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Leveraging ROTI map derived from Indonesian GNSS receiver network for advancing study of Equatorial Plasma Bubble in Southeast/East Asia

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Earth and Planetary Physics 2025年第1期9卷 101-116页

作者： Prayitno Abadi Ihsan N.Muafiry Teguh N.Pratama Angga Y.Putra Suraina Gatot H.Pramono Sidik T.Wibowo Febrylian F.Chabibi Umar A.Ahmad Wildan P.Tresna Asnawi research Center for Climate and Atmosphere Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia School of Electrical Engineering Telkom UniversityBandungIndonesia Directorate of Laboratory Management Facilities and Science and Technology Park Indonesian National Research and Innovation Agency(BRIN)PontianakIndonesia Geophysics Laboratory Master Program in PhysicsUniversitas Gadjah Mada(UGM)YogyakartaIndonesia research Center for Space Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia Indonesian Geospatial Information Agency(BIG) JakartaIndonesia research Center for Photonics Indonesian National Research and Innovation Agency(BRIN)Tangerang SelatanIndonesia department of Earth and Planetary Sciences Hokkaido UniversitySapporoJapan

This paper highlights the crucial role of Indonesia’s GNSS receiver network in advancing Equatorial Plasma Bubble(EPB)studies in Southeast and East Asia,as ionospheric irregularities within EPB can disrupt GNSS signals and degrade positioning *** by the Indonesian Geospatial Information Agency(BIG),the Indonesia Continuously Operating Reference Station(Ina-CORS)network comprises over 300 GNSS receivers spanning equatorial to southern low-latitude ***-CORS is uniquely situated to monitor EPB generation,zonal drift,and dissipation across Southeast *** provide a practical tool for EPB research,by sharing two-dimensional rate of Total Electron Content(TEC)change index(ROTI)derived from this *** generate ROTI maps with a 10-minute resolution,and samples from May 2024 are publicly available for further scientific *** preliminary findings from the ROTI maps of Ina-CORS are ***,the Ina-CORS ROTI maps reveal that the irregularities within a broader EPB structure persist longer,increasing the potential for these irregularities to migrate farther ***,we demonstrate that combined ROTI maps from Ina-CORS and GNSS receivers in East Asia and Australia can be used to monitor the development of ionospheric irregularities in Southeast and East *** have demonstrated the combined ROTI maps to capture the development of ionospheric irregularities in the Southeast/East Asian sector during the G5 Geomagnetic Storm on May 11,*** observed simultaneous ionospheric irregularities in Japan and Australia,respectively propagating northwestward and southwestward,before midnight,whereas Southeast Asia’s equatorial and low-latitude regions exhibited irregularities *** sharing ROTI maps from Indonesia and integrating them with regional GNSS networks,researchers can conduct comprehensive EPB studies,enhancing the understanding of EPB behavior across Southeast and East Asia and contributing significantly to ionosphe

关键词： Equatorial Plasma Bubble(EPB) GNSS receivers’network Indonesia Continuously Operating Reference Station(Ina-CORS) ionospheric map Rate of TEC change index(ROTI)map

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Timing of biomarker changes preceding Alzheimer's disease:for diagnosis,treatment or prevention?

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Science China(Life Sciences) 2025年第2期68卷 575-577页

作者： Meina Quan innovation Center for Neurological Disorders and department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China National Medical Center for Neurological Diseases and National clinical research Center for Geriatric Diseases Beijing 100053China Center of Alzheimer’s Disease Beijing Institute of Brain DisordersCollaborative Innovation Center for Brain DisordersBeijing 100053China

The pathophysiological and behavioural features of Alzheimer’s disease(AD)have been extensively investigated in transgenic mouse models,including the temporal sequence of each pathophysiological change and behavioural abnormality,a summary of which was recently presented by our team in this Journal(Li et al.,2023).Nevertheless,studying such features and timings directly in human patients before symptoms occur is challenging.

