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World Journal of Clinical Cases 2024年第5期12卷 973-979页

作者： Yao-Bang Bai Feng Zhao Zhen-Hua Wu Guo-Ning Shi Nan Jiang Intensive Care Unit Department of Cardiac SurgeryTianjin Chest HospitalTianjin 300222China department of Cardiac Surgery Tianjin Chest HospitalTianjin 300222China

BACKGROUND Venoarterial(VA)extracorporeal membrane oxygenation(ECMO),an effective short-term circulatory support method for refractory cardiogenic shock,is widely ***,retrospective analyses have shown that VA-ECMO-assisted cases were associated with a relatively high mortality rate of approximately 60%.Embolization in important organs caused by complications of left ventricular thrombosis(LVT)during VA-ECMO is also an important *** the incidence of LVT during VA-ECMO is not high,the consequences of embolization are *** SUMMARY A 37-year-old female patient was admitted to hospital because of fever for 4 d and palpitations for 3 *** excluding the diagnosis of coronary heart disease,we established a diagnosis of“clinically explosive myocarditis”.The patient still had unstable hemodynamics after drug treatment supported by VA-ECMO,with heparin for *** day 4 of ECMO support,a left ventricular thro-mbus attached to the papillary muscle root of the mitral valve was found by transthoracic *** ventricular decompression was performed and ECMO was successfully removed,but the patient eventually died of multiple cerebral *** LVT with high mobility during VA-ECMO may cause embolism in important ***,a"wait and see"strategy should be avoided.

关键词： Venoarterial extracorporeal membrane oxygenation Left ventricular thrombosis Cerebral embolism Magnetic Resonance Imaging Therapy Case report

MicroRNA (let-7b-5p)-targeted DARS2 regulates lung adenocarcinoma growth by PI3K/AKT signaling pathway

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Oncology Research 2024年第3期32卷 517-528页

作者： YUANYUAN XU XIAOKE CHEN department of Oncology Surgery Shanghai Lung Cancer CenterShanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiChina

Background:The aberrant intraellular expression of a mitochondrial aspartyl tRNA synthetase 2(DARS2)has been reported in human *** its critical role and detailed mechanism in lung adenocarcinoma(LUAD)remain ***:Initially,The Cancer Genome Atlas(TCGA)based Gene Expression Profiling Interactive Analysis(GEPIA)database (http:/***/)was used to analyze the prognostic relevance of DARS2 expression in ***,cell counting kit(CCK)8,immunostaining,and transwell invasion assays in LUAD cell lines in vitro,as well as DARS2 silence on LUAD by tumorigenicity experiments in wivo in nude mice,were ***,we analyzed the expression levels of p-PI3K(phosphorylated Phosphotylinosital3 kinase),PI3K,AKT(Protein Kinase B),p-AKT(phosphorylated Protein Kinase B),PCNA(proliferating cell nudear antigen),cleaved-caspase 3,E cadherin,and N-cadherin proteins using the Westem blot ***:LUAD tissues showed higher DARS2 expression compared to normal *** of DARS2 could be related to Tumor-Node-Metastasis(TNM)stage,high lymph node metastasis,and inferior ***2 silence decreased the proliferation,migration,and invasion abilities of LUAD *** addition,the DARS2 downregulation decreased the PCNA and N-cadherin expression and increased cleaved:caspase 3 and E cadherin expressions in LUAD cells,coupled with the inactivation of the PI3K/AKT signaling ***,DARS2 silence impaired the tumonigenicity of LUAD in ***,let:7b-5p could recognize DARS2 through a complementary ***,the increased let 7b 5p expression attenuated the promo oncogenic action of DARS2 during LUAD progression,which were inversely correlated to each other in the LUAD tssues Conclusion:In summary,let 7b-5p,downregulated DARS2 expression,regulating the progression of LUAD cells by the PI3K/AKT signaling pathway.

