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Journal of Forensic Science and Medicine 2024年第1期10卷 68-71页

作者： Sapna Patel Deepika Gurumurthy Smitha Rani Sheela Devi department of Pathology JSSAHERMysoreKarnatakaIndia2Department of Forensic MedicineJSSAHERMysoreKarnatakaIndia

Pulmonary alveolar proteinosis(PAP)is an idiopathic rare diffuse pulmonary disease,first described in 1958 by Rosen et *** estimated prevalence is about 1 in 3.7-6.9×10^(6) with a male:female ratio of 1:1-2:*** of the patient’s age ranges between 20 and 50 *** on microscopy is characterized by the presence of massive insoluble,amorphous,phospholipid-rich protein deposits in the bronchial and alveolar *** patients with acquired PAP present with cough and exertional *** has been studied that there is increased risk of superinfection in PAP with opportunistic organisms like pneumocystis and vice *** diagnosis of Pneumocystis jirovecii pneumonia rests on the demonstration of the organism within the alveoli by special stains like Grocott Methenamine Silver *** contagiosum(MC)is a common superficial skin infection caused by the *** is characterized by painless papules commonly seen in children and immunocompromised ***,we present a 34-year-old female who had complaints of severe difficulty in breathing and was brought dead to our *** external examination,she had multiple warts over chest,abdomen,and over *** examination was *** of kidney,lung,and skin biopsy of genital warts sent for histopathological examination revealed acute tubular necrosis,*** with PAP,and MC respectively.

关键词： Bronchoalveolar lavage molluscum contagiosum Pneumocystis jirovecii pulmonary alveolar proteinosis

Long-term outcomes of surgical treatment for pulmonary carcinoid tumors： 20 years＇ experience with 131 patients

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Chinese Medical Journal 2012年第17期125卷 3022-3026页

作者： ZHONG Chen-xi YAO Feng ZHAO Heng SHI Jian-xin FAN Li-ming department of Thoracic surgery Shanghai Chest Hospital affiliated to Shanghai Jiao Tong UniversityShanghai 200030China

Background Bronchial carcinoids are rare malignant neuroendocrine neoplasms. Some issues regarding surgical treatment of bronchial carcinoids remain controversial, including the role of bronchoplastic surgery and necessity of systematic lymphadenectomy. Methods This retrospective study involved 131 consecutive patients surgically treated for carcinoid tumors at Shanghai chest Hospital between March 1990 and August 2010. Results Eighty-nine （67.9%） of the patients were male, and the mean age was 46 years, ranging from 17 to 81 years. Preoperative fiberoptic bronchoscopy was performed in all patients. Endoscopic biopsy was performed in 100 patients with central tumors, and 70 （70%） patients were diagnosed as bronchial carcinoid. The resections performed consisted of 31 pneumonectomie, 32 Iobectomies, 26 bilobectomies, 34 sleeve Iobectomies, six bronchoplastic procedures without lung resection, and two segmentectomies. During a median of 87 months follow-up, there were nine recurrences including three local recurrences and 6 distant recurrences. No bronchial recurrences were observed. The 3-, 5- and 10-year overall survival rates of pneumonectom and bronchoplastic surgery （including sleeve Iobectomy and bronchoplastic procedure without lung resection） were 93.2%, 81.0% and 69.4%, 97.5%, 91.9% and 70.0%, respectively. Multivariate Cox regression indicated that histology and nodal status were significant independent prognostic factors. Conclusions Bronchoplastic surgery should be considered whenever possible for central carcinoids. Systematic lymphadenectomy is recommended for bronchial carcinoid patients. Histology and nodal status were significant independent prognostic factors of overall survival of patients with bronchial carcinoid.

