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Bioresorbable Multilayer Photonic Cavities as Temporary Implants for Tether-Free Measurements of Regional Tissue Temperatures

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Biomedical Engineering Frontiers 2021年第1期2卷 89-102页

作者： Wubin Bai Masahiro Irie Zhonghe Liu Haiwen Luan Daniel Franklin Khizar Nandoliya Hexia Guo Hao Zang Yang Weng Di Lu Di Wu Yixin Wu Joseph Song Mengdi Han Enming Song Yiyuan Yang Xuexian Chen Hangbo Zhao Wei Lu Giuditta Monti Iwona Stepien Irawati Kandela Chad R.Haney Changsheng Wu Sang Min Won Hanjun Ryu Alina Rwei Haixu Shen Jihye Kim Hong-Joon Yoon Wei Ouyang Yihan Liu Emily Suen Huang-yu Chen Jerry Okina Jushen Liang Yonggang Huang Guillermo A.Ameer Weidong Zhou John A.Rogers department of Materials Science and Engineering Northwestern UniversityEvanstonIllinois 60208USA Querrey Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIllinois 60208USA department of Electrical Engineering University of Texas at ArlingtonArlingtonTX 76019USA department of Mechanical Engineering Northwestern UniversityEvanstonIllinois 60208USA department of chemistry Northwestern UniversityEvanstonIllinois 60208USA department of Biomedical Engineering Northwestern UniversityEvanstonIllinois 60208USA department of Materials Science and Engineering University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA Academy for Advanced Interdisciplinary Studies Peking UniversityBeijingChina department of Aerospace and Mechanical Engineering University of Southern CaliforniaLos AngelesCA 90089USA The Center for Developmental Therapeutics Northwestern UniversityEvanstonIllinois 60208USA Center for Advanced Molecular Imaging Northwestern UniversityEvanstonIllinois 60208USA department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwonRepublic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea department of Neurobiology Northwestern UniversityEvanstonIllinois 60208USA department of Chemical Engineering Northwestern UniversityEvanstonIllinois 60208USA department of Civil and Environmental Engineering Northwestern UniversityEvanstonIllinois 60208USA department of Electrical Engineering and Computer Science Northwestern UniversityEvanstonIllinois 60208USA Northwestern Medicine Feinberg School of MedicineNorthwestern UniversityEvanstonIllinois 60208USA Center for Advanced Regenerative Engineering Northwestern UniversityEvanstonIllinois 60208USA

Objective and Impact ***-time monitoring of the temperatures of regional tissue microenvironments can serve as the diagnostic basis for treating various health conditions and *** thermal sensors allow measurements at surfaces or at near-surface regions of the skin or of certain body *** at depth require implanted devices connected to external readout electronics via physical interfaces that lead to risks for infection and movement constraints for the ***,surgical extraction procedures after a period of need can introduce additional risks and ***,we report a wireless,bioresorbable class of temperature sensor that exploits multilayer photonic cavities,for continuous optical measurements of regional,deep-tissue microenvironments over a timeframe of interest followed by complete clearance via natural body *** designs decouple the influence of detection angle from temperature on the reflection spectra,to enable high accuracy in sensing,as supported by in vitro experiments and optical *** with devices implanted into subcutaneous tissues of both awake,freely moving and asleep animal models illustrate the applicability of this technology for in vivo *** results demonstrate the use of bioresorbable materials in advanced photonic structures with unique capabilities in tracking of thermal signatures of tissue microenvironments,with potential relevance to human healthcare.

关键词： signature constraints multilayer

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Author Spotlight

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CCS chemistry 2021年第2期3卷 303-305页

作者： Yang, Ying-Wei Chen, Long Arizona State Univ Tempe AZ 85287 USA Univ Calif los angeles Los Angeles CA 90024 USA Univ Calif Irvine Irvine CA 92717 USA Jilin Univ Coll Chem Changchun Jilin Peoples R China Max Planck Inst Polymer Res MPIP Mainz Germany Tianjin Univ Tianjin Peoples R China

Ying-Wei Yang(杨英威)***-Wei Yang graduated from the department of chemistry at Nankai university with a *** *** received his *** Physical chemistry from Nankai university in 2005 under the direction of *** *** 2005 to 2010,he worked as a postdoctoral fellow at Arizona State university(with Professor John Chaput),university of california.

