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Progress and challenges in research of the mechanisms of anhedonia in major depressive disorder

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General Psychiatry 2022年第1期35卷 20-25页

作者： Yun-Ai Su Tianmei Si department of clinical psychopharmacology Peking University Sixth HospitalBeijingPeople's Republic of China department of clinical psychopharmacology Peking University Institute of Mental HealthBeijingPeople's Republic of China NHC Key Laboratory of Mental Health(Peking University) BeijingPeople's Republic of China National clinical Research Center for Mental Disorders(Peking University Sixth Hospital) BeijingPeople's Republic of China

There is an increasing heavy disease burden of major depressive disorder(MDD)*** high diagnostic heterogeneity and complicated pathological mechanisms of MDD pose significant *** is much evidence to support anhedonia as a core feature of *** the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition,anhedonia is further emphasised as a key item in the diagnosis of major depression with melancholic *** is a multifaceted symptom that includes deficits in various aspects of reward processing,such as anticipatory anhedonia,consummatory anhedonia,and decision-making *** is expected to become an important clinicopathological sign for predicting the treatment outcome of MDD and assisting clinical decision ***,the precise neurobiological mechanisms of anhedonia in MDD are not clearly *** this paper,we reviewed(1)the current understanding of the link between anhedonia and MDD;(2)the biological basis of the pathological mechanism of anhedonia in MDD;and(3)challenges in research on the pathological mechanisms of anhedonia in MDD.A more in-depth understanding of anhedonia associated with MDD will improve the diagnosis,prediction,and treatment of patients with MDD in the future.

关键词： diagnosis mechanisms treatment

Effects of the combination of second-generation antipsychotics on serum concentrations of aripiprazole and dehydroaripiprazole in Chinese patients with schizophrenia

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General Psychiatry 2021年第2期34卷 87-98页

作者： Ping Jiang Xiujia Sun Juanjuan Ren Hongmei Liu Zhiguang Lin Junwen Liu Xinyu Fang Chen Zhang department of Biochemistry and psychopharmacology Shanghai Mental Health CenterShanghaiChina Shanghai Key Laboratory of Psychotic Disorders ShanghaiChina

Background Aripiprazole(ARI)is often prescribed alone or in combination with other second-generation antipsychotics(SGAs)to treat patients with ***,this may increase the potential clinical significance of drug-drug *** drug monitoring(TDM)is an important and fundamental tool both when administering ARI alone and in combination with other SGAs to monitor ARI pharmacokinetics,adjust the dosage and thereby achieve more effective and safer *** This study retrospectively investigated the effects of four SGA comedications(clozapine,risperidone,quetiapine(QTP)and olanzapine)and other potential factors(sex,age and ARI dose)on the serum concentrations of ARI and dehydroaripiprazole(DARI)in Chinese patients with schizophrenia using TDM *** High-performance liquid chromatography was used to test the serum concentrations of ARI,DARI and ARI+*** addition,steady-state dose-adjusted serum concentrations(ie,concentration-to dose ratios,C:D ratios)of ARI,DARI and ARI+DARI;sex;age;ARI dose and SGA comedication dose between 299 inpatients with schizophrenia who received ARI or SGA comedication were all collected and ***’s correlation and multiple linear regression analysis were used to evaluate bivariate associations between ARI dose and serum ARI and DARI concentrations and describe the effect of independent variables on serum ARI and DARI concentrations,*** There were significant differences in the C:D ratios of ARI(χ^(2)=−3.21,p=0.001)and ARI+DARI(χ^(2)=−2.50,p=0.01)between the ARI and SGA groups,as well as in the C:D ratios of ARI(χ^(2)=−3.59,p<0.001)and ARI+DARI(χ^(2)=−3.10,p=0.002)between the female patients in the two *** the four SGAs,only QTP had significant effects on the C:D ratios of ARI(Z=−4.12,p<0.001)and ARI+DARI(Z=−3.62,p<0.001)when compared with the ARI group in the whole sample and on the C:D ratios of ARI,DARI and ARI+DARI(Z=−3.96,p<0.001;Z=−2.22,p=0.03;Z=−3.75,p<0.00

关键词： dosage patients schizophrenia

Nuclear receptors modulate inflammasomes in the pathophysiology and treatment of major depressive disorder

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World Journal of Psychiatry 2021年第12期11卷 1191-1205页