关键词： pulmonary carcinoid diagnosis surgery long-term follow-up

Explainable Conformer Network for Detection of COVID-19 Pneumonia from chest CT Scan: From Concepts toward Clinical Explainability

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Computers, Materials & Continua 2024年第1期78卷 1171-1187页

作者： Mohamed Abdel-Basset Hossam Hawash Mohamed Abouhawwash S.S.Askar Alshaimaa A.Tantawy Faculty of Computers and Informatics Zagazig UniversityZagazig44519Egypt department of Computational Mathematics Scienceand Engineering(CMSE)Michigan State UniversityEast LansingMI48824USA department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt department of Statistics and Operations Research College of ScienceKing Saud UniversityP.O.Box 2455Riyadh11451Saudi Arabia

The early implementation of treatment therapies necessitates the swift and precise identification of COVID-19 pneumonia by the analysis of chest CT *** study aims to investigate the indispensable need for precise and interpretable diagnostic tools for improving clinical decision-making for COVID-19 *** paper proposes a novel deep learning approach,called Conformer Network,for explainable discrimination of viral pneumonia depending on the lung Region of Infections(ROI)within a single modality radiographic CT ***,an efficient U-shaped transformer network is integrated for lung image ***,a robust transfer learning technique is introduced to design a robust feature extractor based on pre-trained lightweight Big Transfer(BiT-L)and finetuned on medical data to effectively learn the patterns of infection in the input ***,this work presents a visual explanation method to guarantee clinical explainability for decisions made by Conformer *** evaluation of real-world CT data demonstrated that the diagnostic accuracy of ourmodel outperforms cutting-edge studies with statistical *** Conformer Network achieves 97.40% of detection accuracy under cross-validation *** model not only achieves high sensitivity and specificity but also affords visualizations of salient features contributing to each classification decision,enhancing the overall transparency and trustworthiness of our *** findings provide obvious implications for the ability of our model to empower clinical staff by generating transparent intuitions about the features driving diagnostic decisions.

关键词： Deep learning COVID-19 multi-modal medical image fusion diagnostic image fusion

Titanium internal fixation system used for sternum reconstruction after resection of chondrosarcoma

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Chinese Medical Journal 2010年第18期123卷 2621-2622页

作者： LIU Zheng-cheng ZHAO Heng department of Thoracic surgery Shanghai Chest Hospital Affiliated to Shanghai Jiao Tong University Shanghai 200030 China

Chondrosarcoma is the most common malignant primary chest wall tumor, only 20% of these cases involve sternum. Current therapy for chondrosarcoma requires adequate surgical excision and radiation therapy, chemotherapy... 详细信息

关键词： sternum chondrosarcoma reconstruction

Evaluation of the hemolysis and fluid dynamics of a ventricular assist device under the pulsatile flow condition

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Journal of Hydrodynamics 2019年第5期31卷 965-975页

作者： Huan Li Zhe Gou Feng Huang Xiao-dong Ruan Wen-wei Qian Xin Fu State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China College of Metrology and Measurement Engineering China Jiliang UniversityHangzhou 310018China department of Cardio-chest surgery Zhejiang Provincial Peopled HospitalHangzhou 310014China

When the rotary blood pumps are used as ventricular assist devices,the pump flow rate will have a pulsatile component even at a constant impeller rotational speed due to the remaining beating of the natural ***,previous studies on the in vitro hemolysis evaluation of a rotary blood pump have always been conducted under steady states and this pulsation was not taken into *** this study,the hemolysis in a centrifugal blood pump is evaluated under the pulsatile flow condition in *** required time-varying flow rate is obtained by conducting a system simulation of the pump-assisted cardiovascular system,and realized by controlling a pulsation unit in the *** results of our tests indicate a significant increase in hemolysis under the pulsatile flow condition compared with the non-pulsatile *** reveal the flow characteristics responsible for the higher hemolysis,transient computational fluid dynamic simulations are then *** study suggests that traditional hemolysis evaluation under the steady states may not fully represent the hemolytic performance in the clinical *** the ventricular assist pumps at the design stage,eliminating the concern about the extra hemolysis under the pulsatile condition will be helpful for the subsequent in vivo experiments.

关键词： Ventricular assist devices hemolysis pulsatile flow cardiovascular system numerical simulation

Cryptococcus infection with asymptomatic diffuse pulmonary disease in an immunocompetent patient:A case report

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World Journal of Clinical Cases 2021年第11期9卷 2619-2626页

作者： Yong Li Lei Fang Fang-Qun Chang Fang-Zhou Xu Yan-Bei Zhang department of Geriatric Respiratory and Critical Care The First Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina department of Tuberculosis Anhui Medical University Clinical College of Chest&Anhui Chest HospitalHefei 230000Anhui ProvinceChina

