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Accurate visualization colorectal cancer by monitoring viscosity variations with a novel mitochondria-targeted fluorescent probe

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Chinese Chemical Letters 2025年第2期36卷 319-322页

作者： Fan Zheng Runsha Xiao Shuai Huang Zhikang Chen Chen Lai Anyao Bi Heying Yao Xueping Feng Zihua Chen Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South University Hunan Key laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases Central South University department of General Surgery Xiangya Hospital Central South University Hunan Key laboratory of Precise Diagnosis and Treatment of Gastrointestinal Tumor Xiangya Hospital Central South University National clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University department of Oncology Xiangya Hospital Central South University department of Otolaryngology-head and Neck Surgery and Institute of Medical Sciences Xiangya Hospital Central South University

Colorectal cancer(CRC) is one of the most prevalent malignant tumors worldwide, exhibiting high morbidity and mortality. Lack of efficient tools for early diagnosis and surgical resection guidance of CRC have been a serious threat to the long-term survival rate of the CRC patients. Recent studies have shown that relative higher viscosity was presented in tumor cells compared to that in normal cells, leading to viscosity as a potential biomarker for CRC. Herein, we reported the development of a series of novel viscosity-sensitive and mitochondria-specific fluorescent probes(HTB, HTI, and HTP) for CRC *** them, HTB showed high sensitivity, minimal background interference, low cytotoxicity, and significant viscous response capability, making it an ideal tool for distinguishing colorectal tumor cells from normal cells. Importantly, we have successfully utilized HTB to visualize in a CRC-cells-derived xenograft(CDX) model, enriching its medical imaging capacity, which laid a foundation for further clinical translational application.

关键词： Bioimaging Cancer diagnosis Colorectal cancer Fluorescent probe Mitochondrial-targeted Viscosity

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The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing Ning Shi Lv Qian Wang Yuzhen Xu department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina department of central laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

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Oxidative degradation and upcycling of polyethylene wastes

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Science China Chemistry 2025年第2期68卷 430-443页

作者： Yizhen Che Yanfen Wu Zhiqiang Niu State Key laboratory of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Ordos laboratory Ordos 017010China

Plastics have become omnipresent in modern life due to their versatility and ***,this convenience comes at the cost of substantial waste *** inherent chemical stability of plastics complicates its recycling,leading to environmental pollution and ecological *** mini-review highlights recent advancements in addressing this challenge by oxidative transformation of polyethylene(PE)into new functional polymers,value-added chemicals,and carbon-based *** first discuss the introduction of hydroxyl,carbonyl groups onto PE with a focus on the functionalization degree and ***,approaches for PE oxidation into dicarboxylic acids and short-chain oxidized PE are described and compared,with an emphasis on the tandem reactions for converting mixed dicarboxylic acids into other value-added *** also briefly discuss the oxidative transformation of PE into carbon-based materials and summarize the progress in qualitative and quantitative analysis of oxidation ***,we conclude this mini-review by highlighting the challenges and opportunities in the field.

关键词： oxidation polyethylene upcycling chemical conversion plastics

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Associations of multiple metals exposure with immunoglobulin levels in pregnant women:Hangzhou Birth Cohort Study

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Journal of Environmental Sciences 2025年第5期151卷 560-572页

作者： Jiena Zhou Lanfei Jin Yexinyi Zhou Kunhong Zhong Kegui Huang Qi Zhang Jun Tang Xue Zhang Lihe Peng Shuai Li Na Lv Dongdong Yu Qinheng Zhu Jing Guo Qiong Luo Guangdi Chen department of Public Health and Key Laboratory of Reproductive Genetics(Ministry of Education)Women’s HospitalZhejiang University School of MedicineHangzhou 310058China department of clinical laboratory Shaw HospitalZhejiang University School of MedicineHangzhou 310018China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051China Jiashan County Center for Disease Control and Prevention JiashanZhejiang 314199China department of clinical laboratory Women’s HospitalZhejiang University School of MedicineHangzhou 310020China department of Obstetrics Women’s HospitalZhejiang University School of MedicineHangzhou 310020China