作者： Han Wang Wei-Jing Kan Yuan Feng Lei Feng Yang Yang Pei Chen Jing-Jie Xu Tian-Mei Si Ling Zhang Gang Wang Jing Du The National clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders Beijing Anding HospitalBeijing 100088Beijing ProvinceChina department of clinical psychopharmacology Peking University Institute of Mental HealthBeijing 100191Beijing ProvinceChina State Key Laboratory for Conservation and Utilization of Bio-resources in Yunnan Yunnan UniversityKunming 650091Yunnan ProvinceChina

Major depressive disorder(MDD)is highly prevalent and is a significant cause of mortality and morbidity ***,conventional pharmacological treatments for MDD produce temporary remission in<50%of patients;therefore,there is an urgent need for a wider spectrum of novel antidepressants to target newly discovered underlying disease *** evidence has shown that immune inflammation,particularly inflammasome activity,plays an important role in the pathophysiology of *** this review,we summarize the evidence on nuclear receptors(NRs),such as glucocorticoid receptor,mineralocorticoid receptor,estrogen receptor,aryl hydrocarbon receptor,and peroxisome proliferator-activated receptor,in modulating the inflammasome activity and depression-associated *** review provides evidence from an endocrine perspective to understand the role of activated NRs in the pathophysiology of MDD,and to provide insight for the discovery of antidepressants with novel mechanisms for this devastating disorder.

关键词： Major depressive disorder Immune inflammation Inflammasome Nuclear receptors

Ontogeny of vocal rhythms in harbor seal pups: an exploratory study

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Current Zoology 2019年第1期65卷 107-120页

作者： Andrea RAViGNANi Christopher T. Kello Koen de Reus Sonja A KoTz Simone Dalla BELLA Margarita Mendez-Arostegui Beatriz Rapado-Tamarit Ana Rubio-Garcia Bart de BoER Research department Sealcentre Pieterburen Pieterburen The Netherlands Artificial Intelligenee Lab Vrije Universiteit Brussel Brussels Belgium Cognitive and Information Sciences University of California Merced CA USA Basic and Applied NeuroDynamics Lab Faculty of Psychology and Neuroscience Department of Neuropsychology & Psychopharmacology Maastricht University Maastricht The Netherlands department of Neuropsychology Max-Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany International Laboratory for Brain Music and Sound Research (BRAMS) Montreal QC Canada department of Psychology University of Montreal Montreal QC Canada department of Cognitive Psychology WSFiZ in Warsaw Warsaw Poland

Puppyhood is a very active social and vocal period in a harbor seal's life Ph oca vitulina. An important feature of vocalizations is their temporal and rhythmic structure, and understanding vocal timing and rhythms in harbor seals is critical to a cross-species hypothesis in evolutionary neuroscience that links vocal learning, rhythm perception, and synchronization. This study utilized analytical techniques that may best capture rhythmic structure in pup vocalizations with the goal of examining whether (1) harbor seal pups show rhythmic structure in their calls and (2) rhythms evolve over time. Calls of 3 wild-born seal pups were recorded daily over the course of 1-3 weeks;3 temporal features were analyzed using 3 complementary techniques. We identified temporal and rhythmic structure in pup calls across different time windows. The calls of harbor seal pups exhibit some degree of temporal and rhythmic organization, which evolves over puppyhood and resembles that of other species' in teractive comm un icati on. We suggest n ext steps for investigating call structure in harbor seal pups and propose comparative hypotheses to test in other pinniped species.

关键词： bioacoustics pinnipeds rhythm timing vocal development

Classification of musical hallucinations and the characters along with neural-molecular mechanisms of musical hallucinations associated with psychiatric disorders

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World Journal of Psychiatry 2024年第9期14卷 1386-1396页

作者： Xin Lian Wei Song Tian-Mei Si Naomi Zheng Lian department of Radiology and Biomedical Imaging Shanxi Bethune HospitalShanxi Academy of Medical SciencesTaiyuan 030032Shanxi ProvinceChina department of Psychiatry and Behavioral Neurosciences McMaster UniversityHamilton L8S 4L8ONCanada department of psychopharmacology Peking University Sixth HospitalBeijing 100191China department of Psychiatry Hartford HealthCareSt Vincent’s Medical CenterWestportCT 06088United States

