decline during *** effective intervention strategies should be developed to deal with the continuously increasing burden caused by NCDs in China.

关键词： prevalence mortality diseases

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Future challenges and solutions for safety in China:China CDC’s exploration of injury prevention strategies

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Global Health Journal 2018年第2期2卷 14-23页

作者： Leilei Duan Pengpeng Ye Linhong Wang National Center for chronic and noncommunicable diseases control and prevention Chinese Center for Disease Control and PreventionBeijing 100050China

As an important component of worldwide injury prevention,China has made great contribution to the *** is serving as a model for other countries in the world,especially developing countries,and China’s experience has great implications for *** the description of the present situation and trends of China’s injury prevention work and review for its development history,this paper has also introduced the existing issues and the current challenges,and informed the e orts of the sta in related eld to nd solutions from di erent *** of them jointly boosted the development of global injury prevention.

关键词： injury prevention and control Chinese Center for Disease control and prevention National Center for chronic and Non-communicable Disease control and prevention

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Cancer Mortality--China, 2018

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China CDC weekly 2020年第5期2卷 63-68页

作者： Yunning Liu Wei Wang Jiangmei Liu Peng Yin Jinlei Qi Jinling You Lijun Wang Maigeng Zhou National Center for chronic and noncommunicable Disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina.

Introduction Cancer is an important public health concern with heavy disease burden in *** 2017,cancer is the leading cause of death,with around 2.60 million deaths,which accounts for 26.07%of all *** study aims to present cancer mortality in China in 2018 to provide evidence for cancer control and *** Mortality data from China Cause of Death Reporting System(CDRS)and population data from National Bureau of Statistics are used for cancer mortality estimation.A descriptive analysis was conducted to demonstrate the results.

关键词： mortality Cancer cancer

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Exploring Pharmacogenetic Testing for Hypertension Management in China

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China CDC weekly 2023年第35期5卷 785-787页

作者： Zhenping Zhao Maigeng Zhou National Center for chronic and noncommunicable Disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina

Hypertension,or high blood pressure,is a predominant precursor of premature mortality,affecting an estimated 270 million people in China alone,and is also a major global health concern(1).Hence,effective management of hypertension is vital for averting severe adverse cardiac or cerebrovascular incidents,decreasing early mortality rates,and curtailing disability.

关键词： mortality cardiac alone

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China CDC in Action-Hypertension prevention and control

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China CDC weekly 2020年第40期2卷 783-786页

作者： Lei Hou Bo Chen Yibing Ji Baohua Wang Jing Wu National Center for chronic and noncommunicable Disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina

Summary Hypertension contributes to a quarter of all-cause mortality in *** Chinese government has put forward aims to control and prevent hypertension,and China CDC and other professional public health institutions have carried out a series of related efforts including the promotion of related policies and legislation,the improvement of modifiable risk factors of hypertension in the population,and promoting the National Primary Public Health Services to discover and manage patients with *** CDC has conducted multiple hypertension-related campaigns such as advocating for salt reduction,weight loss,and increased physical ***,on behalf of the Chinese government,China CDC has organized and carried out the construction of national demonstration areas for the comprehensive prevention and control of chronic diseases.

关键词： prevention mortality behalf

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