关键词： Lung adenocarcinoma Prognosis PI3K/AKT pathway Mitochondrial asparty-tRNA synthetase MicroRNAs

International standard of Traditional Chinese Medicine techniques: the operating specification for Traditional Chinese Medicine enema(2022)

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Journal of Traditional Chinese Medicine 2024年第5期44卷 1035-1043页

作者： YU Miao PEI Xiaohua department of General surgery Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University department of chest and Breast Surgery Beijing University of Chinese Medicine Xiamen Hospital

Chinese Medicine Enema is one of the external therapies in Traditional Chinese Medicine(TCM), which has been widely used clinically. The "International Standard of Traditional Chinese Medicine Techniques: The Operating Specifications for Chinese Medicine Enema is drawn up by the Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University and Beijing University of Chinese Medicine Xiamen Hospital in collaboration with domestic TCM universities and hospitals. The specification includes definition, operating process, points for attention and contraindications. It is targeted to provide reference for TCM providers at home and abroad with TCM background in clinical decision-making.

关键词： Chinese Medicine Enema international standard operating specifications traditional Chinese medical technology

Increased Incidence of Severe Adverse Events in Non-Small Cell Lung Cancer Patients with Previous Tuberculosis Episode Treated with PD-1 Inhibitors

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Biomedical and Environmental Sciences 2024年第7期37卷 785-789页

作者： Hui Zhang Jinfeng Yuan Yuanyuan Xu Mengjie Yang Jialin Lyu Xinjie Yang Shuyan Sheng Zhe Qian Qunhui Wang Yu Pang Ying Hu department of Medical Oncology Beijing Chest HospitalCapital Medical University&Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China department of Bacteriology and Immunology Beijing Key Laboratory on Drug-Resistant Tuberculosis ResearchBeijing Chest HospitalCapital Medical University/Beijing Tuberculosis&Thoracic Tumor Research InstituteBeijing 101149China Chinese Center for Disease Control and Prevention Beijing 102206China

Lung cancer is the top cause of cancer deaths *** in immune checkpoint inhibitors(ICIs)have transformed cancer treatment,but their use in lung cancer has led to more side *** study examined if past pulmonary tuberculosis(TB)affects ICIs’effectiveness and safety in lung cancer *** reviewed lung cancer patients treated with ICIs at Beijing chest Hospital from January 2019 to August 2022.

关键词： Lung lung Cancer

Chinese expert consensus on immunotherapy for advanced non-small cell lung cancer with oncogenic driver mutations(2023 edition)

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Chinese Medical Journal 2024年第9期137卷 1016-1018页

作者： The Society of Cancer Precision Medicine of Chinese Anti-Cancer Association The Lung Cancer Expert Group of Chinese Medical Association Publishing House Baohui Han Hua Zhong 不详 department of Respiratory Medicine Shanghai Chest HospitalSchool of MedicineShanghai JiaoTong UniversityShanghai 20030China Shanghai chest Hospital Shanghai Jiao Tong University School of Medicine

Non-small cell lung cancer(NSCLC)with oncogenic driver mutations was previously deemed“forbidden territory”for immunotherapy.[1]With the continuous generation of evidence,immunotherapy is expected to bring hope for such NSCLC with oncogenic driver mutations after acquired tyrosine kinase inhibitor(TKI)***,given the intricate interplay between driven mutations,targeted therapy,and immune microenvironment,the efcacy of immunotherapy in advanced NSCLC patients with diverse oncogenic driver mutations remains a topic of ongoing *** this context,Chinese Expert Consensus on Immunotherapy for Advanced NSCLC with Oncogenic Driver Mutations(2022 edition)wasrst launched in 2022 by the Society of Cancer Precision Medicine of Chinese Anti-Cancer Association and the Lung Cancer Expert Group of Chinese Medical Journals,aiming to provide standardized treatment guidance for clinical practice.

