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Hepatocellular carcinoma presenting as an extrahepatic mass:A case report and review of literature

World Journal of Gastrointestinal Oncology 2024年第5期16卷 2241-2252页

作者： Wei Kelly Wu Krutika Patel Chandrasekhar Padmanabhan Kamran Idrees department of Surgery Vanderbilt University Medical CenterNashvilleTN 37232United States department of Pathology Microbiology and ImmunologyVanderbilt University Medical CenterNashvilleTN 37232United States Division of Surgical Oncology and Endocrine Surgery Department of SurgeryVanderbilt University Medical CenterNashvilleTN 37232United States

BACKGROUND Hepatocellular carcinoma(HCC)is a primary liver tumor generally diagnosed based on radiographic *** disease is typically associated with increased tumor diameter,multifocality,and vascular *** report a case of a patient who presented with extrahepatic HCC metastasis to a portocaval lymph node with occult hepatic primary on computed tomography(CT).We review the literature for cases of extrahepatic HCC presentation without known hepatic lesions and discuss strategies to differentiate between metastatic and ectopic *** SUMMARY A 67-year-old male with remotely treated hepatis C was referred for evaluation of an enlarging portocaval,mixed cystic-solid *** CT evaluations demonstrated steatosis,but no cirrhosis or liver *** ultrasound demonstrated a normal-appearing pancreas,biliary tree,and *** needle aspiration yielded atypical *** differential diagnosis included duodenal or pancreatic cyst,lymphoproliferative cyst,stromal or mesenchymal lesions,nodal involvement from gastrointestinal or hematologic malignancy,or duodenal gastrointestinal stromal *** review by a multidisciplinary tumor board,the patient underwent open surgical resection of a 5.2 cm×5.5 cm retroperitoneal mass with pathology consistent with moderately-differentiated *** resonance imaging(MRI)subsequently demonstrated a 1.2 cm segment VIII hepatic lesion with late arterial enhancement,fatty sparing,and intrinsic T1 *** fetoprotein was 23.3 ng/*** patient was diagnosed with HCC with portocaval nodal ***:We surveyed the literature for HCC presenting as extrahepatic masses without history of concurrent or prior intrahepatic *** identified 18 cases of extrahepatic HCC ultimately found to represent metastatic lesions,and 30 cases of extrahepatic HCC found to be primary,ectopic *** Hepatocellular carcinoma can seldomly present with extrahepatic metastasis in the setting of

关键词： Extrahepatic Metastasis Portocaval Lymph node Case report

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Pancreatic pseudocyst:The past,the present,and the future

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 1986-2002页

作者： Jonathan GA Koo Matthias Yi Quan Liau Igor A Kryvoruchko Tamer AAM Habeeb Christopher Chia Vishal G Shelat department of General Surgery Khoo Teck Puat HospitalSingapore 768828Singapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore department of Surgery No.2 Kharkiv National Medical UniversityKharkiv 61022Ukraine department of General Surgery Faculty of Medicine Zagazig UniversitySharkia 44511Egypt department of Gastroenterology Woodlands General HospitalSingapore 737628Singapore department of General Surgery Tan Tock Seng HospitalSingapore 308433Singapore

A pancreatic pseudocyst is defined as an encapsulated fluid collection with a welldefined inflammatory wall with minimal or no *** diagnosis cannot be made prior to 4 wk after the onset of *** clinical presentation is often nonspecific,with abdominal pain being the most common *** a diagnosis is suspected,contrast-enhanced computed tomography and/or magnetic resonance imaging are performed to confirm the diagnosis and assess the characteristics of the *** ultrasound with cyst fluid analysis can be performed in cases of diagnostic *** of the pancreas can lead to complications such as hemorrhage,infection,and *** management of pancreatic pseudocysts depends on the presence of symptoms and the development of complications,such as biliary or gastric outlet *** options include endoscopic or surgical *** aim of this review was to summarize the current literature on pancreatic pseudocysts and discuss the evolution of the definitions,diagnosis,and management of this condition.