BACKGROUND Musical hallucinations(MH)involve the false perception of music in the absence of external stimuli which links with different *** pathomechanisms of MH encompass various *** etiological classification of MH is of particular importance and offers valuable insights to understand MH,and further to develop the effective treatment of *** the recent decades,more MH cases have been reported,revealing newly identified medical and psychiatric causes of *** imaging studies reveal that MH activates a wide array of brain *** up-to-date analysis on MH,especially on MH comorbid psychiatric conditions is *** To propose a new classification of MH;to study the age and gender differences of MH in mental disorders;and neuropathology of *** Literatures searches were conducted using keywords such as“music hallucination,”“music hallucination and mental illness,”“music hallucination and gender difference,”and“music hallucination and psychiatric disease”in the databases of PubMed,Google Scholar,and Web of *** cases were collected and categorized based on their *** t-test and ANOVA were employed(P<0.05)to compare the age differences of MH different etiological *** neuroimaging studies of neural networks regulating MH and their possible molecular mechanisms were *** Among the 357 yielded publications,294 MH cases were *** average age of MH cases was 67.9 years,with a predominance of females(66.8%females vs 33.2%males).MH was classified into eight groups based on their etiological *** analysis of MH cases indicates varying associations with psychiatric *** We carried out a more comprehensive review of MH *** the first time according to our knowledge,we demonstrated the psychiatric conditions linked and/or associated with MH from statistical,biological and molecular point of view.

关键词： Pathomechanism Etiological factors Classification Gender difference Neuropathway Psychotic musical hallucination and non-psychotic musical hallucination Neuropathway Biological and molecular mechanism

Advances in functional MRI research in bipolar disorder:from the perspective of mood states

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General Psychiatry 2024年第1期37卷 33-43页

作者： Yankun Wu Yun-Ai Su Linlin Zhu Jitao Li Tianmei Si department of clinical psychopharmacology Peking University Sixth HospitalPeking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)BeijingChina Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratoryof Mental Health(Peking University)National Clinical Research Centerfor Mental Disorders(Peking University Sixth Hospital)BeijingChina

Bipolar disorder is characterised by recurrent and alternating episodes of mania/hypomania and *** breakthroughs in functional MRI techniques have uncovered the functional neuroanatomy of bipolar ***,the pathophysiology underlying mood instability,mood switching and the development of extreme mood states is less well *** reviewpresents a comprehensive overviewof current evidence from functional MRI studies from the perspective of mood *** first summarise the disrupted brain activation patterns and functional connectivity that have been reported in bipolar disorder,irrespective of the mood *** next focus on research that solely included patients in a single mood state for a better understanding of the pathophysiology of bipolar disorder and research comparing patients with different mood states to dissect mood state-related ***,we briefly summarise current theoretical models and conclude this review by proposing potential avenues for future research.A comprehensive understanding of the pathophysiology with consideration of mood states could not only deepen our understanding of how acute mood episodes develop at a neurophysiological level but could also facilitate the identification of biological targets for personalised treatment and the development of new interventions for bipolar disorder.

关键词： anatomy bipolar functional

Brain Signaling in Psychiatric Disorders: What Can They Tell Us in the Absence of Behavioral Differences?

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Journal of Behavioral and Brain Science 2015年第8期5卷 333-337页

作者： Jodi M. Gilman James M. Bjork Timothy E. Wilens Center for Addiction Medicine Massachusetts General Hospital Boston MA USA department of Psychiatry Harvard Medical School Boston MA USA department of Psychiatry Virginia Commonwealth University Richmond VA USA clinical and Research Programs in Pediatric psychopharmacology Adult ADHD Massachusetts General Hospital Boston MA USA

This is a commentary on the often-observed phenomenon of observing task-based brain signaling differences between clinical populations and healthy control participants in the absence of any behavioral decrements in the clinical group. We offer several explanations for why brain-based differences amid normative performance may be of interest to researchers and clinicians. First, neural processing in the clinical group may not be as efficient as that in the control group. Second, differences in activation could reveal important differences in the cognition behind the (normative) behavior. Third, differences in activation may be prognostic biomarkers of injury or decline. In addition, we contend that similar behavior between groups is important in properly interpreting brain data. Finally, we offer caveats and future directions to further clarify brain mechanisms underlying behavior in clinical populations.

关键词： fMRI Neuroimaging Normative Behavior Normative Performance Neural Efficiency Prognostic Biomarker

DUSP8 inhibits LPS-induced acute lung injury by regulating macrophage response

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Life Research 2021年第3期4卷 55-63页