Metal may affect maternal immune function,but few epidemiological studies have reported the associations between multiple-metal exposure and maternal immunoglobulin(Ig)*** on the Hangzhou Birth Cohort Study,1059 participants were included,and eleven metals in whole blood samples and serum IgA,IgG,IgE and IgM levels were *** regression,quantile-based g-computation(QGC),and Bayesian kernel machine regression(BKMR)models were used to evaluate the *** with the first tertile of metal levels,arsenic(As)was negatively associated with IgE(β=-0.25,95%confidence interval(CI)=-0.48 to-0.02).Moreover,significant associations of manganese(Mn)with IgA,IgG and IgM were demonstrated(β=0.10,95%CI=0.04 to 0.18;β=0.07,95%CI=0.03 to 0.12;β=0.10,95%CI=0.03 to 0.18,respectively).Cadmium(Cd)were associated with higher levels of *** models showed the positive association of the metalmixtures with IgA and IgG,with Mn playing amajor *** and Cd had positive contributions to IgM,while As had negative contributions to *** the BKMR models,the latent continuous outcomes of IgA and IgG showed a significant increase when all the metals were at their 60th percentile or above compared to those at their 50th ***,exposure to metals was associated with maternal Igs,and mainly showed that Mn was associated with increased levels of IgA,IgG and IgM,and As was associated with low IgE levels.

关键词： Metals Immunoglobulin Pregnant woman Quantile-based g-computation (QGC) Bayesian kernel machine regression (BKMR)

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Tandem asymmetric dearomatized functionalization reaction of phenols with Evans-ynamides enabled by divergent electrophiles

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Science China Chemistry 2025年第2期68卷 649-660页

作者： Ying-Qi Zhang Gan-Lu Qian Yun Liu Jia-Hui Li Xin Hong Zhou Xu Bo Zhou Long-Wu Ye State Key laboratory of Physical Chemistry of Solid Surfaces Key Laboratory of Chemical Biology of Fujian Provinceand College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Center of Chemistry for Frontier Technologies Department of ChemistryState Key Laboratory of Clean Energy UtilizationZhejiang UniversityHangzhou 310027China Jiangsu Key laboratory of New Drug Research and clinical Pharmacy School of PharmacyXuzhou Medical UniversityXuzhou 221004China State Key laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China State Key laboratory of Organometallic Chemistry Chinese Academy of SciencesShanghai 200032China

Herein,we disclose a highly regio-/chemoselective tandem asymmetric dearomatized halofunctionalization reaction of phenoltethered ynamides with diverse electrophilic halogenation sources in a catalyst-free manner for the practical and rapid assembly of a series of halogenated spirocyclic ***,the related dearomatized selenation and protonation are also achieved,affording the corresponding selenated and protonated spirocycles in high ***,the enantioselectivities of these products can be perfectly induced by Evans auxiliaries(99%ees).Significantly,this protocol not only represents the first tandem asymmetric halofunctionalization reaction of phenol derivatives,but also constitutes the first asymmetric halogenation/selenation of *** calculations indicate a remote induction model of Evans chiral auxiliary-attached keteniminium.

关键词： alkynes cyclization dearomatization Evans chiral auxiliary spirocycles

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Corrosion resistance and antibacterial properties of Ti−3Cu alloy prepared by selective laser melting

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Transactions of Nonferrous Metals Society of China 2025年第1期35卷 143-156页

作者： Meng-zhen ZHU Jing-lei MIAO Xiong-wen ZHOU Er-lin ZHANG Zhi-lin LIU Hai-lin YANG State Key laboratory of Powder Metallurgy Central South UniversityChangsha 410083China The Third Xiangya Hospital Central South UniversityChangsha 410013China department of Prosthodontics Centre of StomatologyXiangya HospitalCentral South UniversityChangsha 410008China Key laboratory for Anisotropy and Texture of Materials Ministry of EducationSchool of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Light Alloy Research Institute College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China

The corrosion resistance and antibacterial properties of Ti−3Cu alloy prepared by selective laser melting were evaluated using electrochemical experiments and a variety of antibacterial *** is found that the charge transfer resistance of Ti−3Cu alloy was 4.89×10^(5)Ω∙cm^(2),which was doubled the data obtained by CP-Ti *** antibacterial rates of Ti−3Cu alloy against *** and *** were 45.0%and 54.5%.And the antibacterial rates increased with the prolongation of cultivation time,reaching up to 62.8%and 68.6%,*** in-situ nano Ti_(2)Cu precipitates were homogeneously distributed in the matrix of the Ti−3Cu alloy,which was the key reason of increasing the corrosion ***,the microscale electric fields between theα-Ti matrix and the Ti_(2)Cu was responsible for the enhancement of the antibacterial properties.

