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Correlation between diabetic peripheral neuropathy and thyroid hormone sensitivity in elderly patients with type 2 diabetes mellitus

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World Journal of Diabetes 2025年第2期16卷 71-80页

作者： Si-Jia Fei Jing-Yi Luo Wei-Hao Wang Li-Xin Guo Qi Pan department of Endocrinology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

BACKGROUND Diabetic peripheral neuropathy(DPN)is a common complication of type 2 diabetes mellitus(T2DM),significantly affecting patients’quality of life and imposing a substantial economic *** studies have highlighted the role of thyroid hormones in diabetes complications,particularly in elderly patients with ***,the relationship between thyroid hormone sensitivity and DPN remains *** To investigate the correlation between thyroid hormone sensitivity and DPN in elderly patients with *** In a cohort of 256 elderly patients with T2DM,propensity score matching was used to balance age,sex,and diabetes *** data were collected to calculate thyroid hormone sensitivity and analyze its correlation with DPN.A random forest model was used to evaluate the diagnostic value of free triiodothyronine/free thyroxine(FT_(3)/FT_(4))for *** Patients with DPN had a lower FT_(3)/FT_(4) ratio[(0.302±0.053)vs(0.316±0.049),P=0.040].Quartile stratification showed decreasing DPN prevalence with higher FT_(3)/FT_(4) ***’s correlation analysis showed that a lower FT_(3)/FT_(4) ratio was associated with higher glycated hemoglobin,fasting blood glucose,reduced nerve conduction velocity,and electrical skin *** regression indicated a positive relationship between the median FT_(3)/FT_(4) ratio and bilateral foot electrochemical skin conductance[odds ratio(OR):1.019;95%CI:1.005-1.034;P=0.007]and sural nerve sensory amplitude(OR:1.310;95%CI:1.008-1.703;P=0.043).Receiver operating characteristic analysis using a random forest model showed that incorporating FT_(3)/FT_(4) improved predictive performance for DPN,with an area under the curve of 0.74,sensitivity of 0.79,specificity of 0.64,and accuracy of *** In elderly patients with T2DM with euthyroidism,a lower FT_(3)/FT_(4) ratio is correlated with increased DPN incidence,affecting both large and small nerve ***_(3)/FT_(4) is an effective predicto

关键词： Diabetic peripheral neuropathy Thyroid hormone sensitivity Type 2 diabetes mellitus Elderly Free triiodothyronine/free thyroxine ratio

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Prognostic model for esophagogastric variceal rebleeding after endoscopic treatment in liver cirrhosis: A chinese multicenter study

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World Journal of Gastroenterology 2025年第2期31卷 85-101页

作者： Jun-Yi Zhan Jie Chen Jin-Zhong Yu Fei-Peng Xu Fei-Fei Xing De-Xin Wang Ming-Yan Yang Feng Xing Jian Wang Yong-Ping Mu Cell Biology Laboratory Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Liver Diseases Shanghai Academy of Chinese MedicineShanghai 201203China Clinical Key Laboratory of Traditional chinese medicine of Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Key Laboratory of Liver and Kidney Disease of the Ministry of Education Shanghai University of Traditional Chinese MedicineShanghai 201203China department of Gastroenterology and Hepatology Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Institute of Liver Disease Fudan UniversityShanghai 200032China Evidence-Based medicine Center Fudan UniversityShanghai 200032China department of Gastrointestinal Endoscopy Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China department of Hepatology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

BACKGROUND Rebleeding after recovery from esophagogastric variceal bleeding(EGVB)is a severe complication that is associated with high rates of both incidence and *** its clinical importance,recognized prognostic models that can effectively predict esophagogastric variceal rebleeding in patients with liver cirrhosis are *** To construct and externally validate a reliable prognostic model for predicting the occurrence of esophagogastric variceal *** This study included 477 EGVB patients across 2 cohorts:The derivation cohort(n=322)and the validation cohort(n=155).The primary outcome was rebleeding events within 1 *** least absolute shrinkage and selection operator was applied for predictor selection,and multivariate Cox regression analysis was used to construct the prognostic *** validation was performed with bootstrap *** assessed the discrimination,calibration and accuracy of the model,and performed patient risk *** Six predictors,including albumin and aspartate aminotransferase concentrations,white blood cell count,and the presence of ascites,portal vein thrombosis,and bleeding signs,were selected for the rebleeding event prediction following endoscopic treatment(REPET)*** predicting rebleeding within 1 year,the REPET model ex-hibited a concordance index of 0.775 and a Brier score of 0.143 in the derivation cohort,alongside 0.862 and 0.127 in the validation ***,the REPET model revealed a significant difference in rebleeding rates(P<0.01)between low-risk patients and intermediate-to high-risk patients in both *** We constructed and validated a new prognostic model for variceal rebleeding with excellent predictive per-formance,which will improve the clinical management of rebleeding in EGVB patients.