作者： Qing-Bao Xu Chen-Xi Tang Li He Wen Cheng Ping Jiang Xiao-Ya Wang department of Emergency Nanchong Central HospitalThe Second Clinical Medical CollegeNorth Sichuan Medical CollegeNanchongSichuanChina department of Nursing Nanchong Central HospitalThe Second Clinical Medical CollegeNorth Sichuan Medical CollegeNanchongSichuanChina department of Neurology Nanchong Central HospitalThe Second Clinical Medical CollegeNorth Sichuan Medical CollegeNanchongSichuanChina department of Critical Care Medicine Nanchong Central HospitalThe Second Clinical Medical CollegeNorth Sichuan Medical CollegeNanchongSichuanChina department of Biochemistry and psychopharmacology Shanghai Mental Health CenterShanghai Jiaotong University School of MedicineShanghaiChina department of Neurosurgery Nanchong Central HospitalThe Second Clinical Medical CollegeNorth Sichuan Medical CollegeNanchongSichuanChina

Background:Although many studies focus on investigating the new therapeutic target of acute lung injury(ALI),there still needs more works on exploring the role of other molecular in the pathology of *** specificity phosphatase(DUSP)8 has been reported to participate in the process of ***,the potential role of DUSP8 in lipopolysaccharide(LPS)-induced murine ALI is still ***:Firstly,murine ALI was established by LPS treatment and further measured by hematoxylin-eosin ***,the expression of DUSP8 in lung tissues was analyzed by real-time polymerase chain ***,DUSP8 overexpression vector was utilized and the protein level of DUSP8 was detected by western ***,the pathologic injury was measured by hematoxylin-eosin staining and wet/dry ***,we cultured bone-marrow-derived macrophages and detected the expression of DUSP8 by real-time polymerase chain reaction and western blot after LPS *** addition,DUSP8 overexpression vector was transfected into bone-marrow-derived macrophages and the levels of related inflammatory cytokines were measured by enzyme-linked immunosorbent ***:Compared with the control mice,DUSP8 significantly decreased in LPS-induced murine ***,DUSP8 overexpression could attenuate the pathology of ALI by altering lung inflammation and ***,DUSP8 was also reduced in LPS-treated BMDM and reached a peak at ***,DUSP8 overexpression could reduce the productions of related inflammatory cytokines,such as interleukin-1β,tumor necrosis factor-αand interleukin-6 in LPS-treated bone-marrow-derived ***:DUSP8 is reduced in LPS-induced murine acute lung injury and DUSP8 overexpression could ameliorate the pathologic injury of ALI by altering macrophage inflammation responses.

关键词： Dual specificity phosphatase 8 Acute lung injury Inflammation Macrophage

Treating comorbid anxiety and depression: Psychosocial and pharmacological approaches

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World Journal of Psychiatry 2015年第4期5卷 366-378页

作者： Jeremy D Coplan Cindy J Aaronson Venkatesh Panthangi Younsuk Kim department of Psychiatry Division of Neuro- psychopharmacology State University of New York Downstate Medical Center department of Psychiatry Icahn School of Medicine at Mount Sinai State University of New York Downstate Medical Center

Comorbid anxiety with depression predicts poor outcomes with a higher percentage of treatment resistance than either disorder occurring alone. Overlap of anxiety and depression complicates diagnosis and renders treatment challenging. A vital step in treatment of such comorbidity is careful and comprehensive diagnostic assessment. We attempt to explain various psychosocial and pharmacological approaches for treatment of comorbid anxiety and depression. For the psychosocial component, we focus only on generalized anxiety disorder based on the following theoretical models:(1) "the avoidance model";(2) "the intolerance of uncertainty model";(3) "the meta-cognitive model";(4) "the emotion dysregulation model"; and(5) "the acceptance based model". For depression, the following theoretical models are explicated:(1) "the cognitive model";(2) "the behavioral activation model"; and(3) "the interpersonal model". Integration of these approaches is suggested. The treatment of comorbid anxiety and depression necessitates specific psychopharmacological adjustments as compared to treating either condition alone. Serotonin reuptake inhibitors are considered first-line treatment in uncomplicated depression comorbid with a spectrum of anxiety disorders. Short-acting benzodiazepines(BZDs) are an important "bridging strategy" to address an acute anxiety component. In patients with comorbid substance abuse, avoidance of BZDs is recommended and we advise using an atypical antipsychotic in lieu of BZDs. For mixed anxiety and depression comorbid with bipolar disorder, we recommend augmentation of an antidepressant with either lamotrigine or an atypical agent. Combination and augmentation therapies in the treatment of comorbid conditions vis-à-vis monotherapy may be necessary for positive outcomes. Combination therapy with tricyclic antidepressants, gabapentin and selective serotonin/norepinephrine reuptake inhibitors(e.g., duloxetine) are specifically useful for comorbid chronic pain syndro

关键词： Generalized anxiety disorder Cognitive behavioral therapy Treatment-resistant mood disorders Bipolar disorder comorbid with anxiety Augmentation strategies Major depressive disorder