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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang Li Xingping Quan Jinfen Chen Yan Han Li Yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina department of Electrical and computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

On modeling with multiplicative differential equations

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Applied mathematics(A Journal of Chinese Universities) 2011年第4期26卷 425-438页

作者： Agamirza E.Bashirov Emine Misirli Ycel Tandogdu Ali zyapici department of mathematics Eastern Mediterranean University department of mathematics Ege University department of computer Engineering Lefke European University

This work is aimed to show that various problems from different fields can be modeled more efficiently using multiplicative calculus, in place of Newtonian calculus. Since multiplicative calculus is still in its infancy, some effort is put to explain its basic principles such as exponential arithmetic, multiplicative calculus, and multiplicative differential equations. Examples from finance, actuarial science, economics, and social sciences are presented with solutions using multiplicative calculus concepts. Based on the encouraging results obtained it is recommended that further research into this field be vested to exploit the applicability of multiplicative calculus in different fields as well as the development of multiplicative calculus concepts.

关键词： Gompertz function elasticity exponential arithmetic multiplicative calculus growth.

A Secure Elliptic Curve-Based RFID Protocol

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Journal of computer Science & Technology 2009年第2期24卷 309-318页

作者： Santi Martínez Magda Valls Concepció Roig Josep M. Miret Francesc Giné computer Science department Universitat de Lleida mathematics department Universitat de Lleida

Nowadays, the use of Radio Frequency Identification （RFID） systems in industry and stores has increased Nevertheless, some of these systems present privacy problems that may discourage potential users. Hence, high confidence and efficient privacy protocols are urgently needed. Previous studies in the literature proposed schemes that are proven to be secure, but they have scalability problems. A feasible and scalable protocol to guarantee privacy is presented in this paper. The proposed protocol uses elliptic curve cryptography combined with a zero knowledge-based authentication scheme. An analysis to prove the system secure, and even forward secure is also provided.

关键词： elliptic curve cryptography forward security RFID zero knowledge

A New Class of Generalized Close-to-Starlike Functions Defined by the Srivastava-Attiya Operator

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Acta Mathematica Sinica,English Series 2013年第5期29卷 833-840页

作者： H.M.SRIVASTAVA Dorina RADUCANU Grigore S.SLGEAN department of mathematics and Statistics University of Victoria Faculty of mathematics and computer Science Transilvania University of Brasov Faculty of mathematics and computer Science Babe s-Bolyai University

In this paper, we consider a new class CS＊s,b of generalized close-to-starlike functions, which is defined by means of the Srivastava-Attiya operator Js,b involving the Hurwitz-Lerch Zeta function φ（z, s, a）. Basic results such as inclusion relations, coefficient inequalities and other interesting properties of this class are investigated. Relevant connections of some of the results presented here with those that were obtained in earlier investigations are pointed out briefly.

关键词： Analytic functions starlike functions convex functions close-to-starlike functions Srivastava-Attiya operator inclusion results coefficient bounds coefficient inequalities hadamard product (or convolution)

CONTROL OF VEHICLE PLATOONS FOR HIGHWAY SAFETY AND EFFICIENT UTILITY:CONSENSUS WITH COMMUNICATIONS AND VEHICLE DYNAMICS

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Journal of Systems Science & Complexity 2014年第4期27卷 605-631页

作者： WANG Le Yi SYED Ali YIN Gang George PANDYA Abhilash ZHANG Hongwei department of Electrical and computer Engineering Wayne State University department of mathematics Wayne State University department of computer Science Wayne State University

Platoon formation of highway vehicles is a critical foundation for autonomous or semiautonomous vehicle control for enhanced safety,improved highway utility,increased fuel economy,and reduced emission toward intelligent transportation *** control encounters great challenges from vehicle control,communications,team coordination,and *** paper introduces a new method for coordinated control of platoons by using integrated network consensus decisions and vehicle *** achieve suitable coordination of the team vehicles based on terrain and environmental conditions,the emerging technology of network consensus control is modified to a weighted and constrained consensus-seeking *** are introduced and their convergence properties are *** methodology employs neighborhood information through on-board sensors and V2 V or V2 I communications,but achieves global coordination of the entire *** ability of the methods in terms of robustness,disturbance rejection,noise attenuation,and cyber-physical interaction is analyzed and demonstrated with simulated case studies.