BACKGROUND Cryptococcus presenting as an opportunistic pathogen mainly affects immunocompromised patients,but the disseminated form of infection is rare among immunocompetent *** partial radiographic characteristics of pulmonary cryptococcosis mimic lung carcinoma,leading to unnecessary open chest exploratory surgery,and the lack of a gold-standard noninvasive diagnostic increases the risk of *** emission tomography/computed tomography(PET/CT),a sensitive method for distinguishing malignant tumors,coupled with cryptococcal latex agglutination test showing a high positive rate may overcome these *** A 36-year-old man presented for general examination,without health *** CT showed multiple pulmonary nodules and a mass with high maximum standardized uptake ***,we suspected primary malignancy with hematogenous *** his routine fungal analysis had been negative,subsequent CT-guided percutaneous core needle biopsy and histopathology examination indicated a diagnosis of pulmonary ***(200 mg/d)antifungal drug treatment was initiated,and 1 mo later the pulmonary mass had reduced in size markedly(on chest CT scan)without any *** Serologic and PET/CT examinations may not rule out cryptococcosis,and percutaneous lung puncture is critical under all circumstances.

关键词： Cryptococcus Immunocompetent Positron emission tomography Computed tomography Cryptococcal latex agglutination test Lung diseases Fungal Case report

Vaspin alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence

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Emergency and Critical Care Medicine 2024年第1期4卷 4-15页

作者： Haiying Rui Huaxiang Yu Dan Zou Kai Chi Ping Xu Xiaoshuai Song Lulu Liu Xuting Wu Jinxin Wang Li Xue department of Emergency Medicine and chest Pain Center Qilu Hospital of Shandong UniversityJinanShandongChina Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine Institute of Emergency and Critical Care Medicine of Shandong UniversityQilu Hospital of Shandong UniversityJinanShandongChina Key Laboratory of Emergency and Critical Care Medicine of Shandong Province Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong ProvinceShandong Provincial Engineering Laboratory for Emergency and Critical Care MedicineQilu Hospital of Shandong UniversityJinanShandongChina The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of EducationChinese Ministry of Health and Chinese Academy of Medical SciencesThe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineQilu Hospital of Shandong UniversityJinanShandongChina.

Background:Visceral adipose tissue-derived serine protease inhibitor(vaspin),a secretory adipokine,protects against insulin *** studies have demonstrated that serum vaspin levels are decreased in patients with coronary artery disease and that vaspin protects against myocardial ischemia-reperfusion injury and ***,it remains unclear whether vaspin exerts specific effects on pathological cardiac ***:An in vivo study was conducted using a cardiac hypertrophy model established by subcutaneous injection of isoproterenol(ISO)in C57BL/6 and vaspin-ko *** was administered intraperitoneally to mice,for further study.H9c2 cells and neonatal rat ventricular myocytes(NRVMs)were treated with ISO to induce *** vaspin fusion protein,the proteasome inhibitor MG132,and chloroquine diphosphate were used for further mechanistic ***:Here,we provide the first evidence that vaspin knockdown results in markedly exaggerated cardiac hypertrophy,fibrosis,and cardiomyocyte senescence in mice treated with ***,the administration of exogenous recombinant human vaspin protected NRVMs in vitro against ISO-induced hypertrophy and ***,vaspin significantly potentiated the ISO-induced decrease in *** rapamycin and chloroquine diphosphate regulated autophagy in vivo and in vitro,respectively,and participated in vaspin-mediated ***,the PI3K-AKT-mTOR pathway plays a critical role in vaspin-mediated autophagy in cardiac tissues and *** data showed that vaspin downregulated the p85 and p110 subunits of PI3K by linking p85 and p110 to NEDD4L-mediated ubiquitination ***:Our results show,for the first time,that vaspin functions as a critical regulator that alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence,providing potential preventive and therapeutic targets for pathological cardiac hyper

关键词： Autophagic flux Myocardial senescence Pathological cardiac hypertrophy Ubiquitination Vaspin

Diagnosis of tuberculous uveitis by the macrogenome of intraocular fluid:A case report and review of the literature

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World Journal of Clinical Cases 2023年第14期11卷 3248-3255页