关键词： prevention Alzheimer diagnosis

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Magneto-Electro-Elastic Analysis of Doubly-Curved Shells: Higher-Order Equivalent Layer-Wise Formulation

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Computer Modeling in Engineering & Sciences 2025年第2期142卷 1767-1838页

作者： Francesco Tornabene Matteo Viscoti Rossana Dimitri department of innovation Engineering University of SalentoLecce73100Italy

Recent engineering applications increasingly adopt smart materials,whose mechanical responses are sensitive to magnetic and electric *** this context,new and computationally efficient modeling strategies are essential to predict the multiphysic behavior of advanced structures ***,the manuscript presents a higher-order formulation for the static analysis of laminated anisotropic magneto-electro-elastic doubly-curved shell *** fundamental relations account for the full coupling between the electric field,magnetic field,and mechanical *** configuration variables are expanded along the thickness direction using a generalized formulation based on the Equivalent Layer-Wise ***-order polynomials are selected,allowing for the assessment of prescribed values of the configuration variables at the top and bottom sides of *** addition,an effective strategy is provided for modeling general surface distributions of mechanical pressures and electromagnetic external *** model is based on a continuum-based formulation which employs an analytical homogenization of the multifield material properties,based on Mori&Tanaka approach,of a magneto-electro-elastic composite material obtained from a piezoelectric and a piezomagnetic phase,with coupled magneto-electro-elastic effects.A semi-analytical Navier solution is applied to the fundamental equations,and an efficient post-processing equilibrium-based procedure is here used,based on the numerical assessment with the Generalized Differential Quadrature(GDQ)method,to recover the response of three-dimensional *** formulation is validated through various examples,investigating the multifield response of panels of different curvatures and lamination *** efficient homogenization procedure,based on the Mori&Tanaka approach,is employed to obtain the three-dimensional constitutive relation of magneto-electro-elastic *** model is validated against three-d

关键词： Magneto-electro-elastic materials equivalent layer-wise generalized differential quadrature higher-order theories navier solution recovery procedure smart structures

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Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning Li Yakun Gu Wei Ma Yuying Guan Mengyuan Guo Qianqian Shao Xunming Ji Jia Liu department of clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

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Integrating machine learning and human use experience to identify personalized pharmacotherapy in Traditional Chinese Medicine:a case study on resistant hypertension

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Journal of Traditional Chinese Medicine 2025年第1期45卷 192-200页

作者： CHE Qianzi LIU Dasheng XIANG Xinghua TIAN Yaxin XIE Feibiao XU Wenyuan LIU Jian WANG Xuejie WANG Liying BAI Weiguo HAN Xuejie YANG Wei department of Medical Statistics Institute of Basic Research in Clinical MedicineChina Academy of Chinese Medical Sciences department of Science and Education Medical Statistics Teaching and Research OfficeInstitute of Basic Research in Clinical MedicineChina Academy of Chinese Medical Sciences Computer department Xiyuan Hospital of the China Academy of Chinese Medical Sciences Traditional Chinese Medicine Standards research Center Medical Statistics Teaching and Research OfficeInstitute of Basic Research in Clinical MedicineChina Academy of Chinese Medical Sciences

OBJECTIVE: To enhance the understanding of identifying personalized pharmacotherapy options in Traditional Chinese Medicine(TCM), and further support the registration of new TCM drugs. METHODS: Generalized Boosted Models and XGBoost were employed to construct a classification model to identify the bad prognosis factors in resistant hypertension(RH) patients. Furthermore, we used association analysis to explore the rules of "symptomsyndrome" and "symptom-herb" for the major influencing factors, in order to summarize prescription pattern and applicable patients of TCM. RESULTS: Patients with major adverse cardiac events mostly have complex symptoms of phlegm, stasis, deficiency and fire intermingled with each other, and finally summarized the human experience of using Chinese herbal medicine to precisely intervene in some symptoms of RH patients on the basis of conventional Western medical treatment. CONCLUSIONS: Machine learning algorithms can make full use of human use experience and evidence to save clinical trial resources and accelerate the development of TCM varieties.

