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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： Laura Huggon Emma L.Clayton UK Dementia Research Institute at King’s College London LondonUK department of Basic and clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(ALS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and ALS affecting upper and lower motor neurons),these two diseases are complexly *** and ALS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

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Altered thermal sensitivity in facial skin in chronic whiplash-associated disorders

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International Journal of Oral Science 2013年第3期5卷 150-154页

作者： Birgitta Hggman-Henrikson Ewa Lampa Erik Nordh department of Odontology Clinical Oral Physiology Umea University department of pharmacology and clinical Neurosciences Division of Clinical Neurophysiology Ume University

There is a close functional relationship between the jaw and neck regions and it has been suggested that trigeminal sensory impairment can follow whiplash *** of manageable routines for valid assessment of the facial sensory capacity is thus needed for comprehensive evaluations of patients exposed to such *** present study investigated facial thermal thresholds in patients with chronic whiplash-associated disorders（WADs）with both a qualitative method and quantitative sensory testing（QST）.Ten women with pain and dysfunction following a whiplash injury were compared to 10 healthy age-matched *** detection thresholds were assessed by qualitative chair-side testing and by QST according to the *** test sites in the facial skin（overlying each trigeminal branch bilaterally,and the midpoint of the chin）were *** detection warm and cold thresholds were defined as the mean values of 10 individual *** the WAD patients,the qualitative assessment demonstrated both reduced and increased sensitivity compared to the healthy,whereas QST systematically showed significantly higher detection thresholds（i.e.,decreased sensitivity）for both cold and warm *** the individuals who were assessed as having increased sensitivity in the qualitative assessment,the QST displayed either normal or higher thresholds,i.e.,decreased *** results suggest that QST is more sensitive for detecting thermal sensory disturbances in the face than a qualitative *** impaired thermal sensitivity among the patients corroborates the notion of altered thermal detection capacity induced by WAD-related pain.

关键词： jaw neck quantitative sensory testing thermal thresholds trigeminal whiplash injury

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Pyroptosis,ferroptosis,and autophagy in spinal cord injury:regulatory mechanisms and therapeutic targets

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Neural Regeneration Research 2025年第10期20卷 2787-2806页

作者： Qingcong Zheng Du Wang Rongjie Lin Weihong Xu department of Spinal Surgery the First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Arthritis clinical and Research Center Peking University People’s HospitalBeijingChina department of Orthopedic Surgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Regulated cell death is a form of cell death that is actively controlled by *** studies have shown that regulated cell death plays a key role after spinal cord *** and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal ***,a complex form of cell death that is interconnected with various regulated cell death mechanisms,has garnered significant attention in the study of spinal cord *** injury triggers not only cell death but also cellular survival *** signaling pathways play pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury by regulating pyroptosis,ferroptosis,and ***,this review aims to comprehensively examine the mechanisms underlying regulated cell deaths,the signaling pathways that modulate these mechanisms,and the potential therapeutic targets for spinal cord *** analysis suggests that targeting the common regulatory signaling pathways of different regulated cell deaths could be a promising strategy to promote cell survival and enhance the repair of spinal cord ***,a holistic approach that incorporates multiple regulated cell deaths and their regulatory pathways presents a promising multi-target therapeutic strategy for the management of spinal cord injury.

关键词： autophagy cell death ferroptosis inflammation pathological mechanisms pyroptosis regulated cell death regulatory pathways spinal cord injury therapeutic targets

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5-Hydroxytryptamine-induced proliferation of pulmonary artery smooth muscle cells are extracellular signal-regulated kinase pathway dependent

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Acta Pharmacologica Sinica 2005年第5期26卷 563-567页

作者： Dan SONG,Huai-liang WANG~2,Shuang WANG,Xin-hua ZHANGdepartment of clinical pharmacology,China Medical University,Shenyang 110001,China department of clinical pharmacology China Medical University Shenyang China

