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Reference values of carotid intima-media thickness and arterial stiffness in Chinese adults based on ultrasound radio frequency signal: A nationwide, multicenter study

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中华医学杂志(英文版) 2024年第15期137卷 1802-1810页

作者： Xing Changyang Xie Xiujing Wu Yu Xu Lei Guan Xiangping Li Fan Zhan Xiaojun Yang Hengli Li Jinsong Zhou Qi Mu Yuming Zhou Qing Ding Yunchuan Wang Yingli Wang Xiangzhu Zheng Yu Sun Xiaofeng Li Hua Zhang Chaoxue Zhao Cheng Qiu Shaodong Yan Guozhen Yang Hong Mao Yinjuan Zhan Weiwei Ma Chunyan Gu Ying Chen Wu Xie Mingxing Jiang Tianan Yuan Lijun department of Ultrasound Medicine Tangdu Hospital Air Force Medical University Xi’an Shaanxi China department of Ultrasound Medicine The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China department of Ultrasound Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China department of Ultrasound Xi’an Hospital of Traditional Chinese Medicine Xi’an Shaanxi China Ultrasound Medical Diagnosis Center Shaanxi Provincial People’s Hospital Xi’an Shaanxi China department of Ultrasound Hospital of Northwestern Polytechnical University Xi’an Shaanxi China department of Ultrasound Xi’an No. Hospital The First Affiliated Hospital of Northwest University Xi’an Shaanxi China department of Ultrasound Diagnosis The Second Affiliated Hospital Xi’an Medical College Xi’an Shaanxi China department of Ultrasound Xi’an Gem Flower ChangQing Hospital Xi’an Shaanxi China department of Ultrasound The Second Affiliated Hospital of Xi’an Jiaotong University China Xi’an Shaanxi China department of Echocardiography First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang China department of Ultrasound Renmin Hospital of Wuhan University Wuhan Hubei China department of Ultrasound Yan’an Hospital The Affiliated Hospital of Kunming Medical University Kunming Yunnan China department of Ultrasound Yan’an University Xianyang Hospital Xianyang Shaanxi China department of Function Examination Beijing University of Chinese Medicine Third Affiliated Hospital Beijing China department of Ultrasound Xi’an Central Hospital Xi’an Shaanxi China Cadre’s Wards Ultrasound department Diagnostic Ultrasound Center First Hospital of Jilin University Changchun Jilin China department of Echocardiography Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University Urumqi Xinjiang China department of Ultrasound First Affiliated Hospital of Anhui Medical University Hefei

Background: Carotid intima-media thickness (IMT) and diameter, stiffness, and wave reflections, are independent and important clinical biomarkers and risk predictors for cardiovascular diseases. The purpose of the present study was to establish nationwide reference values of carotid properties for healthy Chinese adults and to explore potential clinical ***: A total of 3053 healthy Han Chinese adults (1922 women) aged 18-79 years were enrolled at 28 collaborating tertiary centers throughout China between April 2021 and July 2022. The real-time tracking of common carotid artery walls was achieved by the radio frequency (RF) ultrasound system. The IMT, diameter, compliance coefficient, β stiffness, local pulse wave velocity (PWV), local systolic blood pressure, augmented pressure (AP), and augmentation index (AIx) were then automatically measured and reported. Data were stratified by age groups and sex. The relationships between age and carotid property parameters were analyzed by Jonckheere-Terpstra test and simple linear regressions. The major clinical determinants of carotid properties were identified by Pearson’s correlation, multiple linear regression, and analyses of ***: All the parameters of carotid properties demonstrated significantly age-related trajectories. Women showed thinner IMT, smaller carotid diameter, larger AP, and AIx than men. The β stiffness and PWV were significantly higher in men than women before forties, but the differences reversed after that. The increase rate of carotid IMT (5.5 μm/year in women and 5.8 μm/year in men) and diameter (0.03 mm/year in both men and women) were similar between men and women. For the stiffness and wave reflections, women showed significantly larger age-related variations than men as demonstrated by steeper regression slopes (allP for age by sex interaction <0.05). The blood pressures, body mass index (BMI), and triglyceride levels were identified as major clinical determinants o

关键词： Intima-media thickness Arterial stiffness Reference values Ultrasound radio frequency signal Wave reflections

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Myosteatosis is associated with coronary artery calcification in patients with type 2 diabetes