关键词： Esophagogastric variceal bleeding Variceal rebleeding Liver cirrhosis Prognostic model Risk stratification Secondary prophylaxis

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Lipid levels and insulin resistance markers in patients with colorectal cancer:Propensity score matching analysis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 130-142页

作者： Ren-Hao Hu Dong-Yi Yan Ke-Hui Zhang Di Zhang Xi-Mao Cui Xiao-Hua Jiang Shun Zhang department of Gastrointestinal surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China School of medicine Tongji UniversityShanghai 200092China department of Emergency medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

BACKGROUND Colorectal cancer(CRC)is a prevalent malignant neoplasm characterized by subtle early *** To investigate the correlation among serum lipid profiles,the triglyceride-glucose(TyG)index,and the atherosclerotic index(AI)in patients with ***,it explored the clinical diagnostic utility of combining serum lipids with cancer antigens in the context of *** A retrospective analysis encompassed 277 patients with CRC and 1034 healthy *** Following propensity score matching,patients with CRC exhibited significantly reduced levels of serum triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol(LDL-C),as well as a diminished TyG ***,they displayed elevated AI levels compared to their healthy *** in advanced stages exhibited lower serum levels of TG,TC,and LDL-C compared to those in early *** with positive lymph node metastasis demonstrated reduced levels of TG,LDL-C,and the TyG *** operating characteristic analysis revealed that the combination of the TyG index,carcinoembryonic antigen,and carbohydrate antigen 19-9 yielded the highest positive prediction rate for CRC at 75.3%.CONCLUSION Preoperative serum lipid profiles exhibit a robust association with patients with *** concurrent assessment of multiple serum lipids and cancer antigens effectively enhances the diagnostic accuracy for CRC.

关键词： Colorectal cancer Serum lipids Triglyceride-glucose index Atherosclerotic index Diagnostic marker

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Research Progress of chinese medicine Monomers in Treatment of Cholangiocarcinoma

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chinese Journal of Integrative medicine 2025年第2期31卷 170-182页

作者： WANG Xiang WANG Xiao-qing LUO Kai BAI He QU Jia-lin ZHANG Gui-xin department of General surgery the Second Hospital of Dalian Medical UniversityDalianLiaoning Province(116027)China Clinical Laboratory of Integrative medicine First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning Province(116021)China Hepatobiliary surgery department Shandong Provincial Third HospittalShandong UniversityJinan(250031)China Institute(College)of Integrative medicine Dalian Medical UniversityDalianLiaoning Province(116044)China

Cholangiocarcinoma(CCA)is a malignant tumor originating from ***,it remains unclear about the pathogenesis of this carcinoma,which may be related to multiple ***,CCA is mainly treated by surgery,chemotherapy,and *** them,surgery is the only potentially curative option for ***,the high malignancy and asymptomatic nature of CCA may lead to poor treatment *** has been demonstrated that chinese medicine(CM)plays a significant role in various antitumor ***,CM exhibits fewer side effects and high ***,the in vitro application of CM monomers has been explored in many domestic and foreign *** article mainly reviews the signaling pathways and molecular mechanisms of CM monomers in the treatment of CCA in recent *** findings are expected to provide new insights into the treatment of CCA.

关键词： cholangiocarcinoma chinese medicine monomers antitumor signaling pathways molecular mechanisms review

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Protein-based functional hydrogel improves cutaneous nerve repair and diabetic wound healing

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Nano Research 2025年第1期18卷 586-596页