Aim:To investigate the effect of 5-hydroxytryptamine transporter(5-HTT)inhibi-tor fluoxetine and antisense oligodeoxynucleotide(ODN)to extracelluar signal-regulated kinases(ERKs)on pulmonary arterial smooth muscle cells(PASMCs)proliferation induced by ***:Liposomal transfection was used tointroduce ODNs to ERK1/2 into cultured rat PASMCs and the transfection effi-ciency was measured by observing the uptake of the fluorecein isothiocynate(FITC)-labeled antisense ODN in *** effects of 5-HTT selective inhibi-tor fluoxetine and ODNs on the proliferation of PASMCs were evaluated by cellnumber counting and cell cycle analysis,and measured by microculture tetrazo-lium(MTT)assay and flow cytometry(FCM),***:Liposomesmediated the transfection of ODNs into PASMCs with high *** showed fluoxetine(10μmol/L,1 μmol/L,and 100 nmol/L)concentrationdependently inhibited the proliferation of PASMCs induced by 5-HT(1 μmol/L)*** proliferation rate of PASMCs by 5-HT was significantly inhibited bypretreatment with ERK1/2 antisense ODN(0.2μmol/L)from 251%±18% to 86%±5%(P<0.01).Flow cytometric analysis of cell cycle distribution showed that theincrease of 5-HT induced S phase fraction(SPF)and proliferation index(PI)weresignificantly inhibited by fluoxetine(1μmol/L)or antisense ODN with SPF from36%±4% to 26%±3% and 24%±4%,and PI from 34%±2% to 29%±2% and 24%±2%,***:5-HTT mediates the mitogenic effect of 5-HT onPASMCs and the proliferation of PASMCs induced by 5-HT is dependent onERKs signal pathway.

关键词： antisense oligodeoxyribonucleotides serotonin membrane transport proteins pulmonary hypertension vascular smooth muscle fluxetine mitogen-activated protein kinases

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Visualizing traumatic brain injury:ocular clues for diagnosis and assessment

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Neural Regeneration Research 2025年第5期20卷 1399-1400页

作者： Morteza Abyadeh Vivek Gupta Yuyi You Joao A.Paulo Mehdi Mirzaei ProGene Technologies Pty Ltd SydneyNSWAustralia department of clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie Medical SchoolMacquarie UniversityMacquarie ParkNorth RydeSydneyNSWAustralia department of Cell Biology Harvard Medical SchoolBostonMAUSA

Traumatic brain injury (TBI) is defined as damage to the brain resulting from an external sudden physical force or shock to the *** is considered a silent public health epidemic causing significant death and disability *** were 64,000 TBI related deaths reported in the USA in 2020,with about US$76 billion in direct and indirect medical costs annually.

关键词： diagnosis ocular injury

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Down-regulation of p210bcr/ablby curcumin involves disrupting molecular chaperone functions of Hsp90

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Acta Pharmacologica Sinica 2006年第6期27卷 694-699页

作者： Li-xian WU Jian-hua XU~2 Xiu-wang HUANG Kun-zhong ZHANG Cai-xia WEN Yuan-zhong CHEN~3 2 Institute of clinical pharmacology,department of pharmacology,Fujian Medical University 3 Fujian Institute of Hematology,Fuzhou 350004,China department of pharmacology Institute of Clinical Pharmacology Fujian Medical University Fuzhou China Fujian Institute of Hematology Fuzhou China

