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Neutrophil-to-lymphocyte ratio associated with renal function in type 2 diabetic patients

World Journal of clinical Cases 2024年第14期12卷 2308-2315页

作者： Jin-Li Gao Jue Shen Li-Ping Yang Li Liu Kai Zhao Xiao-Rong Pan Lei Li Ji-Ji Xu department of Prevention and Health Care Community Health Service Center of Miaohang TownShanghai 200443China department of Prevention and Health Care Community Health Service Center of Songnan TownShanghai 200434China department of General Practice Community Health Service Center of Songnan TownShanghai 200434China department of Administrative Community Health Service Center of Songnan TownShanghai 200434China

BACKGROUND Type 2 diabetes mellitus(T2DM)is a leading risk factor for the development and progression of chronic kidney disease(CKD).However,an accurate and con-venient marker for early detection and appropriate management of CKD in in-dividuals with T2DM is *** studies have demonstrated a strong correlation between the neutrophil-to-lymphocyte ratio(NLR)and ***-theless,the predictive value of NLR for renal damage in type 2 diabetic patients remains *** study included 1040 adults aged 65 or older with T2DM from Shanghai's community Health Service *** total number of neutrophils and lym-phocytes was detected,and NLR levels were *** was defined as an estimated glomerular filtration rate≤60 mL/min/1.73 m².Participants were di-vided into four groups based on NLR *** clinical data and biochemical characteristics were compared among groups.A multivariate logistic regression model was used to analyze the association between NLR levels and *** Significant differences were found in terms of sex,serum creatinine,blood urea nitrogen,total cholesterol,and low-density lipoprotein cholesterol among patients with T2DM in different NLR groups(Pclinical and pathological parameters(P=0.0001,odds ratio=1.41,95%confidence intervals:1.18-1.68).CONCLUSION An elevated NLR in patients with T2DM is associated with higher prevalence of CKD,suggesting that it could be a marker for the detection and evaluation of diabetic kidney disease.

关键词： Type 2 diabetes mellitus Neutrophil-to-lymphocyte ratio Chronic kidney disease Logistic regression Diabetes mellitus

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Effectiveness of colorectal cancer screening integrating non-genetic and genetic risk: a prospective study based on UK Biobank data

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Cancer Biology & Medicine 2024年第8期21卷 712-723页

作者： Yu Zhang Chao Sheng Zhangyan Lyu Hongji Dai Fangfang Song Fengju Song Yubei Huang Kexin Chen department of epidemiology and Biostatistics Key Laboratory of Molecular Cancer EpidemiologyKey Laboratory of Prevention and Control of Human Major DiseasesMinistry of EducationNational Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjin Medical UniversityTianjin 300060China

Objective: Few studies have evaluated the benefits of colorectal cancer(CRC) screening integrating both non-genetic and genetic risk factors. Here, we aimed to integrate an existing non-genetic risk model(QCancer-10) and a 139-variant polygenic risk score to evaluate the effectiveness of screening on CRC incidence and ***: We applied the integrated model to calculate 10-year CRC risk for 430,908 participants in the UK Biobank, and divided the participants into low-, intermediate-, and high-risk groups. We calculated the screening-associated hazard ratios(HRs) and absolute risk reductions(ARRs) for CRC incidence and mortality according to risk ***: During a median follow-up of 11.03 years and 12.60 years, we observed 5,158 CRC cases and 1,487 CRC deaths, respectively. CRC incidence and mortality were significantly lower among screened than non-screened participants in both the intermediateand high-risk groups [incidence: HR: 0.87, 95% confidence interval(CI): 0.81±0.94;0.81, 0.73±0.90;mortality: 0.75, 0.64±0.87;0.70, 0.58±0.85], which composed approximately 60% of the study population. The ARRs(95% CI) were 0.17(0.11±0.24) and 0.43(0.24±0.61), respectively, for CRC incidence, and 0.08(0.05±0.11) and 0.24(0.15±0.33), respectively, for mortality. Screening did not significantly reduce the relative or absolute risk of CRC incidence and mortality in the low-risk group. Further analysis revealed that screening was most effective for men and individuals with distal CRC among the intermediate to high-risk ***: After integrating both genetic and non-genetic factors, our findings provided priority evidence of risk-stratified CRC screening and valuable insights for the rational allocation of health resources.

