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Dysregulation of genes involved in the long-chain fatty acid transport in pancreatic ductal adenocarcinoma

World Journal of Gastrointestinal Oncology 2025年第1期17卷 199-206页

作者： Radu Cristian Poenaru Elena Milanesi Andrei Marian Niculae Anastasia-Maria Dobre Catalina Vladut Mihai Ciocîrlan Daniel Vasile Balaban Vlad Herlea Maria Dobre Mihail Eugen Hinescu faculty of medicine Carol Davila University of Medicine and PharmacyBucharest 050474Romania department of Radiobiology Victor Babes National Institute of PathologyBucharest 050096Romania department of pathology Victor Babes National Institute of PathologyBucharest 050096Romania department of Gastroenterology Prof.Dr.Agrippa Ionescu Clinical Emergency HospitalBucharest 011356Romania department of pathology Fundeni Clinical InstituteBucharest 022258Romania

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is an aggressive lethal malignancy with limited options for treatment and a 5-year survival rate of 11%in the United *** for other types of tumors,such as colorectal cancer,aberrant de novo lipid synthesis and reprogrammed lipid metabolism have been suggested to be associated with PDAC development and *** To identify the possible involvement of lipid metabolism in PDAC by analyzing in tumoral and non-tumoral tissues the expression level of the most relevant genes involved in the long-chain fatty acid(FA)import into *** A gene expression analysis of FASN,CD36,SLC27A1,SLC27A2,SLC27A3,SLC27A4,SLC27A5,ACSL1,and ACSL3 was performed by qRT-PCR in 24 tumoral PDAC tissues and 11 samples from non-tumoral pancreatic tissues obtained via fine needle aspiration or via surgical *** genes were considered significantly dysregulated between the groups when the p value was<0.05 and the fold change(FC)was≤0.5 and≥*** We found that three FA transporters and two long-chain acyl-CoA synthetases genes were significantly upregulated in the PDAC tissue compared to the non-tumoral tissue:SLC27A2(FC=5.66;P=0.033),SLC27A3(FC=2.68;P=0.040),SLC27A4(FC=3.13;P=0.033),ACSL1(FC=4.10;P<0.001),and ACSL3(FC=2.67;P=0.012).We further investigated any possible association between the levels of the analyzed mRNAs and the specific characteristics of the tumors,including the anatomic location,the lymph node involvement,and the presence of metastasis.A significant difference in the expression of SLC27A3(FC=3.28;P=0.040)was found comparing patients with and without lymph nodes involvement with an overexpression of this transcript in 17 patients presenting tumoral cells in the lymph *** Despite the low number of patients analyzed,these preliminary results seem to be *** lipid metabolism through a broad strategy could be a beneficial way to treat this *** in vitro and in vivo s

关键词： Carcinoma Pancreatic ductal Fatty acid transport Gene expression Biomarkers

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The collaborative cross mouse for studying the effect of host genetic background on memory impairments due to obesity and diabetes

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Animal Models and Experimental medicine 2025年第1期8卷 126-141页

作者： Avia Paz Kareem Midlej Osayd Zohud Iqbal MLone Fuad A.Iraqi department of clinical Microbiology and Immunology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael

Background:Over the past few decades,a threefold increase in obesity and type 2 diabetes(T2D)has placed a heavy burden on the health-care system and *** studies have shown correlations between obesity,T2D,and neurodegenera-tive diseases,including *** is imperative to further understand the relation-ship between obesity,T2D,and cognitive ***:This investigation tested and evaluated the cognitive impact of obesity and T2D induced by high-fat diet(HFD)and the effect of the host genetic background on the severity of cognitive decline caused by obesity and T2D in collaborative cross(CC)*** CC mice are a genetically diverse panel derived from eight inbred ***:Our findings demonstrated significant variations in the recorded phenotypes across different CC lines compared to the reference mouse line,C57BL/***037 line exhibited a substantial increase in body weight on HFD,whereas line CC005 ex-hibited differing responses based on *** tolerance tests revealed significant variations,with some lines like CC005 showing a marked increase in area under the curve(AUC)values on *** weights,including brain,spleen,liver,and kidney,varied significantly among the lines and sexes in response to *** tests using the Morris water maze indicated that cognitive performance was differentially affected by diet and genetic ***:Our study establishes a foundation for future quantitative trait loci map-ping using CC lines and identifying genes underlying the comorbidity of Alzheimer's disease(AD),caused by obesity and *** genetic components may offer new tools for early prediction and prevention.