关键词： doctor Arizona california

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海洋环境中乙烷和丙烷的分布及生物转化

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地球科学进展 2022年第4期37卷 370-381页

作者：袁媛庄光超毛士海刘佳睿刘喜停杨桂朋深海圈层与地球系统前沿科学中心和海洋化学理论与工程技术教育部重点实验室中国海洋大学山东青岛266100 青岛海洋科学与技术试点国家实验室海洋生态与环境科学功能实验室山东青岛266237 中国海洋大学化学化工学院山东青岛266100 department of Earth Planetary and Space SciencesUniversity of CaliforniaLos AngelesCAUSA 9009 中国海洋大学海洋地球科学学院山东青岛266100

海洋沉积物中蕴含着大量以甲烷(CH_(4))、乙烷(C_(2)H_(6))和丙烷(C_(3)H_(8))为主要成分的烷烃化合物,与甲烷类似,乙烷与丙烷也是重要的温室气体。水合物分解和油气渗漏会释放这些烷烃化合物到海水及大气中,对海洋生态环境及全球气候... 详细信息

海洋沉积物中蕴含着大量以甲烷(CH_(4))、乙烷(C_(2)H_(6))和丙烷(C_(3)H_(8))为主要成分的烷烃化合物,与甲烷类似,乙烷与丙烷也是重要的温室气体。水合物分解和油气渗漏会释放这些烷烃化合物到海水及大气中,对海洋生态环境及全球气候产生重要影响。海洋环境中的微生物对烷烃的氧化作用有效降低了海洋烷烃气体的排放通量。系统综述了海洋环境中乙烷和丙烷的分布及生物转化机制的最新研究进展,归纳出以下认识:①海水中乙烷与丙烷的分布特征明显,主要受到水文、化学及生物等环境参数的影响;②海洋环境中乙烷与丙烷的生物来源主要有海水中浮游植物生产释放和沉积物中厌氧微生物生成,产甲烷菌可以利用多种底物生成乙烷与丙烷;③乙烷和丙烷的好氧氧化主要由烷烃氧化菌完成,并且该过程中伴随一定程度的碳氢同位素分馏;④沉积物中乙烷与丙烷的厌氧氧化通常与硫酸盐还原耦合,目前已对参与氧化乙烷与丙烷的硫酸盐还原菌及厌氧氧化机制有了初步认识。总结和回顾了海洋环境中乙烷和丙烷的来源、分布及微生物代谢过程,可为未来深入理解碳氢化合物的生物地球化学循环奠定基础。

关键词：乙烷丙烷微生物生物地球化学循环海洋沉积物

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Erratum to： Questions about NgAgo

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Protein & Cell 2017年第1期8卷 77-77页

作者： Shawn Burgess Linzhao Cheng Feng Gu Junjiu Huang Zhiwei Huang Shuo Lin Jinsong Li Wei Li Wei Qin Yujie Sun Zhou Songyang wensheng Wei Qiang Wu Haoyi Wang Xiaoqun Wang Jing-Wei Xiong Jianzhong Xi Hui Yang Bin Zhou Bo Zhang National Human Genome Research Institute NIH Bethesda MD USA Division of Hematology in department of Medicine Johns Hopkins University School of Medicine Baltimore MD 21205 USA Stem Cell Program in the Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA Center for Vision Research Eye Hospital Wenzhou Medical University Wenzhou 325035 China Stem Cell and Functional Genomics Laboratory School of Life Sciences Sun Yat-sen University Guangzhou 510275 China HIT Center of Life Sciences Harbin Institute of Technology Harbin 150080 China department of Molecular Cell and Developmental Biology University of California Los Angeles Los Angeles CA 90095 USA Institute of biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China State Key Laboratory of Stem cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China College of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Shenzhen 518055 China PKU BIOPIC Beijing 100871 China BIOPIC ICG CLS and School of Life Sciences Peking University Beijing 100871 China Center for Comparative Biomedicine Institute of Systems Biomedicine Shanghai Jiao Tong University Shanghai 200240 China Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Institute of Molecular Medicine Peking University Beijing 100871 China College of Engineering Peking University Beijing 106871 China Laboratory of Disease Models in Non-Human Primates Institute of Neuroscience Shanghai Chinese Academy of Sciences Shanghai 200031 China College of Life Sciences Peking University Beijing 100871 China

In the original publication of this article the Figure 1E legend has been incorrectly published.

关键词： Erratum Questions NgAgo

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衰老的脊髓小胶质细胞呈现表型异质并倾向性靶向运动神经元及其突触

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神经损伤与功能重建 2023年第11期18卷 F0003-F0003页

作者： Ryan W Castro Mikayla C Lopes Lindsay M De Biase Gregorio Valdez 杜一星(编译) Neuroscience Graduate Program Brown UniversityProvidenceRhode IslandUSA. Molecular Biology Cell Biology&Biochemistry Graduate ProgramBrown UniversityProvidenceRhode IslandUSA. department of Physiology David Geffen School of Medicine at UCLALos AngelesCaliforniaUSA. department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRhode IslandUSA. Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Scienceand Center on the Biology of AgingBrown UniversityProvidenceRhode IslandUSA. 不详