关键词： human clinical experience machine learning new drugs registration personalized pharmacotherapy

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Composite score of PD-1+CD8+ tumor-infiltrating lymphocytes and CD57+CD8+ tumor ascites lymphocytes is associated with prognosis and tumor immune microenvironment of patients with advanced high-grade serous ovarian cancer

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Chinese Journal of Cancer research 2025年第01期 73-99页

作者： Tianhui He Jie Zhang Lin Zeng Zhongnan Yin Bo Yu Xi Zhang Xiaoxue Yang Chunliang Shang Lixiang Xue Hongyan Guo department of Obstetrics and Gynecology Peking University Third Hospital Center of Basic Medical research Institute of Medical Innovation and Research Peking University Third Hospital Biobank Peking University Third Hospital research Center of clinical Epidemiology Peking University Third Hospital

Objective: The expression of programmed death 1（PD-1） on CD8+T cells is associated with their activation and exhaustion, while CD57 serves as a senescence marker. The impact of PD-1+and CD57+CD8+T cells on the prognosis of patients with advanced high-grade serous ovarian cancer（HGSOC） remain ***: We assessed the percentages of PD-1+and CD57+CD8+T cells in tumor-infiltrating lymphocytes（TILs, n=85） and tumor ascites lymphocytes（TALs, n=87） using flow cytometry. The optimal cutoffs for these markers in TILs and TALs were determined through the log-rank maximization method. Gene expression analysis elucidated the tumor immune microenvironment（TIME, n=36）.Results: Patients with higher PD-1+CD8+TILs（>87.8%） exhibited longer platinum-free interval（PFI） and overall survival（OS）. In contrast, those with elevated CD57+CD8+TALs（>28.69%） were more likely to experience chemotherapy and had lower complete remission rates, shorter PFI and OS. PD-1+CD8+TILs are primarily displayed an effector memory state with strong proliferative and secretory capabilities. Approximately 50% of CD57+CD8+TALs were terminally differentiated, exhibiting significantly impaired proliferation. Based on the proportions of PD-1+CD8+TILs and CD57+CD8+TALs, patients were categorized into good, median and poor prognosis groups, with median PFI of 47.78, 27.29 and 11.96 months, respectively（P<0.0001）. Median OS for these groups was not reach, 49.23 and 30.92 months, respectively（P<0.0001）. Patients with poor prognosis exhibit significantly reduced CD8+T cell proportion and increased M2 macrophage in the TIME, alongside downregulation of multiple T cell activation-related ***: Lower levels of PD-1+CD8+TILs and higher CD57+CD8+TALs, assessed prior to treatment,correlated with poor prognosis and suppressive TIME in advanced HGSOC.

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Influence mechanism of the flow of high-skilled talents on technological evolution in emerging countries

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Journal of Geographical Sciences 2025年第02期35卷 409-431页

作者： JIN Wenwan ZHU Shengjun LIN Xiongbin department of Geography and Spatial Information Technology Zhejiang Collaborative Innovation Center for Land and Marine Spatial Utilization and Governance Research Ningbo University College of Urban and Environmental Sciences Peking University

Globalization has resulted in a notable rise in the flow of high-skilled talent from emerging countries to developed nations. Current research on transnational talent flow mainly focuses on the destination countries, with less attention given to the perspective of the sending countries, particularly lacking a dynamic discussion on its impact on technological evolution in the origin countries. Based on the OECD REGPAT database, this paper aims to explore how talent groups migrating to developed countries facilitate the return of knowledge and technology to emerging countries and achieve breakthroughs in their technological evolution paths, while further discussing the potential mechanisms involved. The findings of this paper are as follows:(1) The technological development of emerging countries is a path-dependent process, where countries often branch into new technologies related to their preexisting knowledge base. Consequently, knowledge feedback from high-skilled talents increases the likelihood of sending countries developing unrelated technologies.(2) The mobility of talents across borders fosters more international collaborations and citations for patents that are unrelated to the local knowledge base, thus enriching the technological paths of sending countries.(3) The mobility of high-skilled talents primarily affects complex technologies, which have significant economic effects that encourage imitation by other ***, the effect on novel technologies is less significant due to their strong geographical stickiness. In general, this paper addresses the gaps in existing research on talent outflow and the technological evolution of origin countries, providing empirical evidence for the positive role of transnational talent mobility in the technological catch-up of emerging ***, it offers recommendations for talent export, import, and innovation policy formulation in these countries.