关键词： collaborative cross mouse diabetes host genetic background memory impairments obesity

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Haematology results,inflammatory haematological ratios,and inflammatory indices in cervical cancer:How is the difference between cancer stage?

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World Journal of Experimental medicine 2025年第1期15卷 80-87页

作者： Phey Liana Hanif Gusneri Syahbiran Nurmalia Purnama Sari Kemas Yakub Rahadiyanto Raissa Nurwany Wahyudi Nurhidayat Tungki Pratama Umar department of clinical pathology Faculty of MedicineUniversitas Sriwijaya-Dr.Mohammad Hoesin General HospitalPalembang 30114Sumatera SelatanIndonesia department of medicine Programme Faculty of MedicineUniversitas SriwijayaPalembang 30114Sumatera SelatanIndonesia department of clinical pathology Faculty of MedicineUniversitas SriwijayaPalembang 30114Sumatera SelatanIndonesia department of Physiology and Medical Physics Faculty of MedicineUniversitas SriwijayaPalembang 30114Sumatera SelatanIndonesia department of Radiotherapy Dr.Mohammad Hoesin General HospitalPalembang 30114Sumatera SelatanIndonesia Division of Surgery and Interventional Science Faculty of Medical SciencesUniversity College LondonLondon WC1E 6BTUnited Kingdom

BACKGROUND Cervical cancer is a prevalent form of cancer affecting women worldwide and it is the second most common cancer among women in Indonesia,accounting for 8.5%of all cancer-related *** cancer progression can be evaluated through laboratory tests to detect anaemia,an increased platelet count,and elevated inflammatory markers,therefore,effective laboratory examination is crucial for early detection and treatment of cervical *** To evaluate the association between laboratory findings(haematology,haematology index,and inflammatory index)and the clinical stage of cervical *** This cross-sectional study analyzed adult cervical cancer patients’data from medical records and laboratory results including sociodemographic status,histopathological finding,clinical stage,and complete haematology *** data was analyzed by the one-way ANOVA(normal data distribution),while the Kruskal-Wallis test was used for non-parametric data(abnormal distribution),followed by appropriate post-hoc *** categorical data was analyzed by the Chi-square or Fisher Exact *** significance level was established at a P valueclinical laboratory test results based on the clinical stage of cervical cancer,including haemoglobin levels(P<0.001),leucocytes(P<0.001),neutrophils(P<0.001),monocytes(P=0.002),lymphocytes(P=0.006),platelets(P<0.001),neutrophil-lymphocyte ratio/NLR(P<0.001),lymphocyte-monocyte ratio/LMR(P<0.001),and plateletlymphocyte ratio/PLR(P<0.001).There were also significant differences in the systemic inflammatory index(SII)and systematic inflammatory response index(SIRI)between stage III+IV cervical cancer and stage II(SII P<0.001;SIRI P=0.001)and stage I(SII P<0.001;SIRI P=0.016),ass

关键词： Cervical cancer Haematology Haematology index Inflammation Malignancy

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Effect of electroacupuncture on pain after periodontal flap surgery:a randomized controlled trial

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Journal of Traditional Chinese medicine 2025年第1期45卷 184-191页

作者： Emre Bulut Didem ?zkal Emino?lu Yasemin ?ay?r department of Periodontology Faculty of DentistryAtatürk University department of Family medicine Faculty of MedicineAtatürk University