关键词： Colorectal cancer screening polygenic risk score incidence mortality

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Esophageal intramural pseudodiverticulosis

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World Journal of Gastroenterology 2024年第2期30卷 137-145页

作者： Masako Shintaku department of Gastroenterology Japan Community Healthcare Organization Hoshigaoka Medical CenterHirakata 573-8511OsakaJapan

Esophageal intramural pseudodiverticulosis(EIPD)is a disease of unknown pathogenesis characterized by usually systemic,cystic dilatation of the excretory ducts of esophageal submucosal *** this article,I review the epidemiology,clinical manifestations,endoscopic findings,esophagographic findings,and histopathology of EIPD.I also discuss the etiology and possible pathogenesis of EIPD based on my experiences with this disease and a review of the *** usually presents with dysphagia in middle-aged *** is often complicated with secondary infections,most commonly *** esophagography,EIPD is delineated as small,multiple,flask-shaped outward projections within the esophageal *** recent years,EIPD has been mainly diagnosed by endoscopic findings of multiple,localized,small mucosal *** orifices of the“pseudodiverticula”periodically open and close,and excrete mucus onto the mucosal *** histopathological examination,the luminal surface of dilated ducts in EIPD is covered by multilayered,hyperplastic epithelial cells,but myoepithelial cells in the glandular acini are well *** of EIPD is usually symptomatic therapy,and prevention of the infectious complications is *** etiology and pathogenesis of EIPD are largely unknown,but functional abnormalities of autonomic nerve fibers innervating the esophageal glands likely play an important role,since the structures of the glands are basically preserved in this disease.

关键词： Esophageal endoscopy Esophageal intramural pseudodiverticulosis Esophagography Dysphagia

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Effects and mechanisms of Helicobacter pylori infection on the occurrence of extra-gastric tumors

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World Journal of Gastroenterology 2024年第37期30卷 4090-4103页

作者： Shi-Qing Zhao Hui-Ling Zheng Xiao-Tian Zhong Zi-Ye Wang Yi Su Yan-Yan Shi Research center of clinical epidemiology Peking University Third HospitalBeijing 100191China Health Science center Peking UniversityBeijing 100191China department of Gastroenterology Peking University Third HospitalBeijing 100191China

Helicobacter pylori(***)colonizes the human stomach and many studies have discussed the mechanisms of *** infection leading to gastric diseases,including gastric ***,increasing data have shown that the infection of *** may contribute to the development of extra-gastric diseases and ***,systemic immune responses,microbiome disorders,and hypergastrinemia caused by *** infection are associated with many extra-gastric *** review highlights recent discoveries;discusses the relationship between *** and various extra-gastric tumors,such as colorectal cancer,lung cancer,cholangiocarcinoma,and gallbladder carcinoma;and explores the mechanisms of extra-gastric carcinogenesis by ***,these findings refine our understanding of the pathogenic processes of ***,provide guidance for the clinical treatment and management of ***-related extra-gastric tumors,and help improve prognosis.

关键词： Helicobacter pylori Extra-gastric tumors Immune system response Mucosal barrier Gut microbiome

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Association of physical activity with risk of chronic kidney disease in China:A population-based cohort study

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Journal of Sport and Health Science 2024年第2期13卷 204-211页

作者： Kexiang Shi Yunqing Zhu Jun Lv Dianjianyi Sun Pei Pei Huaidong Du Yiping Chen Ling Yang Bing Han Rebecca Stevens Junshi Chen Zhengming Chen Liming Li Canqing Yu China Kadoorie Biobank collaborative group department of epidemiology&Biostatistics School of Public HealthPeking University Health Science CenterBeijing 100191China Peking University center for Public Health and Epidemic Preparedness&Response Beijing 100191China Key Laboratory of epidemiology of Major Diseases(Peking University) Ministry of EducationBeijing 100191China clinical Trial Service Unit&Epidemiological studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK Medical Research Council Population Health Research Unit at the University of Oxford Oxford OX37LFUK NCDs Prevention and Control department Henan Center for Disease Control and PreventionZhengzhou 450016China China National center for Food Safety Risk Assessment Beijing 100022China 不详