关键词： Pancreatic pseudocyst Pancreatic fluid collection Cystic pancreatic lesions Pancreatitis Endoscopic ultrasound

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Diffusion-weighted magnetic resonance imaging with short T1 inversion recovery-echo planar imaging combined with dual-head coincidence single photon emission computed tomography for diagnosing solitary pulmonary nodule

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Chinese Medical Journal 2010年第24期123卷 3717-3721页

作者： WANG Wei XU Jin-zhi ZHANG Tong SHEN Bao-zhong department of Medical imaging First Hospital of Harbin Medical University Harbin Heilongjiang 150001 China department of Thoracic Surgery Fourth Hospital of Harbin Medical University Harbin Heilongjiang 150001 China department of Medical imaging Fourth Hospital of Harbin Medical University Harbin Heilongjiang 150001 China

Positron emission tomography （PET） using 18F-fluorodeoxyglucose （FDG） has not been widely used in China for expensive cost （$1200）. Dual-head coincidence single photon emission computed tomography （DHC-SPECT） can depict many of the lesions depicted with a PET scanner in the lungs, which is used in place of PET-CT for discriminating malignant from benign pulmonary nodules in many studies. However, DHC-SPECT has inevitable false-negative results because the sensitivity for small lesions less than 2.0 cm is limited, and has high false-positive rate for active inflammatory nodules. Furthermore,DHC-SPECT also has a considerably higher cost （$300 in China） than other imaging examination.

关键词： diffusion-weighted imaging magnetic resonance imaging decision tree analysis dual-head coincidence single photon emission computed tomography solitary pulmonary nodules lung cancer

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Tuberous sclerosis complex combined with primary lymphedema:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2642-2648页

作者： Xing-Peng Li Xiao-Li Sun Xin Liu Zhe Wen Li-Hua Jiang Yan Fu Yun-Long Yue Ren-Gui Wang department of Radiology Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijing 100038China department of Lymph Surgery Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijing 100038China department of Nuclear Medicine Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijing 100038China department of MRI Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijing 100038China

BACKGROUND Tuberous sclerosis complex(TSC)and primary lymphedema(PLE)are both rare diseases,and it is even rarer for both to occur in the same *** this work,we have provided a detailed description of a patient's clinical presentation,imaging findings,and *** a retrospective analysis was conducted on 14 published relevant case *** SUMMARY A 16-year-old male came to our hospital for treatment due to right lower limb *** swelling is already present from *** patient’s memory had been progressively *** had occurred 1 year prior at an unknown *** patient was diagnosed with TSC combined with PLE through multimodal imaging examination:computed tomography,magnetic resonance imaging,and *** patient underwent *** swelling of the patient's right lower limb significantly improved after *** did not *** taking antiepileptic drugs and *** TSC with PLE is a rare and systemic *** can detect lesions of this disease,which are important for diagnosis and treatment.

关键词： Tuberous sclerosis complex Lymphedema Sirolimus Multimodal imaging examination Case report

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Clinical review and literature analysis of hepatic epithelioid angiomyolipoma in alcoholic cirrhosis: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2382-2388页

作者： Jing-Qiang Guo Jia-Hui Zhou Kun Zhang Xin-Liang Lv Chao-Yong Tu department of Hepatobiliary and Pancreatic Surgery Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina department of Pathology Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina department of General Surgery The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND Hepatic epithelioid angiomyolipoma(HEA)has a low incidence and both clinical manifestations and imaging lack ***,it is easy to misdiagnose HEA as other tumors of the liver,especially in the presence of liver diseases such as hepatitis *** article reviewed the diagnosis and treatment of a patient with HEA and alcoholic cirrhosis,and analyzed the literature,in order to improve the understanding of this *** SUMMARY A 67-year-old male patient with a history of alcoholic cirrhosis was admitted due to the discovery of a space-occupying lesion in the *** on the patient’s history,laboratory examinations,and imaging examinations,a malignant liver tumor was considered and laparoscopic partial hepatectomy was *** pathology showed *** outpatient follow-up,the patient showed no sign of *** HEA is difficult to make a definite diagnosis before *** has the poten-tial for malignant *** conditions permit,surgical treatment is recom-mended.