关键词： immunotherapy cancer lung

Identification of pathological characteristics in pulmonary tuberculosis using polarization-sensitive optical coherence tomography

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Journal of Innovative Optical Health Sciences 2024年第6期17卷 97-106页

作者： Yun Ding Zhuoqun Yuan Xiaojiang Zhao Guozheng Gao Xin Li Yanmei Liang Clinical School of Thoracic Tianjin Medical University TianjinP.R.China department of Thoracic Surgery Fujian Provincial Hospital FujianP.R.China Institute of Modern Optics Nankai University Tianjin Key Laboratory of Micro-scale Optical Information Science and Technology Tianjin 300350P.R.China School of Medicine Tianjin University TianjinP.R.China department of Pathology Tianjin Chest Hospital No.261Taierzhuang South Road Jinnan District Tianjin 300222P.R.China department of Thoracic Surgery Tianjin chest Hospital TianjinP.R.China

The low detection rate of Mycobacterium tuberculosis in clinical practice leads to a high rate of missed diagnosis for pulmonary tuberculosis(PTB).As a noninvasive,high-resolution,real-time imaging technology,polarization-sensitive optical coherence tomography(PS-OCT)may be feasible for the rapid identification of pathological *** study aimed to explore the feasibility of using PS-OCT to identify pathological features of *** the experiments,PTB samples containing some surrounding lung tissues were imaged using *** is demonstrated that PS-OCT images showed good consistency with the corresponding pathological images and were able to identify PTB-related characteristic pathological *** think PS-OCT can serve as an effective supplement for the diagnosis of PTB,enabling rapid and accurate diagnosis,and aiding in the understanding of the pathological characteristics and pathophysiological processes of PTB.

关键词： Pulmonary tuberculosis PS-OCT pathological features.

Mycobacterium gordoniasis of the cervical lymph nodes:A case report

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World Journal of Clinical Cases 2024年第19期12卷 3995-4002页

作者： Ling Peng Rong Ma Yong Li Jie Cheng department of Tuberculosis Anhui Provincial Chest HospitalHefei 230022Anhui ProvinceChina

BACKGROUND Owing to the advancement in bacterial identification techniques,the detection rate of non-tuberculous mycobacterium(NTM)has been on the *** from Mycobacterium tuberculosis,the clinical symptoms of NTM are not easily detected,and the clinical efficacy and prognosis are somewhat *** report a case of Mycobacterium gordoniasis of cervical lymph node diagnosed in Anhui chest Hospital in July *** SUMMARY Upon examination,the patient who weighed 67.5 kg,was human immunodeficiency virus negative,healthy,without hypertension,diabetes,heart disease and other basic diseases microscopic analysis revealed granulomatous inflammation with coagulation necrosis in the lymphocyte,and tuberculosis was not ruled *** computed tomography scans of the neck and chest indicated the presence of a single grayish-yellow and grayish-brown tissue,the dimensions of which was top of form 10.5 cm×3.0 cm×1.5 *** pathological consultation in our hospital,the diagnosis was confirmed as NTM *** This case report and the clinical epidemiological research on improving NTM have important guiding significance for improving decision-making in clinical treatments.

关键词： Mycobacterium gordoniasis Cervical lymph nodes Literature analysis Clinical treatments Case Report

Interaction between adolescent sleep rhythms and gender in an obese population

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World Journal of Clinical Cases 2024年第1期12卷 86-94页

作者： Nan-Nan Wu Guo-Li Yan Hong-Yu Zhang Ling Sun Min Hou Guang-Ming Xu department of Laboratory Medicine Tianjin Chest HospitalTianjin 300222China Mental Health Center of Tianjin Medical University Tianjin Anding HospitalTianjin 300222China department of Child and Adolescent Psychology Mental Health Center of Tianjin Medical UniversityTianjin 300222China

BACKGROUND The obesity rate of adolescents is gradually increasing,which seriously affects their mental health,and sleep plays an important role in adolescent *** To investigate the relationship between sleep rhythm and obesity among adolescents and further explores the interactive effect of sleep rhythm and gender on adolescent obesity,providing a theoretical basis for developing interventions for adolescent *** Research data source Tianjin Mental Health Promotion Program for *** April to June 2022,this study selected 14201 students from 13 middle schools in a certain district of Tianjin as the research subject using the convenient cluster sampling *** these students,13374 accepted and completed the survey,with an effective rate of 94.2%.The demographic data and basic information of adolescents,such as height and weight,were collected through a general situation *** sleep rhythm of adolescents was evaluated using the reduced version of the morningness-eveningness *** A total of 13374 participants(6629 females,accounting for 49.56%;the average age is 15.21±1.433 years)were *** them,the survey showed that 2942 adolescent were obesity,accounting for 22%and 2104 adolescent were overweight,accounting for 15.7%.Among them,1692 male adolescents are obese,with an obesity rate of 25.1%,higher than 18.9%of female *** is a statistically significant difference between the three groups(χ2=231.522,P<0.000).The obesity group has the smallest age(14.94±1.442 years),and there is a statistical difference in age among the three groups(F=69.996,P<0.000).Obesity rates are higher among individuals who are not-only-child,have residential experience within six months,have family economic poverty,and have evening-type sleep(P<0.05).Logistic regression analysis shows a correlation between sleep rhythm and adolescent ***-type sleep rhythm can increase the risk of obesity in male adoles