Background:Information on the association between physical activity(PA)and the risk of chronic kidney disease(CKD)is *** aimed to explore the associations of total,domain-specific,and intensity-specific PA with CKD and its subtypes in ***:The study included 475,376 adults from the China Kadoorie Biobank aged 30-79 years during 2004-2008 at *** interviewer-administered questionnaire was used to collect the information about PA,which was quantified as metabolic equivalent of task hours per day(MET-h/day)and categorized into 4 groups based on *** regression was used to analyze the association between PA and CKD ***:During a median follow-up of 12.1 years,5415 incident CKD cases were documented,including 1159 incident diabetic kidney disease(DKD)cases and 362 incident hypertensive nephropathy(HTN)*** PA was inversely associated with CKD risk,with an adjusted hazard ratio(HR,95%confidence interval(95%CI))of 0.83(0.75-0.92)for incident CKD in the highest quartile of total PA as compared with participants in the lowest *** results were observed for risk of DKD and HTN,and the corresponding HRs(95%CIs)were 0.75(0.58-0.97)for DKD risk and 0.56(0.37-0.85)for HTN *** nonoccupational PA,low-intensity PA,and moderate-to-vigorous-intensity PA were significantly associated with a decreased risk of CKD,with HRs(95%CIs)of 0.80(0.73-0.88),0.85(0.77-0.94),and 0.85(0.76-0.95)in the highest quartile,***:PA,including nonoccupational PA,low-intensity PA,and moderate-to-vigorous-intensity PA,was inversely associated with the risk of CKD,including DKD,HTN,and other CKD,and such associations were dose dependent.

关键词： Chronic kidney disease Domain Intensity Physical activity

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The Association Between Preserved Ratio Impaired Spirometry and Mortality –– 10 CKB Study Areas, China, 2004–2022

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China CDC weekly 2024年第43期6卷 1120-1125,I0003页

作者： Yalei Ke Xinyi Zhang Dianjianyi Sun Pei Pei Huaidong Du Yiping Chen Ling Yang Xiaoming Yang Kang Wang Junshi Chen Zhengming Chen Jun Lv Liming Li Canqing Yu department of epidemiology and Biostatistics School of Public HealthPeking University Health Science CenterBeijingChina Peking University center for Public Health and Epidemic Preparedness&Response BeijingChina Key Laboratory of epidemiology of Major Diseases(Peking University) Ministry of EducationBeijingChina clinical Trial Service Unit&Epidemiological studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxfordUK Shibei center for Disease Control and Prevention Qingdao CityShandong ProvinceChina China National center for Food Safety Risk Assessment BeijingChina State Key Laboratory of Vascular Homeostasis and Remodeling Peking UniversityBeijingChina.

What is already known about this topic?China has the world’s most significant public health and economic burden of chronic respiratory ***,the association between preserved ratio impaired spirometry(PRISm)and mortality risk is *** is added by this report?The PRISm group exhibited a 37%higher risk of allcause mortality than the normal group,and the risks of death from cardiovascular diseases,neoplasms,respiratory diseases,and infectious and parasitic diseases were also increased in ***,the presence of respiratory symptoms or disease was associated with an increased risk of mortality in *** are the implications for public health practice?It is imperative to enhance public awareness of PRISm and to implement measures to facilitate the regression of PRISm toward normal lung function.