关键词： Hepatic epithelioid angiomyolipoma Alcoholic cirrhosis magnetic resonance imaging computed tomography Immunohistochemistry Misdiagnose analysis Case report

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Photoacoustic/ultrasound dual-modal imaging of human nails: A pilot study

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Journal of Innovative Optical Health Sciences 2024年第6期17卷 15-28页

作者： Yanting Wen Yijie Huang Lin Huang Dan Wu Renbin Zhong Shixie Jiang Yudi Zhang Ting Liu Xiaotian Liu Huabei Jiang department of Ultrasound Chengdu Fifth People's Hospital Chengdu 611137P.R.China School of Computer Science and Technology Chongqing University of Posts and Telecommunications Chongqing 400065 P.R.China School of Electronic Science and Engineering University of Electronic Science and Technology Chengdu 611731 P.R.China department of Psychiatry University of Florida College of Medicine GainesvilleFL 32610USA department of Medical Engineering University of South Florida Tampa 33620USA

Traditional diagnostic techniques including visual examination,ultrasound(US),and magnetic resonance imaging(MRI)have limitations of in-depth information for the detection of nail disorders,resolution,and *** pilot study,for thefirst time,evaluates a dualmodality imaging system that combines photoacoustic tomography(PAT)with the US for the multiparametric quantitative assessment of human *** study involved a small cohort offive healthy volunteers who underwent PAT/US imaging for acquiring the nail unit *** PAT/US dual-modality imaging successfully revealed thefine anatomical structures and microvascular distribution within the nail and nail ***,this system utilized multispectral PAT to analyze functional tissue parameters,including oxygenated hemoglobin,deoxyhemoglobin,oxygen saturation,and collagen under tourniquet and cold stimulus tests to evaluate changes in the microcirculation of the nail *** quantitative analysis of multispectral PAT reconstructed images demonstrated heightened sensitivity in detecting alterations in blood oxygenation levels and collagen content within the nail bed,under simulated different physiological *** pilot study highlights the potential of PAT/US dual-modality imaging as a real-time,noninvasive diagnostic modality for evaluating human nail health and for early detection of nail bed pathologies.

关键词： Nail photoacoustic tomography ultrasound multi-modality quantitative parameter

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New approaches for precise response evaluation in hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第12期20卷 3059-3068页

作者： Koichi Hayano Jorge M Fuentes-Orrego Dushyant V Sahani Division of Abdominal imaging and Intervention Department of RadiologyMassachusetts General Hospital

With the increasing clinical use of cytostatic and novel biologic targeted agents,conventional morphologic tumor burden assessments,including World Health Organization criteria and Response Evaluation Criteria in Solid Tumors,are confronting limitations because of their difficulties in distinguishing viable tumor from necrotic or fibrotic ***,the investigation for reliable quantitative biomarkers of therapeutic response such as metabolic imaging or functional imaging has been *** this review,we will discuss the conventional and new approaches to assess tumor *** targeted therapy or locoregional therapies can induce biological changes much earlier than morphological changes,these functional tumor burden analyses are very ***,some of them have not gone thorough all steps for standardization and ***,these new techniques and criteria will play an important role in the cancer management,and provide each patient more tailored therapy.

关键词： Hepatocellular carcinoma World Health Organization criteria Response Evaluation Criteria in Solid Tumors European Association for the Study of Liver computed tomography perfusion Dynamic contrast-enhanced-magnetic resonance imaging Diffusion-weighted imaging Positron emission tomography

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Improving the radiological diagnosis of hepatic artery thrombosis after liver transplantation: Current approaches and future challenges

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World Journal of Transplantation 2024年第1期14卷 1-8页

作者： Cristian Lindner Raúl Riquelme Rodrigo San Martín Frank Quezada Jorge Valenzuela Juan P Maureira Martín Einersen department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile department of Radiology Hospital Clínico Regional Guillermo Grant BenaventeConcepción 4030000Chile department of Statistics Catholic University of MauleTalca 3460000Chile Neurovascular Unit Department of RadiologyHospital Clínico Regional Guillermo Grant BenaventeConcepción 4030000Chile

Hepatic artery thrombosis(HAT)is a devastating vascular complication following liver transplantation,requiring prompt diagnosis and rapid revascularization treatment to prevent graft *** present,imaging modalities such as ultrasound,computed tomography,and magnetic resonance play crucial roles in diagnosing *** imaging techniques have improved sensitivity and specificity for HAT diagnosis,they have limitations that hinder the timely diagnosis of this *** this sense,the emergence of artificial intelligence(AI)presents a transformative opportunity to address these diagnostic *** development of machine learning algorithms and deep neural networks has demonstrated the potential to enhance the precision diagnosis of liver transplant complications,enabling quicker and more accurate detection of *** article examines the current landscape of imaging diagnostic techniques for HAT and explores the emerging role of AI in addressing future challenges in the diagnosis of HAT after liver transplant.