Aim:To investigate the effects of curcumin（Cur）on p210ber/abllevel in K562 cells,and the relationship between these effects and the molecular chaperone functionsof heat shock protein 90（Hsp90）.Methods:Flow cytometry and Western blotwere used to examine the abundance of p210bcr/abl,Hsp90,p23,Hsp70,and p60Hopin K562 cells treated with *** transcription polymerase chain reaction（RT-PCR）was used to determine the bcr-abl mRNA level in K562 cells treated *** co-immunoprecipitation of p210bcr/abland its molecular chaperones,theimmunoprecipitate was then subjected to Western blot analysis with anti-Hsp90,anti-Hsp70,anti-p23,and ***:An exposure of K562 cells toCur produced time-dependent down-regulation of p210bcr/abl,the inhibition rate ofp210bcr/ablin K562 cells determined by flow cytometry after treatment with Cur 27.2μmol/L for 1h,6h,12h and 24 h was 31.2%,63.7%,81.3% and 94.5%,*** contrast,Cur had almost no influence on bcr-abl mRNA *** withCur for 24 h reduced the association of p210bcr/ablwith Hsp90/p23 complex,whileincreasing the association of p210bcr/ablwith Hsp70/p60Hopcomplex;however,thetotal protein abundance of Hsp90,p23,and p60Hopin K562 cells had no apparentchange,while Hsp70 increased ***:Down-regulation ofp210bcr/ablby Cur involves dissociating the binding of p210bcr/ablwith Hspg0/*** contrast,the association of p210bcr/ablwith HspT0/p60Hopcomplexincreased.

关键词： curcumin molecular chaperones bcr-abl fusion proteins heat shock protein 90

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Mechanisms behind elevated serum levels of plasminogen activator inhibitor-1 in frontotemporal lobar degeneration

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Neural Regeneration Research 2025年第8期20卷 2317-2318页

作者： Francesco Angelucci Jakub Hort Memory Clinic Department of NeurologySecond Faculty of MedicineCharles University and Motol University HospitalPragueCzech Republic International clinical Research Centre St.Anne’s University HospitalBrnoCzech Republic

Frontotemporal lobar degeneration(FTLD)is a form of progressive dementia characterized by degeneration of the frontal and temporal lobes of the *** pathology involves a series of cognitive,behavioral,and neurological ... 详细信息

关键词： degeneration elevated pathology

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Bile acid signaling through farnesoid X and TGR5 receptors in hepatobiliary and intestinal diseases

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Hepatobiliary & Pancreatic Diseases International 2015年第1期14卷 18-33页

作者： Bojan Stanimirov Karmen Stankov Momir Mikov department of pharmacology Toxicology and Clinical Pharmacology Faculty of Medicine University of Novi Sad clinical Centre of Vojvodina Faculty of Medicine University of Novi Sad School of Pharmacy Curtin University

BACKGROUND： The well-known functions of bile acids（BAs） are the emulsification and absorption of lipophilic xenobiotics. However, the emerging evidences in the past decade showed that BAs act as signaling molecules that not only autoregulate their own metabolism and enterohepatic recirculation, but also as important regulators of integrative metabolism by activating nuclear and membrane-bound G protein-coupled receptors. The present review was to get insight into the role of maintenance of BA homeostasis and BA signaling pathways in development and management of hepatobiliary and intestinal *** SOURCES： Detailed and comprehensive search of PubM ed and Scopus databases was carried out for original and review ***： Disturbances in BA homeostasis contribute to the development of several hepatobiliary and intestinal disorders, such as non-alcoholic fatty liver disease, liver cirrhosis, cholesterol gallstone disease, intestinal diseases and both hepatocellular and colorectal ***： Further efforts made in order to advance the understanding of sophisticated BA signaling network may be promising in developing novel therapeutic strategies related not only to hepatobiliary and gastrointestinal but also systemic diseases.

关键词： bile acid metabolism non-alcoholic fatty liver disease cholestatic liver diseases gallstone disease intestinal disease hepatocellular carcinoma

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Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

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Neural Regeneration Research 2025年第1期20卷 130-138页

作者： Ilaria Martinelli Jessica Mandrioli Andrea Ghezzi Elisabetta Zucchi Giulia Gianferrari Cecilia Simonini Francesco Cavallieri Franco Valzania department of Neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly clinical and Experimental Medicine Ph.D.Program University of Modena and Reggio EmiliaModenaItaly department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Neurology Unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during *** multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.

关键词： amyotrophic lateral sclerosis(ALS) autonomic extramotor genotype-phenotype multisystem involvement Parkinson’s disease sensory SOD1 superoxide dismutase 1 urinary vocal cord palsy

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