关键词： function. impaired neoplasms

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Mapping global research trends: Nutrition associations with nonalcoholic fatty liver disease - a Scopus bibliometric analysis

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World Journal of Gastroenterology 2024年第24期30卷 3106-3119页

作者： Muna Shakhshir Sa'ed H Zyoud department of Nutrition An-Najah National University HospitalNablus 44839Palestine department of Public Health College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine department of clinical and community Pharmacy College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Poison Control and Drug Information center College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine clinical Research center An-Najah National University HospitalNablus 44839Palestine

BACKGROUND Several bibliometric analyses have been carried out to identify research hotspots and trends in nonalcoholic fatty liver disease(NAFLD)***,there are still significant knowledge gaps that must be filled to advance our understanding of and ability to treat *** To evaluate,through bibliometric and visual analysis,the current status of related research,related research frontiers,and the developmental trends in the field of diet and *** We retrieved publications about diet and NAFLD published between 1987 and 2022 from ***,we used VOSviewer 1.6.20 to perform bibliometric analysis and *** We found a total of 1905 studies,including 1637(85.93%)original articles and 195(10.24%)reviews,focused on the examination of NAFLD and its correlation with diet that were published between 1987 and *** the remaining five types of documents,38 were letters,notes,editorials,meeting minutes,or brief surveys,representing 1.99%of the total *** countries with the most publications on this topic were China(n=539;28.29%),followed by the United States(n=379;19.90%),Japan(n=133;6.98%),and South Korea(n=127;6.6%).According to the citation analysis,the retrieved papers were cited an average of 32.3 times and had an h-index of 106,with 61014 total *** two main clusters on the map included those related to:(1)Inflammation and oxidative stress;and(2)Dietary interventions for *** This was the first study to use data taken from Scopus to visualize network mapping in a novel bibliometric analysis of studies focused on diet and *** 2017,the two domains that received the most attention were“dietary interventions for NAFL”’and“‘inflammation and oxidative stress implicated in NAFLD and its correlation with diet.”We believe that this study provides important information for academics,dietitians,and doctors,and that additional research on dietary interventions and NAFLD is warranted.

关键词： Dietary Nutrition Bibliometric Nonalcoholic fatty liver Scopus VOSviewer

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Prioritization of risk genes in colorectal cancer by integrative analysis of multi-omics data and gene networks

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Science China(Life Sciences) 2024年第1期67卷 132-148页

作者： Ming Zhang Xiaoyang Wang Nan Yang Xu Zhu Zequn Lu Yimin Cai Bin Li Ying Zhu Xiangpan Li Yongchang Wei Shaokai Zhang Jianbo Tian Xiaoping Miao department of epidemiology and Biostatistics School of Public HealthDepartment of Gastrointestinal OncologyZhongnan Hospital of Wuhan UniversityDepartment of Radiation OncologyRenmin Hospital of Wuhan UniversityTaiKang Center for Life and Medical SciencesWuhan UniversityWuhan 430071China Research center of Public Health Renmin hospital of Wuhan UniversityWuhan UniversityWuhan 430060China department of Cancer epidemiology The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalHenan Engineering Research Center of Cancer Prevention and ControlHenan International Joint Laboratory of Cancer PreventionZhengzhou 450008China department of Gastrointestinal Surgery Renmin Hospital of Wuhan UniversityWuhan 430060China department of Radiation Oncology Renmin Hospital of Wuhan UniversityWuhan 430060China department of Gastrointestinal Oncology Hubei Cancer Clinical Study CenterZhongnan Hospital of Wuhan UniversityWuhan 430062China department of epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430073China Jiangsu Collaborative Innovation center for Cancer Personalized Medicine Nanjing Medical UniversityNanjing 211166China