关键词： Collision avoidance communications consensus control networked systems platoon con-trol safety vehicle dynamics.

Riesz-Kolmogorov theorem in variable exponent Lebesgue spaces and its applications to Riemann-Liouville fractional differential equations

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Science China mathematics 2018年第10期61卷 1807-1824页

作者： Baohua Dong Zunwei Fu Jingshi Xu department of mathematics Nanjing University of Information Science and Technology department of mathematics Linyi University department of computer Science The University of Suwon department of mathematics Hainan Normal University

In this paper, we obtain the necessary and sufficient condition of the pre-compact sets in the variable exponent Lebesgue spaces, which is also called the Riesz-Kolmogorov theorem. The main novelty appearing in this approach is the constructive approximation which does not rely on the boundedness of the Hardy-Littlewood maximal operator in the considered spaces such that we do not need the log-H¨older continuous conditions on the variable exponent. As applications, we establish the boundedness of Riemann-Liouville integral operators and prove the compactness of truncated Riemann-Liouville integral operators in the variable exponent Lebesgue spaces. Moreover, applying the Riesz-Kolmogorov theorem established in this paper, we obtain the existence and the uniqueness of solutions to a Cauchy type problem for fractional differential equations in variable exponent Lebesgue spaces.

关键词： Lebesgue space with variable exponent Riesz-Kolmogorov theorem Riemann-Liouville fractionalcalculus fixed-point theorem

Stability of a cubic functional equation in intuitionistic random normed spaces

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Applied mathematics and Mechanics(English Edition) 2010年第1期31卷 21-26页

作者：张石生 John Michael RASSIAS Reza SAADATI department of mathematics Yibin University Section of mathematics and Informatics Pedagogical DepartmentNational and Capodistrian University of Athens department of mathematics and computer Science Amirkabir University of Technology

In this paper, the stability of a cubic functional equation in the setting of intuitionistic random normed spaces is proved. We first introduce the notation of intuitionistic random normed spaces. Then, by virtue of this notation, we study the stability of a cubic functional equation in the setting of these spaces under arbitrary triangle norms. Furthermore, we present the interdisciplinary relation among the theory of random spaces, the theory of intuitionistic spaces, and the theory of functional equations.

关键词： stability cubic functional equation random normed space intuitionistic random normed spaces

Uniform and L-convergence of Logarithmic Means of Walsh-Fourier Series

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Acta Mathematica Sinica,English Series 2006年第2期22卷 497-506页

作者： G.GáT U.GOGINAVA Institute of mathematics and computer Science College of Nyiregyhaza department of Mechanics and mathematics Tbilisi State University

The （NSrlund） logarithmic means of the Fourier series of the integrable function f is：1/lnn-1∑k=1Sk（f）/n-k, where ln：=n-1∑k=11/k.In this paper we discuss some convergence and divergence properties of this logarithmic means of the Walsh-Fourier series of functions in the uniform, and in the L^1 Lebesgue norm. Among others, as an application of our divergence results we give a negative answer to a question of Móricz concerning the convergence of logarithmic means in norm.

关键词： Walsh system Norlund logarithmic means Convergence divergence properties

FURTHER INVESTIGATION INTO APPROXIMATION OF A COMMON SOLUTION OF FIXED POINT PROBLEMS AND SPLIT FEASIBILITY PROBLEMS

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Acta Mathematica Scientia 2016年第3期36卷 913-930页

作者： Y.SHEHU O.T.MEWOMO F.U.OGBUISI department of mathematics University of Nigeria School of mathematics Statistics and Computer ScienceUniversity of Kwazulu-Natal

The purpose of this paper is to study and analyze an iterative method for finding a common element of the solution set ~ of the split feasibility problem and the set F（T） of fixed points of a right Bregman strongly nonexpansive mapping T in the setting of p- uniformly convex Banach spaces which are also uniformly smooth. By combining Mann＇s iterative method and the Halpern＇s approximation method, we propose an iterative algorithm for finding an element of the set F（T）∩Ω moreover, we derive the strong convergence of the proposed algorithm under appropriate conditions and give numerical results to verify the efficiency and implementation of our method. Our results extend and complement many known related results in the literature.

关键词： strong convergence split feasibility problem uniformly convex uniformly smooth fixed point problem right Bregman strongly nonexpansive mappings