OBJECTIVE: To examine the effect of electroacupuncture(EA) application on postoperative pain levels and the amount of analgesic use in patients who underwent periodontal flap surgery. METHODS: In this prospective, randomized and controlled study, patients planned for periodontal surgery were divided into two groups [EA group(n = 22): patients who received electroacupuncture and control group(n = 22): patients who did not receive electroacupuncture]. Electroacupuncture was applied bilaterally to the Hegu(LI4), Daying(ST5), and Jiache(ST5) points of the patients in the EA group immediately before and after the flap surgery for 30 min at a frequency of 50 Hz to each point at a current that the patient could tolerate. The patients in the control group underwent flap surgery without applying electroacupuncture. Patients were asked to record their pain levels on the visual analog scale and the number of analgesic tablets they took during the 7 postoperative days on the given form. RESULTS: The total mean score of pain felt in the EA group(16.60 ± 2.78) was found to be significantly lower than that in the control group(31.37 ± 2.78)(P = 0.001). No significant difference was found between the groups regarding the amount of analgesics taken(4.77 ± 4.72, 5.82 ± 3.11)(P = 0.111). CONCLUSIONS: Our study shows that electroacupuncture application is beneficial in reducing pain after periodontal flap surgery. Overall, more research is needed to fully understand the effects of electroacupuncture on postoperative pain.

关键词： analgesics electroacupuncture pain, postoperative periodontitis randomized controlled trial

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SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN M.OTIFI department of pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nM against JAK2 kinase and 200.9 nM against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nM,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 Molecular docking Molecular dynamics simulation

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From text to image:challenges in integrating vision into ChatGPT for medical image interpretation

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Neural Regeneration Research 2025年第2期20卷 487-488页

作者： Shunsuke Koga Wei Du department of pathology and Laboratory medicine Hospital of the University of PennsylvaniaPhiladelphiaPAUSA

Large language models(LLMs),such as ChatGPT developed by OpenAI,represent a significant advancement in artificial intelligence(AI),designed to understand,generate,and interpret human language by analyzing extensive text *** potential integration into clinical settings offers a promising avenue that could transform clinical diagnosis and decision-making processes in the future(Thirunavukarasu et al.,2023).This article aims to provide an in-depth analysis of LLMs’current and potential impact on clinical *** ability to generate differential diagnosis lists underscores their potential as invaluable tools in medical practice and education(Hirosawa et al.,2023;Koga et al.,2023).

关键词： image diagnosis text

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Prevalence of RUNX1 gene alterations in de novo adult acute myeloid leukemia

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World Journal of Experimental medicine 2025年第1期15卷 65-79页

作者： Hoda M Abd El-Ghany Mona S El Ashry Mona S Abdellateif Ahmed Rabea Nada Sultan Omnia Y Abd El Dayem department of clinical pathology Faculty of MedicineCairo UniversityCairo 11976Al QāhirahEgypt department of clinical pathology National Cancer InstituteCairo UniversityCairo 11976Al QāhirahEgypt department of Cancer Biology National Cancer InstituteCairo UniversityCairo 11976Al QāhirahEgypt department of Medical Oncology National Cancer InstituteCairo UniversityCairo 11976Al QāhirahEgypt