作者： Hanzhi Lu Mingrui Cui Yi Wang Xinran Du Xinyi Zhou Yuhan Fang Xiaoyan Gao Ying Peng Jianyong Zhu Guang Yang Fulun Li department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative medicine College of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620China Clinical Laboratory medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Cutaneous nerve regeneration in diabetic wounds remains a challenge for current clinical ***,a natural protein-based functional hydrogel is developed using keratin as the sole matrix,and protocatechuic aldehyde(PA)and zinc ions as the building blocks through dual-dynamic crosslinking reactions of thiol-aldehyde addition and catecholzinc ions *** unique structural design endows the hydrogel with excellent injectability,skin adhesion,self-healing and antibacterial ability,and *** addition,this hydrogel acts as a drug carrier for the loading and sustained release of phellopterin(PP),a natural compound extracted from traditional chinese medicine Angelica *** findings demonstrate that the PP-loaded hydrogel promotes cutaneous nerve regeneration,angiogenesis and tissue remodeling in the full-thickness wounds in both db/db and streptozotocin-induced C57BL/6 diabetic mice,notably by the synergistic effect of zinc ions and PP,showing a great potential in diabetic wound therapy.

关键词： functional hydrogel cutaneous nerve regeneration dynamic crosslinking diabetic wounds

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Accurate prediction of essential proteins using ensemble machine learning

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chinese Physics B 2025年第1期34卷 108-115页

作者： Dezhi Lu Hao Wu Yutong Hou Yuncheng Wu Yuanyuan Liu Jinwu Wang School of medicine Shanghai UniversityShanghai 200444China Shanghai Key Laboratory of Orthopaedic Implants Department of Orthopaedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China University of Shanghai for Science and Technology Shanghai 200093China

Essential proteins are crucial for biological processes and can be identified through both experimental and computational *** experimental approaches are highly accurate,they often demand extensive time and *** address these challenges,we present a computational ensemble learning framework designed to identify essential proteins more *** method begins by using node2vec to transform proteins in the protein–protein interaction(PPI)network into continuous,low-dimensional *** also extract a range of features from protein sequences,including graph-theory-based,information-based,compositional,and physiochemical ***,we leverage deep learning techniques to analyze high-dimensional position-specific scoring matrices(PSSMs)and capture evolutionary *** then combine these features for classification using various machine learning *** enhance performance,we integrate the outputs of these algorithms through ensemble methods such as voting,weighted averaging,and *** approach effectively addresses data imbalances and improves both robustness and *** ensemble learning framework achieves an AUC of 0.960 and an accuracy of 0.9252,outperforming other computational *** results demonstrate the effectiveness of our approach in accurately identifying essential proteins and highlight its superior feature extraction capabilities.

关键词： protein-protein interaction(PPI) essential proteins deep learning ensemble learning

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Malignant perivascular epithelioid cell tumor of the colorectum:Clinicopathological characterization,diagnosis and treatment process of 7 cases

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 67-73页

作者： Ming-Fei Ma Zhen-Yu Chi Li-Juan Zhao Wei Zhai Wen Zhong Song Wang department of Pharmacy The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina department of surgery People's Hospital of AnjiHuzhou 313300Zhejiang ProvinceChina department of Colorectal surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Perivascular epithelioid cell tumor(PEComa)of the colorectum is exceedingly rare,with only a few published *** presents with a wide spectrum of biological behavior,ranging from benign to *** prognosis for malignant PEComa is poor and there is little consensus on its *** To fully characterize PEComa and standardize its diagnosis and *** Patients with colorectal malignant PEComa were identified from the First Affiliated Hospital,Zhejiang University School of medicine and People's Hospital of *** with controversial pathology and cases lost to follow-up were excluded,leaving seven remaining cases that formed the basis of the *** collected relevant clinicopathological,therapeutic and followup *** stage and progression were assessed by contrast-enhanced computed tomography at baseline and at 3-month *** The mean age was 43 years,with a range of 5 years to 73 *** average body mass index was 21.8±3.0 kg/m^(2),and 71.4%of cases occurred in the *** main symptoms of colorectal PEComas were abdominal mass and *** most common microscopic finding of malignant behavior was infiltrative *** analysis found that 6/7 cases were positive for HMB45,5/7 were positive for melan-A,and 3/5 were positive for *** watch-and-wait approach to treatment was a risky *** resection was preferable to systemic *** median progression-free survival exceeded 38 months,longer than previously *** Radical or extended resection is the key to prolonged survival of malignant *** meaningful studies are urgently needed to establish the standardized diagnosis and treatment.