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World Journal of Diabetes 2024年第3期15卷 429-439页

作者： Fu-Peng Liu Mu-Jie Guo Qing Yang Yan-Ying Li Yan-Gang Wang Mei Zhang The Affiliated hospital of Medical College Qingdao University Qingdao UniversityQingdao 266071Shandong ProvinceChina department of Endocrinology The Affiliated Hospital of Jining Medical UniversityJining 272029Shandong ProvinceChina department of Medical imaging The Affiliated Hospital of Jining Medical UniversityJining 272029Shandong ProvinceChina department of Clinical Nutrition The Affiliated Hospital of Jining Medical UniversityJining 272029Shandong ProvinceChina department of Endocrinology The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina

BACKGROUND Myosteatosis,rather than low muscle mass,is the primary etiologic factor of sarcopenia in patients with type 2 diabetes mellitus(T2DM).Myosteatosis may lead to a series of metabolic dysfunctions,such as insulin resistance,systematic inflammation,and oxidative stress,and all these dysfunctions are closely associated with the acceleration of T2DM and *** To investigate the association between myosteatosis and coronary artery calcification(CAC)in patients with *** Patients with T2DM,who had not experienced major cardiovascular events and had undergone both abdominal and thoracic computed tomography(CT)scans,were *** mean skeletal muscle attenuation was assessed using abdominal CT images at the L3 *** CAC score was determined from thoracic CT images using the Agatston scoring *** was diagnosed according to Martin’s *** CAC(SCAC)was defined when the CAC score exceeded *** regression and decision tree analyses were *** A total of 652 patients with T2DM were *** them,167(25.6%)patients had *** regression analysis demonstrated that myosteatosis,age,duration of diabetes,cigarette smoking,and alcohol consumption were independent risk factors of *** was significantly associated with an increased risk of SCAC(OR=2.381,P=0.003).The association between myosteatosis and SCAC was significant in the younger patients(OR=2.672,95%CI:1.477-4.834,P=0.002),but not the older patients(OR=1.456,95%CI:0.863-2.455,P=0.188),and was more prominent in the population with lower risks of *** decision tree analyses prioritized older age as the primary variable for *** older patients,cigarette smoking was the main contributing factor for SCAC,while in younger patients,it was *** Myosteatosis is a novel risk factor for atherosclerosis in patients with T2DM,especially in the population with younger ages and fewer traditional ri

关键词： Type 2 diabetes Myosteatosis Muscle quality Coronary artery calcification Atherosclerosis cardiovascular diseases

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Blood cell counts and nonalcoholic fatty liver disease: Evidence from Mendelian randomization analysis

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World Journal of Hepatology 2024年第8期16卷 1145-1155页

作者： Bin Hu Ai-Hong Wan Xi-Qiao Xiang Yuan-Hao Wei Yi Chen Zhen Tang Chang-De Xu Zi-Wei Zheng Shao-Ling Yang Kun Zhao department of Laboratory Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital South CampusShanghai 201499China department of Cardiology Shanghai Jiao Tong University Affiliated Sixth People's Hospital South CampusShanghai 201499China department of Positron Emission Tomography-Computed Tomography imaging Center Shanghai Jiao Tong University Affiliated Sixth People's Hospital South CampusShanghai 201499China department of School of Public Health Harbin Medical UniversityHarbin 150081Heilongjiang ProvinceChina department of cardiovascular Ultrasound Medicine Center Shanghai Eighth People's HospitalShanghai 200235China

BACKGROUND Previous research has highlighted correlations between blood cell counts and chronic liver ***,the causal relationships remain *** To evaluate the causal effect of blood cell traits on liver enzymes and nonalcoholic fatty liver disease(NAFLD)*** Independent genetic variants strongly associated with blood cell traits were extracted from a genome-wide association study(GWAS)conducted by the Blood Cell ***-level data for liver enzymes were obtained from the United Kingdom *** data were obtained from a GWAS meta-analysis(8434 cases and 770180 controls,discovery dataset)and the Fingen GWAS(2275 cases and 372727 controls,replication dataset).This analysis was conducted using the inverse-variance weighted method,followed by various sensitivity *** One SD increase in the genetically predicted haemoglobin concentration(HGB)was associated with aβof 0.0078(95%CI:0.0059-0.0096),0.0108(95%CI:0.0080-0.0136),0.0361(95%CI:0.0156-0.0567),and 0.0083(95%CI:00046-0.0121)for alkaline phosphatase(ALP),alanine aminotransferase(ALT),aspartate aminotransferase,and gammaglutamyl transferase,*** predicted haematocrit was associated with ALP(β=0.0078,95%CI:0.0052-0.0104)and ALT(β=0.0057,95%CI:0.0039-0.0075).Genetically determined HGB and the reticulocyte fraction of red blood cells increased the risk of NAFLD[odds ratio(OR)=1.199,95%CI:1.087-1.322]and(OR=1.157,95%CI:1.071-1.250).The results of the sensitivity analyses remained *** Novel causal blood cell traits related to liver enzymes and NAFLD development were revealed through Mendelian randomization analysis,which may facilitate the diagnosis and prevention of NAFLD.