关键词： Liver transplantation Postoperative complications Hepatic artery Thrombosis Radiology Artificial intelligence

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Detecting prostate cancer and prostatic calcifications using advanced magnetic resonance imaging

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Asian Journal of Andrology 2017年第4期19卷 439-443页

作者： Shewei Dou Yan Bai Ankit Shandil Degang Ding Dapeng Shi E Mark Haacke Meiyun Wang department of Radiology Henan Provincial People's Hospital and The People's Hospital of Zhengzhou University Zhengzhou 450003 Henan China department of Postgraduate Education School of International Education Zhengzhou University Zhengzhou 450001 Henan China department of Urology Henan Provincial People's Hospital and The People's Hospital of Zhengzhou University Zhengzhou 450003 Henan China department of Radiology Wayne State University Detroit 48202 MI USA department of Administration Magnetic Resonance Innovations Inc. Detroit 48202 USA.

Prostate cancer and prostatic calcifications have a high incidence in elderly men. We aimed to investigate the diagnostic capabilities of susceptibility-weighted imaging in detecting prostate cancer and prostatic calcifications. A total number of 156 men, including 34 with prostate cancer and 122 with benign prostate were enrolled in this study. computed tomography, conventional magnetic resonance imaging, diffusion-weighted imaging, and susceptibility-weighted imaging were performed on all the patients. One hundred and twelve prostatic calcifications were detected in 87 patients. The sensitivities and specificities of the conventional magnetic resonance imaging, apparent diffusion coefficient, and susceptibility-filtered phase images in detecting prostate cancer and prostatic calcifications were calculated. McNemar＇s Chi-square test was used to compare the differences in sensitivities and specificities between the techniques. The results showed that the sensitivity and specificity of susceptibility-filtered phase images in detecting prostatic cancer were greater than that of conventional magnetic resonance imaging and apparent diffusion coefficient （P 〈 0.05）. In addition, the sensitivity and specificity of susceptibility-filtered phase images in detecting prostatic calcifications were comparable to that of computed tomography and greater than that of conventional magnetic resonance imaging and apparent diffusion coefficient （P 〈 0.05）. Given the high incidence of susceptibility-weighted imaging （SWl） abnormality in prostate cancer, we conclude that susceptibility-weighted imaging is more sensitive and specific than conventional magnetic resonance imaging, diffusion-weighted imaging, and computed tomography in detecting prostate cancer. Furthermore, susceptibility-weighted imaging can identify prostatic calcifications similar to computed tomography, and it is much better than conventional magnetic resonance imaging and diffusion-weighted imaging.

关键词： calcification computed tomography diffusion-weighted imaging magnetic resonance imaging prostate cancer susceptibility-weighted imaging

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High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1487-1496页

作者： Nao Furuya Atsushi Yamaguchi Naohiro Kato Syuhei Sugata Takuro Hamada Takeshi Mizumoto Yuzuru Tamaru Ryusaku Kusunoki Toshio Kuwai Hirotaka Kouno Kazuya Kuraoka Yoshiyuki Shibata Sho Tazuma Takeshi Sudo Hiroshi Kohno Shiro Oka department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan department of Gastroenterology Hiroshima University HospitalHiroshima 734-8551HiroshimaJapan department of Pathology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan

BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination ***,it can be diagnosed by pancreatic juice cytology from indirect *** previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct(MPD)and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography(ERCP).We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range,but without caudal MPD dilatation on magnetic resonance cholangiopancreatography(MRCP).CASE SUMMARY A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision,which revealed pancreatic *** revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD ***,course observation was *** 24 mo,MRCP revealed an increased caudal MPD caliber and a larger pancreatic *** performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology *** performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade *** parenchyma invasion was not observed,and curative resection was *** High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation.

关键词： Pancreatic cancer Pancreatic intraepithelial neoplasm High-grade pancreatic intraepithelial neoplasm magnetic resonance cholangiopancreatography Carcinoma in situ Case report

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