关键词： Perivascular epithelioid cell tumor Colorectum Malignant Resection Mammalian target of rapamycin inhibitor

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Application of myxovirus resistance protein A in the etiological diagnosis of infections in adults

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World Journal of Emergency medicine 2025年第1期16卷 35-42页

作者： Tianpeng Hu Yan Li Shengtao Yan Lichao Sun Rui Lian Jieqiong Yu Jie Chen Xiaoyu Liu Guoqiang Zhang department of Emergency medicine China-Japan Friendship HospitalBeijing 100029China Graduate School Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

BACKGROUND: Inappropriate antibiotic treatment for patients with viral infections has led to a surge in antimicrobial resistance, increasing mortality and healthcare costs. Viral and bacterial infections are often difficult to distinguish. Myxovirus resistance protein A(MxA), an essential antiviral factor induced by interferon after viral infection, holds promise for distinguishing between viral and bacterial infections. This study aimed to determine the ability of Mx A to distinguish viral from bacterial ***: We quantified MxA in 121 infected patients via dry immunofluorescence chromatography. The Kruskal-Wallis test and receiver operating characteristic(ROC) curve analysis were used to determine the diagnostic value of Mx A, either alone or in combination with C-reactive protein(CRP) or procalcitonin(PCT), in patients with viral, bacterial, or ***: The value of MxA(ng/mL) was significantly higher in patients with viral infections than in those with bacterial and co-infections(82.3 [24.5–182.9] vs. 16.4 [10.8–26.5], P<0.0001)(82.3 [24.5–182.9] vs. 28.5 [10.2–106.8], P=0.0237). The area under the curve(AUC) of the ROC curve for distinguishing between viral and bacterial infections was 0.799(95% confidence interval [95% CI] 0.696–0.903), with a sensitivity of 68.9%(95% CI 54.3%–80.5%) and specificity of 90.0%(95% CI 74.4%–96.5%) at the threshold of 50.3 ng/mL. Combining the MxA level with the CRP or PCT level improved its ability. MxA expression was low in cytomegalovirus(15.8 [9.6–47.6] ng/mL) and Epstein-Barr virus(12.9 [8.5–21.0] ng/mL) ***: Our study showed the diagnostic efficacy of Mx A in distinguishing between viral and bacterial infections, with further enhancement when it was combined with CRP or PCT. Moreover, EpsteinBarr virus and human cytomegalovirus infections did not elicit elevated Mx A expression.

关键词： Myxovirus resistance protein A Viral infections C-reactive protein Procalcitonin Biomarker

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Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients

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Science China(Life Sciences) 2025年第1期68卷 297-299页

作者： Junbin Zhou Rongli Wei Guanghan Fan Zhengxing Lian Xuanyu Zhang Linsong Tang Zhetuo Qi Haiyang Xie Shusen Zheng Qiang Wei Xiao Xu department of Hepatobiliary and Pancreatic surgery People’s Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui UniversityLishui 323000China NHFPC Key Laboratory of Combined Multi-Organ Transplantation Hangzhou 310003China Key Laboratory of Integrated Oncology and Intelligent medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People’s HospitalHangzhou 310006China department of Hepatobiliary and Pancreatic surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China department of Urology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China department of Hepatobiliary and Pancreatic surgery Department of Liver TransplantationShulan(Hangzhou)HospitalHangzhou 310011China Hangzhou Medical College Hangzhou 310059China Zhejiang University School of medicine Hangzhou 310058China

Dear Editor,Liver transplantation(LT)is the only curative therapy for patients with endstage liver disease(He et al.,2023;Ling et al.,2022).Post-transplant hypertriglyceridemia(PTHT),which has an incidence of up to 32.8%in 6 months after LT,is one of the major post-transplant complications(Toshima et al.,2020).With the prolongation of the recipient’s survival time,the incidence of PTHT is increasing,becoming an important factor that affects the recipient’s quality of life and survival *** with various metabolic complications,including PTHT,have a 1.78 times higher risk of atherosclerotic cardiovascular disease(ASCVD)development and death than recipients without these complications(Jiménez Pérez et al.,2016).Studies have shown that PTHT,accompanied by other posttransplant metabolic complications and immunosuppressants,are important risk factors for post-transplant ASCVD and mediate 19%–42% of nongraft-related deaths(Davis and Shadab Siddiqui,2017;Jiménez-Pérez et al.,2016).However,early prediction of PTHT remains a major challenge.

关键词： liver graft

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Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai Yin department of Otolaryngology Head and Neck surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina department of Otorhinolaryngology-Head and Neck surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

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