Genome-wide association studies(GWASs)have identified over 140 colorectal cancer(CRC)-associated loci;however,target genes at the majority of loci and underlying molecular mechanisms are poorly ***,we utilized a Bayesian approach,integrative risk gene selector(iRIGS),to prioritize risk genes at CRC GWAS loci by integrating multi-omics *** a result,a total of 105 high-confidence risk genes(HRGs)were identified,which exhibited strong gene dependencies for CRC and enrichment in the biological processes implicated in *** the 105 HRGs,CEBPB,located at the 20q13.13 locus,acted as a transcription factor playing critical roles in *** subsequent assays indicated the tumor promoter function of CEBPB that facilitated CRC cell proliferation by regulating multiple oncogenic pathways such as MAPK,PI3K-Akt,and Ras ***,by integrating a fine-mapping analysis and three independent case-control studies in Chinese populations consisting of 8,039 cases and 12,775 controls,we elucidated that rs1810503,a putative functional variant regulating CEBPB,was associated with CRC risk(OR=0.90,95%CI=0.86–0.93,P=1.07×10^(−7)).The association between rs1810503 and CRC risk was further validated in three additional multi-ancestry populations consisting of 24,254 cases and 58,741 ***,the rs1810503 A to T allele change weakened the enhancer activity in an allele-specific manner to decrease CEBPB expression via longrange promoter-enhancer interactions,mediated by the transcription factor,REST,and thus decreased CRC *** summary,our study provides a genetic resource and a generalizable strategy for CRC etiology investigation,and highlights the biological implications of CEBPB in CRC tumorigenesis,shedding new light on the etiology of CRC.

关键词： susceptibility genes gene screening models multi-omics GWAS CEBPB long-range promoter-enhancer interactions

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Immune cell pair ratio captured by imaging mass cytometry has superior predictive value for prognosis of non-small cell lung cancer than cell fraction and density

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Cancer Communications 2024年第5期44卷 589-592页

作者： Jian-Rong Li Chao Cheng Institute for clinical and Translational Research Baylor College of MedicineHoustonTexasUSA Section of epidemiology and Population Sciences Department of MedicineBaylor College of MedicineHoustonTexasUSA Dan L Duncan Comprehensive Cancer center Baylor College of MedicineHoustonTexasUSA

Infiltrating immune cells in the tumor microenvironment(TME)play critical roles in the initiation,progression,and metastasis of cancer[1].Previous studies have reported that the infiltration levels of various immune cell types are significantly associated with patient prognosis in different cancers[2,3].Specifically,in non-small cell lung cancer(NSCLC)the prognostic associations of major immune cell types have been investigated[4–6],however,some of the reported associations are inconsistent and remain debated[7].Limited by technical issues,most studies focused on a few immune cell lineages or relied on inferred immune cell levels from computational *** investigate the prognostic effects of all major immune cell types unbiasedly,more systematic high-quality immune cell profiling data with matched patient survival information are needed.

关键词： prognosis cancer lung

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Prevalence and Risk Factors for Chronic Obstructive Pulmonary Disease Among Adults Aged 50 and Above-10 CKB Study Areas,China,2020–2021

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China CDC weekly 2024年第43期6卷 1126-1131页

作者： Wei Yu Yongbing Lan Dianjianyi Sun Pei Pei Ling Yang Yiping Chen Huaidong Du Yingcai Yang Dan Schmidt Junshi Chen Zhengming Chen Jun Lyu Liming Li Canqing Yu department of epidemiology&Biostatistics School of Public HealthPeking UniversityBeijingChina Peking University center for Public Health and Epidemic Preparedness&Response BeijingChina Key Laboratory of epidemiology of Major Diseases(Peking University) Ministry of EducationBeijingChina clinical Trial Service Unit&Epidemiological studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxfordUnited Kingdom Shinan District center for Disease Control and Prevention Qingdao CityShandong ProvinceChina China National center for Food Safety Risk Assessment BeijingChina State Key Laboratory of Vascular Homeostasis and Remodeling Peking UniversityBeijingChina.

What is already known about this topic?The prevalence of COPD in Chinese individuals aged 50 years and above was obviously higher than that in younger adults,but the risk factors for this age group were *** is added by this report?The prevalence was estimated at 12.8%and 5.7%for males and females over 50 in 2020–2021,with confirmed risk factors of cigarette smoking,a family history of respiratory diseases,respiratory symptoms,and a history of cough or respiratory diseases during *** are the implications for public health practice?The findings may help clinicians and the public identify individuals at high risk of COPD and take targeted measures in a timely manner.

关键词： respiratory diseases prevalence

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