关键词： Adolescent Obesity Sleep rhythm Gender Interaction

Targeted metabolomics study of fatty-acid metabolism in lean metabolic-associated fatty liver disease patients

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World Journal of Gastroenterology 2024年第27期30卷 3290-3303页

作者： Pei-Qi Sun Yi-Fu Yuan Qin Cao Xiao-Yan Chen Yuan-Ye Jiang Wen-Min Dong Li-Li Guo department of Gastroenterology Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai 200062China department of Pharmacy Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China Central Laboratory Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China

BACKGROUND The annual incidence of metabolic-associated fatty liver disease(MAFLD)in China has been increasing and is often overlooked owing to its insidious *** 50%of the patients have a normal weight or are not *** are said to have lean-type MAFLD,and few studies of such patients are *** MAFLD is associated with abnormal lipid metabolism,lipid-targeted metabolomics was used in this study to provide experimental evidence for early diagnosis and *** and analyze metabolic ***-Q-Orbitrap/MS content determination was used to determine serum palmitic acid(PA),oleic acid(OA),linoleic acid(LA),and arachidonic acid(AA)levels in lean-type MAFLD *** Urea nitrogen and uric acid levels were higher in lean-type MAFLD patients than in healthy individuals(P*** levels of PA,OA,LA,and AA were significantly increased compared with healthy *** The metabolic profiles of lean-type MAFLD patients and healthy participants differed significantly,yielding 65 identified ***,OA,LA,and AA exhibited the most significant changes,offering valuable clinical guidance for prevention and treatment of lean-type MAFLD.

关键词： Lean-type metabolic-associated fatty liver disease Targeted serum metabolomics Fatty acids Principal component analysis Orthogonal partial least squares-discriminant analysis

Impact of the Rapid Recovery Concept on Complications and Patient Quality of Life in the Perioperative Nursing of Robot-Assisted Radical Oesophageal Cancer

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Open Journal of Nursing 2024年第1期14卷 1-10页

作者： Rongrong Jiang Li Han Xiaoshan Ye Jiaqi Wu Jiahuan Weng Lihui Chen chest department Cancer Prevention and Treatment Center Sun Yat-sen University Guangzhou China

Aim: This study evaluates the impact of Enhanced Recovery After Surgery (ERAS) nursing on postoperative complications and quality of life in patients undergoing robot-assisted minimally invasive esophagectomy (RAMIE). Methods: A total of 150 patients who underwent RAMIE from January 2020 to January 2022 at our hospital were randomly assigned to either the observation group or the control group, with 75 patients in each. The control group received standard perioperative management and nursing care, while the observation group was treated with ERAS nursing strategies. Interventions continued until discharge, and outcomes such as postoperative complications, quality of life, and nutritional status were compared between the groups. Results: The observation group exhibited a significantly lower incidence of postoperative adverse reactions compared to the control group (P ionally, all dimension scores of the Short-Form 36 Health Survey (SF-36), including the total score, were higher in the observation group (P < 0.05). Furthermore, the Nutritional Risk Screening (NRS) scores for impaired nutritional status and disease severity, along with the total NRS score, were significantly lower in the observation group compared to the control group (P Conclusion: Implementing ERAS nursing in the perioperative care of patients undergoing RAMIE is associated with reduced postoperative complications and enhanced postoperative quality of life and nutritional status. .

关键词： Robot-Assisted Radical Esophageal Cancer Surgery Rapid Rehabilitation Surgical Nursing Perioperative Period Complications Quality of Life