BACKGROUND Acute myeloid leukemia(AML)is a complicated disease with uncontrolled hematopoietic precursor proliferation induced by various genetic ***-related transcription factor-1(RUNX1)is commonly disrupted by chromosomal translocations in hematological *** To characterize RUNX1 gene rearrangements and copy number variations in newly diagnosed adult AML patients,with an emphasis on the impact of clinical and laboratory features on the *** Fluorescence in situ hybridization was used to test RUNX1 gene alterations in 77 newly diagnosed adult AML ***1,FLT3/ITD,FLT3/TKD,and KIT mutations were tested by *** clinical and laboratory findings were studied in relation to RUNX1 *** RUNX1 abnormalities were detected by fluorescence in situ hybridization in 41.6%of patients:20.8%had translocations,22.1%had amplification,and 5.2%had *** prevailed in AML-M2(P=0.019)with a positive expression of myeloperoxidase(P=0.031),whereas deletions dominated in M4 and M5 subtypes(P=0.008)with a positive association with CD64 expression(P=0.05).The modal chromosomal number was higher in cases having amplifications(P=0.007)and lower in those with deletions(P=0.008).RUNX1 abnormalities were associated with complex karyotypes(P<0.001)and were mutually exclusive of NPM1 *** 44 months of follow-up,RUNX1 abnormalities affected neither patients’response to treatment nor overall *** RUNX1 abnormalities were mutually exclusive of NPM1 ***1 abnormalities affected neither patients’response to treatment nor overall survival.

关键词： Acute myeloid leukemia Deletion Disease-free survival Fluorescence in-situ hybridization Karyotyping RUNX1

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Regeneration mechanisms and therapeutic strategies for neuromuscular junctions in aging and diseases

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Neural Regeneration Research 2025年第1期20卷 193-194页

作者： Masashi Fujitani Abu Md Mamun Tarif Yoshinori Otani department of Anatomy and Neuroscience Faculty of MedicineShimane UniversityShimaneJapan

The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout *** NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).

关键词： aging structure Figure

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Differences in diversity and composition of mucosa-associated colonic microbiota in colorectal cancer and non-colorectal cancer in Indonesia

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World Journal of Gastroenterology 2025年第7期31卷 10-25页

作者： Nikko Darnindro Murdani Abdullah Ninik Sukartini Cleopas M Rumende Amanda Pitarini Saskia A Nursyirwan Achmad Fauzi Dadang Makmun Erni J Nelwan Hamzah Shatri Ikhwan Rinaldi Caroline Tanadi Division of Gastroenterology Pancreatobiliary and Digestive EndoscopyDepartment of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General HospitalJakarta 10430Indonesia Division of Gastrohepatology Department of Internal MedicineFatmawati General HospitalJakarta 12430Indonesia Human Cancer Research Center IMERI Faculty of MedicineUniversitas IndonesiaJakarta 10430Indonesia department of clinical pathology Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General HospitalJakarta 10430Indonesia Division of Respirology and Critical Care Department of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General HospitalJakarta 10430Indonesia Division of Tropical medicine and Infectious Disease Department of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General HospitalJakarta 10430Indonesia Division of Psychosomatic and Palliative medicine Department of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General HospitalJakarta 10430Indonesia Division of Haematology and Medical Oncology Department of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General HospitalJakarta 10430Indonesia School of medicine and Health Sciences Atma Jaya Catholic University of IndonesiaJakarta 14440Indonesia

BACKGROUND Colorectal cancer is the third most common malignancy and the fourth leading cause of cancer-related deaths *** studies have shown an association between gut microbiota and colorectal *** microbiota is unique and can be influenced by geographic factors and *** study aimed to determine the diversity and composition of colonic mucosal microbiota in patients with and without colorectal *** To determine the diversity and composition of colonic mucosal microbiota in patients with and without colorectal cancer in *** This case-control study included 59 subjects(35 colorectal cancer patients and 24 non-colorectal cancer patients indicated for colonoscopy at *** Mangunkusumo Gastrointestinal Endoscopy Center and Fatmawati *** examination was performed using 16S rRNA *** analysis was performed using the wf-metagenomics pipeline from EPI2Me-Labs(Oxford Nanopore Technologies platform).RESULTS Patients with colorectal cancer had a higher median index value on the Shannon index(3.28 vs 2.82,P>0.05)and a lower value on the Simpson index(0.050 vs 0.060,P>0.05).Significant differences in beta diversity were observed at the genus(P=0.002)and species levels(P=0.001).Firmicutes,Proteobacteria,Bacteroidetes,and Fusobacteria were the dominant *** genera Bacteroides,Campylobacter,Peptostreptococcus,and Parvimonas were found more frequently in colorectal cancer,while Faecalibacterium,Haemophilus,and Phocaeicola were more frequently found in non-colorectal *** relative abundance of Fusobacterium nucleatum,Bacteroides fragilis,Enterococcus faecalis,Campylobacter hominis,and Enterococcus faecalis species was significantly elevated in patients with colorectal ***,Faecalibacterium prausnitzii,Faecalibacterium duncaniae,and Prevotella copri were more commonly found in non-colorectal *** Patients with colorectal cancer exhibit distinct differences in the