关键词： Blood cell counts Liver enzymes Nonalcoholic fatty liver disease Genome-wide association Mendelian randomization study Causal relationship

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Association between QRS voltages and amyloid burden in patients with cardiac amyloidosis

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Chinese Medical Journal 2024年第3期137卷 365-367页

作者： Jing-Hui Li Changcheng Li Yucong Zheng Kai Yang Yan Huang Huixin Zhang Xianmei Li Xiuyu Chen Linlin Dai Tian Lan Yang Sun Minjie Lu Shihua Zhao department of Magnetic Resonance imaging Fuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China department of Radiology Taian City Central Hospital(The Affiliated Taian City Central Hospital of Qingdao University)Tai’anShandong 271099China department of Radiology Tsinghua University HospitalTsinghua UniversityBeijing 100084China department of Radiology The Fifth People’s Hospital of Huai’anHuai’anJiangsu 223001China department of Radiology Geriatric Hospital of Nanjing Medical UniversityNanjingJiangsu 210000China department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China department of Pathology Fuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

To the Editor:Cardiac amyloidosis(CA)is an infiltrative cardiomyopathy characterized by extracellular deposition of misfolded insoluble amyloid fibrils.^([1])Electrocardiography(ECG)is an essential diagnostic test characterized by low QRS voltages in CA,observed in 20–74%of patients.^([2])Cipriani et al^([3])reported that low QRS voltages could independently predict cardiovascular *** the mechanisms underlying low QRS voltages in CA remain unclear.

关键词： amyloid patients death.

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Prevalence and risk evaluation of cardiovascular disease in the newly diagnosed prostate cancer population in China:A nationwide,multi-center,population-based cross-sectional study

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Chinese Medical Journal 2024年第11期137卷 1324-1331页

作者： Weiyu Zhang Huixin Liu Ming Liu Shi Ying Renbin Yuan Hao Zeng Zhenting Zhang Sujun Han Zhannan Si Bin Hu Simeng Wen Pengcheng Xu Weimin Yu Hui Chen Liang Wang Zhitao Lin Tao Dai Yunzhi Lin Tao Xu department of Urology Peking University People’s HospitalBeijing 100044China department of Clinical Epidemiology and Biostatistics Peking University People’s HospitalBeijing 100044China department of Urology Beijing HospitalNational Center of GerontologyBeijing 100005China Institute of Geriatric Medicine Chinese Academy of Medical SciencesBeijing 100005China department of Urology Wuhan Union HospitalHuazhong University of Science&TechnologyWuhanHubei 430022China department of Urology The Third People’s Hospital of ChengduChengduSichuan 610014China department of Urology West China Hospital of Sichuan UniversityChengduSichuan 610041China department of Urologic Oncology Tianjin Medical University Cancer Institute&HospitalTianjin 300060China department of Urology Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China National Cancer Center Beijing 100021China National Clinical Research Center for Cancer Beijing 100021China department of Urology Liaoning Cancer HospitalShenyangLiaoning 110801China department of Urology The Second Hospital of Tianjin Medical UniversityTianjin 300141China Tianjin Institute of Urology Tianjin Medical UniversityTianjin 300141China department of Urology Lu’an Affiliated Hospital of Anhui Medical UniversityLu’anAnhui 237322China department of Urology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China department of Urology Harbin Medical University Affiliated Cancer HospitalHarbinHeilongjiang 150081China department of Urology The Second Hospital of Dalian Medical UniversityDalianLiaoning 116023China department of Urology Surgery Fujian Cancer HospitalFuzhouFujian 350014China department of Urology Surgery Hunan Cancer HospitalChangshaHunan 410031China department of Urology Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350004China