作者： Yan-Kun Zhang Yan Guan Juan Zhao Li-Fei Wang department of Ophthalmology Hebei Chest HospitalShijiazhuang 050047Hebei ProvinceChina department of Respiratory Hebei Chest HospitalShijiazhuang 050047Hebei ProvinceChina department of Ophthalmology Hebei Eye HospitalXingtai 050010Hebei ProvinceChina

BACKGROUND Tuberculous uveitis caused by tuberculosis infection factors is common,but tuberculous uveitis caused by Mycobacterium tuberculosis found in the intraocular fluid is *** report describes the use of intraocular fluid in the diagnosis of tuberculous uveitis in a patient and reviews the relevant *** SUMMARY A 24-year-old woman who was 31-wk pregnant visited Hebei chest Hospital due to intermittent chest pain,fever,and decreased vision for 3 *** hydrothorax test suggested“tuberculous pleurisy”,and yellow effusion was extracted from the chest tube twice resulting in a total volume of approximately 800 *** patient chose to continue the pregnancy without treatment,and was hospitalized again due to high *** 2 mo of anti-tuberculosis treatment,a healthy boy was delivered by cesarean *** uveitis was diagnosed using tuberculosis Xpert,and intraocular infection was detected by second-generation gene *** systemic treatment,the patient gradually improved,and the corrected visual acuity of the left eye gradually increased from 0.08 to *** The etiology of uveitis is complex,and it is necessary to assess the patient’s general condition and apply molecular biology methods to determine the pathogenesis and guide precise treatment,to improve clinicians’awareness and standardize treatment of the disease.

关键词： Tuberculous uveitis Metagenomic next-generation sequencing Xpert Case

Effect of Bufei granule on stable chronic obstructive pulmonary disease: a randomized, double blinded, placebo-controlled, and multicenter clinical study

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Journal of Traditional Chinese Medicine 2014年第4期34卷 437-444页

作者： Sijia Guo Zengtao Sun Enshun Liu Jihong Feng Min Fu Yuechuan Li Qi Wu department of Respiratory Medicine the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine department of Respiratory Medicine Tianjin Chest Hospital department of Respiratory Medicine Tianjin Haihe Hospital

OBJECTIVE: To study the therapeutic effect Bufei granule, which is a traditional Chinese drug that can enhance the immune function of the lung, on patients with stable chronic obstructive pulmonary disease(COPD).METHODS: This is a randomized, double blinded,placebo-controlled, and multicenter clinical *** medical centers in Tianjin, China, participated in the trial. A total of 140 patients with stable COPD were enrolled and randomized into two groups, with 70 patients in each. The treatment group was treated with Bufei granule, while the control group received Bufei placebo. The pharmacological treatment lasted for 12 weeks from the date of enrollment. Then, the indexes of patients were observed. Data were analyzed to study the effect of Bufei granule, with the frequency of acute exacerbation as the primary outcome. Traditional Chinese Medicine syndromes,Modified British Medical Research Council dyspnea scale score, ***'s respiratory questionnaire scores, pulmonary function, and serum inflammatory marker levels [including interleukin-6(IL-6), interleukin-8, tumor necrosis factor-α, and transformation growth factor-β1]were the secondary ***: During the 12-week treatment, treatment and control groups had no adverse *** analysis of the indexes obtained from all patients showed that the therapeutic effect in the treatment group was significantly better than that in the control group because most of the similar probabilities of primary and secondary outcomes were less than 0.05,except for the level of ***: Bufei granule can treat patients with stable COPD by lowering the frequency of acute exacerbation, improving the quality of life,and alleviating the severity of inflammation.

关键词： Bufei Granule Pulmonary disease chronic obstructive Stable stage Randomized controlledtrial

Translational medicine in China: Awareness is increasing and research is advancing

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Science China(Life Sciences) 2013年第9期56卷 861-862页

作者： DOU XueLin CAO ZhiLi YING HongYan BAI ChunMei department of Medical Oncology Peking Union Medical College Hospital Chinese Academy of Medical Sciences &Peking Union Medical College department of chest surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

Translational medicine, which was first described by the director of the National Institutes of Health in 2003, has received worldwide attention. It is now well understood by Chinese physicians and scientists that this people-oriented process can provide a bridge between basic science and clinical practice, by considering clinical problems.

关键词：中国医学转化美国国立卫生研究院临床实践基础科学以人为本科学家