关键词： selective laser melting Ti−3Cu alloy microstructure corrosion resistance antibacterial properties

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Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin Feifei Yuan Hongbin Lu Jianzhong Hu Yong Cao Chengjun Li department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

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A dynamic peripheral immune landscape during human pregnancy

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Fundamental Research 2025年第1期5卷 391-406页

作者： Xiuxing Liu Lei Zhu Zhaohao Huang Zhaohuai Li Runping Duan He Li Lihui Xie Xiaozhen Chen Wen Ding Binyao Chen Yuehan Gao Juan Su Xianggui Wang Wenru Su State Key laboratory of Ophthalmology Zhongshan Ophthalmic CenterGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceSun Yat-Sen UniversityGuangzhou 510060China Eye Center of Xiangya Hospital Central South UniversityChangsha 410078China Hunan Key laboratory of Skin Cancer and Psoriasis Xiangya HospitalCentral South UniversityChangsha 410008China Guangzhou Women and Children's Medical Center Guangzhou Medical UniversityGuangzhou 510623China department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Engineering Research Center of Skin Health and Disease Central South UniversityChangsha 410008China National clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key laboratory of Ophthalmology Changsha 410078China

Extensive immune adaptations occur during pregnancy to ensure successful ***,these changes can increase the risk of disease in the ***,we conducted single-cell RNA sequencing on peripheral blood mononuclear cells from pregnant women at different stages of pregnancy to elucidate the dynamic transcriptional changes in the maternal immune *** reduced cytotoxicity phenotype in highly variable cytotoxic T and natural killer cell types were observed during *** T-and B-cell response-related MHC-II and CD40 signaling as well as enhanced protolerance inducible costimulator and activin signaling may underlie the pregnancy-related weakening of adaptive ***,pro-inflammatory genes and pathways were upregulated in monocytes,possibly to compensate for the reduced T-cell ***,the transition from adaptive immune reduction to activation in late pregnancy in dendritic cells and CD4^(+)T cells was also ***,we proposed a novel view of the pro-aging effect of pregnancy from the perspective of immunity,and this effect may be restored *** work expands our knowledge of pregnancy immunity and may provide insights into the altered disease risks during pregnancy.

关键词： Single-cell RNA sequencing Pregnancy Maternal immune system Aging Immune tolerance Dampened adaptive immunity

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Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

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Nano-Micro Letters 2025年第3期17卷 389-439页

作者： Xiao Wang Jia Zeng Donglin Gan Kun Ling Mingfang He Jianshu Li Yongping Lu Scientific and Technological Innovation Center for Biomedical Materials and clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

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Value Iteration-Based Distributed Adaptive Dynamic Programming for Multi-Player Differential Game With Incomplete Information

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IEEE/CAA Journal of Automatica Sinica 2025年第2期12卷 436-447页

作者： Yun Zhang Yuqi Wang Yunze Cai the department of Automation Shanghai Jiao Tong University the Key laboratory of System Control and Information Processing Ministry of Education of China the National Key laboratory of Air-based Information Perception and Fusion

In this paper, a distributed adaptive dynamic programming(ADP) framework based on value iteration is proposed for multi-player differential games. In the game setting,players have no access to the information of others' system parameters or control laws. Each player adopts an on-policy value iteration algorithm as the basic learning framework. To deal with the incomplete information structure, players collect a period of system trajectory data to compensate for the lack of information. The policy updating step is implemented by a nonlinear optimization problem aiming to search for the proximal admissible policy. Theoretical analysis shows that by adopting proximal policy searching rules, the approximated policies can converge to a neighborhood of equilibrium policies. The efficacy of our method is illustrated by three examples, which also demonstrate that the proposed method can accelerate the learning process compared with the centralized learning framework.

关键词： Distributed adaptive dynamic programming incomplete information multi-player differential game (MPDG) value iteration

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