Background:cardiovascular disease(CVD)has emerged as the leading cause of death from prostate cancer(PCa)in recent decades,bringing a great disease burden *** with preexisting CVD have an increased risk for major adverse cardiovascular events when treated with androgen deprivation therapy(ADT).The present study aimed to explore the prevalence and risk evaluation of CVD among people with newly diagnosed PCa in ***:Clinical data of newly diagnosed PCa patients were retrospectively collected from 34 centers in China from 2010 to 2022 through convenience *** was defined as myocardial infarction,arrhythmia,heart failure,stroke,ischemic heart disease,and *** risk was estimated by calculating Framingham risk scores(FRS).Patients were accordingly divided into low-,medium-,and high-risk groups.χ2 or Fisher’s exact test was used for comparison of categorical ***:A total of 4253 patients were enrolled in the present study.A total of 27.0%(1147/4253)of patients had comorbid PCa and CVD,and 7.2%(307/4253)had two or more *** enrolled population was distributed in six regions of China,and approximately 71.0%(3019/4253)of patients lived in urban *** imaging and pathological evaluation,most PCa patients were diagnosed at an advanced stage,with 20.5%(871/4253)locally progressing and 20.5%(871/4253)showing *** of them initiated prostatectomy(46.6%,1983/4253)or regimens involving ADT therapy(45.7%,1944/4253)for prostate *** the present PCa cohort,43.1%(1832/4253)of patients had hypertension,and half of them had poorly controlled blood *** FRS stratification,as expected,a higher risk of CVD was related to aging and metabolic ***,we also found that patients with treatment involving ADT presented an originally higher risk of CVD than those without *** was in accordance with clinical practice,i.e.,aged patients or patients at advanced oncological stages were inclined to accept sys

关键词： Prostate cancer Castration cardiovascular disease Prevalence cardiovascular risk

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Long-term outcomes of titanium-nitride-oxide coated stents and drug-eluting stents in acute coronary syndrome:A systematic review and meta-analysis

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World Journal of Cardiology 2024年第5期16卷 293-305页

作者： Muhammad Ahmed Ali Fahim Afia Salman Hira Anas Khan Syed Muhammad Hasan Muskan FatimaBhojani Sarah Aslam Amna Zia Ul Haq Vishal Reddy Bejugam Beena Muntaha Nasir Wajiha Gul Abdul Moeed Abdelrahman S Abdalla Muhammad Majid Muhammad Sohaib Asghar Md Al Hasibuzzaman department of Internal Medicine Dow University of Health SciencesKarachi 74200Pakistan department of Internal Medicine North Central Bronx HospitalBronxNY 10467United States department of Urology Center for Academic MedicineStanford University School of MedicinePalo AltoCA 33872United States department of cardiovascular imaging Cleveland ClinicClevelandOH 44195United States Division of Nephrology and Hypertension Mayo Clinic RochesterRochesterMN 55905United States Institute of Nutrition and Food Science University of DhakaDhaka 1000Bangladesh

BACKGROUND In severe cases of coronary artery disease,percutaneous coronary intervention provide promising *** stent used could be a drug-eluting stent(DES)or a titanium-nitride-oxide coated stent(TiNOS).AIM To compare the 5-year effectiveness and safety of the two stent *** The following systematic review and meta-analysis was conducted in accordance with the preferred reporting items for systematic reviews and meta-analysis guidelines,and PubMed/MEDLINE,Scopus,and Cochrane Central were searched from inception till August *** outcomes were major adverse cardiac events(MACE),cardiac death,myocardial infarction(MI),cardiac death or MI,and ischemia-driven total lesion revascularization(ID-TLR).RESULTS Four randomized controlled trials(RCT),which analyzed a sum total of 3045 patients with acute coronary syndrome(ACS)after a median follow-up time of 5 years were *** statistically insignificant,an increase in the ID-TLR was observed in patients receiving TiNOSs vs *** addition,MI,cardiac death and MI,and definite stent thrombosis(DST)were significantly decreased in the TiNOS *** analysis revealed no significant results with meta-regression presenting non-ST elevated MI(NSTEMI)as a statistically significant covariate in the outcome of *** TiNOS was found to be superior to DES in terms of MI,cardiac death or MI,and DST outcomes,however,the effect of the two stent types on ID-TLR and MACE was not significant.A greater number of studies are required to establish an accurate comparison of patient outcomes in TiNOS and DES.