关键词： emerging countries mechanism research path-breaking talent flow technological evolution

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Hygro-Thermo-Mechanical Equivalent Layer-Wise Theory of Laminated Shell Structures

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Computer Modeling in Engineering & Sciences 2025年第2期142卷 1697-1765页

作者： Francesco Tornabene Matteo Viscoti Rossana Dimitri department of innovation Engineering University of SalentoLecce73100Italy

This study presents a generalized two-dimensional model for evaluating the stationary hygro-thermo-mechanical response of laminated shell structures made of advanced *** introduces a generalized kinematic model,enabling the assessment of arbitrary values of temperature variation and mass concentration variation for the unvaried configuration at the top and bottom *** is achieved through the Equivalent Layer-Wise description of the unknown field variable using higher-order polynomials and zigzag *** addition,an elastic foundation is modeled utilizing the Winkler-Pasternak *** fundamental equations,derived from the total free energy of the system,are solved analytically using Navier’s ***,the Fourier-based generalized differential quadrature numerical method is adopted to efficiently recover the through-the-thickness distribution of secondary variables in agreement with the hygro-thermal loading *** formulation is applied in some examples of investigation where the response of panels of different curvature and lamination schemes is evaluated under external hygro-thermal fluxes and prescribed values of temperature and moisture *** addition,this study investigates the effect of the hygro-thermal coupling due to Dufour and Soret *** present formulation is verified to be a valuable tool for reducing computational effort and determining the effect on the mechanical response of laminated structures in a thermal and hygrometric environment.

关键词： Dufour and Soret effects equivalent layer-wise hygro-thermal analysis generalized differential quadrature Navier solution smart structures

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research and development of the pulse acquisition system and the pulse biomimetic reproduction system

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Journal of Traditional Chinese Medicine 2025年第1期45卷 213-220页

作者： YI Kai MA Yunjing GUO Shen LIU Heng XU Bin the First clinical College Liaoning University of Traditional Chinese Medicine research and Development department Shenyang Traditional Chinese Medicine Intelligent Medical Equipment Industry Technology Research Institute

The paper is an introduction to the front-end pulse acquisition and the back-end pulse biomimetic reproduction system. This system is capable of faithfully replicating the complete pulse waveform collected at the front end. Traditional Chinese Medicine(TCM) practitioners analyze and diagnose the pulse patterns at the replication end. Meanwhile, the obtained pulse waveforms are analyzed and learnt by a neural network based on key diagnostic points in TCM pulse taking, which enables the determination of the corresponding relationships between different pulse waveforms and various pulse patterns in TCM pulse taking. With the support of clinical samples, an auxiliary diagnostic system for TCM pulse patterns ensures the accuracy of pulse pattern replication.

关键词： medicine, Chinese traditional pulse acquisition system pulse biomimetic reproduction system pulse taking

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Strain accumulation in the Mentawai Forearc Sliver,Indonesia,inferred from continuous GNSS-derived strain rate

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Geodesy and Geodynamics 2025年第1期16卷 1-6页

作者： Leni Sophia Heliani Cecep Pratama Adi Wibowo David Prambudi Sahara Susilo Susilo Sidik Tri Wibowo Ayu Nur Safii Oktadi Prayoga Ajat Sudrajat Mizan Bustanul Fuady Bisri Evi Dwi Kurniasari Sheilla Evelinda Nicholas Genta Setiawan Gunawan department of Geodetic Engineering Universitas Gadjah Mada department of Computer Science Universitas Diponegoro Global Geophysics research Group Institut Teknologi Bandung research Center for Geological Disaster National Research and Innovation Agency Geospatial Information Agency Meteorological Climatological and Geophysical Agency Graduate School of International Cooperation Studies Kobe University Graduate School of Geodetic Engineering Universitas Gadjah Mada

The Mentawai Forearc Sliver(MFS) is characterized by oblique deformation formed as slip partitioned between normal and parallel trench plate convergence. The surge of great earthquakes from 2004 to2012 along the adjacent Sunda trench left a large unbroken segment known as the Mentawai Seismic Gap. Here, we adopted continuous Global Navigation Satellite System(GNSS) observation data to identify the present regional crustal deformation using geodetic strain rates. The principal strain rate, dilatation rate, and maximum shear strain rate are about 0.13 microstrain/yr, 0.2 microstrain/yr, and 0.1 microstrain/yr, respectively, with the range of its uncertainties between 0.01 and 0.04 microstrain/yr. The dilatation and maximum shear strain rates reveal the spatial coverage of strike-slip duplex and backthrust tectonics along the Mentawai Forearc Sliver.

关键词： Mentawai Forearc Dilatation Shear Geodetic

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