研究发现小胶质细胞随着年龄的增长和疾病的不同而获得独特的区域依赖性有害特征,从而导致神经元功能障碍和大脑退化。然而,目前尚不清楚脊髓中的小胶质细胞是否表现出类似的表型异质性。本研究对3、16、23和30个月大的小鼠的脊髓小胶... 详细信息

研究发现小胶质细胞随着年龄的增长和疾病的不同而获得独特的区域依赖性有害特征,从而导致神经元功能障碍和大脑退化。然而,目前尚不清楚脊髓中的小胶质细胞是否表现出类似的表型异质性。本研究对3、16、23和30个月大的小鼠的脊髓小胶质细胞进行区域分析。我们使用光学和电子显微镜发现脊髓小胶质细胞在衰老过程中获得越来越活跃的表型,且该现象与区域无关。然而,衰老会导致腹侧而非背角的小胶质细胞失去其空间组织。衰老的腹角小胶质细胞也会聚集在运动神经元胞体周围,它们与运动神经元突触的接触增加;而运动神经元突触已被证明会随着年龄的增长而消失。这些发现表明,在衰老过程中小胶质细胞可能会影响运动神经元接收和传递运动命令的能力。为了更深入地研究衰老脊髓小胶质细胞,我们对FACS分离的3、18、22和29个月大小鼠的小胶质细胞进行RNA测序。我们发现,脊髓小胶质细胞在衰老过程中获得与大脑中小胶质细胞相似的转录特性,其中包括在小胶质细胞-神经元相互作用和炎症中发挥作用的基因表达的改变。到29个月大时,脊髓小胶质细胞表现出额外且独特的转录变化,已知并预计会导致衰老并改变溶酶体和核糖体调节。总之,这项工作为靶向小胶质细胞以改善脊髓中与衰老相关的变化,特别是运动回路的变化奠定了基础。

关键词：衰老小胶质细胞运动神经元脊髓突触

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Breast Cancer Risk Genes-Association Analysis in More than 113,000 Women

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四川生理科学杂志 2021年第1期43卷 7-7页

作者： Leila Dorling The authors' affiliations are as follows: the Centre for Cancer Genetic Epidemiology Departments of Public Health and Primary Care (L.D. S. Carvalho J.A. K.A.P. Q.W. M.K.B. J.D. B.D. N. Mavaddat K. Michailidou A.C.A. P.D.P.P. D.F.E.) and Oncology (C.L. P.A.H. C. Baynes D.M.C. L.F. V.R. M. Shah P.D.P.P. A.M.D. D.F.E.) University of Cambridge Cambridge the Centre for Genomic and Experimental Medicine MRC Institute of Genetics and Molecular Medicine (A. Campbell D.J.P.) and the Centre for Cognitive Ageing and Cognitive Epidemiology Department of Psychology (D.J.P.) University of Edinburgh the Cancer Research UK Edinburgh Centre (D.A.C. J.F.) and the Usher Institute of Population Health Sciences and Informatics University of Edinburgh Medical School (A. Campbell J.F.) Edinburgh the Divisions of Informatics Imaging and Data Sciences (E.F.H.) Cancer Sciences (A. Howell) Population Health Health Services Research and Primary Care (A. Lophatananon K. Muir) and Evolution and Genomic Sciences School of Biological Sciences (W.G.N. E.M.V. D.G.E.) University of Manchester the NIHR Manchester Biomedical Research Unit (E.F.H.) and the Nightingale Breast Screening Centre Wythenshawe Hospital (E.F.H. H.I.) Academic Health Science Centre and North West Genomics Laboratory Hub and the Manchester Centre for Genomic Medicine St. Mary's Hospital Manchester University NHS Foundation Trust (W.G.N. E.M.V. D.G.E.) Manchester the School of Cancer and Pharmaceutical Sciences Comprehensive Cancer Centre Guy's Campus King's College London London (E.J.S.) the Institute of Cancer and Genomic Sciences University of Birmingham Birmingham (I.T.) and the Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre University of Oxford Oxford (I.T.) - all in the United Kingdom the Human Genotyping-CEGEN Unit Human Cancer Genetic Program (A.G.-N. M.R.A. N.Á. B.H. R.N.-T.) and the Human Genetics Group (V.F. A.O. J.B.) Spanish National Cancer Research

Background:Genetic testing for breast cancer susceptibility is widely used,but for many genes,evidence of an association with breast cancer is weak,underlying risk estimates are imprecise,and reliable subtype-specific risk estimates are ***:We used a panel of 34 putative susceptibility genes to perform sequencing on samples from 60,466 women with breast cancer and 53,461 *** separate analyses for protein-truncating variants and rare missense variants in these genes,we estimated odds ratios for breast cancer overall and tumor *** evaluated missense-variant associations according to domain and classification of pathogenicity.

关键词： cancer Breast Cancer

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