关键词： Stents Drug-eluting Major adverse cardiac events All-cause death Meta-analysis

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Coinfection with hepatic cystic and alveolar echinococcosis with abdominal wall abscess and sinus tract formation:A case report

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World Journal of Hepatology 2024年第2期16卷 279-285页

作者： Miao-Miao Wang Xiu-Qing An Jin-Ping Chai Jin-Yu Yang Ji-De A Xiang-Ren A School of Continuing Education Qinghai UniversityXining 810000Qinghai ProvinceChina department of Internal Medicine-cardiovascular Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina department of General Surgery Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina department of Hepatic Hydatidosis Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina department of Medical Laboratory Medicine Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina

BACKGROUND Hepatic cystic and alveolar echinococcosis coinfections,particularly with concurrent abscesses and sinus tract formation,are extremely *** article presents a case of a patient diagnosed with this unique presentation,discussing the typical imaging manifestations of both echinococcosis types and detailing the diagnosis and surgical treatment experience *** SUMMARY A 39-year-old Tibetan woman presented with concurrent hepatic cystic and alveolar echinococcosis,accompanied by abdominal wall abscesses and sinus tract *** conventional imaging examinations suggested only hepatic cystic echinococcosis,but intraoperative and postoperative pathological examination revealed the *** radical resection of the lesions,the patient’s condition improved,and she was discharged soon *** outpatient follow-ups confirmed no recurrence of the hydatid lesion and normal surgical wound *** mixed hepatic cystic and alveolar echinococcosis with abdominal wall abscesses and sinus tract formations are rare,the general treatment approach remains consistent with that of simpler infections of alveolar *** Lesions involving the abdominal wall and sinus tract formation,may require radical ***-term prognosis includes albendazole and follow-up examinations.

关键词： Cystic echinococcosis Alveolar echinococcosis Abdominal wall abscess Surgical treatment Sinus tract Case report

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Exploring non-invasive diagnostics for metabolic dysfunctionassociated fatty liver disease

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World Journal of Gastroenterology 2024年第28期30卷 3447-3451页

作者： Biao Qu Zheng Li department of Clinical Pharmacology The Second Hospital of Anhui Medical UniversityHefei 230601Anhui ProvinceChina Jiangsu Engineering Research Center of cardiovascular Drugs Targeting Endothelial Cells College of Health SciencesSchool of Life SciencesJiangsu Normal UniversityXuzhou 221000Jiangsu ProvinceChina

The population with metabolic dysfunction-associated fatty liver disease(MAFLD)is increasingly common *** of people at risk of progression to advanced stages is necessary to timely offer interventions and appropriate *** biopsy is currently considered the gold standard for the diagnosis and staging of MAFLD,but it has associated risks and *** has spurred the exploration of non-invasive diagnostics for MAFLD,especially for steatohepatitis and *** non-invasive approaches mostly include biomarkers and algorithms derived from anthropometric measurements,serum tests,imaging or stool metagenome ***,they still need rigorous and widespread clinical validation for the diagnostic performance.

关键词： Metabolic dysfunction-associated fatty liver disease Non-invasive diagnostics Circulating biomarkers imaging biomarkers Stool microbial biomarkers

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What benefit can be obtained from magnetic resonance imaging diagnosis with artificial intelligence in prostate cancer compared with clinical assessments?

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Military Medical Research 2024年第2期11卷 268-286页

作者： Li-Tao Zhao Zhen-Yu Liu Wan-Fang Xie Li-Zhi Shao Jian Lu Jie Tian Jian-Gang Liu School of Engineering Medicine Beihang UniversityBeijing 100191China School of Biological Science and Medical Engineering Beihang UniversityBeijing 100191China CAS Key Laboratory of Molecular imaging Institute of AutomationBeijing 100190China University of Chinese Academy of Sciences Beijing 100080China department of Urology Peking University Third HospitalPeking UniversityBeijing 100191China Key Laboratory of Big Data‑Based Precision Medicine(Beihang University) Ministry of Industry and Information Technology of the People's Republic of ChinaBeijing 100191China Beijing Engineering Research Center of cardiovascular Wisdom Diagnosis and Treatment Beijing 100029China