关键词： Gastrointestinal microbiome Biodiversity Intestinal mucosa Colorectal cancer Human

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Cerbera odollam fruit extracts enhance anti-cancer activity of sorafenib in HCT116 and HepG2 cells

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Chinese Herbal medicines 2025年第1期17卷 108-126页

作者： Supawadee Parhira Orakot Simanurak Khemmachat Pansooksan Julintorn Somran Apirath Wangteeraprasert Zhihong Jiang Liping Bai Pranee Nangngam Dumrongsak Pekthong Piyarat Srisawang department of Pharmaceutical Technology Faculty of Pharmaceutical Sciences Naresuan University Center of Excellence for Innovation in Chemistry Naresuan University Center of Excellence for Environmental Health and Toxicology Faculty of Pharmaceutical Sciences Naresuan University department of Physiology Faculty of Medical Science Naresuan University department of Pharmaceutical Chemistry and Pharmacognosy Faculty of Pharmaceutical Sciences Naresuan University department of pathology Faculty of Medicine Naresuan University department of medicine Faculty of Medicine Naresuan University State Key Laboratory of Quality Research in Chinese medicine Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease Macau Institute for Applied Research in Medicine and Health Macau University of Science and Technology department of Biology Faculty of Science Naresuan University department of Pharmacy Practice Faculty of Pharmaceutical Sciences Naresuan University Center of Excellence in Medical Biotechnology Faculty of Medical Science Naresuan University

Objective:While higher therapeutic doses of toxic cardiac glycosides derived from Cerbera odollam are frequently employed in cases of suicide or homicide,ongoing research is investigating the potential anticancer properties of low-concentration extracts obtained from the fruits of *** present study aimed to determine the enhanced anticancer effects and minimize potential side effects of combining extracts from *** fruits from Thailand with sorafenib against HCT116 and HepG2 ***:The dried powder of fresh green fruits of *** was fractionated,and its phytochemical contents,including total cardiac glycosides,phenolics,flavonoids,and triterpenoids,were *** cytotoxic effects of these fractions were evaluated against HCT116 and HepG2 cells using the MTT *** fractions showing the most significant response in HCT116 and HepG2 cells were subsequently combined with sorafenib to examine their synergistic *** induction,cell cycle progression,and mitochondrial membrane potential（MMP） were then *** underlying mechanism of the apoptotic effect was further investigated by analyzing reactive oxygen species（ROS） generation and the expression levels of antioxidant ***:Phytochemical analysis showed that ***-ethyl acetate fraction（COEtOAc） was rich in cardiac glycosides,phenolics,and flavonoids,while the dichloromethane fraction（CODCM） contained high levels of triterpenoids and *** 24 h treatment,HCT116 showed the most significant response to COEtOAc,while HepG2 responded well to CODCM with IC50values of（42.04±16.94） μg/mL and（123.75±14.21） μg/m L,***,COEtOAc（20 μg/mL） or CODCM（30 μg/mL）,both administered at sub-IC50concentrations,were combined with sorafenib at 6 μmol/L for HCT116 cells and2 μmol/L for HepG2 cells,incubated for 24 *** combination resulted in a significant suppression in cell viability by approximately 50%.The combination of treatments marked

关键词： apoptosis Cerbera odollam Gaertn. HCT116 HepG2 reactive oxygen species sorafenib

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