The present study aimed to explore the potential of artificial intelligence(AI)methodology based on magnetic resonance(MR)images to aid in the management of prostate cancer(PCa).To this end,we reviewed and summarized the studies comparing the diagnostic and predictive performance for PCa between AI and common clinical assessment methods based on MR images and/or clinical characteristics,thereby investigating whether AI methods are generally superior to common clinical assessment methods for the diagnosis and prediction fields of ***,we found that,in the included studies of the present study,AI methods were generally equal to or better than the clinical assessment methods for the risk assessment of PCa,such as risk stratification of prostate lesions and the prediction of therapeutic outcomes or PCa *** particular,for the diagnosis of clinically significant PCa,the AI methods achieved a higher summary receiver operator characteristic curve(SROC-AUC)than that of the clinical assessment methods(0.87 vs.0.82).For the prediction of adverse pathology,the AI methods also achieved a higher SROC-AUC than that of the clinical assessment methods(0.86 vs.0.75).Second,as revealed by the radiomics quality score(RQS),the studies included in the present study presented a relatively high total average RQS of 15.2(11.0–20.0).Further,the scores of the individual RQS elements implied that the AI models in these studies were constructed with relatively perfect and standard radiomics processes,but the exact generalizability and clinical practicality of the AI models should be further validated using higher levels of evidence,such as prospective studies and open-testing datasets.

关键词： Clinically significant prostate cancer Adverse pathology Radiomics quality score Artificial intelligence Magnetic resonance imaging

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Long non-coding RNA-AK138945 regulates myocardial ischemia-reperfusion injury via the miR-1-GRP94 signaling pathway

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Frigid Zone Medicine 2024年第1期4卷 31-40页

作者： Yanying Wang Jian Huang Han Sun Jie Liu Yingchun Shao Manyu Gong Xuewen Yang Dongping Liu Zhuo Wang Haodong Li Yanwei Zhang Xiyang Zhang Zhiyuan Du Xiaoping Leng Lei Jiao Ying Zhang State Key Laboratory of Frigid Zone cardiovascular Diseases and Pharmacology Department of Pharmacy college of Harbin Medical UniversityHarbin 150081China The Fourth department of Medical Oncology Harbin Medical University Cancer HospitalHarbin 150040China department of Ultrasound imaging the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Cancer Institute The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao Cancer InstituteQingdao 266071China College of Bioinformatics Science and Technology Harbin Medical UniversityHarbin 150081China

Objective:Myocardial ischemia-reperfusion injury(MIRI)is one of the leading causes of death from cardiovascular disease in humans,especially in individuals exposed to cold *** non-coding RNAs(lncRNAs)regulate MIRI through multiple *** study explored the regulatory effect of lncRNA-AK138945 on myocardial ischemia-reperfusion injury and its ***:In vivo,8-to 12-weeks-old C57BL/6 male mice underwent ligation of the left anterior descending coronary artery for 50 minutes followed by reperfusion for 48 *** vitro,the primary cultured neonatal mouse ventricular cardiomyocytes(NMVCs)were treated with 100μmol/L hydrogen peroxide(H_(2)O_(2)).The knockdown of lncRNA-AK138945 was evaluated to detect cardiomyocyte apoptosis,and a glucose-regulated,endoplasmic reticulum stress-related protein 94(GRP94)inhibitor was used to detect myocardial ***:We found that the expression level of lncRNA-AK138945 was reduced in MIRI mouse heart tissue and H2O2-treated ***,the proportion of apoptosis in cardiomyocytes increased after lncRNA-AK138945 was *** expression level of Bcl2 protein was decreased,and the expression level of Bad,Caspase 9 and Caspase 3 protein was *** further study found that miR-1a-3p is a direct target of lncRNA-AK138945,after lncRNA-AK138945 was silenced in cardiomyocytes,the expression level of miR-1a-3p was increased while the expression level of its downstream protein GRP94 was ***,treatment with a GRP94 inhibitor(PU-WS13)intensified H2O2-induced cardiomyocyte *** overexpression of FOXO3,the expression levels of lncRNA-AK138945 and GRP94 were increased,while the expression levels of miR-1a-3p were ***:LncRNA-AK138945 inhibits GRP94 expression by regulating miR-1a-3p,leading to cardiomyocyte *** transcription factor Forkhead Box Protein O3(FOXO3)participates in cardiomyocyte apoptosis induced by endoplasmic reticulum s

关键词： myocardial ischemia reperfusion lncRNA apoptosis microRNAGRP94

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